Evidence of Erroneous Deductions and their Possible Effects on the Initial Learning of the Concept of Cell in Primary School

En este trabajo se han obtenido evidencias sobre dificultades para procesar información referida al concepto de célula en estudiantes de escuela primaria. Se identificaron posibles deducciones erróneas que podrían establecer estudiantes de 5to grado (10-11 años) que intentaran procesar cognitivamente, y por primera vez, la información de libros de texto escolares y del discurso docente sobre el tema y se diseñó un cuestionario con el objetivo de hallar evidencia de estas deducciones. Fue posible detectar algunas evidencias de construcción de modelos explicativos incipientes siendo destacable la aparición de modelos consistentes, pero científicamente incorrectos. Luego, se aplicó el mismo cuestionario a estudiantes de 6to y 7mo grado (11-13 años) y se observó que algunos patrones de respuesta se mantenían e, incluso, se afianzaban. Estos modelos podrían dar cuenta del origen de errores o dificultades en la comprensión del concepto célula en estudiantes de niveles educativos subsiguientes.In this paper we have obtained some evidence on difficulties in processing information about the cell among primary school students. We identified possible misleading deductions that 5th grade students (10-11 years) could establish when trying, for the first time, to cognitively process information on the subject from school textbooks and teacher discourse, and we designed a questionnaire to find evidence of these deductions. It was possible to detect some evidence of incipient explanatory models. It is important to highlight the emergence of consistent but scientifically incorrect models. Then, the same questionnaire was applied to 6th and 7th grade students (11-13 years), and it was found that some response patterns prevailed and were even reinforced. These models could account for the origin of errors or difficulties in understanding the concept of cell among students of subsequent educational levels.Fil: Edelsztein, Valeria Carolina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Formación e Investigación en Enseñanza de las Ciencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Galagovsky, Lydia Raquel. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Formación e Investigación en Enseñanza de las Ciencias; Argentin

Spinal dural arteriovenous fistula in a patient with gait disturbances

We present a case of a man who came to our hospital with complaint of progressive gait disturbances, paresthesias, erectile dysfunction, bowel and bladder retention. IMAGING FINDINGS We present a case of a 67-year-old patient with no remarkable previous clinical history. He came to our hospital complaining of 40 day progressive gait disturbances especially for the initial steps, paresthesias in his left lower limb, and specifically asked, he also referred progressive erectile dysfunction and 20 to 25 days evolution of bowel and bladder retention. The patient was sent to the radiology department for a lumbar MRI with suspicion of medullar compression. In the sagittal T2-weighted sequences cord oedema was perceived and perimedullary flow voids were identified Within the next weeks the patient referred an improvement in the lower limbs sensitivity and the gait disturbances, being able to walk about 5-6 Km a day, but he did not notice an improvement in the bowel retention. Follow-up MRI showed resolution of the spinal cord oedem

Elecciones generales del 14 de mayo de 1995: cobertura periodística de Radio Universidad

Radio Universidad Nacional de La Plata adoptó y mantuvo como política periodística e informativa cubrir exhaustivamente las elecciones nacionales, provinciales, locales y universitarias mediante programas especiales, con numerosos móviles, periodistas acreditados en las sedes de las parcialidades y contactos telefónicos con otras radios universitarias para intercambiar al aire la información y resultados de cada distrito. El 14 de mayo de 1995 se celebraron los comicios en los que resultó reelecto el presidente Carlos S. Menem, el gobernador de la provincia de Buenos Aires, Eduardo Duhalde, y el intendente de La Plata, Julio Alak, entre otros funcionarios ejecutivos y legisladores. Con la conducción periodística de Cintia Rodil y Mariano Pérez de Eulate, se emite el programa especial (del cual se puede escuchar un fragmento) para llevar los resultados, circunstancias electorales y declaraciones de los protagonistas a lo largo de seis horas.Este programa especial de LR 11 Radio Universidad Nacional de La Plata fue realizado por: Conducción: Cintia Rodil y Mariano Pérez de Eulate Periodistas acreditados: Virginia Venere, Alejandro Caviglione Técnicos operadores: Daniel Curubeto y Roberto Fuentes Técnico en exteriores: Hugo Peluso Locución: Roberto Larraya Producción general: Daniel García Produción: Cintia Neve y Sabrina Carrasco Servicio informativo: Betina Rolfi y Mario ArtecaRadio Universidad Nacional de La Plat

Discovery of Novel Inhibitors of Uridine Diphosphate-N-Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa, an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients.

Pseudomonas aeruginosa is of major concern for cystic fibrosis patients where this infection can be fatal. With the emergence of drug-resistant strains, there is an urgent need to develop novel antibiotics against P. aeruginosa. MurB is a promising target for novel antibiotic development as it is involved in the cell wall biosynthesis. MurB has been shown to be essential in P. aeruginosa, and importantly, no MurB homologue exists in eukaryotic cells. A fragment-based drug discovery approach was used to target Pa MurB. This led to the identification of a number of fragments, which were shown to bind to MurB. One fragment, a phenylpyrazole scaffold, was shown by ITC to bind with an affinity of Kd = 2.88 mM (LE 0.23). Using a structure guided approach, different substitutions were synthesized and the initial fragment was optimized to obtain a small molecule with Kd = 3.57 μM (LE 0.35).M.A.G.D.E. was supported by American leprosy Missions Grant (G88726). J.M.L., S.Y.K. and O.D.P. were funded by the Cystic Fibrosis Trust and Fondation Botnar (Grant No. 6063). C.M. was funded by the Bill and Melinda Gates Foundation, Hit-TB (OPP1024021). J.H. was funded by the Swiss National Science Foundation (SNSF Early PostDoc. Mobility Fellowship P2ZHP2_164947) and the Marie Curie Research Grant Scheme, EU H2020 Framework Programme (H2020-MSCA-IF-2017, ID: 789607). V.M. was funded by the Bill and Melinda Gates Foun- dation, Hit-TB (OPP1024021) and SHORTEN-TB (OPP1158806). KPB and RAF were funded by NIHR Cambridge Biomedical Research Centre. CA, RAF and TLB by the UK Cystic Fibrosis Trust (SRC010). RAF was funded by the Well- come Trust 107032AIA. And RAF and TLB were founded by the UK Cystic Fibrosis Trust (Innovation Hub grant 001)

Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach.

Mycobacterium abscessus (Mab) has emerged as a challenging threat to individuals with cystic fibrosis. Infections caused by this pathogen are often impossible to treat due to the intrinsic antibiotic resistance leading to lung malfunction and eventually death. Therefore, there is an urgent need to develop new drugs against novel targets in Mab to overcome drug resistance and subsequent treatment failure. In this study, SAICAR synthetase (PurC) from Mab was identified as a promising target for novel antibiotics. An in-house fragment library screen and a high-throughput X-ray crystallographic screen of diverse fragment libraries were explored to provide crucial starting points for fragment elaboration. A series of compounds developed from fragment growing and merging strategies, guided by crystallographic information and careful hit-to-lead optimization, have achieved potent nanomolar binding affinity against the enzyme. Some compounds also show a promising inhibitory effect against Mab and Mtb. This work utilizes a fragment-based design and demonstrates for the first time the potential to develop inhibitors against PurC from Mab