Weight loss, glycemic control, and cardiovascular disease risk factors in response to differential diet composition in a weight loss program in type 2 diabetes: a randomized controlled trial.

ObjectiveTo test whether a weight loss program promotes greater weight loss, glycemic control, and improved cardiovascular disease risk factors compared with control conditions and whether there is a differential response to higher versus lower carbohydrate intake.Research design and methodsThis randomized controlled trial at two university medical centers enrolled 227 overweight or obese adults with type 2 diabetes and assigned them to parallel in-person diet and exercise counseling, with prepackaged foods in a planned menu during the initial phase, or to usual care (UC; two weight loss counseling sessions and monthly contacts).ResultsRelative weight loss was 7.4% (95% CI 5.7-9.2%), 9.0% (7.1-10.9%), and 2.5% (1.3-3.8%) for the lower fat, lower carbohydrate, and UC groups (P < 0.001 intervention effect). Glycemic control markers and triglyceride levels were lower in the intervention groups compared with UC group at 1 year (fasting glucose 141 [95% CI 133-149] vs. 159 [144-174] mg/dL, P = 0.023; hemoglobin A1c 6.9% [6.6-7.1%] vs. 7.5% [7.1-7.9%] or 52 [49-54] vs. 58 [54-63] mmol/mol, P = 0.001; triglycerides 148 [134-163] vs. 204 [173-234] mg/dL, P < 0.001). The lower versus higher carbohydrate groups maintained lower hemoglobin A1c (6.6% [95% CI 6.3-6.8%] vs. 7.2% [6.8-7.5%] or 49 [45-51] vs. 55 [51-58] mmol/mol) at 1 year (P = 0.008).ConclusionsThe weight loss program resulted in greater weight loss and improved glycemic control in type 2 diabetes

Democracy under siege: how actors, communication strategies, and emerging phenomena are changing the rules in the public sphere

In the contemporary digital age, democracy faces a formidable challenge: its very essence is under siege. This challenge manifests in various forms, from the rise of populism and the strategic manipulation of emotions in political discourse to the spread of disinformation across digital platforms and the tightening control of communication in non-democratic regions. In the paper the authors explore these phenomena, shedding light on the evolving dynamics in the public sphere and the implications for democratic governance

The circumstellar envelope around the S-type AGB star W Aql Effects of an eccentric binary orbit

The CO(J=3-2) emission from the CSE of the binary S-type AGB star W Aql has been observed at subarcsecond resolution using ALMA. The aim of this paper is to investigate the wind properties of the AGB star and to analyse how the known companion has shaped the CSE. The average mass-loss rate during the creation of the detected CSE is estimated through modelling, using the ALMA brightness distribution and previously published single-dish measurements as observational constraints. The ALMA observations are presented and compared to the results from a 3D smoothed particle hydrodynamics (SPH) binary interaction model with the same properties as the W Aql system and with two different orbital eccentricities. Three-dimensional radiative transfer modelling is performed and the response of the interferometer is modelled and discussed. The estimated average mass-loss rate of W~Aql agrees with previous results. The size of the emitting region is consistent with photodissociation models. The CO(J=3-2) emission is dominated by a smooth component overlayed with two weak arc patterns with different separations. The larger pattern is predicted by the binary interaction model with separations of 10" and therefore likely due to the known companion. It is consistent with a binary orbit with low eccentricity. The smaller separation pattern is asymmetric and coincides with the dust distribution, but the separation timescale (200 yrs) is not consistent with any known process of the system. The separation of the known companions of the system is large enough to not have a very strong effect on the circumstellar morphology. The density contrast across the envelope of a binary with an even larger separation will not be easily detectable, even with ALMA, unless the orbit is strongly asymmetric or the AGB star has a much larger mass-loss rate.Comment: 10 pages, 8 figure

Development of an application (INDITES software) that allows to integrate spatial and temporal information of a vineyard for the development of the digital terroir

