Coding and Encoding: Towards a New Approach to the Study of Syriac and Arabic Translations of Greek Scientific and Philosophical Texts

This essay presents the ERC project ‘Transmission of Classical Scientific and Philosophical Literature from Greek into Syriac and Arabic’ (HUNAYNNET) based at the Institute for Medieval Research of the Austrian Academy of Sciences. The main research question leading the project addresses the contribution of the Syriac tradition in the transfer of Greek scientific literature to the Arabic-speaking world. To fulfill this goal the project is going to provide digital editions of the Syriac and Arabic versions and tools for linguistic corpus-based analysis. The digital Greek–Syriac–Arabic corpus will offer a novel approach for research into the translation techniques and in the history of the transmission of classical Greek literature in Late Antiquity and the Middle Ages

Coding and Encoding: Towards a New Approach to the Study of Syriac and Arabic Translations of Greek Scientific and Philosophical Texts

This essay presents the ERC project ‘Transmission of Classical Scientific and Philosophical Literature from Greek into Syriac and Arabic’ (HUNAYNNET) based at the Institute for Medieval Research of the Austrian Academy of Sciences. The main research question leading the project addresses the contribution of the Syriac tradition in the transfer of Greek scientific literature to the Arabic-speaking world. To fulfill this goal the project is going to provide digital editions of the Syriac and Arabic versions and tools for linguistic corpus-based analysis. The digital Greek–Syriac–Arabic corpus will offer a novel approach for research into the translation techniques and in the history of the transmission of classical Greek literature in Late Antiquity and the Middle Ages

PLVAP as an Early Marker of Glomerular Endothelial Damage in Mice with Diabetic Kidney Disease

Plasmalemma vesicle-associated protein (PLVAP) is the main component of endothelial diaphragms in fenestrae, caveolae, and transendothelial channels. PLVAP is expressed in the adult kidney glomerulus upon injury. Glomerular endothelial injury is associated with progressive loss of kidney function in diabetic kidney disease (DKD). This study aimed to investigate whether PLVAP could serve as a marker for glomerular endothelial damage in DKD. Glomerular PLVAP expression was analyzed in different mouse models of DKD and their respective healthy control animals using automatic digital quantification of histological whole kidney sections. Transgenic mice expressing a dominant-negative GIP receptor (GIPRdn) in pancreatic beta-cells as a model for diabetes mellitus (DM) type 1 and black and tan brachyuric (BTBR) ob/ob mice, as a model for DM type 2, were used. Distinct PLVAP induction was observed in all diabetic models studied. Traces of glomerular PLVAP expression could be identified in the healthy control kidneys using automated quantification. Stainings for other endothelial injury markers such as CD31 or the erythroblast transformation-specific related gene (ERG) displayed no differences between diabetic and healthy groups at the time points when PLVAP was induced. The same was also true for the mesangial cells marker α8Integrin, while the podocyte marker nephrin appeared to be diminished only in BTBR ob/ob mice. Glomerular hypertrophy, which is one of the initial morphological signs of diabetic kidney damage, was observed in both diabetic models. These findings suggest that PLVAP is an early marker of glomerular endothelial injury in diabetes-induced kidney damage in mice

Neoadjuvant image-guided helical intensity modulated radiotherapy of extremity sarcomas – a single center experience

Abstract Background Advanced radiotherapy (RT) techniques allow normal tissue to be spared in patients with extremity soft tissue sarcoma (STS). This work aims to evaluate toxicity and outcome after neoadjuvant image-guided radiotherapy (IGRT) as helical intensity modulated radiotherapy (IMRT) with reduced margins based on MRI-based target definition in patients with STS. Methods Between 2010 to 2014, 41 patients with extremity STS were treated with IGRT delivered as helical IMRT on a tomotherapy machine. The tumor site was in the upper extremity in 6 patients (15%) and lower extremity in 35 patients (85%). Reduced margins of 2.5 cm in longitudinal direction and 1.0 cm in axial direction were used to expand the MRI-defined gross tumor volume, including peritumoral edema, to the clinical target volume. An additional margin of 5 mm was added to receive the planning target volume. The full total dose of 50 Gy in 2 Gy fractions was sucessfully applied in 40 patients. Two patients received chemotherapy instead of surgery due to systemic progression. All patients were included into a strict follow-up program and were seen interdisciplinarily by the Departments of Orthopaedic Surgery and Radiation Oncology. Results Thirty eight patients that received total RT total dose and subsequent resection were analyzed for outcome. After a median follow-up of 38.5 months cumulative OS, local PFS and systemic PFS at 2 years were determined at 78.2, 85.2 and 54.5%, respectively. Two of 6 local recurrences were proximal marginal misses. Negative resection margins were achieved in 84% of patients. The rate of major wound complications was comparable to previous IMRT studies with 36.8%. RT was overall tolerable with low toxicity rates. Conclusions IMRT-IGRT offers neoadjuvant treatment for extremity STS with reduced safety margins and thus low toxicity rates. Wound complication rates were comparable to previously reported frequencies. Two reported marginal misses suggest a word of caution for reduction of longitudinal safety margins