Reconstruction of maxillofacial bone defects: Contemporary methods and future techniques

Reconstruction of maxillofacial continuity defects has always been a challenging tasks for the scientist and surgeons over the years. The main goal of the reconstruction of the maxillofacial region is to restore facial form, function, full rehabilitation of occlusion and articulation. A refinement in surgical technique and methods of reconstruction has improved patient’s quality of life. This manuscript reviewed exciting methods of bone reconstruction and confirms that the ideal system for reconstruction of critical size continuity defect of the jaw bones has yet to be found. Shortcoming and limitation of each method has been discussed. The author highlight recent advances on how tissue engineering which could offer biological substitute to restore, maintain, or improve oro-facial function

A dilogarithmic integral arising in quantum field theory

Recently, an interesting dilogarithmic integral arising in quantum field theory has been closed-form evaluated in terms of the Clausen function $\text{Cl}_2(\theta)$ by Coffey [J. Math. Phys.} 49 (2008), 093508]. It represents the volume of an ideal tetrahedron in hyperbolic space and is involved in two intriguing equivalent conjectures of Borwein and Broadhurst. It is shown here, by simple and direct arguments, that this integral can be expressed by the triplet of the Clausen function values which are involved in one of the two above-mentioned conjectures.Comment: 6 page

Loss of hypothermic and anti-pyretic action of paracetamol in cyclooxygenase-1 knockout mice is indicative of inhibition of cyclooxygenase-1 variant enzymes

Paracetamol (acetaminophen), is a centrally-acting antipyretic analgesic drug, which can also lower body temperature. Despite a century of clinical use, its mechanism of pharmacological action has not been completely elucidated. Previously, we demonstrated significant attenuation in the paracetamol induced hypothermia in parallel with its inhibitory action on the synthesis of brain prostaglandin E₂ (PGE₂) in cyclooxygenase-1 (COX-1) knockout mice in comparison to wild-type mice. The above reported pharmacological actions by paracetamol were completely retained in COX-2 knockout mice. We thus concluded that the mechanism of hypothermic action of paracetamol is dependent on inhibition of a COX-1 gene-derived enzyme. In the current investigation, we provide further support for this notion by demonstrating that the paracetamol-induced hypothermia is not mediated through inhibition of COX-1 as neither the COX-1 selective inhibitor, SC560, nor the COX-1/COX-2 dual inhibitor, indomethacin, induced hypothermia at pharmacologically active doses in mice. In addition, using a COX-2-dependent and PGE₂-mediated model of endotoxin-induced fever, paracetamol induced anti-pyretic and hypothermic actions in COX-1 wild-type mice. These effects were fully or partially attenuated in COX-1 knockout mice after prophylactic or therapeutic administration, respectively. Therapeutically-administered paracetamol also reduced hypothalamic PGE₂ biosynthesis in febrile COX-1 wild-type mice, but not in febrile COX-1 knockout mice. In conclusion, we provide further evidence which suggests that the hypothermic and now anti-pyretic actions of paracetamol are mediated through inhibition of a COX-1 variant enzyme

The virtual human face – superimposing the simultaneously captured 3D photorealistic skin surface of the face on the untextured skin image of the CBCT Scan

The aim of this study was to evaluate the impact of simultaneous capture of the three-dimensional (3D) surface of the face and cone beam computed tomography (CBCT) scan of the skull on the accuracy of their registration and superimposition. 3D facial images were acquired in 14 patients using the Di3d (Dimensional Imaging, UK) imaging system and i-CAT CBCT scanner. One stereophotogrammetry image was captured at the same time as the CBCT and another one hour later. The two stereophotographs were then individually superimposed over the CBCT using VRmesh. Seven patches were isolated on the final merged surfaces. For the whole face and each individual patch; maximum and minimum range of deviation between surfaces, absolute average distance between surfaces, and standard deviation for the 90th percentile of the distance errors were calculated. The superimposition errors of the whole face for both captures revealed statistically significant differences (P=0.00081). The absolute average distances in both separate and simultaneous captures were 0.47mm and 0.27mm, respectively. The level of superimposition accuracy in patches from separate captures ranged between 0.3 and 0.9mm, while that of simultaneous captures was 0.4mm. Simultaneous capture of Di3d and CBCT images significantly improved the accuracy of superimposition of these image modalities

Intragenic homogenization and multiple copies of prey-wrapping silk genes in Argiope garden spiders.

