Resultados del estudio geológico a escala 1/25.000 del término municipal de Madrid.

Se exponen de forma abreviada los rasgos en cuanto a metodología y conclusiones del estudio geológico a escala 1/25000 realizado en el Municipio de Madrid en los años 1982/83. Las diferentes unidades expresadas en la cartografiase describen en función de las pautas mayores observables en los materiales que forman cada una de ellas, analizándose sus relaciones estratigráficas. El Proyecto «Estudio Geológico a escala 1/25000 del Término Municipal de Madrid ha sido llevado a cabo a lo largo de los años 1982-83 como resultado de la colaboración científica entre diversos organismos de la Administración (Facultad de CC. Geológicas-Universidad Complutense, Instituto Geológico y Minero. Ayuntamiento de Madrid, Instituto de Geología de Madrid-CSIC, y otros). Constituye una de las áreas de actuación definidas dentro del Convenio de Colaboración Técnica y Cultural para el conocimiento de las Características del Suelo y Subsuelo de Madrid», propiciado y patrocinado por el Excmo. Ayuntamiento. La financiación del proyecto especifico de Geología ha sido realizada íntegramente por el IGME, organismo encargado además de su supervisión. El desarrollo del Proyecto tiene un marcado carácter interdisciplinar, fruto del trasvase de información entre los distintos grupos que abarca el Convenio general (aparte de los ya referidos, el SGOP, COPLACO, Laboratorio «José Luis Escario» siendo precisamente uno de los objetivos del trabajo el servir de apoyo a las restantes áreas de investigación. Los estudios geológicos realizados se plasman en un total de siete mapas a escala 1/25000 elaborados según la normativa Magna de cartografía geológica mapas que toman como referencia, aunque en algunos casos no las completan y en otros adosan porciones de hojas adyacentes, las hojas 1/25000 de Madrid, Alcorcón, El Pardo, San Femando de Henares, Pozuelo de Alarcón, Alcobendas y Castillo de Viñuelas

Background rejection in NEXT using deep neural networks

[EN] We investigate the potential of using deep learning techniques to reject background events in searches for neutrinoless double beta decay with high pressure xenon time projection chambers capable of detailed track reconstruction. The differences in the topological signatures of background and signal events can be learned by deep neural networks via training over many thousands of events. These networks can then be used to classify further events as signal or background, providing an additional background rejection factor at an acceptable loss of efficiency. The networks trained in this study performed better than previous methods developed based on the use of the same topological signatures by a factor of 1.2 to 1.6, and there is potential for further improvement.The NEXT Collaboration acknowledges support from the following agencies and institutions: the European Research Council (ERC) under the Advanced Grant 339787-NEXT; the Ministerio de Economia y Competitividad of Spain and FEDER under grants CONSOLIDER-Ingenio 2010 CSD2008-0037 (CUP), FIS2014-53371-C04 and the Severo Ochoa Program SEV-2014-0398; GVA under grant PROMETEO/2016/120. Fermilab is operated by Fermi Research Alliance, LLC under Contract No. DE-AC02-07CH11359 with the United States Department of Energy. JR acknowledges support from a Fulbright Junior Research Award.Renner, J.; Farbin, A.; Muñoz Vidal, J.; Benlloch-Rodríguez, J.; Botas, A.; Ferrario, P.; Gómez-Cadenas, J.... (2017). Background rejection in NEXT using deep neural networks. Journal of Instrumentation. 12. https://doi.org/10.1088/1748-0221/12/01/T01004S1

Clinically isolated syndrome: Diagnosis and risk of developing clinically definite multiple sclerosis

Introduction: In most cases, multiple sclerosis (MS) initially presents as clinically isolated syndrome (CIS). Differentiating CIS from other acute or subacute neurological diseases and estimating the risk of progression to clinically definite MS is essential since presenting a second episode in a short time is associated with poorer long-term prognosis. Development: We conducted a literature review to evaluate the usefulness of different variables in improving diagnostic accuracy and predicting progression from CIS to MS, including magnetic resonance imaging (MRI) and such biofluid markers as oligoclonal IgG and IgM bands, lipid-specific oligoclonal IgM bands in the CSF, CSF kappa free light-chain (KFLC) index, neurofilament light chain (NfL) in the CSF and serum, and chitinase 3–like protein 1 (CHI3L1) in the CSF and serum. Conclusions: Codetection of oligoclonal IgG bands and MRI lesions reduces diagnostic delays and suggests a high risk of CIS progression to MS. A KFLC index > 10.6 and CSF NfL concentrations > 1150 ng/L indicate that CIS is more likely to progress to MS within one year (40%–50%); 90% of patients with CIS and serum CHI3L1 levels > 33 ng/mL and 100% of those with lipid-specific oligoclonal IgM bands present MS within one year of CIS onset. Resumen: Introducción: La mayoría de los pacientes con esclerosis múltiple (EM) debutan con un síndrome clínico aislado (SCA). Es importante diferenciar este SCA de otras patologías neurológicas agudas o subagudas y estimar el riesgo de desarrollar una esclerosis múltiple clínicamente definida (EMCD), pues un segundo ataque clínico en un corto periodo de tiempo se asocia con peor pronóstico a largo plazo. Desarrollo: Se realizó una revisión bibliográfica con el objetivo de contrastar diferentes variables, tales como la resonancia magnética (RM) y diferentes marcadores biofluídicos como las bandas oligoclonales IgG (BOC), bandas oligoclonales IgM (BOCM), bandas oligoclonales IgM lípido específicas (BOCM-LE), índice de cadenas ligeras libres Kappa (κ index) mediante la determinación de las cadenas ligera libres kappa en líquido cefalorraquídeo (LCR), neurofilamentos de cadenas ligeras en LCR (NfLL) y suero (NfLS) y la proteína chitinasa 3-like 1 (CHI3L1) en LCR (CHI3L1L) y suero (CHI3L1S), con el objetivo de mejorar la precisión diagnóstica y predecir los riesgos de un segundo ataque clínico tras un SCA. Conclusión: Unas BOC positivas junto con la identificación de lesiones por RM, reducirán el tiempo de diagnóstico y nos indicaran que la mayoría de los pacientes con SCA evolucionaran a EM. Un κ index >10.6 y una concentración de NfLL > 1150 ng/L, nos indican que los SCA tienen más probabilidades de convertirse en EM durante el primer año (40%/50%). El 90% de los pacientes con SCA y niveles de CHI3L1S >33 ng/mL, y el 100% con presencia BOCM-LE se convierten en EM durante el primer año

