Prácticas políticas en grupos juveniles: experiencia Grupo Estudiantil Semilla Política de la Universidad Autónoma de Occidente, Cali-Valle; en el periodo 2007-2011

El presente informe se soporta sobre una teoría central y trabajo de campo, dado que la propuesta no sólo intentaría establecer las prácticas políticas del grupo estudiantil Semilla Política y explorar cómo se compone, conocer el rol de sus integrantes, identificar sus actividades internas, proyectos e incidencia en la vida política, entre otras cosas; sino que, logró establecer a la agrupación juvenil en el contexto del esquema de análisis sobre el sistema político, propuesto por David Easton. La propuesta de establecer las prácticas políticas de determinado grupo con características alternativas, nace de la identificación y del apoyo teórico soportado en estudios investigativos que indagan acerca del comportamiento, trabajo, organización y capacidad de movilización juvenil. La teoría principal del trabajo se centra en el Esquema para el Análisis del Sistema Político1 de David Easton, una teoría que permite entender, entre muchas cosas, las dinámicas interactivas entre la sociedad civil, la política y el Estado. Con esta teoría se busca tener una base teórica que permita comprender, para este trabajo, el proceso de conversión de necesidades de las sociedades, la interacción entre actores del sistema, el funcionamiento interactivo básico del sistema político, entre otros alcances a nivel conceptualProyecto de grado (Comunicador Social-Periodista)-- Universidad Autónoma de Occidente, 2013PregradoComunicador(a) Social – Periodist

Medición de impacto de la educación superior regionalizada de la Universidad de Antioquia. Estudio de caso en la sede del Carmen de Viboral

RESUMEN: Este vídeo presenta los resultados del proyecto de investigación en el marco de la Convocatoria Proyectos de Investigación de Regionalización, 2017

Design of an algorithm for the diagnostic approach of patients with joint pain

Background Rheumatic diseases are a reason for frequent consultation with primary care doctors. Unfortunately, there is a high percentage of misdiagnosis. Objective To design an algorithm to be used by primary care physicians to improve the diagnostic approach of the patient with joint pain, and thus improve the diagnostic capacity in four rheumatic diseases. Methods Based on the information obtained from a literature review, we identified the main symptoms, signs, and paraclinical tests related to the diagnosis of rheumatoid arthritis, spondyloarthritis with peripheral involvement, systemic lupus erythematosus with joint involvement, and osteoarthritis. We conducted 3 consultations with a group of expert rheumatologists, using the Delphi technique, to design a diagnostic algorithm that has as a starting point “joint pain” as a common symptom for the four diseases. Results Thirty-nine rheumatologists from 18 countries of Ibero-America participated in the Delphi exercise. In the first consultation, we presented 94 items to the experts (35 symptoms, 31 signs, and 28 paraclinical tests) candidates to be part of the algorithm; 74 items (25 symptoms, 27 signs, and 22 paraclinical tests) were chosen. In the second consultation, the decision nodes of the algorithm were chosen, and in the third, its final structure was defined. The Delphi exercise lasted 8 months; 100% of the experts participated in the three consultations. Conclusion We present an algorithm designed through an international consensus of experts, in which Delphi methodology was used, to support primary care physicians in the clinical approach to patients with joint pain

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele