9 research outputs found
Observation of gravitational waves from the coalescence of a 2.5â4.5 Mâ compact object and a neutron star
- Author
- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aghaei Abchouyeh Maryam
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akcay Sarp
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi Simone
- Alex iandolo Guido
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés Vallejo Peña Sergio
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi Stefano
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L.
- Arif Shaikh Md
- Aritomi N.
- Armato Federico
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Attadio Francesca
- Aubin Florian
- AVALLONE Guerino
- Azrad D.
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bagui E.
- Baier Jeremy
- Baiotti Luca
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
- Baral Pratyusava
- Barayoga J. C.
- Barish B. C.
- Barker D.
- Barneo Pablo
- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
- Barta DĂĄniel
- Bartoletti A. M.
- Barton Mark Andrew
- Bartos I.
- Basak Soummyadip
- Basalaev Artem
- Bassiri Riccardo
- Basti Andrea
- Bates D. E.
- Bawaj Mateusz
- Baxi P.
- Bayley Joseph
- Baylor Amanda
- Baynard II. P. A.
- Bazzan M.
- Bedakihale V. M.
- Beirnaert Freija
- Bejger MichaĆ
- Belardinelli Daniele
- Bell Angus
- Benedetto V.
- Benoit William
- Bentley Joe
- Bera Sayantani
- Berbel Marina
- Bergamin Fabio
- Berger Beverly
- Bernuzzi Sebastiano
- Beroiz Martin
- Berry Christopher P. L.
- Bersanetti Diego
- Bertolini A.
- Betzwieser Joseph
- Beveridge Damon
- Bevins Nathaniel
- Bhandare R.
- Bhardwaj Uddipta
- Bhatt R.
- Bhattacharjee Dripta
- Bhaumik Shubhagata
- Bhowmick S.
- Bianchi A.
- Bilenko I. A.
- Billingsley GariLynn
- Binetti Alberto
- Bini Sophie
- Birnholtz Ofek
- Bisht A.
- Bitossi Massimiliano
- Blackburn Kent
- Blagg L. A.
- Blair C. D.
- Blair D. G.
- Bobba F.
- Bode Nina
- Boileau Guillaume
- Boldrini Mattia
- Bolingbroke Georgia
- Bolliand A.
- Bondarescu Ruxandra
- Bondu François
- Bonilla Carrasquel Edgard
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- Borchers A.
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- BRANCHESI Marica
- Brandt J.
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- Brillet A.
- Brinkmann M.
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- Burtnyk K.
- Buscicchio Riccardo
- Buskulic D.
- Bustillo J. CalderĂłn
- Buy Christelle
- Byer R. L.
- Cabourn Davies Gareth
- Cabras Giuseppe
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- Cagnoli Gianpietro
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- Calloni E.
- Camp J. B.
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- Carpinelli Massimo
- Carrillo G.
- Carter Jonathan
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- Casentini Claudio
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- Cavaglia Marco
- Cavalieri Roberto
- Cella Giancarlo
- CerdĂĄ-DurĂĄn Pablo
- Cesarini Elisabetta
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- Chakraborty Pratik
- Chalathadka Subrahmanya Shreevathsa
- Chan M.
- Chandra K.
- Chang R. -J.
- Chao Shiuh
- Char Prasanta
- Charlton E. L.
- Charlton Philip
- Chassande-Mottin Eric
- Chatterjee Chayan
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- Chatterjee Deep
- Chattopadhyay Debatri
- Chaturvedi M.
- Chaty Sylvain
- Chatziioannou Katerina
- Chen A.
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- Christensen Nelson
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- Clasey Essick Reed
- Claudio Diaz Mario
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- Codazzo Elena
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- Connolly G.
- Conti Livia
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- Corsi Alessandra
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- Cudell Jean-René
- Cullen Torrey
- Cumming Alan
- Cuoco E.
- Cusinato Marco
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- CĂ©sar Martins Julio
- D'Angelo Beatrice
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- d'Emilio V.
- D'Onofrio Luca
- D'Urso D.
- Dabadie P.
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- DALL'OSSO Simone
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- de rossi camilla
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- Deenadayalan M.
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- Del Pozzo Walter
- Dell'Aquila Daniele
- Deléglise Samuel
- Demos N.
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- Dhani A.
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- Emma Mattia
- Endo K.
- enea romano antonio
- Engl A. J.
- Enloe E.
- Erasmo Peña Arellano Fabiån
- Errico Luciano
- error error
- error error
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- Estevez Dimitri
- Etzel T.
- Evans Matthew J.
- Evstafyeva T.
- Ewing B. E.
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- Faedi F.
- Fafone Viviana
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- Fenyvesi Edit
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- Figura PrzemysĆaw
- Fiori Alessio
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- Fishbach Maya
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- Flaminio R.
- Fleischer Svenja
- Fleming L. S.
- Floden E.
- Foley E. M.
- Fong H.
- Fornal Bartosz
- Forsyth P. W. F.
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- Franchini N.
- Francisco Nuño Siles José
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- Frei Zsolt
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- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
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- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
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- Zhu Zong-Hong
- Zimmerman Aaron
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- Zweizig John
- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- éœäžž éèĄ
- Publication venue
- Publication date
- 23/04/2024
- Field of study
Ultralight vector dark matter search using data from the KAGRA O3GK run
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adamcewicz Christian
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L. Granda
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- AVALLONE Guerino
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bagui E.
- Bai Y.
- Baier Jeremy
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
- Baral Pratyusava
- Barayoga J. C.
- Barish B. C.
- Barker D.
- Barneo Pablo
- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
- Barta DĂĄniel
- Barthelmy S. D.
- Barton Mark Andrew
- Bartos I.
- Basak Soummyadip
- Basalaev Artem
- Bassiri Riccardo
- Basti Andrea
- Bawaj Mateusz
- Baxi P.
- Bayley Joseph
- Baylor Amanda
- Bazzan M.
- Bedakihale V. M.
- Beirnaert Freija
- Bejger MichaĆ
- Belardinelli Daniele
- Bell Angus
- Benedetto V.
- Beniwal D.
- Benoit William
- Bentley Joe
- Bera Sayantani
- Berbel Marina
- Bergamin Fabio
- Berger Beverly
- Bernuzzi Sebastiano
- Beroiz Martin
- Bersanetti Diego
- Bertolini A.
- Betzwieser Joseph
- Beveridge Damon
- Bevins Nathaniel
- Bhandare R.
- Bhardwaj Uddipta
- Bhatt R.
- Bhattacharjee Dripta
- Bhaumik Shubhagata
- Bhowmick S.
- Bianchi A.
- Bilenko I. A.
- Billingsley GariLynn
- Binetti Alberto
- Bini Sophie
- Birnholtz Ofek
- Bisht A.
- Bitossi Massimiliano
- Blackburn Kent
- Blair C. D.
- Blair D. G.
- Bobba F.
- Bode Nina
- Bogaert G.
- Boileau Guillaume
- Boldrini Mattia
- Bolingbroke Georgia
- Bolliand A.
- Bondarescu Ruxandra
- Bondu François
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- Bossilkov V.
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- BRANCHESI Marica
- Breschi Matteo
- Briant Tristan
- Brillet A.
- Brinkmann M.
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- BrockmĂŒller Eike
- Brooks Aidan
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- C. Utina Andrei
- Cabourn Davies Gareth
- Cabras Giuseppe
- Cabrita Ricardo
- Cadonati Laura
- Cagnoli Gianpietro
- Cahillane Craig
- Callaghan J. D.
- Callister T. A.
- Calloni E.
- Camp J. B.
- Caneva Santoro Giada
- CANNAVACCIUOLO Marco
- Cannon Kipp C.
- Cao H.
- Capistran L. A.
- Capocasa Eleonora
- Capote E.
- Carapella G.
- Carbognani F.
- Carlassara M.
- Carlin Julian
- Carolina Silva Oliveira Ana
- Carpinelli Massimo
- Carrillo G.
- Carter Jonathan
- Carullo Gregorio
- Casentini C.
- Castaldi G.
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- Wysocki Daniel
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- Yaala M. Ben
- Yadav Nikesh
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- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- ZadroĆŒny A.
- Zahoor Jan Aasim
- Zannelli A. J.
- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zeoli M.
- Zerrad M.
- Zevin Michael
- Zhang A. C.
- Zhang Jue
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Ya
- Zhao C.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhong S.
- Zhou R.
- Zhu Zong-Hong
- Zucker M. E.
- Zweizig John
- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- æčćšéź
- éœäžž éèĄ
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)BâL gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)BâL gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM
Alpha-protein kinase 3 (ALPK3) truncating variants are a cause of autosomal dominant hypertrophic cardiomyopathy.
- Author
- Abu-Bonsrah Dad
- Akhtar Mohammed M
- Analia Ramos Karina
- Ashworth Michael
- Basurte Elorz Maria Teresa
- Bautista Paves Alicia
- Bilbao Raquel
- Bloch Rasmussen Torsten
- Catalli Claudio
- Chumakova Olga
- de la Higuera Luis
- Dobarro David
- Elliott David A
- Elliott Perry M
- Escobar-Lopez Luis
- Ferreira-Aguar Ana
- Figueroa Ana Virginia
- Franco-Gutierrez Raul
- Fuentes-Cañamero Maria Eugenia
- Futema Marta
- Garcia Pinilla Jose
- Garcia-HernĂĄndez Soledad
- Garcia-Pavia Pablo
- Gener Querol Blanca
- Isidoro-Garcia Maria
- Jager Joanna
- Kwok Cecilia Y T
- Lopes Luis R
- Lorenzini Massimiliano
- Martinez Moreno Marina
- Mezcua Ainhoa
- Monserrat Lorenzo
- Ochoa Juan Pablo
- Ortiz-Genga Martin
- Piqueras-Flores Jesus
- Porrello Enzo R
- Ramon Gimeno Juan
- Revilla-MartĂ Pablo
- Rudzitis Ainars
- Ruiz-Guerrero Luis
- Sandin-Fuentes Maria
- Smith Jacob B
- Stein Ricardo
- Syrris Petros
- Triguero-BocharĂĄn Mayte
- Villacorta Eduardo
- Zateyshchikov Dmitry
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2021
- Field of study
The aim of this study was to determine the frequency of heterozygous truncating ALPK3 variants (ALPK3tv) in patients with hypertrophic cardiomyopathy (HCM) and confirm their pathogenicity using burden testing in independent cohorts and family co-segregation studies. In a discovery cohort of 770 index patients with HCM, 12 (1.56%) were heterozygous for ALPK3tv [odds ratio(OR) 16.11, 95% confidence interval (CI) 7.94-30.02, Pâ=â8.05e-11] compared to the Genome Aggregation Database (gnomAD) population. In a validation cohort of 2047 HCM probands, 32 (1.56%) carried heterozygous ALPK3tv (OR 16.17, 95% CI 10.31-24.87, Pâ Heterozygous ALPK3tv are pathogenic and segregate with a characteristic HCM phenotype
Ofatumumab versus Teriflunomide in Multiple Sclerosis
- Author
- Aaron Carlson
- Achim Berthele
- Adaeze Onuoha
- Adam Wolff
- Adnan Subei
- Agnes Koves
- Ahmad Ata
- Aiden Haghikia
- Aimee Borazanci
- Akram Dastagir
- Albert Saiz Hinarejos
- Alberto Vasquez
- Alena Martinkova
- Alfredo Rodriguez AntigĂŒedad
- Alina Sergeevna Agafina
- Alison Brooke Allen
- Alla Shifrin
- Amit Bar-Or
- Ana Martins Da Silva
- Ana Voldsgaard Jensen
- Andrejs Millers
- Andrew Gale
- Andrew P Keegan
- Andrzej Wiak
- Angel Carrasco
- Angel R Chinea Martinez
- Angela Timoteo
- Angelica Carbajal Ramirez
- Ann Bass
- Anna Naumovna Belova
- Anne Cross
- Annette Okai
- Anselm Kornhuber
- Anshu Rohatgi
- Anton Vladic
- Antonio Uccelli
- Antonio Vasco Salgado
- April Erwin
- Ariel Antezana-Antezana
- Arnfin Bergmann
- Arnon Karni
- Astrid Edland
- Ayse Nur Yuceyar
- Aysun Soysal
- Bar-Or A.
- Barbara Green
- Barbara Willekens
- Bart Van Wijmeersch
- Bartosz Karaszewski
- Beatrijs Wokke
- Belgin Petek Balci
- Ben Turner
- Benedikt Frank
- Bharathy E Sundaram
- Bhupendra Khatri
- Bhupesh Dihenia
- Birte Elias-Hamp
- Bjoern Tackenberg
- Bob W Van Oosten
- Bogdan Gheorghiu
- Bonaventura Casanova Estruch
- Brian Costell
- Brian Steingo
- Brigitte Wildemann
- Bruce L Hughes
- Bruno Brochet
- Carlo Pozzilli
- Carlos Ballario
- Carlos Capela
- Carlos Veira
- Carrie M Hersh
- Cavit Boz
- Celia Oreja-Guevara
- Celine Louapre
- Cesar Castaneda
- Chiara Zecca
- Chris Retief
- Christian Calvo Vildoso
- Christine Lebrun-Frenay
- Christopher Laganke
- Christopher Luzzio
- Cohen J. A.
- Comi G.
- Corey Ford
- Correale J.
- Coyle P. K.
- Craig Edward Herrman
- Craig Senzon
- Cross A. H.
- Csilla Rozsa
- Cynthia Huffman
- Dalia Mickeviciene
- Daniel R Wynn
- David Axel Laplaud
- David Barnes
- David D O Bear
- David H Mattson
- David Lesch
- David Paling
- David Weisman
- de Seze J.
- Deborah A Burke
- Denis Viktorovich Sazonov
- Dennis W Dietrich
- Deren Huang
- Derrick Robertson
- Dheeraj Khurana
- Djamchid Lotfi
- Dmitry Pokhabov
- Don Joseph Alfonso
- Dusan Stefoski
- Edward J Fox
- Egon Kurca
- Ekaterina Igorevna Kairbekova
- Elena Gennadievna Arefieva
- Eli Silber
- Elzbieta Jasinska
- Emily Pharr
- Enrique Alvarez
- Erik Strauss
- Eugen Schlegel
- Eva Meluzinova
- Eva-Maria Maida
- Evanthia Bernitsas
- Faria Amjad
- Farit Axatovich Khabirov
- Filipe Correia
- Florian Then Bergh
- Francesco Sacca
- Francois Emond
- Francois Grandmaison
- Francois Jacques
- Fredrik Piehl
- Fritz Leutmezer
- Gabriel Pardo
- Garry R Cutter
- Gemma Reig Rosello
- Geoffrey Eubank
- Georgi Krastev
- Gerald Mcintosh
- Gereon Nelles
- Giacomo Lus
- Giancarlo Comi
- Giles F Crowell
- Gilles Edan
- Giovanni Castelnovo
- Girolama Alessandra Marfia
- Goodyear A.
- Guntis Karelis
- Guy Laureys
- Halina Bartosik Psujek
- Hana Bokun
- Hans-Peter Hartung
- Haring D. A.
- Hauser S. L.
