The response of cylindrical panels fabricated from symmetrically and unsymmetrically laminated composite materials

Equations are developed which govern the deflection response of long cylindrical panels subjected to a line load. The line load is directed toward the center of curvature of the panel, is located at an arbitrary point along the arc length of the panel, and is included at an arbitrary angle relative to the radial direction. Only the geometrically linear problem is considered and the spatial dependence in the problem is reduced to one independent variable, specifically, the arc length along the panel. The problem is thus solvable in closed form. Both symmetrically laminated and the less common unsymmetrically laminated simply supported panels are studied. The unsymmetrically laminated case was considered because the natural shape of an unsymmetric laminate is cylindrical. Results are presented which show the influence of the location and inclination of the line load on panel deflection. Shallow and deep panels are considered. Both the symmetric and unsymmetric panels exhibit similar behavior, the unsymmetric configurations being less stiff. Limited experimental results are presented

Large Deformation Behavior of Long Shallow Cylindrical Composite Panels

An exact solution is presented for the large deformation response of a simply supported orthotropic cylindrical panel subjected to a uniform line load along a cylinder generator. The cross section of the cylinder is circular and deformations up to the fully snapped through position are investigated. The orthotropic axes are parallel to the generator and circumferential directions. The governing equations are derived using laminated plate theory, nonlinear strain-displacement relations, and applying variational principles. The response is investigated for the case of a panel loaded exactly at midspan and for a panel with the load offset from midspan. The mathematical formulation is one dimensional in the circumferential coordinate. Solutions are obtained in closed-form. An experimental apparatus was designed to load the panels. Experimental results of displacement controlled tests performed on graphite-epoxy curved panels are compared with analytical predictions

FUNDAMENTAL INVESTIGATION OF LIQUID-METAL LUBRICATED JOURNAL BEARINGS. Quarterly Technical Report No. 1

The objective of this program is to investigate the fundamentals of liquid-metal lubricated hydrodynamic bearings, leading to the development of design criteria and performance estimates

EMSL Quarterly Highlights Report Second Quarter, Fiscal Year 2010 (January 1, 2010 through March 31, 2010)

The Environmental Molecular Sciences Laboratory (EMSL) is a U.S. Department of Energy (DOE) national scientific user facility located at Pacific Northwest National Laboratory (PNNL) in Richland, Washington. EMSL is operated by PNNL for the DOE-Office of Biological and Environmental Research. At one location, EMSL offers a comprehensive array of leading-edge resources and expertise. Access to the instrumentation and expertise is obtained on a peer-reviewed proposal basis. Staff members work with researchers to expedite access to these capabilities. The "EMSL Quarterly Highlights Report" documents current research and activities of EMSL staff and users

Regression, developmental trajectory and associated problems in disorders in the autism spectrum: the SNAP study

We report rates of regression and associated findings in a population derived group of 255 children aged 9-14 years, participating in a prevalence study of autism spectrum disorders (ASD); 53 with narrowly defined autism, 105 with broader ASD and 97 with non-ASD neurodevelopmental problems, drawn from those with special educational needs within a population of 56,946 children. Language regression was reported in 30% with narrowly defined autism, 8% with broader ASD and less than 3% with developmental problems without ASD. A smaller group of children were identified who underwent a less clear setback. Regression was associated with higher rates of autistic symptoms and a deviation in developmental trajectory. Regression was not associated with epilepsy or gastrointestinal problems

Barriers to enrollment in a randomized controlled trial of hydrocortisone for cardiovascular insufficiency in term and late preterm newborn infants.

ObjectiveTo analyze reasons for low enrollment in a randomized controlled trial (RCT) of the effect of hydrocortisone for cardiovascular insufficiency on survival without neurodevelopmental impairment (NDI) in term/late preterm newborns.Study designThe original study was a multicenter RCT. Eligibility: ⩾34 weeks' gestation, <72 h old, mechanically ventilated, receiving inotrope. Primary outcome was NDI at 2 years; infants with diagnoses at high risk for NDI were excluded. This paper presents an analysis of reasons for low patient enrollment.ResultsTwo hundred and fifty-seven of the 932 otherwise eligible infants received inotropes; however, 207 (81%) had exclusionary diagnoses. Only 12 infants were randomized over 10 months; therefore, the study was terminated. Contributing factors included few eligible infants after exclusions, open-label steroid therapy and a narrow enrollment window.ConclusionDespite an observational study to estimate the population, very few infants were enrolled. Successful RCTs of emergent therapy may require fewer exclusions, a short-term primary outcome, waiver of consent and/or other alternatives

Role of early second-trimester uterine artery Doppler screening to predict small-for-gestational-age babies in nulliparous women

Background Trophoblastic invasion of the uterine spiral arteries substantially increases compliance to accommodate increased blood flow to the placenta. Failure of this process impedes uterine artery blood flow, and this may be detected by uterine artery Doppler flow studies. However, the clinical utility of uterine artery Doppler flow studies in the prediction of adverse pregnancy outcomes in a general population remains largely unknown. Objective We sought to determine the utility of early second-trimester uterine artery Doppler studies as a predictor of small-for-gestational-age neonates. Study Design Nulliparous women with a viable singleton pregnancy were recruited during their first trimester into an observational prospective cohort study at 8 institutions across the United States. Participants were seen at 3 study visits during pregnancy and again at delivery. Three indices of uterine artery Doppler flow (resistance index, pulsatility index, and diastolic notching) were measured in the right and left uterine arteries between 16 weeks 0 days’ and 22 weeks 6 days’ gestation. Test characteristics for varying thresholds in the prediction of small for gestational age (defined as birthweight <5th percentile for gestational age [Alexander growth curve]) were evaluated. Results Uterine artery Doppler indices, birthweight, and gestational age at birth were available for 8024 women. Birthweight <5th percentile for gestational age occurred in 358 (4.5%) births. Typical thresholds for the uterine artery Doppler indices were all associated with birthweight <5th percentile for gestational age (P < .0001 for each), but the positive predictive values for these cutoffs were all <15% and areas under receiver operating characteristic curves ranged from 0.50-0.60. Across the continuous scales for these measures, the areas under receiver operating characteristic curves ranged from 0.56-0.62. Incorporating maternal age, early pregnancy body mass index, race/ethnicity, smoking status prior to pregnancy, chronic hypertension, and pregestational diabetes in the prediction model resulted in only modest improvements in the areas under receiver operating characteristic curves ranging from 0.63-0.66. Conclusion In this large prospective cohort, early second-trimester uterine artery Doppler studies were not a clinically useful test for predicting small-for-gestational-age babies