Personalized medicine : the impact on chemistry

An effective strategy for personalized medicine requires a major conceptual change in the development and application of therapeutics. In this article, we argue that further advances in this field should be made with reference to another conceptual shift, that of network pharmacology. We examine the intersection of personalized medicine and network pharmacology to identify strategies for the development of personalized therapies that are fully informed by network pharmacology concepts. This provides a framework for discussion of the impact personalized medicine will have on chemistry in terms of drug discovery, formulation and delivery, the adaptations and changes in ideology required and the contribution chemistry is already making. New ways of conceptualizing chemistry’s relationship with medicine will lead to new approaches to drug discovery and hold promise of delivering safer and more effective therapies

A sex difference in the context-sensitivity of dominance perceptions

Although dominance perceptions are thought to be important for effective social interaction, their primary function is unclear. One possibility is that they simply function to identify individuals who are capable of inflicting substantial physical harm, so that the perceiver can respond to them in ways that maximize their own physical safety. Another possibility is that they are more specialized, functioning primarily to facilitate effective direct (i.e., violent) intrasexual competition for mates, particularly among men. Here we used a priming paradigm to investigate these two possibilities. Facial cues of dominance were more salient to women after they had been primed with images of angry men, a manipulation known to activate particularly strong self-protection motivations, than after they had been primed with images of angry women or smiling individuals of either sex. By contrast, dominance cues were more salient to men after they had been primed with images of women than when they had been primed with images of men (regardless of the emotional expressions displayed), a manipulation previously shown to alter men's impressions of the sex ratio of the local population. Thus, men's dominance perceptions appear to be specialized for effective direct competition for mates, while women's dominance perceptions may function to maximize their physical safety more generally. Together, our results suggest that men's and women's dominance perceptions show different patterns of context-sensitivity and, potentially, shed new light on the routes through which violence and intrasexual competition have shaped dominance perceptions

Modelling the impact of earthquake activity on real estate values: a multi-level approach

Purpose – This paper seeks to look at the impact of recent earthquake activity on house prices and their spatial distribution in the Istanbul housing market. Design/Methodology/Approach – The paper employs a multi-level approach within an event study framework to model changes in the pattern of house prices in Istanbul. The model allows us to isolate the effects of earthquake risk and explore the differential impact in different submarkets in two study periods - one before (2007) and one after (2012) recent earthquake activity in the Van region, which although in Eastern Turkey, served to alter the perceptions of risk through the wider geographic region. Findings – The analysis shows that their are variations in the size of price discounts in submarkets resulting from the differential influence of recent earthquake activity on perceived risk of damage. The model results show that the spatial impacts of these changes are not transmitted evenly across the study area. Rather it is clear that submarkets at the cheaper end of the market have proportionately larger negative impacts on real estate values. Practical implications – The methods introduced in this study can be used by real estate agents, valuers, and insurance companies to help them more accurately assess the likely impacts of changes in the perceived risk of earthquake activity (or other environmental events such as flooding) on the formation of house prices in different market segments. Originality/value – The paper represents an attempt to develop a novel extension of the standard use of hedonic models in event studies to investigate the impact of natural disasters on real estate values. The value of the approach is that it is able to better capture the granularity of the spatial effects of environmental events than the standard approach

Magnetised Thermal Self-focusing and Filamentation of Long-Pulse Lasers in Plasmas Relevant to Magnetised ICF Experiments

In this paper we study the influence of the magnetised thermal conductivity on the propagation of a nanosecond $10^{14} \mathrm{Wcm}^{-2}$ laser in an underdense plasma by performing simulations of a paraxial model laser in a plasma with the full Braginskii magnetised transport coefficients. Analytic theory and simulations show the shortening of the self-focal length of a laser beam in a plasma as a result of the reduction of the plasma thermal conductivity in a magnetic field. Furthermore the filamentation of a laser via the thermal mechanism is found to have an increased spatial growth rate in a magnetised plasma. We discuss the effect of these results on recent magnetised inertial fusion experiments where filamentation can be detrimental to laser propagation and uniform laser heating. We conclude the application of external magnetic fields to laser-plasma experiments requires the inclusion of the extended electron transport terms in simulations of laser propagation.Comment: 10 pages, 9 figure

It’s the way he tells them (and who is listening):men’s dominance is positively correlated with their preference for jokes told by dominant-sounding men

While much research has explored humorous exchange in relation to mate choice, recent perspectives have emphasized the importance of humor for monitoring interest within social partnerships more generally. Indeed, given that similarity is thought to be important in the maintenance of social partnerships, we may expect humor appreciation to vary according to the degree of similarity between humor producers and recipients. In the current study we report evidence for such variation that is specific to men’s judgments of other men’s humor. Here we manipulated voice pitch in a set of ‘one-liner’ jokes to create low-pitched and high-pitched versions of men and women telling jokes. A composite measure of men’s own dominance was positively correlated with their preference for jokes told by other men with lowered voice pitch (a vocal cue to dominance). A follow-up study demonstrated that self-reported dominance was positively related to men’s choice of low-pitch men as friends when judging humorous audio clips but not when judging neutral control audio clips, suggesting that humor may be important in mediating the effect of dominance on friendship choice. These studies indicate systematic variation in humor appreciation related to friendship choices which may function to promote cohesion within male partnerships based on status