- Hayrettin Tumani
- Heinz Wiendl
- Helle Hvilsted Nielsen
- Hemanth Rao
- Husnu Efendi
- Igor Antoncic
- Igor Stolyarov
- Igor Vyacheslavovich Litvinenko
- Irina Aleksandrovna Sokolova
- Israel Steiner
- Ivan Milanov
- Ivana Stetkarova
- Ivaylo Tarnev
- Iwona Jastrzebska
- J Michael Hemphill
- Jack H Florin
- Jacqueline Nicholas
- James Napier
- James Overell
- James Scott
- Jan Lycke
- Jan Mares
- Jaroslaw Slawek
- Jason M Silversteen
- Javier Vasallo
- Jean-Raphael Schneider
- Jeanette Wendt
- Jeannette Lechner-Scott
- Jeffrey A Cohen
- Jeffrey Cohen
- Jeffrey Gross
- Jeffrey Groves
- Jeffrey Kaplan
- Jerome de Seze
- Jerry S Wolinsky
- Jessica Stulc
- Jeyaraj Durai Pandian
- Jo Caekebeke
- Joanna A Cooper
- Joao Cerqueira
- Joao De Sa
- John Foley
- John Parratt
- John Scagnelli
- Jolana Markova
- Jolanta Kalnina
- Jonathan C Calkwood
- Jorge Correale
- Jorge Gustavo Jose
- Jose Carlos Alvarez Cermeño
- Jose Martinez Rodriguez
- Jose Meca Lallana
- Jose Pizarro Otero
- Jose Rafecas
- Joshua Katz
- Joy Dev Mukherji
- Juan Antonio Garcia Merino
- Juan Jose Lopez Prieto
- Juha Pekka Eralinna
- Juliette S Saad
- Julio Perez
- Kakarieka A.
- Kappos L.
- Karine Geens
- Karl-Otto Sigel
- Katherine Standley
- Katrin Gross-Paju
- Keith Edwards
- Kenneth Sharlin
- Kerloeguen C.
- Khurram Bashir
- Kimberly Wagner
- Konstantinos Kilidireas
- Konstantinos Voumvourakis
- Kore Liow
- Kristina Svendsen
- Krisztina Kovacs
- Krzysztof Selmaj
- Larisa Ivanovna Volkova
- Larry Lee Blankenship Jr
- Laszlo Mate
- Laszlo Vecsei
- Laura Brambilla
- Lekha Pandit
- Leppert D.
- Li B.
- Liesly Lee
- Liliana Montoya
- Livia De Sousa
- Lluis Ramio Torrenta
- Lon D Lynn
- Lucia Forero Diaz
- Lucienne Costa Frossard Franca
- Ludo Vanopdenbosch
- Ludwig Kappos
- Luis Querol Gutierrez
- Lyubomir Haralanov
- M Mateo Paz Soldan
- Maciej Maciejowski
- Mads Ravnborg
- Marc Debouverie
- Marco Salvetti
- Maria Manova Slavova
- Maria Nikolaevna Zaharova
- Maria Vafaevna Davydovskaya
- Marie Sarah Gagne Brosseau
- Marija Bosnjak Pasic
- Mario Habek
- Marja-Liisa Sumelahti
- Mark Agius
- Mark Allan Goldstein
- Mark Cascione
- Mark Freedman
- Mark Janicki
- Marta Vachova
- Martin Cloutier
- Martin Gavidia
- Martin R Bialow
- Martin Stangel
- Martin Valis
- Mary Denise Hughes
- Massimo Filippi
- Matthew Craner
- Matthew J Baker
- Matthias Boehringer
- Mauro Zaffaroni
- Meena Angamuthu Kanikannan
- Merschhemke M.
- Michael Isaacs
- Michaela Tyblova
- Michal Dufek
- Michelle Apperson
- Michelle B Kuczma
- Mirela Cerghet
- Miroslav Brozman
- Miroslaw Dziki
- Monika Adamczyk Sowa
- Montalban X.
- Murat Terzi
- Nadezhda Alekseevna Malkova
- Natalia Agafonovna Totolyan
- Nathaniel Robb Whaley
- Nikolaos Fakas
- Nikolaos Grigoriadis
- Nikolay Vasilievich Dorogov
- Norma Haydee Deri
- Olaf Martin Hoffmann
- Olivier Deryck
- Ondrej Skoda
- Pahari Ghosh
- Paolo Gallo
- Patricia K Coyle
- Patrick Oschmann
- Patrick Vermersch
- Paul K Winner
- Pavel Hradilek
- Pavle Repovic
- Pedro Serrano Castro
- Penko Shotekov
- Per Soelberg SĂžrensen
- Peter Koleda
- Peter Turcani
- Peter Valkovic
- Peter Van Domburg
- Peter Vestergaard Rasmussen
- Pierre Clavelou
- Pierre Labauge
- Pingili R.
- Praful Kelkar
- Radi Shahien
- Rafael Arroyo Gonzalez
- Rahul Chakor
- Rahul Kulkarni
- Ramanathan K.
- Randall Trudell
- Raquel Gouveia
- Rasa Kizlaitiene
- Raymond Hupperts
- Reinhard Hohlfeld
- Ricardo Ayala
- Richard Sater
- Robert Bonek
- Robert Carruthers
- Robert Fairborn Armstrong
- Robert Naismith
- Robert Thomas Nahouraii
- Rogier Q Hintzen
- Romero Rekha Pillai
- Ron Milo
- Ronald S Murray
- Roopkumar Gursahani
- Samuel Hunter
- Sangeeta Ravat
- Sara Eichau Madueño
- Sara Qureshi
- Sarah Morrow
- Satori Maria
- Selmaj K.
- Sergio Martinez Yelamos
- Serhan Sevim
- Serkan Ozakbas
- Sharon Lynch
- Sibyl Wray
- Silke Walter
- Silva Butkovic Soldo
- Silvia R Delgado
- Silvia Rossi
- Simona Bonavita
- Somsak Tiamkao
- Srinivasa Rangasetty
- Stacy Donlon
- Stanley Cohan
- Stanya Smith
- Stella Anatolievna Sivertseva
- Stephen C Reingold
- Stephen L Hauser
- Stuart James Shafer
- Sulev Haldre
- Suresh Kumar
- Susan Azalone
- Susan Hibbs
- Susana Liwacki
- Suzanne Hodgkinson
- Sylvia Menck
- Tamara A Miller
- Tamara Castillo Trivino
- Thomas Doerner
- Thomas Giancarlo
- Thy-Sheng Lin
- Till Sprenger
- Tjalf Ziemssen
- Tobias Derfuss
- Tomic D.
