An empirical test of the estimation of historical effective population size using Drosophila melanogaster

The availability of a large number of high-density markers (SNPs) allows the estimation of historical effective population size (Ne) from linkage disequilibrium between loci. A recent refinement of methods to estimate historical Ne from the recent past has been shown to be rather accurate with simulation data. The method has also been applied to real data for numerous species. However, the simulation data cannot encompass all the complexities of real genomes, and the performance of any estimation method with real data is always uncertain, as the true demography of the populations is not known. Here, we carried out an experimental design with Drosophila melanogaster to test the method with real data following a known demographic history. We used a population maintained in the laboratory with a constant census size of about 2800 individuals and subjected the population to a drastic decline to a size of 100 individuals. After a few generations, the population was expanded back to the previous size and after a few further generations again expanded to twice the initial size. Estimates of historical Ne were obtained with the software GONE both for autosomal and X chromosomes from samples of 17 individuals sequenced for the whole genome. Estimates of the historical effective size were able to infer the patterns of changes that occurred in the populations showing generally good performance of the method. We discuss the limitations of the method and the application of the software carried out so farMinisterio de Ciencia, Innovación y Universidades | Ref. PID2020-114426GB- C21Ministerio de Educación, Cultura y Deporte | Ref. FPU16/02299Ministerio de Ciencia, Innovación y Universidades | Ref. FPU18/04642Universidade de Vigo/CISUG | Ref. Financiamiento de acceso abiertoCRUE-CSIC | Ref. Financiamiento de acceso abiertoXunta de Galicia | Ref. ED431C 2020-0

Human-robot interaction torque estimation methods for a lower limb rehabilitation robotic system with uncertainties

Lower limb rehabilitation robot (LLRR) users, to successfully conduct isotonic exercises, require real-time feedback on the torque they exert on the robot to meet the goal of the treatment. Still, direct torque measuring is expensive, and indirect encoder-based estimation strategies, such as inverse dynamics (ID) and Nonlinear Disturbance Observers (NDO), are sensitive to Body Segment Inertial Parameters (BSIPs) uncertainties. We envision a way to minimize such parametric uncertainties. This paper proposes two human–robot interaction torque estimation methods: the Identified ID-based method (IID) and the Identified NDO-based method (INDO). Evaluating in simulation the proposal to apply, in each rehabilitation session, a sequential two-phase method: (1) An initial calibration phase will use an online parameter estimation to reduce sensitivity to BSIPs uncertainties. (2) The torque estimation phase uses the estimated parameters to obtain a better result. We conducted simulations under signal-to-noise ratio (SNR) = 40 dB and 20% BSIPs uncertainties. In addition, we compared the effectiveness with two of the best methods reported in the literature via simulation. Both proposed methods obtained the best Coefficient of Correlation, Mean Absolute Error, and Root Mean Squared Error compared to the benchmarks. Moreover, the IID and INDO fulfilled more than 72.2% and 88.9% of the requirements, respectively. In contrast, both methods reported in the literature only accomplish 27.8% and 33.3% of the requirements when using simulations under noise and BSIPs uncertainties. Therefore, this paper extends two methods reported in the literature and copes with BSIPs uncertainties without using additional sensors

Capitulo 2. Ciencias Naturales y Ciencias Básicas, Ingeniería y Tecnología

La diseminación de la Levitación Magnética, a pesar de lo antiguo de su tecnología, ha sido limitada. Debido a sus inconvenientes prácticos de implementación, su uso es bastante restringido, comparado con otras tecnologías (SCMaglev japonés, Transrapid alemán, o productos comerciales para ocio y entretenimiento). Con el boom de las tecnologías limpias y amigables con el medio ambiente y en concordancia con los objetivos del milenio, es pertinente plantearse el objetivo de optimizar el proceso de Levitación Magnética para generar un aprovechamiento de las ventajas de esta tecnología a nivel mecánico, eléctrico, y ambiental.  Actualmente la UNAD adelanta un proyecto de investigación cuyo objetivo es generar un modelo físico matemático de levitación magnética para aplicaciones en ingeniería. De este proyecto se ha derivado una primera revisión sistemática de los principios físicos y los modelos vigentes en Levitación Magnética

Human-Robot Interaction Torque Estimation Methods for a Lower Limb Rehabilitation Robotic System with Uncertainties

