The role of imaging in early hip OA

SummaryHip osteoarthritis (OA) is characterized by cartilage degradation, subchondral bone sclerosis and osteophyte formation. Nowadays, OA is thought to develop via different etiologies that all lead to a similar form of end stage joint degradation. One of these subtypes is related to an abnormal shaped hip joint, like acetabular dysplasia and a cam deformity. These bony abnormalities are highly predictive for development of hip OA, but they are likely to already be present from childhood. This suggests that these deformations induce OA changes in the hip, well before extensive hip degradation becomes present three to four decades later. Accurate detection and successful characterization of these early OA events might lead to better treatment options for hip OA besides nowadays available invasive joint replacement surgery. However, current diagnostic imaging techniques like radiographs or plain magnetic resonance imaging (MRI), are not sensitive enough to detect these subtle early OA changes. Nor are they able to disentangle intertwined and overlapping cascades from different OA subtypes, and neither can they predict OA progression. New and more sensitive imaging techniques might enable us to detect first OA changes on a cellular level, providing us with new opportunities for early intervention. In this respect, shape analysis using radiography, MRI, computed tomography (CT), single photon emission computed tomography (SPECT)/CT, and positron emission tomography (PET) might prove promising techniques and be more suited to detect early pathological changes in the hip joint. A broad application of these techniques might give us more understanding what can be considered physiological adaptation of the hip, or when early OA really starts. With a more clear definition of early OA, more homogenous patient populations can be selected and help with the development of new disease modifying OA interventions

Development of explosive forming techniques for Saturn V components Final report, 24 Jun. 1964 - 28 Jan. 1966

Explosive forming techniques development for aluminum alloy, carbon steel, and titanium components for Saturn V launch vehicl

On invariants of almost symplectic connections

We study the irreducible decomposition under Sp(2n, R) of the space of torsion tensors of almost symplectic connections. Then a description of all symplectic quadratic invariants of torsion-like tensors is given. When applied to a manifold M with an almost symplectic structure, these instruments give preliminary insight for finding a preferred linear almost symplectic connection on M . We rediscover Ph. Tondeur's Theorem on almost symplectic connections. Properties of torsion of the vectorial kind are deduced

Socioeconomic determinants of geographic disparities in campylobacteriosis risk: a comparison of global and local modeling approaches

BACKGROUND: Socioeconomic factors play a complex role in determining the risk of campylobacteriosis. Understanding the spatial interplay between these factors and disease risk can guide disease control programs. Historically, Poisson and negative binomial models have been used to investigate determinants of geographic disparities in risk. Spatial regression models, which allow modeling of spatial effects, have been used to improve these modeling efforts. Geographically weighted regression (GWR) takes this a step further by estimating local regression coefficients, thereby allowing estimations of associations that vary in space. These recent approaches increase our understanding of how geography influences the associations between determinants and disease. Therefore the objectives of this study were to: (i) identify socioeconomic determinants of the geographic disparities of campylobacteriosis risk (ii) investigate if regression coefficients for the associations between socioeconomic factors and campylobacteriosis risk demonstrate spatial variability and (iii) compare the performance of four modeling approaches: negative binomial, spatial lag, global and local Poisson GWR. METHODS: Negative binomial, spatial lag, global and local Poisson GWR modeling techniques were used to investigate associations between socioeconomic factors and geographic disparities in campylobacteriosis risk. The best fitting models were identified and compared. RESULTS: Two competing four variable models (Models 1 & 2) were identified. Significant variables included race, unemployment rate, education attainment, urbanicity, and divorce rate. Local Poisson GWR had the best fit and showed evidence of spatially varying regression coefficients. CONCLUSIONS: The international significance of this work is that it highlights the inadequacy of global regression strategies that estimate one parameter per independent variable, and therefore mask the true relationships between dependent and independent variables. Since local GWR estimate a regression coefficient for each location, it reveals the geographic differences in the associations. This implies that a factor may be an important determinant in some locations and not others. Incorporating this into health planning ensures that a needs-based, rather than a “one-size-fits-all”, approach is used. Thus, adding local GWR to the epidemiologists’ toolbox would allow them to assess how the impacts of different determinants vary by geography. This knowledge is critical for resource allocation in disease control programs

The Rise and Fall of the Hip: From Skeletal Development to Osteoarthritis

__Abstract__ Osteoarthritis is a common disease and accounts for a detrimental impact on the quality of life. The etiology of the disease is largely unknown and hence its treatment is limited to pain management until the patient can undergo total joint replacement. In this thesis, we first investigated the role of hip morphology in the development of hip osteoarthritis. It was found that a cam deformity (a non-spherical femoral head due to extra bone formation) is highly associated with development of hip osteoarthritis. We further provided a definition for the presence of a cam deformity. Finally, we investigated if and how a cam deformity develops during skeletal maturation. A cam deformity develops gradually and only during adolescence in between the age of around 13 to 17 years. Its development is a result of high impact sports practice during skeletal growth. In conclusion, in this thesis we found a relatively new risk factor for the development of osteoarthritis (cam deformity). Interestingly, the development of a cam deformity can possibly be prevented during skeletal maturation by adjusting the loads applied to the hip, which might substantially decrease the future prevalence of hip osteoarthritis

On the G_2 bundle of a Riemannian 4-manifold

We study the natural G_2 structure on the unit tangent sphere bundle SM of any given orientable Riemannian 4-manifold M, as it was discovered in \cite{AlbSal}. A name is proposed for the space. We work in the context of metric connections, or so called geometry with torsion, and describe the components of the torsion of the connection which imply certain equations of the G_2 structure. This article is devoted to finding the G_2-torsion tensors which classify our structure according to the theory in \cite{FerGray}.Comment: Completely improved, new examples, 26 page

Composition algebras and the two faces of G2G_{2}

We consider composition and division algebras over the real numbers: We note two r\^oles for the group $G_{2}$: as automorphism group of the octonions and as the isotropy group of a generic 3-form in 7 dimensions. We show why they are equivalent, by means of a regular metric. We express in some diagrams the relation between some pertinent groups, most of them related to the octonions. Some applications to physics are also discussed.Comment: 11 pages, 3 figure

The G_2 sphere over a 4-manifold

We present a construction of a canonical G_2 structure on the unit sphere tangent bundle S_M of any given orientable Riemannian 4-manifold M. Such structure is never geometric or 1-flat, but seems full of other possibilities. We start by the study of the most basic properties of our construction. The structure is co-calibrated if, and only if, M is an Einstein manifold. The fibres are always associative. In fact, the associated 3-form results from a linear combination of three other volume 3-forms, one of which is the volume of the fibres. We also give new examples of co-calibrated structures on well known spaces. We hope this contributes both to the knowledge of special geometries and to the study of 4-manifolds.Comment: 13 page

The prevalence of cam and pincer morphology and its association with development of hip osteoarthritis

Our understanding of femoroacetabular impingement syndrome is slowly improving. The number of studies on all aspects (etiology, prevalence, pathophysiology, natural history, treatment, and preventive measures) of femoroacetabular impingement syndrome has grown exponentially over the past few years. This commentary provides the latest updates on the prevalence of cam and pincer hip morphology and its relationship with development of hip osteoarthritis (OA). Cam and pincer morphology is highly prevalent in the general population and in this paper is presented for different subgroups based on age, sex, ethnicity, and athletic activity. Methodological issues in determining prevalence of abnormal hip morphology are also discussed. Cam morphology has been associated with development of hip OA, but the association between pincer morphology and hip OA is much less clear. Results from reviewed studies, as well as remaining gaps in literature on this topic, are critically discussed and put into perspective for the clinician