- Troy Desai
- Valeria Studer
- Valerie Delvaux
- Varun K Saxena
- Veit Ulrich Becker
- Vera Straeten
- Viera Hancinova
- Vincent Van Pesch
- Virgina Meca Lallana
- Virginia Simnad
- Vladimir Donath
- Vladimira Vuletic
- Waldemar Fryze
- Wiendl H.
- Willi R.
- William David Honeycutt
- William E McElveen
- William Logan
- William Wagner
- Xavier Montalban
- Xaviere Montalban Gairin
- Yves Lapierre
- Zita Biro
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2020
- Field of study
BACKGROUND: Ofatumumab, a subcutaneous anti-CD20 monoclonal antibody, selectively depletes B cells. Teriflunomide, an oral inhibitor of pyrimidine synthesis, reduces T-cell and B-cell activation. The relative effects of these two drugs in patients with multiple sclerosis are not known. METHODS: In two double-blind, double-dummy, phase 3 trials, we randomly assigned patients with relapsing multiple sclerosis to receive subcutaneous ofatumumab (20 mg every 4 weeks after 20-mg loading doses at days 1, 7, and 14) or oral teriflunomide (14 mg daily) for up to 30 months. The primary end point was the annualized relapse rate. Secondary end points included disability worsening confirmed at 3 months or 6 months, disability improvement confirmed at 6 months, the number of gadolinium-enhancing lesions per T1-weighted magnetic resonance imaging (MRI) scan, the annualized rate of new or enlarging lesions on T2-weighted MRI, serum neurofilament light chain levels at month 3, and change in brain volume. RESULTS: Overall, 946 patients were assigned to receive ofatumumab and 936 to receive teriflunomide; the median follow-up was 1.6 years. The annualized relapse rates in the ofatumumab and teriflunomide groups were 0.11 and 0.22, respectively, in trial 1 (difference, -0.11; 95% confidence interval [CI], -0.16 to -0.06; P<0.001) and 0.10 and 0.25 in trial 2 (difference, -0.15; 95% CI, -0.20 to -0.09; P<0.001). In the pooled trials, the percentage of patients with disability worsening confirmed at 3 months was 10.9% with ofatumumab and 15.0% with teriflunomide (hazard ratio, 0.66; Pâ=â0.002); the percentage with disability worsening confirmed at 6 months was 8.1% and 12.0%, respectively (hazard ratio, 0.68; Pâ=â0.01); and the percentage with disability improvement confirmed at 6 months was 11.0% and 8.1% (hazard ratio, 1.35; Pâ=â0.09). The number of gadolinium-enhancing lesions per T1-weighted MRI scan, the annualized rate of lesions on T2-weighted MRI, and serum neurofilament light chain levels, but not the change in brain volume, were in the same direction as the primary end point. Injection-related reactions occurred in 20.2% in the ofatumumab group and in 15.0% in the teriflunomide group (placebo injections). Serious infections occurred in 2.5% and 1.8% of the patients in the respective groups. CONCLUSIONS: Among patients with multiple sclerosis, ofatumumab was associated with lower annualized relapse rates than teriflunomide. (Funded by Novartis; ASCLEPIOS I and II ClinicalTrials.gov numbers, NCT02792218 and NCT02792231.)
Long-term efficacy and safety of eculizumab in Japanese patients with generalized myasthenia gravis: A subgroup analysis of the REGAIN open-label extension study
- Author
- Acary Souza Bulle Oliveira
- Adam Hart
- Adife Veske
- Aditya Kumar
- Aikaterini Dimitriou
- Akihiro Mukaino
- Akiko Kanzaki
- Akiyuki Uzawa
- Akshay Shah
- Alan Ross Berger
- Albert Hietala
- Alberta Locatelli
- Alejandra Dalila Garcia
- Alejandro Tobon Gonzales
- Alex Fondaw
- Ali Malekniazi
- Allessandro Filla
- Alzira Alves de Siqueira Carvalho
- Amaiak Chilingaryan
- Amanda Anderson
- Amelia Evoli
- Amna Shah
- Amy Saklad
- Amy Woodall
- Ana Carolina Amaral Andrade
- Ana Lazaro
- Ana Paula Melo
- Andrea Corse
- Andrea Kelley
- Andrea Swenson
- Angela Andoin
- Angela Campanella
- Angela Marsili
