The Holy Revival of Thirumurugan at Arupatai Veedu

The Thirumurugatrupadai worships Murugu, the ancient deity of the past. Literature guides spiritual attainment through civilised world life. "Thirumurugatrupadai" stands as proof of such a purpose. Thirumurugatrupadai guides us to attain freedom from birth with the highest aim of 'listening to the greatness of the great'. The ideological aim is that the Lord himself will come as a wise teacher to conquer the mature soul. It may be said that the concept of the poet who has been presented with a gift orienting the poet who is yet to receive the prize is similar to the position in which Gnanaguru directs the matured soul towards God. The manner, in which the holiness of God is conveyed in the Arupatai Veedu (The Six Abodes of God Murugan), such as Nakkeerar, Thiruparankundram, etc., signifies the realisation of the divine power in all the six yogic states of the body and the eternal attachment to the path of bliss. Moreover, the way in which the worship of Lord Murugan has been put forward in the form of hill-topography is the guidance of the realisation of "sovereignty in nature'. Thirumurugan's position as the inner light in all objects can be seen in Thiruparankundram, the greatness of Thirumurugan, the precious being, with six faces and twelve hands because of his great grace to the living beings, in Thiruchiralaivai, in Thiruavinankudi, where Thirumurugan is the great object worshipped by all, in Thiruvinankudi, where Thirumurugan is the inner object of the six letters, in Thiruveragam, and in Thiruthanikai, the greatness of Kumaran resides. In addition, Thirumurukatrupatai enables the devotees to realise the ability of Thirumurugan to reside everywhere and is praised as a temple for redressal of grievances by placing it in the eyes of Pazhamuthir Solai. Moreover, Thirumurugan's ability to show his great form, which transcends the sky, as a small one for his devotee to see, is indicative of the devotional principle that 'God is always humble to his devotees'

PHYTOCHEMICAL, GAS CHROMATOGRAPHY WITH MASS SPECTROMETRY ANALYSIS OF ANDROGRAPHIS SERPYLLIFOLIA METHANOL LEAF EXTRACT AND ITS ANTIOXIDANT AND ANTIBACTERIAL ACTIVITIES

Objective: The present study is to evaluate the preliminary study of phytochemical screening and biological applications of Andrographis serpyllifolia methanol leaf extracts. Methods: The methanol leaf extracts of A. serpyllifolia was prepared using Soxhlet apparatus and the extract was analyzed using gas chromatography with mass spectrometry (GC-MS). In vitro antioxidant activity was determined by superoxide dismutase, catalase, glutathione peroxidase, and glutathione S-transferase. Further, the antibacterial activity of methanolic leaf extract of A. serpyllifolia was tested against various human pathogens by using agar disc diffusion method. Results: Preliminary phytochemical screening and GC-MS results revealed phenols, aromatic carboxylic acids, and esters in the chloroform extract to be the molecules responsible for the antioxidant and antibacterial activity of A. serpyllifolia methanol extract and fractions showed the presence of various secondary metabolites present. Conclusion: The present study strongly recommended that the methanolic extract of A. serpyllifolia leaves possesses compounds that inhibit the growth of microbes as wells excellent antioxidant activities. The study further suggested the potential therapeutic use of these extract in cancer study

Acute otitis externa: Consensus definition, diagnostic criteria and core outcome set development.

OBJECTIVE: Evidence for the management of acute otitis externa (AOE) is limited, with unclear diagnostic criteria and variably reported outcome measures that may not reflect key stakeholder priorities. We aimed to develop 1) a definition, 2) diagnostic criteria and 3) a core outcome set (COS) for AOE. STUDY DESIGN: COS development according to Core Outcome Measures in Effectiveness Trials (COMET) methodology and parallel consensus selection of diagnostic criteria/definition. SETTING: Stakeholders from the United Kingdom. SUBJECTS AND METHODS: Comprehensive literature review identified candidate items for the COS, definition and diagnostic criteria. Nine individuals with past AOE generated further patient-centred candidate items. Candidate items were rated for importance by patient and professional (ENT doctors, general practitioners, microbiologists, nurses, audiologists) stakeholders in a three-round online Delphi exercise. Consensus items were grouped to form the COS, diagnostic criteria, and definition. RESULTS: Candidate COS items from patients (n = 28) and literature (n = 25) were deduplicated and amalgamated to a final candidate list (n = 46). Patients emphasised quality-of-life and the impact on daily activities/work. Via the Delphi process, stakeholders agreed on 31 candidate items. The final COS covered six outcomes: pain; disease severity; impact on quality-of-life and daily activities; patient satisfaction; treatment-related outcome; and microbiology. 14 candidate diagnostic criteria were identified, 8 reaching inclusion consensus. The final definition for AOE was 'diffuse inflammation of the ear canal skin of less than 6 weeks duration'. CONCLUSION: The development and adoption of a consensus definition, diagnostic criteria and a COS will help to standardise future research in AOE, facilitating meta-analysis. Consulting former patients throughout development highlighted deficiencies in the outcomes adopted previously, in particular concerning the impact of AOE on daily life

Liposomal delivery of ferritin heavy chain 1 (FTH1) siRNA in patient xenograft derived glioblastoma initiating cells suggests different sensitivities to radiation and distinct survival mechanisms.

Elevated expression of the iron regulatory protein, ferritin heavy chain 1 (FTH1), is increasingly being associated with high tumor grade and poor survival outcomes in glioblastoma. Glioma initiating cells (GICs), a small population of stem-like cells implicated in therapeutic resistance and glioblastoma recurrence, have recently been shown to exhibit increased FTH1 expression. We previously demonstrated that FTH1 knockdown enhanced therapeutic sensitivity in an astrocytoma cell line. Therefore, in this study we developed a liposomal formulation to enable the in vitro delivery of FTH1 siRNA in patient xenograft derived GICs from glioblastomas with pro-neural and mesenchymal transcriptional signatures to interrogate the effect of FTH1 downregulation on their radiation sensitivity. Transfection with siRNA decreased FTH1 expression significantly in both GICs. However, there were inherent differences in transfectability between pro-neural and mesenchymal tumor derived GICs, leading us to modify siRNA: liposome ratios for comparable transfection. Moreover, loss of FTH1 expression resulted in increased extracellular lactate dehydrogenase activity, executioner caspase 3/7 induction, substantial mitochondrial damage, diminished mitochondrial mass and reduced cell viability. However, only GICs from pro-neural glioblastoma showed marked increase in radiosensitivity upon FTH1 downregulation demonstrated by decreased cell viability, impaired DNA repair and reduced colony formation subsequent to radiation. In addition, the stemness marker Nestin was downregulated upon FTH1 silencing only in GICs of pro-neural but not mesenchymal origin. Using liposomes as a siRNA delivery system, we established FTH1 as a critical factor for survival in both GIC subtypes as well as a regulator of radioresistance and stemness in pro-neural tumor derived GICs. Our study provides further evidence to support the role of FTH1 as a promising target in glioblastoma

L'Avenir de Luchon : journal scientifique, littéraire, annonces et réclames : guide général des baigneurs et des touristes aux eaux thermales, bains de mer de la France et de l'étranger

28 avril 19291929/04/28 (N437)-1929/04/28.Appartient à l’ensemble documentaire : MidiPyren

Immunohistochemistry for Ki-67 expression on the sciatic nerves from the tumor induced and control (untreated) mice indicates that the IL13Rα2 staining pattern was intense in tumor tissue.

<p>Immunohistochemistry for Ki-67 expression on the sciatic nerves from the tumor induced and control (untreated) mice indicates that the IL13Rα2 staining pattern was intense in tumor tissue.</p