Lower limb rehabilitation robot (LLRR) users, to successfully conduct isotonic exercises, require real-time feedback on the torque they exert on the robot to meet the goal of the treatment. Still, direct torque measuring is expensive, and indirect encoder-based estimation strategies, such as inverse dynamics (ID) and Nonlinear Disturbance Observers (NDO), are sensitive to Body Segment Inertial Parameters (BSIPs) uncertainties. We envision a way to minimize such parametric uncertainties. This paper proposes two human–robot interaction torque estimation methods: the Identified ID-based method (IID) and the Identified NDO-based method (INDO). Evaluating in simulation the proposal to apply, in each rehabilitation session, a sequential two-phase method: (1) An initial calibration phase will use an online parameter estimation to reduce sensitivity to BSIPs uncertainties. (2) The torque estimation phase uses the estimated parameters to obtain a better result. We conducted simulations under signal-to-noise ratio (SNR) = 40 dB and 20% BSIPs uncertainties. In addition, we compared the effectiveness with two of the best methods reported in the literature via simulation. Both proposed methods obtained the best Coefficient of Correlation, Mean Absolute Error, and Root Mean Squared Error compared to the benchmarks. Moreover, the IID and INDO fulfilled more than 72.2% and 88.9% of the requirements, respectively. In contrast, both methods reported in the literature only accomplish 27.8% and 33.3% of the requirements when using simulations under noise and BSIPs uncertainties. Therefore, this paper extends two methods reported in the literature and copes with BSIPs uncertainties without using additional sensors

Universidade de Vigo Universidade de Santiago de Compostela Universidade de A Coruña

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La importancia de conocer el idioma

Este proyecto consiste en mejorar el uso cotidiano de la lengua castellana, abordándola desde el vocabulario, la ortografía y la compresión lectora en las distintas asignaturas. Para dar mayor globalidad al ejercicio, se trabaja también estos factores en otros idiomas como el inglés y el francés. Los objetivos son desarrollar un vocabulario adecuado a las distintas materias; escribir correctamente; trabajar la comprensión de los textos; aumentar la cohesión y la coordinación entre alumnos y profesores; fomentar la utilización de distintos métodos de enseñanza-aprendizaje; fomentar el interés con actividades motivadoras e innovadoras en la enseñanza curricular; y potenciar el trabajo en grupo e individual. Las actividades llevadas a la práctica son acordes a la edad y a los objetivos propuestos. Se elaboran listados de palabras de ortografía dudosa, se trabajan textos para acceder a su comprensión, se hacen concursos de ortografía, se cuelgan carteles por pasillos y aulas con palabras significativas, se fabrican tarjetas para jugar-aprendiendo en clases y tutorías, y se utilizan programas de ordenador que refuerzan el aprendizaje de vocabulario y ortografía. La metodología pone en activo tanto a profesores como a alumnos. Los primeros se encargan de hacer los listados de palabras y de preparar y dar formato a las pruebas eliminatorias del concurso. Los alumnos se encargan de buscar la información necesaria para definir las palabras, hacer los carteles y exponer las conclusiones. La evaluación consiste principalmente en reuniones de profesores que analizan el desarrollo del proyecto, exponen las dificultades encontradas y establecen modificaciones y correcciones en relación a los ejercicios. Como anexo se presentan dos CD-ROM con las actividades realizadas..Madrid (Comunidad Autónoma). Consejería de Educación. Dirección General de Mejora de la Calidad de la EnseñanzaMadridMadrid (Comunidad Autónoma). Subdirección General de Formación del Profesorado. CRIF Las Acacias; General Ricardos 179 - 28025 Madrid; Tel. + 34915250893ES

How do women living with HIV experience menopause? Menopausal symptoms, anxiety and depression according to reproductive age in a multicenter cohort