- Angela Micheels
- Angiola Fasanaro
- Anh Tran
- Anita Mogensen
- Ann D'Hondt
- Anna Gonzalez
- Anne Cooley
- Anne Mette Ostergaard Autzen
- Anneke van der Kooi
- Annelies Depreitere
- Annelies Vanhee
- Anthony Amato
- Antonella Di Pasquale
- April McVey
- Arshira Seddigh
- Arzu Meherremova
- Ashley Mallon
- Aya Mizugami
- Ayse Kutlu
- Baki Dogan
- Barbara Lokaitis
- Barbora Kurkova
- Barohn
- Bengu Balkan
- Benison Keung
- Benjamin Brooks
- Beth DiSanzo
- Betsy Mosmiller
- Boscoe
- Brajesh Agrawal
- Brian Droker
- Brian Minton
- Brigitta Szabadosne
- Brittany Harvey
- Bruno Bezerra Rosa
- Bryan Kim
- Burns
- Burns
- Buzzard
- Can Ebru Bekircan-Kurt
- Cansu Semiz
- Carlo Antozzi
- Carlos Casasnovas
- Carol Herbert
- Carolina Miranda
- Caroline Schotte
- Cecile Phan
- Celal Tuga
- Chafic Karam
- Chafic Karam
- Charlene Hafer-Macko
- Charlotte Smetcoren
- Christian Homedes-Pedret
- Christopher Nance
- Claire Brown
- Clara Schommer
- Claudio Gabriel Mazia
- Colleen Pineda
- Conti-Fine
- Craig Donahue
- Cristiani Fernanda Butinhao
- Csilla Rozsa
- Cynthia Bodkin
- Cynthia Carter
- Dai Matsuse
- Daisuke Yamamoto
- Dallas Forshew
- Daniel Ambrosio
- Daniel Dicapua
- Danielle Sheldon
- Dave Watling
- David Feder
- Debbie Davies
- Debora Dada Martineli Torres
- Dennis Jeffery
- Derrick Blackmore
- Diana Dimitrova
- Donna Carnes
- Doreen Ho
- DĂ©lphine Mahieu
- Elaine Weiner
- Elena Bravver
- Elena Cortes Vicente
- Eliana Reyes
- Elisabet Arribas-Ibar
- Elizabeth Watt
- Emiko Tsuda
- Engel-Nitz
- Enrico Marano
- Eri Kobayashi
- Erica Nogueira Coelho
- Eriko Higuchi
- Eriko Miyawaki
- Exuperio Diez Tejedor
- Ezgi Yilmaz
- Fabio Barroso
- Faisal Sohail
- Fanny OâBrien
- Fatima Maqsood
- Fernanda Carrara
- Fernanda Troili
- Filiz Muharrem
- Fiona Norwood
- Floyd Jones
- Francesco SaccĂ
- Francisco Javier Rodriguez de Rivera
- Frank Lin
- Fredrik Piehl
- Fumie Meguro
- Gabor Lovas
- Gabriel Paiva
- Gabrielle Rico
- Gal Maier
- Gedeonne Jakab
- Giannis Sokratous
- Gil Wolfe
- Giorgia Camera
- Giorgia Puorro
- Giovanni Antonini
- Girija Sadalage
- Gisela Gili
- Gonzalo Mazuela
- Gonzalo Vidal
- Gulmohor Roy
- Gulsah Becerikli
- Gulsah Orsel
- Gustavo Duran
- Guy Van den Abeele
- Gyorgyi Szabo
- H. James Jones
- Hakan Cavus
- Harpreet Kaur
- Heena Olalde
- Heike Arndt
- Henning Andersen
- Hidekazu Suzuki
- Hillmen
- Hirokazu Shiraishi
- Hiroyuki Murai
- Hisako Kobayashi
- Hong Vu
- Howard
- Howard
- Hui Gong
- Huned Patwa
- Husnu Efendi
- Iandra Souza
- Igor Dias Brockhausen
- Ihsan Sengun
- Ikuko Kamegamori
- Ikuko Yasuda
- Irene Yang
- Isabel Illa
- Ivana Jurajdova
- Iveta Novakova
- Jaana Eriksson
- Jaimin Shah
- Jakit Gollogly
- James Gilchrist
- James Howard Jr
- Jan De Bleecker
- Jan Vynckier
- Jana Junkerova
- Jane Distad
- Jane Pedersen
- Janice Massey
- Jaretzki
- Jayashri Srinivasan
- Jeffery Statland
- Jeffrey Guptill
- Jeffrey Narayan
- Jeffrey Rosenfeld
- Jenna Seelback
- Jeri Sieren
- Jerry Locheke
- Jing-Jing Wang
- Jiri Pitha
- Joan HĂžjgaard
- Joan Nye
- Joanne Nemeth
- John Kincaid
- John Kissel
- John Loor
- John Vissing
- Jonathan Katz
- Jonathan McKinnon
- Jordan Jara
- Jordana Gonçalves Geraldo
- Jordi Diaz-Manera
- Josep Gamez
- Joseph Chad Hoyle
- Judit Matolcsi
- Juha-Pekka Eralinna
- Julie Agriesti
- Julie Khoury
- Julie Steele
- Juliet Saba
- Jun Kawamata
- Justin Kwan
- Kaitlyn McKenna
- Kaori Osakada
- Kaori Uwasa
- Kara Patrick
- Karan Alcon
- Karen Callison
- Karen Zakalik
- Katarina Reguliova
- Kate Beck
- Katherine Amato
- Kathryn Johns
- Kathy de Koning
- Katrien De Mey
- Katsuhisa Masaki
- Kawaguchi
- Kazumi Futono
- Kazumi Takada
- Keiko Kikutake
- Kelley Emmons
- Kenichi Tsukita
- Kenji P. Fujita
- Kenkichi Nozaki
- Kerry Naunton
- Kevin Daniels
- Khema Sharma
- Kida
- Kimberly Robeson
- Kimiaki Utsugisawa
- Koichi Narikawa
