International relations’ first great debate: context and tradition

According to International Relations (IR) orthodoxy, the story of three Great Debates accounts for the most important theoretical developments in the discipline. Over the last decade, critical historiographers have established that the story of a First Debate, which tells of a struggle between idealism and realism between the 1920s and 1940s, is a misleading caricature of early academic international thought. This article adds to this critical literature by tracing the manner in which the story of a First Debate became a part of disciplinary orthodoxy between the 1950s and 1980s. Our analysis reveals that a myth of a First Debate was produced when more recent scholars detached the concept of a struggle between idealism and realism from both the unique historical milieu in which this dichotomy was conceived, and the rhetorical purposes for which it was employed. We use these findings to make the case for a contextual approach to disciplinary historiography, and to illuminate the historical contingency of contemporary notions of scholarly purpose in IR

Slavery and Marriage in African Societies

This article introduces a special issue focusing upon linkages between enslavement and marriage within African societies from the 1830s to the present day. The right to make decisions over marriage is one of the core powers which masters have historically exercised over individuals whom they enslaved. The exercise of this right had far-reaching ramifications for lived experiences of enslavement, with slaves – usually women and girls – being forced into conjugal relationships where their labour, sexuality and reproductive capacity were at the disposal of their husband/master. This article introduces two major themes that cut across the issue's contributions: direct connections and comparative analogies. The former refers to scenarios where marriage and enslavement directly intersected and overlapped, while the latter refers to claims that at least some African marriages were analogous to enslavement. Comparisons between marriage and slavery have been a recurring feature of African politics throughout the period considered here. They have also been frequently paired with moral denunciations and calls for change by actors as different as European colonial administrators and African victims-turned-activists. At the same time, the legitimizing cloak of marriage has been repeatedly used to deliberately obscure the continuing legacies of slavery

Editorial: From Exceptional Cases to Everyday Abuses: Labour exploitation in the global economy

This article introduces a special issue on economic systems and everyday abuses of labour rights. In recent decades, neoliberal policies have transformed both the world economy and the world of work. Hard-won rights and protections have been eroded by deregulation, outsourcing, and subcontracting. New forms of unstable, isolated, and insecure work have emerged. This introduction examines the driving forces behind the increasing prominence of precarious work, the accelerating role of migrant labour within global economic systems, and the political relationship between everyday abuses and forms of severe exploitation which have recently come to be defined as human trafficking and modern slavery. We argue that a singular focus upon individual cases of extreme exploitation is unlikely to be effective, and can also draw attention away from the larger systems, interests, and abuses that are associated with the smooth and regular operations of the global economy. We also suggest that at least some of the energies which have recently been expended debating the contentious category of ‘modern slavery’ could be usefully redirected towards lower profile interventions concerned with worker and migrant rights. There are never going to be simple or straightforward solutions to labour abuses, so it is necessary to take many bumpy paths simultaneously, with small steps forward and some steps backward

The Economics of Boxing Regulation in California

Boxing was legalized in California through a statewide referendum in 1924that simultaneously set up a regulatory authority with broad powers to control the industry. This study examines the economic performance of the boxing industry, the case for regulatory intervention, and the effects of the specific kinds of regulatory rules that have been imposed. While regulation in California is widely believed to be an important factor explaining the unusually low rates of death and injury in boxing matches in the state, it is also shown to have anticompetitive effects. Several changes in regulatory procedures are proposed that would not reduce the extent to which regulation protects boxers, but would serve to enhance the competitive performance of the industry

The Economics of Boxing Regulation in California

Boxing was legalized in California through a statewide referendum in 1924that simultaneously set up a regulatory authority with broad powers to control the industry. This study examines the economic performance of the boxing industry, the case for regulatory intervention, and the effects of the specific kinds of regulatory rules that have been imposed. While regulation in California is widely believed to be an important factor explaining the unusually low rates of death and injury in boxing matches in the state, it is also shown to have anticompetitive effects. Several changes in regulatory procedures are proposed that would not reduce the extent to which regulation protects boxers, but would serve to enhance the competitive performance of the industry

In utero exposure to transient ischemia-hypoxemia promotes long-term neurodevelopmental abnormalities in male rat offspring

The impact of transient ischemic-hypoxemic insults on the developing fetal brain is poorly understood despite evidence suggesting an association with neurodevelopmental disorders such as schizophrenia and autism. To address this, we designed an aberrant uterine hypercontractility paradigm with oxytocin to better assess the consequences of acute, but transient, placental ischemia-hypoxemia in term pregnant rats. Using MRI, we confirmed that oxytocin-induced aberrant uterine hypercontractility substantially compromised uteroplacental perfusion. This was supported by the observation of oxidative stress and increased lactate concentration in the fetal brain. Genes related to oxidative stress pathways were significantly upregulated in male, but not female, offspring 1 hour after oxytocin-induced placental ischemia-hypoxemia. Persistent upregulation of select mitochondrial electron transport chain complex proteins in the anterior cingulate cortex of adolescent male offspring suggested that this sex-specific effect was enduring. Functionally, offspring exposed to oxytocin-induced uterine hypercontractility showed male-specific abnormalities in social behavior with associated region-specific changes in gene expression and functional cortical connectivity. Our findings, therefore, indicate that even transient but severe placental ischemia-hypoxemia could be detrimental to the developing brain and point to a possible mitochondrial link between intrauterine asphyxia and neurodevelopmental disorders

Governing the world at a distance : the practice of global benchmarking

Benchmarking practices have rapidly diffused throughout the globe in recent years. This can be traced to their popularity amongst non-state actors, such as civil society organisations and corporate actors, as well as states and international organisations (IOs). Benchmarks serve to both ‘neutralise’ and ‘universalise’ a range of overlapping normative values and agendas, including freedom of speech, democracy, human development, environmental protection, poverty alleviation, ‘modern’ statehood, and ‘free’ markets. The proliferation of global benchmarks in these key areas amounts to a comprehensive normative vision regarding what various types of transnational actors should look like, what they should value, and how they should behave. While individual benchmarks routinely differ in terms of scope and application, they all share a common foundation, with normative values and agendas being translated into numerical representations through simplification and extrapolation, commensuration, reification, and symbolic judgements. We argue that the power of benchmarks chiefly stems from their capacity to create the appearance of authoritative expertise on the basis of forms of quantification and numerical representation. This politics of numbers paves the way for the exercise of various forms of indirect power, or ‘governance at a distance’, for the purposes of either status quo legitimation or political reform

Resolving the neural circuits of anxiety

Although anxiety disorders represent a major societal problem demanding new therapeutic targets, these efforts have languished in the absence of a mechanistic understanding of this subjective emotional state. While it is impossible to know with certainty the subjective experience of a rodent, rodent models hold promise in dissecting well-conserved limbic circuits. The application of modern approaches in neuroscience has already begun to unmask the neural circuit intricacies underlying anxiety by allowing direct examination of hypotheses drawn from existing psychological concepts. This information points toward an updated conceptual model for what neural circuit perturbations could give rise to pathological anxiety and thereby provides a roadmap for future therapeutic development.National Institute of Diabetes and Digestive and Kidney Diseases (U.S.) (NIH Director’s New Innovator Award DP2-DK-102256-01)National Institute of Mental Health (U.S.) (NIH) R01-MH102441-01)JPB Foundatio