The high-redshift Universe with the International X-ray Observatory

We discuss some of the main open issues related to the light-up and evolution of the first accreting sources powering high redshift luminous quasars. We discuss the perspectives of future deep X-ray surveys with the International X-ray Observatory and possible synergies with the Wide Field X-ray Telescope.Comment: 6 pages, 6 figures. Proceedings of "The Wide Field X-ray Telescope Workshop", held in Bologna, Italy, Nov. 25-26 2009. To appear in Memorie della Societ\`a Astronomica Italiana 2010 (arXiv:1010.5889

Relativistic Iron lines at high redshifts

The shape and the intensity of the 6.4 keV iron line bring unique information on the geometrical and physical properties of the supermassive black hole and the surrounding accreting gas at the very center of Active Galactic Nuclei. While there are convincing evidences of a relativistically broadened iron line in a few nearby bright objects, their properties at larger distances are basically unknown. We have searched for the presence of iron line by fully exploiting Chandra observations in the deep fields. The line is clearly detected in the average spectra of about 250 sources stacked in several redshift bins over the range z=0.5-4.0. We discuss their average properties with particular enphasys on the presence and intensity of a broad component.Comment: 6 pages, 4 figures. To appear in the proceedings of "Relativistic Astrophysics and Cosmology - Einstein's Legacy" (Eds.: B. Aschenbach, V. Burwitz, G. Hasinger, and B. Leibundgut), 7 - 11 November 2005, Munich, German

Is there any evidence that ionised outflows quench star formation in type 1 quasars at z<1?

The aim of this paper is to test the basic model of negative AGN feedback. According to this model, once the central black hole accretes at the Eddington limit and reaches a certain critical mass, AGN driven outflows blow out gas, suppressing star formation in the host galaxy and self-regulating black hole growth. We consider a sample of 224 quasars selected from the SDSS at z<1 observed in the infrared band by Herschel. We evaluate the star formation rate in relation to several outflow signatures traced by the [OIII]4959,5007 and [OII]3726,3729 emission lines in about half of the sample with high quality spectra. Most of the quasars show asymmetric and broad wings in [OIII], which we interpret as outflow signatures. We separate the quasars in two groups, ``weakly'' and ``strongly'' outflowing, using three different criteria. When we compare the mean star formation rate in five redshift bins in the two groups, we find that the SFRs are comparable or slightly larger in the strongly outflowing quasars. We estimate the stellar mass from SED fitting and the quasars are distributed along the star formation main sequence, although with a large scatter. The scatter from this relation is uncorrelated with respect to the kinematic properties of the outflow. Moreover, for quasars dominated in the infrared by starburst or by AGN emission, we do not find any correlation between the star formation rate and the velocity of the outflow, a trend previously reported in the literature for pure starburst galaxies. We conclude that the basic AGN negative feedback scenario seems not to agree with our results. Although we use a large sample of quasars, we did not find any evidence that the star formation rate is suppressed in the presence of AGN driven outflows on large scale. A possibility is that feedback is effective over much longer timescales than those of single episodes of quasar activity.Comment: 18 pages, new version that implements the suggestions of the referee and matches the AA published versio

Brain, cognition, and language development in spinal muscular atrophy type 1: a scoping review

Aim: To summarize the current knowledge on brain involvement in spinal muscular atrophy (SMA) type 1, focusing on brain pathology, cognition, and speech/language development. / Method: A scoping review was performed using the methodology of the Joanna Briggs Institute. Five databases and references from relevant articles were searched up to December 2019. Articles were screened on the basis of titles and abstracts. Full‐text papers published in peer‐reviewed journals in English were selected. / Results: Nineteen articles met eligibility criteria. Eight case series/reports on brain pathology showed abnormalities in few SMA type 0/1 cases, supported by findings in three post‐mortem examinations in mice. Four studies (three case–control, one cross‐sectional) on cognition reported contradictory results, with impaired cognitive performances in recent, small groups with SMA type 1. Four studies (three cross‐sectional, one observational) on speech/language showed that untreated SMA type 1 patients rarely achieve functional and intelligible speech, with data limited to parent reports/non‐formal evaluations. / Interpretation: Brain involvement is an under‐investigated aspect of SMA type 1, requiring further exploration in longitudinal studies. A deeper knowledge of brain involvement would improve the interpretation of clinical phenotypes and the personalization of rehabilitation programmes supporting patients' autonomies and quality of life. Additionally, it may help to define further outcome measures testing the efficacy of current and new developing drugs on this domain

The primordial environment of super massive black holes: large scale galaxy overdensities around z∼6z\sim6 QSOs with LBT

