Caracterização ontogenética de cultivares brasileiras de trigo.

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Gonococcal Acute Septic Arthritis in Immunocompetent Patients

The objective of this study is to estimate the clinical evolution and the biological values and of three cases suffering from Gonococcal acute septic arthritis (GASA).Our study is based in a thoroughfully screening of 18 patients hospitalized in our service during the period of time of March 2011 – July 2016. Among those 18 cases, 12 of them (66.7%) were diagnosed with Acute Septic Arthritis (ASA) due to Staphylococcus aureus, 3 cases (16.65%) were diagnosed with ASA due to Neisseria gonorrhoeae, and 3 other cases (16.65%) were diagnosed with ASA due to Streptococcus pneumoniae, Escherichia coli and Echinella corrodens. Two sexually active women at the seventh and tenth day of an untreated suppurative cervico-vaginitis and one man at the eighth day of an untreated suppurative urethritis were consulted at the Service of Infectious Diseases of University Hospital Center “Mother Theresa”, because of: severe pains in left wrist, in the left elbow and in the right knee, swollen of those articulation, difficulties in their movements, shivering and a high fever of   38-39.2ºC. Neisseria gonorrhea was insolated in three cases in blood cultures and cervical/urethral samples and they were sensitive towards Cyclines, Cephalosporins and Fluoroquinolones. All three patients were immunocompetent. Keywords: Neisseria gonorrhea, Acute Septic Arthritis, Biological values

Pro-asthmatic cytokines regulate unliganded and ligand-dependent glucocorticoid receptor signaling in airway smooth muscle

To elucidate the regulation of glucocorticoid receptor (GR) signaling under pro-asthmatic conditions, cultured human airway smooth muscle (HASM) cells were treated with proinflammatory cytokines or GR ligands alone and in combination, and then examined for induced changes in ligand-dependent and -independent GR activation and downstream signaling events. Ligand stimulation with either cortisone or dexamethsone (DEX) acutely elicited GR translocation to the nucleus and, comparably, ligand-independent stimulation either with the Th2 cytokine, IL-13, or the pleiotropic cytokine combination, IL-1β/TNFα, also acutely evoked GR translocation. The latter response was potentiated by combined exposure of cells to GR ligand and cytokine. Similarly, treatment with either DEX or IL-13 alone induced GR phosphorylation at its serine-211 residue (GRSer211), denoting its activated state, and combined treatment with DEX+IL-13 elicited heightened and sustained GRSer211phosphorylation. Interestingly, the above ligand-independent GR responses to IL-13 alone were not associated with downstream GR binding to its consensus DNA sequence or GR transactivation, whereas both DEX-induced GR:DNA binding and transcriptional activity were significantly heightened in the presence of IL-13, coupled to increased recruitment of the transcriptional co-factor, MED14. The stimulated GR signaling responses to DEX were prevented in IL-13-exposed cells wherein GRSer211 phosphorylation was suppressed either by transfection with specific serine phosphorylation-deficient mutant GRs or treatment with inhibitors of the MAPKs, ERK1/2 and JNK. Collectively, these novel data highlight a heretofore-unidentified homeostatic mechanism in HASM cells that involves pro-asthmatic cytokine-driven, MAPK-mediated, non-ligand-dependent GR activation that confers heightened glucocorticoid ligand-stimulated GR signaling. These findings raise the consideration that perturbations in this homeostatic cytokine-driven GR signaling mechanism may be responsible, at least in part, for the insensirtivity to glucocorticoid therapy that is commonly seen in individuals with severe asthma

Educational profile of young soccer players in the State of Rio de Janeiro

O estudo teve como objetivo descrever o perfil escolar de atletas que atuam no Estado do Rio de Janeiro e que se encontram no período da escolarização básica. O estudo teve uma abordagem quantitativa e qualitativa. Foram realizadas entrevistas estruturadas com amostra não probabilística composta por 417 jogadores das categorias de base, inscritos no ano de 2009 na Federação de Futebol do Estado do Rio de Janeiro e 30 entrevistas semiestruturadas. Os resultados apontaram que os atletas permanecem na escola, todavia a troca de turno escolar e o baixo capital cultural podem afetar negativamente a sua trajetória escolar. A profissionalização no futebol torna-se um projeto familiar e talvez incida sobre o foco que o atleta tenha sobre o processo de escolarização. Os dados sugerem que quanto maior os investimentos do atleta na carreira, maior será a probabilidade de secundarizar os investimentos escolares.The study aimed to describe the educational profile of athletes who work in the State of Rio de Janeiro and in the period of basic schooling. The study had a quantitative and qualitative approach. Structured interviews were conducted with non-probability sample consists of 417 players of the base categories, inscribed in the year 2009 in the Soccer Federation of Rio de Janeiro State and 30 semi-structured interviews. The results showed that the athletes remain at the school; however the flight rotation and low cultural capital can negatively affect his career. To become a professional of soccer is a project which involves all athlete’s family, and maybe this is what makes him not prioritize his formal education. Our data suggest that the more the athlete invest in his career, the more the probability of putting school in the background