1,664 research outputs found
PatologÃa de ligamentos en la meseta tibial
X Congreso Nacional de PaleopatologÃa. Univesidad Autónoma de Madrid, septiembre de 200
PatologÃa escapulo-clavicular en un sujeto de Morella
X Congreso Nacional de PaleopatologÃa. Univesidad Autónoma de Madrid, septiembre de 200
PatologÃa traumática: estudio anatómico y paleopatológico de fracturas de miembros superiores e inferiores de la antigua población de Castielfabid (Rincón de Ademuz, Valencia)
X Congreso Nacional de PaleopatologÃa. Univesidad Autónoma de Madrid, septiembre de 200
TendinopatÃa del radio: estudio anatómico y paleopatológico
X Congreso Nacional de PaleopatologÃa. Univesidad Autónoma de Madrid, septiembre de 200
TendinopatÃa de una clavÃcula: estudio anatómico y paleopatológico
X Congreso Nacional de PaleopatologÃa. Univesidad Autónoma de Madrid, septiembre de 200
Miositis calcificante: estudio antropométrico y paleopatológico de tres casos
X Congreso Nacional de PaleopatologÃa. Univesidad Autónoma de Madrid, septiembre de 200
Quaking RNA bindings proteins as mediator of oncolytic HSV vectors in huma hepatoma cells
Comunicaciones a congreso
Attrition in a Multi-Component Smoking Cessation Study for Females
Limiting attrition (i.e., participant dropout before the conclusion of a study) is a major challenge faced by researchers when implementing clinical trials. Data from a smoking cessation trial for females (N = 246) were analyzed in order to identify baseline smoking-related, demographic and psychological characteristics affecting likelihood of early (i.e., before the quit attempt) and late (i.e., after the quit attempt) dropout. There were a number of significant demographic predictors of attrition. Participants with at least one child living at home were at increased risk of both early and late dropout. Non-Whites were at increased risk of early dropout, while not having a college degree put one at increased risk of late dropout. Age was found to be a protective factor in that the older a participant was, the less likely she was to drop out in the early stages of the trial. With respect to psychological variables, weight concerns increased risk of attrition, as did the experience of guilt. In terms of smoking-related variables, mean cigarettes per day was not a significant predictor of attrition, although length of longest prior quit attempt was a significant predictor of early dropout when age was removed from the regression
The Influence of In Vitro Gastrointestinal Digestion on the Anticancer Activity of Manuka Honey
Manuka honey (MH) is a natural food with many beneficial properties to human health,
thanks to its high variety of bioactive compounds; however, little is known about its bioaccessibility.
The aim of this study was to evaluate and compare the polyphenol compounds, the antioxidant
capacity and the anticancer activity of MH subjected to an in vitro gastrointestinal digestion in human
HCT-116 colon cancer cells. Raw MH and digested MH (DMH) were assessed for total polyphenols
and flavonoids by spectrophotometric and HPLC-ESI-MS/MS analysis, and total antioxidant capacity
(TAC) using different methods. Cell viability, intracellular ROS production, apoptosis, cell cycle and
colony formation capacity were tested after treatment with MH or DMH. Results showed that total
polyphenols, total flavonoids and TAC were significantly (p < 0.05) reduced after in vitro digestion.
In addition, MH and DMH at 8, 16 and 24 mg/mL had similar effects in inducing intracellular ROS
production and in inhibiting the colon formation ability; MH induced a more marked apoptosis
compared to DMH, while cell cycle was blocked in S phase by MH and in Sub G1 phase by DMH.
Our results increase knowledge of the effect of gastrointestinal digestion on the biological effect of
honey against colorectal cancer
Prevalence and Prognostic Influence of Peripheral Arterial Disease in Patients ≥40 Years Old Admitted into Hospital Following an Acute Coronary Event
AbstractObjectiveA significant proportion of patients with ischemic heart disease have associated peripheral arterial disease (PAD), but many are asymptomatic and this condition remains underdiagnosed. We aimed to study the prevalence of PAD in patients with an acute coronary syndrome (ACS) and to evaluate its influence in hospital clinical outcomes.MethodsThe PAMISCA register is a prospective, multicenter study involving patients ≥40 years old with ACS admitted to selected Spanish hospitals. All patients had their ankle-brachial index (ABI) measured between days 3 and 7 after the ischemic event.Results1410 ACS patients (71.4% male) were included. PAD determined by ABI was documented in 561 patients (39.8%). Factors independently related to PAD were age (OR: 1.04; 95% CI: 1.03–1.06; p<0.001), smoking (OR: 1.88; 95% CI: 1.41–2.49; p<0.0001), diabetes (OR: 1.30; 95% CI: 1.02–1.65; p<0.05), previous cardiac disease (OR: 1.54; 95% CI: 1.22–1.95; p<0.001) and previous cerebrovascular disease (OR: 1.90; 95% CI: 1.28–2.80; p<0.001). Following the ACS, an ABI≤0.90 was associated with increased cardiovascular mortality (OR: 5.45; 95% CI: 1.16–25.59; p<0.05) and a higher risk of cardiovascular complications.ConclusionThe prevalence of PAD in patients ≥40 years presenting with ACS is high and it is associated with increased cardiovascular risk
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