- Krishna Pokala
- Kristen Roe
- Kristin Huynh
- Lara Katzin
- Laura Diez Porras
- Laura Echevarria
- Laura Fionda
- Laura Golden
- Laura Haar
- Laura Herbelin
- Laurie Gutmann
- Legendre
- Lena Bjarbo
- Lesly Welsh
- Liang Lu
- Licht
- Liene Duarte Silva
- Linda Wagemaekers
- Lindsay Zilliox
- Lisa Hobson-Webb
- Lisa Smith
- Lorenzo Maggi
- Lorraine Dishman
- Lotte Vinge
- Louisa Mezache
- Lucas Eduardo Pazetto
- Luciana Renata Cubas Volpe
- Luciana Souza Duca
- Ludwig Gutmann
- Luis Antonio Querol Gutierrez
- Luiz Augusto da Silva
- Luiz Otavio Maia Gonçalves
- Maki Jingu
- Makoto Samukawa
- Mamatha Pasnoor
- Manisha Chopra
- Marcela Silva
- Marcela Wolfova
- Marcelo Annes
- Marcelo Chaves
- Marcelo Rugiero
- Marguerite Engel
- Maria Antonia Alberti Aguilo
- Maria da Penha Ananias Morita
- Maria Pasanisi
- Maria Salvado
- Maria Sastre
- Marianne de Visser
- Mariela Bettini
- Marina Pozo
- Martin Bilsker
- Mary Varghese
- Maryanne Burdette
- Masahiro Mori
- Masakatsu Motomura
- Masaki Saitoh
- Masako Tsurumaru
- Masanori Takahashi
- Masayuki Makamori
- Matsuki
- Matteo Garibaldi
- Maureen Walsh
- Mayuko Noshiro
- Mazen Dimachkie
- Megan Kramer
- Megumi Koga
- Meinoshin Okumura
- Melanie Glenn
- Melinda Horvath
- Michael Benatar
- Michael Hehir
- Michael Pulley
- Michael Weiss
- Michaela Tyblova
- Michal Vytopil
- Miguel Wilken
- Mihoko Takada
- Mikko Laaksonen
- Mireya Fernandez-Fournier
- Miriam Freimer
- Misa Shimpo
- Miwako Sato
- Miyuki Morikawa
- Mohamed Kazamel
- Mohamed Mahdi-Rogers
- Mohammad Alsharabati
- Mohammad Sanjak
- Mohammed Salajegheh
- Mona Elsayed
- Muppidi
- Muppidi
- Murai
- Murai
- Murai
- Murat Terzi
- Murilo Santos Engel
- Musa Kazim Onar
- Muzeyyen Ugur
- Nadia Sattar
- Namie Taichi
- Namita Goyal
- Nanna Witting
- Naoki Kawaguchi
- Naoko Ishiyama
- Natalia Julia Palacios
- Natalia Prando
- NatĂĄlia Assis
- Naya McKinnon
- Nazire Pinar Acar
- Neelam Goyal
- Nicholas Silvestri
- Nicholas Ventura
- Nicolas Vandenbussche
- Nicole Jenci
- Nicole Kressin
- Nivedita Jerath
- Nuria Vidal
- Ohito Tano
- Olga Zapletalova
- Olivier Stevens
- Olli Oksaranta
- Ozlem Tun
- Pamela CĂ©sar
- Paolo Emilio Alboini
- Patricia Fernandes
- Patricia Padilla
- Pedro Lopez Ruiz
- Petra Tilkin
- Pharmaceuticals and Medical Devices Agency Japan
- Philip Van Damme
- Pilar Gomez Salcedo
- Pilar Sune
- Pinar Ozcelik
- Pravin Torane
- Raffaele Iorio
- Ratna Bhavaraju-Sanka
- Rebecca Traub
- Rebekah Garcia
- Renata Martins Ribeiro
- Renato Mantegazza
- Ricardo Rojas Garcia
- Richard Barohn
- Richard Nowak
- Rikako Kurihara
- Rikki Roderus
- Riley Snook
- Robert Miller
- Robert Pascuzzi
- Rosana Rocha
- Rother
- Rudy Mercelis
- Rumi Takeyama
- Rup Tandan
- Sabrina Pol
- Sachiko Kamakura
- Said Beydoun
- Saiju Jacob
- Salma Akhter
- Sanaz Karimi
- Sanders
- Sandi Mumfrey-Thomas
- Sandra Guingrich
- Santos
- Sara-Claude Michon
- Sarada Sakamuri
- Sarah Plevka
- Sarah Verjans
- Scott Cunningham
- Scott Tierney
- Seda Aydinlik
- Sedat Sen
- Seiko Yoshida
- Sevim Erdem-Ozdamar
- Shachie Aranke
- Shannon Lucy
- Sharmeen Alam
- Sharon Chelnick
- Sharon Downing
- Shin Hisahara
- Shirley Paulose
- Shirli Toska
- Shizuka Asada
- Shoko Amamoto
- Shuichiro Suzuki
- Shun Shimohama
- Shunsuke Yoshimura
- Sien Van Daele
- Silvia Bonanno
- Sivakumar Sathasivam
- Soichiro Funaka
- Sonia Garcia
- Srikanth Muppidi
- Stefania Morino
- Stephanie Kohlrus
- Stephanie Scala
- Suh
- Susan Strom
- Susanne Krogh
- Tahseen Mozaffar
- Taira Uehara
- Takashi Hayashi
- Takashi Murahara
- Takuya Matsushita
- Tamar Gibson
- Tamires Cristina Gomes da Silva
- Taylor Darnell
- Teiichiro Mitazaki
- Teresa Costabile
- Terry McClain
- Terry McClain
- Tessa Marburger
- Tetsuya Akiyama
- Tetsuya Kanai
- Thabata Veiga
- Thomas Cochrane
- Thomas Harbo
- Tina Liu
- Tiyonnoh Cash
- Tomihiro Imai
