Development of techniques and associated instrumentation for high temperature emissivity measurements Quarterly progress report, 30 Sep. - 31 Dec. 1970

Emittance measurement techniques for space shuttle materials in high temperature environmental simulatio

Development of techniques and associated instrumentation for high temperature emissivity measurements

The calibrating and testing procedures for the radiometric emittance measurement apparatus are described. Test results are given for the NBS platinum-rhodium standard (SRM No. 1409), the NBS oxidized Kanthal standard, and the oxidized Rene 41 materials. Results indicate that with the platinum-rhodium standard the measurement system compared with the NBS data to within 0.02 for both total and spectral normal emitttance. Data from the Kanthal strip was consistently higher than NBS values. For oxidized Rene 41, no significant changes in as prepared emittance was observed. The emittance was stable for temperatures up to 1150 K

Radiative properties of advanced spacecraft heat shield materials

Experimental results are presented to show the effects of simulated reentry exposure by convective heating and by radiant heating on spectral and total emittance of statically oxidized Inconel 617 and Haynes HS188 superalloys to 1260 K and a silicide coatea (R512E) columbium 752 alloy to 1590 K. Convective heating exposures were conducted in a supersonic arc plasma wind tunnel using a wedge-shaped specimen configuration. Radiant tests were conducted at a pressure of .003 atmospheres of dry air at a flow velocity of several meters per second. Convective heating specimens were subjected to 8, 20, and 38 15-min heating cycles, and radiant heating specimens were tested for 10, 20, 50, and 100 30-min heating cycles. Changes in radiative properties are explained in terms of changes in composition resulting from simulated reentry tests. The methods used to evaluate morphological, compositional and crystallographic changes include: Auger electron spectroscopy; scanning electron microscopy; X-ray diffraction analysis; and electron microprobe analysis

Spirituality, Faith, and Mild Alzheimer\u27s Disease

There is some evidence for a positive association between spirituality, cognitive, and behavioral functioning in people with Alzheimer’s disease (AD). However, to our knowledge there is no published data to date that provides an explanatory model for these findings. Twenty-eight individuals with mild AD received in-depth interviews and measures of cognitive, behavioral, emotional, and spiritual functioning to gain insight into this question in this mixed methods study. Findings revealed that people with mild AD can actively engage in meaningful discussion about how spirituality influences their experience of living with AD; that they remain deeply devoted to a relationship with the transcendent (i.e., God, higher power, spirit) and their spiritual communities; that they value and benefit from the sacred aspects of their day-to-day lives; and that their core spiritual values, beliefs, and practices can be activated to help them adapt to the uncertainty of living with AD. Additionally, persons with AD who are experiencing spiritual struggle tend to experience a greater degree of anxiety, depression, and behavioral changes as compared to those who do not, suggesting that spiritual struggle is a risk factor for poorer outcomes in this population. Implications for future research, clinical practice, and community care are provided including how researchers and clinicians can effectively adapt traditional measures of spirituality for use with this population; the importance of integrating spirituality into the assessment and treatment of people with AD; and the role spiritual communitie

Anticipated resource utilization for injury versus non-injury pediatric visits to emergency departments

Background Childhood injuries are increasingly treated in emergency departments (EDs) but the relationship between injury severity and ED resource utilization has not been evaluated. The objective of this study was to compare resource utilization for pediatric injury-related ED visits across injury-severity levels and with non-injury visits, using standardized, validated scales. Methods A retrospective analysis of 2004-2008 ED visits from the Pediatric Emergency Care Applied Research Network Core Data Project. Maximum Abbreviated Injury Scale severity (MAIS) and Severity Classification System (SCS) scores were calculated and compared. MAIS and SCS are ordinal scales from 1 (minor injury) to 6, and 1 (low anticipated resource utilization) to 5, respectively. ED length of stay (LOS) and admission percentages were calculated as comparative proxy measures of resource utilization. Results There were 763,733 injury visits and 2,328,916 non-injury visits, most with SCS of 2 or 3. Of the injured patients, 59.2 % had an MAIS of 1. ED LOS and admission percentage increased with increasing MAIS from 1-5. LOS and admission percentage increased with increasing SCS in both samples. Median LOS was shorter for injured versus non-injured patients with SCS 3-5. Non-injured patients with SCS 2-5 were more likely admitted than injured patients. Most injured patients had an SCS 3 with an MAIS 1-2, or an SCS 2 with an MAIS 1, with no correlation between the two scales. Conclusion While admission rates and LOS increase with increasing AIS and SCS severity, these two classification schemas do not reliably correlate. Similarly, ED visit metrics differ between injured and non-injured patients in similar SCS categories. Although AIS and SCS both have value, these differences should be considered when using these schemas in research and quality improvement

Leptin Reduces the Expression and Increases the Phosphorylation of the Negative Regulators of GLUT4 Traffic TBC1D1 and TBC1D4 in Muscle of ob/ob Mice

Leptin improves insulin sensitivity in skeletal muscle. Our goal was to determine whether proteins controlling GLUT4 traffic are altered by leptin deficiency and in vivo leptin administration in skeletal muscle of wild type and ob/ob mice. Leptin-deficient ob/ob mice were divided in three groups: control, leptin-treated (1 mg/kg/d) and leptin pair-fed ob/ob mice. Microarray analysis revealed that 1,546 and 1,127 genes were regulated by leptin deficiency and leptin treatment, respectively. Among these, we identified 24 genes involved in intracellular vesicle-mediated transport in ob/ob mice. TBC1 domain family, member 1 (Tbc1d1), a negative regulator of GLUT4 translocation, was up-regulated (P = 0.001) in ob/ob mice as compared to wild types. Importantly, leptin treatment reduced the transcript levels of Tbc1d1 (P<0.001) and Tbc1d4 (P = 0.004) in the leptin-treated ob/ob as compared to pair-fed ob/ob animals. In addition, phosphorylation levels of TBC1D1 and TBC1D4 were enhanced in leptin-treated ob/ob as compared to control ob/ob (P = 0.015 and P = 0.023, respectively) and pair-fed ob/ob (P = 0.036 and P = 0.034, respectively) mice. Despite similar GLUT4 protein expression in wild type and ob/ob groups a different immunolocalization of this protein was evidenced in muscle sections. Leptin treatment increased GLUT4 immunoreactivity in gastrocnemius and extensor digitorum longus sections of leptin-treated ob/ob mice. Moreover, GLUT4 protein detected in immunoprecipitates from TBC1D4 was reduced by leptin replacement compared to control ob/ob (P = 0.013) and pair-fed ob/ob (P = 0.037) mice. Our findings suggest that leptin enhances the intracellular GLUT4 transport in skeletal muscle of ob/ob animals by reducing the expression and activity of the negative regulators of GLUT4 traffic TBC1D1 and TBC1D4