CatedresBackground: To estimate the prevalence and severity of menopausal symptoms and anxiety/depression and to assess the differences according to menopausal status among women living with HIV aged 45-60 years from the cohort of Spanish HIV/AIDS Research Network (CoRIS). Methods: Women were interviewed by phone between September 2017 and December 2018 to determine whether they had experienced menopausal symptoms and anxiety/depression. The Menopause Rating Scale was used to evaluate the prevalence and severity of symptoms related to menopause in three subscales: somatic, psychologic and urogenital; and the 4-item Patient Health Questionnaire was used for anxiety/depression. Logistic regression models were used to estimate odds ratios (ORs) of association between menopausal status, and other potential risk factors, the presence and severity of somatic, psychological and urogenital symptoms and of anxiety/depression. Results: Of 251 women included, 137 (54.6%) were post-, 70 (27.9%) peri- and 44 (17.5%) pre-menopausal, respectively. Median age of onset menopause was 48 years (IQR 45-50). The proportions of pre-, peri- and post-menopausal women who had experienced any menopausal symptoms were 45.5%, 60.0% and 66.4%, respectively. Both peri- and post-menopause were associated with a higher likelihood of having somatic symptoms (aOR 3.01; 95% CI 1.38-6.55 and 2.63; 1.44-4.81, respectively), while post-menopause increased the likelihood of having psychological (2.16; 1.13-4.14) and urogenital symptoms (2.54; 1.42-4.85). By other hand, post-menopausal women had a statistically significant five-fold increase in the likelihood of presenting severe urogenital symptoms than pre-menopausal women (4.90; 1.74-13.84). No significant differences by menopausal status were found for anxiety/depression. Joint/muscle problems, exhaustion and sleeping disorders were the most commonly reported symptoms among all women. Differences in the prevalences of vaginal dryness (p = 0.002), joint/muscle complaints (p = 0.032), and sweating/flush (p = 0.032) were found among the three groups. Conclusions: Women living with HIV experienced a wide variety of menopausal symptoms, some of them initiated before women had any menstrual irregularity. We found a higher likelihood of somatic symptoms in peri- and post-menopausal women, while a higher likelihood of psychological and urogenital symptoms was found in post-menopausal women. Most somatic symptoms were of low or moderate severity, probably due to the good clinical and immunological situation of these women

COVID-19 in hospitalized HIV-positive and HIV-negative patients : A matched study

CatedresObjectives: We compared the characteristics and clinical outcomes of hospitalized individuals with COVID-19 with [people with HIV (PWH)] and without (non-PWH) HIV co-infection in Spain during the first wave of the pandemic. Methods: This was a retrospective matched cohort study. People with HIV were identified by reviewing clinical records and laboratory registries of 10 922 patients in active-follow-up within the Spanish HIV Research Network (CoRIS) up to 30 June 2020. Each hospitalized PWH was matched with five non-PWH of the same age and sex randomly selected from COVID-19@Spain, a multicentre cohort of 4035 patients hospitalized with confirmed COVID-19. The main outcome was all-cause in-hospital mortality. Results: Forty-five PWH with PCR-confirmed COVID-19 were identified in CoRIS, 21 of whom were hospitalized. A total of 105 age/sex-matched controls were selected from the COVID-19@Spain cohort. The median age in both groups was 53 (Q1-Q3, 46-56) years, and 90.5% were men. In PWH, 19.1% were injecting drug users, 95.2% were on antiretroviral therapy, 94.4% had HIV-RNA < 50 copies/mL, and the median (Q1-Q3) CD4 count was 595 (349-798) cells/μL. No statistically significant differences were found between PWH and non-PWH in number of comorbidities, presenting signs and symptoms, laboratory parameters, radiology findings and severity scores on admission. Corticosteroids were administered to 33.3% and 27.4% of PWH and non-PWH, respectively (P = 0.580). Deaths during admission were documented in two (9.5%) PWH and 12 (11.4%) non-PWH (P = 0.800). Conclusions: Our findings suggest that well-controlled HIV infection does not modify the clinical presentation or worsen clinical outcomes of COVID-19 hospitalization

Incidence, associated factors and clinical impact of severe infections in a large, multicentric cohort of patients with systemic lupus erythematosus.

To estimate the incidence of severe infection and investigate the associated factors and clinical impact in a large systemic lupus erythematosus (SLE) retrospective cohort. All patients in the Spanish Rheumatology Society Lupus Registry (RELESSER) who meet ≥4 ACR-97 SLE criteria were retrospectively investigated for severe infections. Patients with and without infections were compared in terms of SLE severity, damage, comorbidities, and demographic characteristics. A multivariable Cox regression model was built to calculate hazard ratios (HRs) for the first infection. A total of 3658 SLE patients were included: 90% female, median age 32.9 years (DQ 9.7), and mean follow-up (months) 120.2 (±87.6). A total of 705 (19.3%) patients suffered ≥1 severe infection. Total severe infections recorded in these patients numbered 1227. The incidence rate was 29.2 (95% CI: 27.6-30.9) infections per 1000 patient years. Time from first infection to second infection was significantly shorter than time from diagnosis to first infection (p Severe infection constitutes a predictor of poor prognosis in SLE patients, is more common in Latin-Americans and is associated with age, previous infection, and smoking. Antimalarials exerted a protective effect