We investigated the presence of galaxy overdensities around four $z\sim6$ QSOs, namely SDSS J1030+0524 (z = 6.28), SDSS J1148+5251 (z = 6.41), SDSS J1048+4637 (z = 6.20) and SDSS J1411+1217 (z = 5.95), through deep $r$-, $i$- and $z$- band imaging obtained with the wide-field ($\sim23'\times25'$) Large Binocular Camera (LBC) at the Large Binocular Telescope (LBT). We adopted color-color selections within the $i-z$ vs $r-z$ plane to identify samples of $i$-band dropouts at the QSO redshift and measure their relative abundance and spatial distribution in the four LBC fields, each covering $\sim8\times8$ physical Mpc at $z\sim6$. The same selection criteria were then applied to $z$-band selected sources in the $\sim$1 deg$^2$ Subaru-XMM Newton Deep Survey to derive the expected number of dropouts over a blank LBC-sized field ($\sim$0.14 deg$^2$). The four observed QSO fields host a number of candidates larger than what is expected in a blank field. By defining as $i$-band dropouts objects with $z_{AB}1.4$ and undetected in the $r$-band, we found 16, 10, 9, 12 dropouts in SDSS J1030+0524, SDSS J1148+5251, SDSS J1048+4637, and SDSS J1411+1217, respectively, whereas only 4.3 such objects are expected over a 0.14 deg$^2$ blank field. This corresponds to overdensity significances of 3.3, 1.9, 1.7, 2.5$\sigma$, respectively. By considering the total number of dropouts in the four LBC fields and comparing it with what is expected in four blank fields of 0.14 deg$^2$ each, we find that high-z QSOs reside in overdense environments at the $3.7\sigma$ level. This is the first direct and unambiguous measurement of the large scale structures around $z\sim6$ QSOs. [shortened]Comment: 12 pages, 8 figures. Accepted for publication in A&

Magellan Spectroscopy of AGN Candidates in the COSMOS Field

We present spectroscopic redshifts for the first 466 X-ray and radio-selected AGN targets in the 2 deg^2 COSMOS field. Spectra were obtained with the IMACS instrument on the Magellan (Baade) telescope, using the nod-and-shuffle technique. We identify a variety of Type 1 and Type 2 AGN, as well as red galaxies with no emission lines. Our redshift yield is 72% down to i_AB=24, although the yield is >90% for i_AB<22. We expect the completeness to increase as the survey continues. When our survey is complete and additional redshifts from the zCOSMOS project are included, we anticipate ~1100 AGN with redshifts over the entire COSMOS field. Our redshift survey is consistent with an obscured AGN population that peaks at z~0.7, although further work is necessary to disentangle the selection effects.Comment: 19 pages, 14 figures. Accepted to ApJS special COSMOS issue. The full electronic version of Table 2 can be found at http://shaihulud.as.arizona.edu/~jtrump/tab2.tx

Advanced simulation code for alpha spectrometry

A Monte Carlo code, known as AASI, is developed for simulating energy spectra in alpha spectrometry. The code documented here is a comprehensive package where all the major processes affecting the spectrum are included. A unique feature of the code is its ability to take into account coincidences between the particles emitted from the source. Simulations and measurements highlight the importance of coincidences in high-resolution alpha spectrometry. To show the validity of the simulated results, comparisons with measurements and other simulation codes are presented.Comment: 21 pages, 4 figures, to be published in Nucl. Instr. and Meth.

Noncoding RNAs in Duchenne and Becker muscular dystrophies: role in pathogenesis and future prognostic and therapeutic perspectives

Noncoding RNAs (ncRNAs), such as miRNAs and long noncoding RNAs, are key regulators of gene expression at the post-transcriptional level and represent promising therapeutic targets and biomarkers for several human diseases, including Duchenne and Becker muscular dystrophies (DMD/BMD). A role for ncRNAs in the pathogenesis of muscular dystrophies has been suggested, even if it is still incompletely understood. Here, we discuss current progress leading towards the clinical utility of ncRNAs for DMD/BMD. Long and short noncoding RNAs are differentially expressed in DMD/BMD and have a mechanism of action via targeting mRNAs. A subset of muscle-enriched miRNAs, the so-called myomiRs (miR-1, miR-133, and miR-206), are increased in the serum of patients with DMD and in dystrophin-defective animal models. Interestingly, myomiRs might be used as biomarkers, given that their levels can be corrected after dystrophin restoration in dystrophic mice. Remarkably, further evidence demonstrates that ncRNAs also play a role in dystrophin expression; thus, their modulations might represent a potential therapeutic strategy with the aim of upregulating the dystrophin protein in combination with other oligonucleotides/gene therapy approaches

Prediction of Tail-Off Pressure Peak Anomaly on Small-Scale Rocket Motors

Numerical studies intended to predict solid rocket motors anomalies are the major contributors when developing strategies to both limit expensive fire tests and to investigate and understand the physical phenomena from which anomalies can arise. This paper aims to present a mathematical–physical method to evaluate the pressure peak, namely Friedman Curl, occurring at the tail-off phase of small-scale rocket motors. Such phenomenon is linked to the grain solid particles arrangement (i.e., packing effect); indeed, those particles show a tendency to accumulate at a certain distance from the metallic case, implying a local burn rate increment and a combustion chamber pressure rise close to the tail-off phase. Comparisons between experimental and simulated combustion chamber pressure profiles are outlined to prove the effectiveness of the mathematical–physical approach. Simulations were carried out with an internal ballistic simulation tool developed by the authors of this work