ABSTRACT The terroir has been recognized as an important factor in wine quality and style, especially in European vineyards. There is currently a need for quantification of the factors that influence the definition of terroir, incorporating indexes that quantify variables such as soil, plant and climate, which has led to the definition of "Digital Terroir ". This paper proposes a methodology to develop the "digital terroir" through use of emerging technologies, as current procedures that should be use for the study and define of terroir which suffer from having replicable protocols. The study took place in Valdivieso Vineyard, Curicó, Chile, during the 2012 and 2013 seasons, under the Var. Cabernet Sauvignon, Merlot and Carmenere. The Ferari index (MULTIPLEX RESEARCH ™, FORCE-A), was used for the grapes quality quantification, which was obtained from field samples by a high density grid (20x20 m). Moreover, the soil and plant information was obtained by the use of equipment as follows, electrical conductivity (EM38), topography and exposure (RTK) and NDVI (Tetracam ADC). From the fruit quality index distribution curve (Ferari), 7 rated strata was developed by variety and year, which was used for training the respective model classification of the variables associated with the site. The classification algorithms were based on qualifying Boosting and vector machines (SVM). For model training, 75 % of the data was used and allowed the remaining 25 % to verify the calculation error (control data). The classification results were 95 %, 90 % and 80 %, of well classified area (R 2 >0.9 and Mean Absolute Error < 0.1) for Var.Carmenere, Cabernet Sauvignon and Merlot, respectively. Finally, the well defined grape quality area develop could be used for differential harvest and could be use for vineyard management when increase the yield it is the main goal. The described procedure and results are a keystone for the application of INDITES software presented on this work

Reproductive and bloom patterns of Pelagia noctiluca in the Strait of Messina, Italy

Investigations on sexual reproduction of jellyfish are essential to understanding mechanisms and patterns of outbreaks formation. Pelagia noctiluca (Forskål, 1775) (Scyphozoa) is known as the predominant jellyfish species with direct development in Western and Central Mediterranean Sea. In this paper we used integrated morphometric, histological, and biochemical approaches to investigate the annual reproductive biology of P. noctiluca from the Strait of Messina (South Thyrrenian Sea), a key proliferation area for this species due to favourable temperatures and high productivity. From November 2011 to September 2012, P. noctiluca sexual reproduction occurred throughout the year, with two seasonal peaks (autumn, spring) of spawning and embryonic development. Gonads of female P. noctiluca were characterized by a large amount of mature eggs of small size (diameter < 200 mm) during high food availability, whereas fewer, larger eggs (diameter > 200 mm) were detected during low availability of prey. Two morphometric indexes were applied: the Gonad-Somatic Index (GSI, gonadal/somatic tissue dry weight ratio) and Fecundity Index (FI, n eggs mm2 * gonadal dry weight). The FI showed longer spawning periods than the GSI, providing a better causal-mechanistic explanation for the year-round occurrence of P. noctiluca in the Strait of Messina. Protein contents of the gonads changed seasonally, with the highest concentrations during the pre-spawning periods. We suggest that investigations on jellyfish sexual reproduction can provide biological information relevant for understanding mechanisms of jellyfish blooms as well as for the management of coastal zones affected by outbreaks of gelatinous species

WaLiN-GUI: a graphical and auditory tool for neuron-based encoding

Neuromorphic computing relies on spike-based, energy-efficient communication, inherently implying the need for conversion between real-valued (sensory) data and binary, sparse spiking representation. This is usually accomplished using the real valued data as current input to a spiking neuron model, and tuning the neuron's parameters to match a desired, often biologically inspired behaviour. We developed a tool, the WaLiN-GUI, that supports the investigation of neuron models and parameter combinations to identify suitable configurations for neuron-based encoding of sample-based data into spike trains. Due to the generalized LIF model implemented by default, next to the LIF and Izhikevich neuron models, many spiking behaviors can be investigated out of the box, thus offering the possibility of tuning biologically plausible responses to the input data. The GUI is provided open source and with documentation, being easy to extend with further neuron models and personalize with data analysis functions.Comment: 4 pages, 1 figur

A method for the complete analysis of NORM building materials by γ-ray spectrometry using HPGe detectors

[EN] A methodology including software tools for analysing NORM building materials and residues by low-level gamma-ray spectrometry has been developed. It comprises deconvolution of gamma-ray spectra using the software GALEA with focus on the natural radionuclides and Monte Carlo simulations for efficiency and true coincidence summing corrections. The methodology has been tested on a range of building materials and validated against reference materials

Dataset of measured and commented pantograph electric arcs in DC railways

DC railways are characterized by particularly intense arcing caused by pantograph detachment, due to the large current intensity and the general implementation of onboard resonant filters, whose transient response is triggered by electric transients including electric arcs. Electric arc depends on the train speed (the relative speed between the sliding contact over the pantograph and the hot spot on the catenary system), the intensity of the collected pantograph current and the line voltage level. Electric arcs are broadband in nature and can trigger the system transient response dominated by the resonant filter, besides interfering with the operation of onboard equipment (such as for energy conversion and metering)