Nutrición nitrogenda de cereales utilizando abonos con el inhibidor de la nitrificación DMPP

6 páginas, 4 cuadros y 4 figurasLa optimización de la fertilización de los cultivos extensivos es una tarea fundamental para ajustar los costes productivos y para reducir la contaminación de origén agrario, especialmente en lo que al nitrógeno se refiere. Actualmente laszonas vulnerables a la contaminación por nitratos están en constante aumento debido a la inadecuada gestión del nitrógeno en e medio agrario y ganadero. En consecuencia, tanto la Unión Europea como los Gobiernos nacional y autonómicos haNn establecido en estas zonas una serie de normas restrictivas en lo que al uso del nitrógeno en la agricultura se refierwe. Es estudio de las pautas óptimas de fertilización, junto con el uso de abonos ecoeficientes, permitirá un avancesignificativo en este campo.Peer reviewe

Specially Invited Opinions and Research Report of the International Water Law Project: Global Perspectives on the Entry into Force of the UN Watercourses Convention 2014: Part Two

This is the second part of a research report on opinions of prominent international water lawyers from each continent on the potential impacts of the 1997 UN Convention on the Non-Navigational Uses of International Watercourses. The first part of the report was published in Water Policy 16(6). The following compilation is reproduced and adapted from a series of essays that appeared in the blog of the International Water Law Project (www.internationalwaterlaw.org). The series was solicited in preparation for the coming into force of the 1997 UN Convention on the Non-navigational Uses of International Watercourses. The Convention had been pending for 17 years since its adoption by the United Nations General Assembly (UNGA) in 1997. On 19 May 2014, Vietnam became the 35th party to the treaty, bringing the total number of State Parties to 35, the minimum number of ratifications needed to bring that Convention into force. In anticipation of this long-awaited occasion, during the summer of 2014, the International Water Law Project hosted a series of essays on its blog (www.internationalwaterlaw.org/blog/) from some of the most knowledgeable scholars and practitioners worldwide. The series provided unique perspectives and information on the implications of the Convention for international water law and the global management of transboundary watercourses. The outcome was a fantastic, provocative, and timely compilation that offered readers both an introduction and unique insight into the Convention. It also offered readers the opportunity to participate in the discussion and offer their own perspectives and opinions by submitting comments on the various essays. While the essays have been included in the following compilation, the readers’ comments can be found on the International Water Law Project Blog. The International Water Law Project is itself a unique institution. Existing solely on the Internet, the website is one of the premier resources and clearing houses for information on international water law and policy. Its purpose is to educate and provide relevant resources to researchers and the public and to facilitate cooperation over the world’s freshwater resources

Overview of the meteorology and transport patterns during the DAURE field campaign and their impact to PM observations

The experimental campaign “Determination of the sources of atmospheric Aerosols in Urban and RuralEnvironments in Spain “(DAURE) took place in a urban (Barcelona city) and a rural (the Montseny Natural Park) Spanish sites. Its main objective was to study the formation and transport processes of particulate matter in the region during winter and summer time. This paper presents a description of the meteorological conditions during the campaign by means of meteorological observations, high-resolution mesoscale meteorological modelling and backward Lagrangian particle dispersion simulations. Modelling results are in agreement with observations and provide a valuable tool for characterizing transport patterns in relation to episodes of air pollution. An objective classification of the synoptic conditions and a classification of the main local dispersion patterns is presented and discussed. Additionally, themeasured PM1 and PM10 levels in both urban and rural sites are discussed and related to the meteorological conditions observed.Preprin

Cocaine-induced pyoderma gangrenosum-like lesions

Cocaine consumption is increasing at an alarming rate. This drug produces euphoria, anorexia, increased alertness and diminished sleep requirements. It is estimated that up to 80 % of cocaine is contaminated with levamisole, a substance which may potentiate the drug’s chemical effects [ 1 ] . Multiple mucocutaneous manifestations have been associated with cocaine use [ 2 ] , including cocaine-induced pyoderma gangre-nosum (CIPG), cocaine-induced midline destructive lesions (CIMDL) and retiform purpura (RP). We present three cases of cocaine abuse with skin lesions compatible with PG, and review the epidemiological, clinical, histopathological and immunological characteristics of CIPG and RP. We suggest that these two conditions are more closely related than previously thought. Additionally, in our opinion, no specific immunological or histological profile would be indicative of levamisole toxicity