BackgroundSpider silks are spectacular examples of phenotypic diversity arising from adaptive molecular evolution. An individual spider can produce an array of specialized silks, with the majority of constituent silk proteins encoded by members of the spidroin gene family. Spidroins are dominated by tandem repeats flanked by short, non-repetitive N- and C-terminal coding regions. The remarkable mechanical properties of spider silks have been largely attributed to the repeat sequences. However, the molecular evolutionary processes acting on spidroin terminal and repetitive regions remain unclear due to a paucity of complete gene sequences and sampling of genetic variation among individuals. To better understand spider silk evolution, we characterize a complete aciniform spidroin gene from an Argiope orb-weaving spider and survey aciniform gene fragments from congeneric individuals.ResultsWe present the complete aciniform spidroin (AcSp1) gene from the silver garden spider Argiope argentata (Aar_AcSp1), and document multiple AcSp1 loci in individual genomes of A. argentata and the congeneric A. trifasciata and A. aurantia. We find that Aar_AcSp1 repeats have >98% pairwise nucleotide identity. By comparing AcSp1 repeat amino acid sequences between Argiope species and with other genera, we identify regions of conservation over vast amounts of evolutionary time. Through a PCR survey of individual A. argentata, A. trifasciata, and A. aurantia genomes, we ascertain that AcSp1 repeats show limited variation between species whereas terminal regions are more divergent. We also find that average dN/dS across codons in the N-terminal, repetitive, and C-terminal encoding regions indicate purifying selection that is strongest in the N-terminal region.ConclusionsUsing the complete A. argentata AcSp1 gene and spidroin genetic variation between individuals, this study clarifies some of the molecular evolutionary processes underlying the spectacular mechanical attributes of aciniform silk. It is likely that intragenic concerted evolution and functional constraints on A. argentata AcSp1 repeats result in extreme repeat homogeneity. The maintenance of multiple AcSp1 encoding loci in Argiope genomes supports the hypothesis that Argiope spiders require rapid and efficient protein production to support their prolific use of aciniform silk for prey-wrapping and web-decorating. In addition, multiple gene copies may represent the early stages of spidroin diversification

Teaching with GSS: Techniques for Enabling Student Participation

Learning requires cognitive effort and two way communication. In the classroom setting, it is difficult to give every student a significant amount of time to participate. Group support systems (GSS) have been shown to make meetings more effective (Nunamaker, Dennis, Valacich, Vogel and George 1991). If the classroom is viewed as a meeting where the students are called upon to contribute, GSS can bring the same benefits to the classroom. This paper first describes our goals for improving classroom learning and then describes our experiences and techniques to help others apply them to their classroom situation. The techniques described are domain independent. They apply to any subject area and almost every level of education

A new strain-based finite element for plane elasticity problems

Purpose The purpose of this paper is to develop a new quadrilateral strain-based element. The element has five nodes, four at the corners as well as an internal node. Design/methodology/approach Through the introduction of the internal node, the numerical performance of the element proved to be superior to existing elements in the literature, even though a static condensation is required. Findings From several numerical examples, it is shown that convergence can be achieved with the use of only a small number of finite elements. The proposed element can be used to solve general plane linear elasticity problems resulting in excellent results. Originality/value The results obtained are comparable with those given by the robust element Q8

Variations of the McEliece Cryptosystem

Two variations of the McEliece cryptosystem are presented. The first one is based on a relaxation of the column permutation in the classical McEliece scrambling process. This is done in such a way that the Hamming weight of the error, added in the encryption process, can be controlled so that efficient decryption remains possible. The second variation is based on the use of spatially coupled moderate-density parity-check codes as secret codes. These codes are known for their excellent error-correction performance and allow for a relatively low key size in the cryptosystem. For both variants the security with respect to known attacks is discussed

Method to reduce the formation of crystallites in ZnO nanorod thin-films grown via ultra-fast microwave heating

© 2018 This paper discusses the nucleation and growth mechanisms of ZnO nanorod thin-films and larger sized crystallites that form within the solution and on surfaces during an ultra-fast microwave heating growth process. In particular, the work focusses on the elimination of crystallites as this is necessary to improve thin-film uniformity and to prevent electrical short circuits between electrodes in device applications. High microwave power during the early stages of ZnO deposition was found to be a key factor in the formation of unwanted crystallites on substrate surfaces. Once formed, the crystallites, grow at a much faster rate than the nanorods and quickly dominate the thin-film structure. A new two-step microwave heating method was developed that eliminates the onset of crystallite formation, allowing the deposition of large-area nanorod thin-films that are free from crystallites. A dissolution-recrystallization mechanism is proposed to explain why this procedure is successful and we demonstrate the importance of the work in the fabrication of low-cost memristor devices