The second moment of Sn(t)S_n(t) on the Riemann hypothesis

Let $S(t) = \tfrac{1}{\pi} \arg \zeta \big(\frac{1}{2} + it \big)$ be the argument of the Riemann zeta-function at the point $\tfrac12 + it$. For $n \geq 1$ and $t>0$ define its antiderivatives as \begin{equation*} S_n(t) = \int_0^t S_{n-1}(\tau) \hspace{0.08cm} \rm d\tau + \delta_n , \end{equation*} where $\delta_n$ is a specific constant depending on $n$ and $S_0(t) := S(t)$. In 1925, J. E. Littlewood proved, under the Riemann Hypothesis, that $$\int_{0}^{T}|S_n(t)|^2 \hspace{0.06cm} \rm dt = O(T),$$ for $n\geq 1$. In 1946, Selberg unconditionally established the explicit asymptotic formulas for the second moments of $S(t)$ and $S_1(t)$. Assuming the Riemann Hypothesis, we give the explicit asymptotic formula for the second moment of $S_n(t)$ up to the second-order term, for $n\geq 1$. Our result conditionally refines Selberg's formula for $S_1(t)$ and makes explicit the estimates given by Littlewood. This extends previous work by Goldston in $1987$, where the case $n=0$ was considered

The competitive ability of weed communities in selected crucifer oilseed crops under different water and nitrogen

Durante los años 2012 y 2013, se llevó a cabo un experimento en el centro de la península cuyo objetivo fue el estudio de la flora arvense en 3 especies de “Brassica” (“B. carinata”, “B. juncea” y “B. nigra”). Las malas hierbas se evaluaron con 2 niveles de riego, con y sin aporte de agua, y con tres dosis de fertilización diferentes: 0, 75 y 150 kg N ha-1. El establecimiento del cultivo de las tres especies de “Brassica” varió en función del año. Las escasas lluvias de 2012 redujeron la densidad y biomasa de la flora arvense en comparación con el año 2013 en el que la pluviometría fue mayor. Los resultados sugieren que la especie “B. nigra” no estaba bien adaptada a nuestras condiciones climáticas continentales, mostrando un rendimiento más bajo que el resto de los cultivares. Por otro lado, la infestación de malas hierbas fue menor en todas las parcelas donde se cultivaba “B. carinata”.A field study was undertaken to examine the interaction and relationships between weeds and three “Brassica” species (“B. carinata”, “B. juncea” and “B. nigra”) grown in 2012 and 2013. We evaluated the weed density, fresh and dry biomass of weeds with 2 water regimes: with and without irrigation, and three different doses of fertilization: 0, 75 and 150 kg N ha-1. Crop establishment of “Brassica” species varied significantly each year. Lower rainfall in 2012 led to lower density, fresh and dry biomass of weeds compared to 2013. The results confirmed that “B. nigra” was not well adapted to our continental climatic conditions, and thus the yield was lower than the other cultivars. The lowest weed infestation occurred in plots where “B. carinata” was grown in all cases

Breast implant-associated anaplastic large cell lymphoma: a review

El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.Breast implant-associated anaplastic large cell lymphoma is a newly recognized provisional entity in the 2017 revision of the World Health Organization Classification of Tumors of Hematopoietic and Lymphoid Tissues. It is an uncommon, slow growing T-cell lymphoma with morphology and immunophenotype similar to anaplastic lymphoma kinase-negative anaplastic large cell lymphoma. However, the presentation and treatment are unique. Breast implant-associated anaplastic large cell lymphoma often presents as a unilateral effusion confined to the capsule of a textured-surface breast implant, a median time of 9 years after the initial implants have been placed. Although it follows an indolent clinical course, breast implant-associated anaplastic large cell lymphoma has the potential to form a mass, to invade locally through the capsule into breast parenchyma or soft tissue and/or to spread to regional lymph nodes. In most cases, an explantation with a complete capsulectomy removing all disease, without chemotherapy is considered to be curative and confers an excellent event free and overall survival. Here we provide a comprehensive review of breast implant-associated anaplastic large cell lymphoma, including history, epidemiology, clinical features, imaging and pathology findings, pathologic handling, pathogenic mechanisms, model for progression, therapy and outcomes as well as an analysis of causality between breast implants and anaplastic large cell lymphoma.Revisión por pare

La hora del museo: la sala Uriburu del Museo Histórico y Colonial de la Provincia de Buenos Aires (Luján, 1932)

El artículo analiza el proceso de creación de la Sala Uriburu del Museo Histórico y Colonial de la Provincia de Buenos Aires instalado en la ciudad de Luján y abierto al público en 1923. La sala fue inaugurada el 4 de septiembre de 1932 y estaba destinada a honrar la memoria del líder de la "Revolución" del 6 de septiembre de 1930. El objetivo es dar cuenta de los múltiples factores que incidieron en su instalación considerando que ella no puede explicarse solamente a través de la relación directa entre coyuntura política, atmósfera nacionalista y la necesidad de crear un mito para perpetuar su memoria. Proponemos entonces explorar las prácticas y dispositivos colectivos indispensables en el proceso de creación de evidencias materiales para sustentar la visualización de un relato histórico.O artigo analisa o processo de instalação da Sala Uriburu, do Museu Histórico e Colonial da Província de Buenos Aires, fundado na cidade de Luján e aberto ao público em 1923. A sala foi inaugurada em 4 de setembro de 1932, e destinava-se a "honrar a memória" do líder da "Revolução" de 6 de setembro de 1930, poucos meses depois de sua morte. O objetivo é dar conta dos múltiplos fatores que incidiram na instalação, considerando que ela não pode ser explicada somente através da relação direta entre conjuntura política, atmosfera nacionalista e a necessidade de criar um mito para perpetuar sua memória. Propomos, então, explorar as práticas e dispositivos coletivos indispensáveis no processo de criação de evidências materiais para sustentar a visualização de um relato histórico.This article analyzes the installation of Uriburu's Hall at the Museo Histórico y Colonial de la Provincia de Buenos Aires, institution established in Luján in 1923. This hall was opened to the public in September 1932, to celebrate the name and memory of the hero of the Revolution of 1930. Far from proposing a direct relationship between politics and museum displays, this article wants to display the several elements that colluded in the creation of this hall

Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis

Altres ajuts: Fondo Europeo de Desarrollo Regional (FEDER), "A way of making Europe".Copy number (CN) polymorphisms of complement C4 play distinct roles in many conditions, including immune-mediated diseases. We investigated the association of C4 CN with systemic sclerosis (SSc) risk. Imputed total C4, C4A, C4B, and HERV-K CN were analyzed in 26,633 individuals and validated in an independent cohort. Our results showed that higher C4 CN confers protection to SSc, and deviations from CN parity of C4A and C4B augmented risk. The protection contributed per copy of C4A and C4B differed by sex. Stronger protection was afforded by C4A in men and by C4B in women. C4 CN correlated well with its gene expression and serum protein levels, and less C4 was detected for both in SSc patients. Conditioned analysis suggests that C4 genetics strongly contributes to the SSc association within the major histocompatibility complex locus and highlights classical alleles and amino acid variants of HLA-DRB1 and HLA-DPB1 as C4-independent signals

CARB-ES-19 Multicenter Study of Carbapenemase-Producing Klebsiella pneumoniae and Escherichia coli From All Spanish Provinces Reveals Interregional Spread of High-Risk Clones Such as ST307/OXA-48 and ST512/KPC-3

ObjectivesCARB-ES-19 is a comprehensive, multicenter, nationwide study integrating whole-genome sequencing (WGS) in the surveillance of carbapenemase-producing K. pneumoniae (CP-Kpn) and E. coli (CP-Eco) to determine their incidence, geographical distribution, phylogeny, and resistance mechanisms in Spain.MethodsIn total, 71 hospitals, representing all 50 Spanish provinces, collected the first 10 isolates per hospital (February to May 2019); CPE isolates were first identified according to EUCAST (meropenem MIC > 0.12 mg/L with immunochromatography, colorimetric tests, carbapenem inactivation, or carbapenem hydrolysis with MALDI-TOF). Prevalence and incidence were calculated according to population denominators. Antibiotic susceptibility testing was performed using the microdilution method (EUCAST). All 403 isolates collected were sequenced for high-resolution single-nucleotide polymorphism (SNP) typing, core genome multilocus sequence typing (cgMLST), and resistome analysis.ResultsIn total, 377 (93.5%) CP-Kpn and 26 (6.5%) CP-Eco isolates were collected from 62 (87.3%) hospitals in 46 (92%) provinces. CP-Kpn was more prevalent in the blood (5.8%, 50/853) than in the urine (1.4%, 201/14,464). The cumulative incidence for both CP-Kpn and CP-Eco was 0.05 per 100 admitted patients. The main carbapenemase genes identified in CP-Kpn were blaOXA–48 (263/377), blaKPC–3 (62/377), blaVIM–1 (28/377), and blaNDM–1 (12/377). All isolates were susceptible to at least two antibiotics. Interregional dissemination of eight high-risk CP-Kpn clones was detected, mainly ST307/OXA-48 (16.4%), ST11/OXA-48 (16.4%), and ST512-ST258/KPC (13.8%). ST512/KPC and ST15/OXA-48 were the most frequent bacteremia-causative clones. The average number of acquired resistance genes was higher in CP-Kpn (7.9) than in CP-Eco (5.5).ConclusionThis study serves as a first step toward WGS integration in the surveillance of carbapenemase-producing Enterobacterales in Spain. We detected important epidemiological changes, including increased CP-Kpn and CP-Eco prevalence and incidence compared to previous studies, wide interregional dissemination, and increased dissemination of high-risk clones, such as ST307/OXA-48 and ST512/KPC-3

Start-up of non-bioaugmented pumice biofilters in flow-through and recirculating flow regime for Mn removal

Biofilters are effectively used for drinking water treatment. However, the long ripening time of virgin media for manganese (Mn) removal is a major concern. In this study, the influence of the flow regime on the ripening time of virgin pumice medium was investigated. For this purpose, pilot-scale experiments were performed to compare the start-up of flow-through and recirculating filter columns using inherent inoculation with the same groundwater source. The systems were operated at 2 m·h1 with gradual flow increments up to 5 m·h1 and avoiding Fe-loading. Effective Mn removal (.90%) in flow-through and recirculating columns was achieved after 8 and 23 days, respectively. Flow-through columns reached compliance with a local drinking water criterion (Mn, 0.1 mg·L1) at 15 cm filter depth in 11 days. Recirculating filter columns required 32 days to reach compliance at 30 cm depth. The start-up in recirculation regime resulted in a water consumption reduction of about 50% compared with flow-through regime. The intermittent provision of the Mn-loading in recirculating regime impacted the Mn-oxidizing bacteria (MOB) concentration in the pumice stone medium. Both flow regimes required a similar total Mn-loading (0.16 and 0.11 kg·Mn·m2, respectively), suggesting that Mn-loading was the limiting factor for the ripening of pumice.</p