- Tomohiro Kawamura
- Tomoko Tsuda
- Tomomi Kobashikawa
- Tomoya Hasuike
- TomĂĄs Augusto Suriane Fialho
- Tuan Vu
- Tugce Kirbas Cavdar
- Tuula Harrison
- Tuzun
- Utsugisawa
- Utsugisawa
- Valentina D'Amato
- Valentina Velez Santamaria
- Valeria Cavalcante Lino
- Valerie Young
- Veena Mathew
- Vern Juel
- Victor Doan
- Vinay Chaudhry
- Waqar Waheed
- Wladimir Pinto
- Yagmur Caliskan
- Yasmeen Shabbir
- Yasuko Maeda
- Yasushi Suzuki
- Yoko Ishiyama
- Yoko Kaneko
- Yoshiko Sano
- Yuen T. So
- Yuka Saito
- Yukiko Ozawa
- Yuko Fujii
- Yumi Yamashita
- Yumiko Nakamura
- Yunxia Wang
- Yuriko Nagane
- Yusuke Fukuda
- Zaeem Siddiqi
- Zhang
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
The terminal complement inhibitor eculizumab was shown to improve myasthenia gravis-related symptoms in the 26-week, phase 3, randomized, double-blind, placebo-controlled REGAIN study (NCT01997229). In this 52-week sub-analysis of the open-label extension of REGAIN (NCT02301624), eculizumab's efficacy and safety were assessed in 11 Japanese and 88 Caucasian patients with anti-acetylcholine receptor antibody-positive refractory generalized myasthenia gravis. For patients who had received placebo during REGAIN, treatment with open-label eculizumab resulted in generally similar outcomes in the Japanese and Caucasian populations. Rapid improvements were maintained for 52 weeks, assessed by change in score from open-label extension baseline to week 52 (mean [standard error]) using the following scales (in Japanese and Caucasian patients, respectively): Myasthenia Gravis Activities of Daily Living (â2.4 [1.34] and â 3.3 [0.65]); Quantitative Myasthenia Gravis (â2.9 [1.98] and â 4.3 [0.79]); Myasthenia Gravis Composite (â4.5 [2.63] and â 4.9 [1.19]); and Myasthenia Gravis Quality of Life 15-item questionnaire (â8.6 [5.68] and â 6.5 [1.93]). Overall, the safety of eculizumab was consistent with its known safety profile. In this interim sub-analysis, the efficacy and safety of eculizumab in Japanese and Caucasian patients were generally similar, and consistent with the overall REGAIN population
Safety and efficacy of eculizumab in anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis (REGAIN): a phase 3, randomised, double-blind, placebo-controlled, multicentre study
- Author
- Abramov Vladislav
- Acar Nazire Pinar
- Agopian Eliz
- Agriesti Julie
- Akhter Salma
- Akiyama Tetsuya
- Alberti Aguilo Maria
- Alboini Paolo Emilio
- Alcon Karan
- Alsharabati Mohammad
- Altiparmak Didem
- Alvermann Sascha
- Alves de Siqueira Carvalho Alzira
- Amaral de Andrade Ana Carolina
- Amato Anthony
- Amato Katherine
- Ambrosio Daniel
- Andersen Henning
- Anderson Amanda
- Andersson Blanka
- Andoin Angela
- Angelini Corrado
- Annes Marcelo
- Antonini Giovanni
- Antozzi Carlo
- Appel Stanley H
- Aranke Shachie
- Arima Hideki
- Arndt Heike
- Arnold Thomas
- Arribas-Ibar Elisabet
- Asada Shizuka
- Atula Sari
- Augusto da Silva Luiz
- Autzen Anne Mette
- Aydinlik Seda
- Azrilin Olga
- Babenko Larisa
- Bali Kuperman Hila
- Balyazin Victor
- Bandukwala Ibrez
- Barohn Richard J
- Beck Kate
- Bednarik Josef
- Bekircan-Kurt Can Ebru
- Benatar Michael
- Berger Alan Ross
- Bernitsas Evanthia
- Bertorini Tulio
- Bettini Mariela
- Bevilacqua Francesca
- Beydoun Said
- Bhavaraju-Sanka Ratna
- Bilsker Martin
- Bird Shawn
- Bjarbo Lena
- Blackmore Derrick
- Blount Ira
- Bodkin Cynthia
- Bonanno Silvia
- Bonifati Domenico Marco
- Bostantzopoulou Sevasti
- Boterhoven Heidi
- Bouhour Franç
- Boz Cavit
- Bratton Joan
- Bravver Elena
- Bril Vera
- Brooks Benjamin
- Brown Gavin
- Brown Morris
- Bulle Oliveira Acary Souza
- Burdette Maryanne
- Burns Ted M
- Butters Janelle
- Caliskan Yagmur
- Callison Karen
- Campanella Angela
- Campbell Natasha
- Carnes Donna
- Carrara Fernanda
- Carter Cynthia
- Casasnovas Pons Carlos
- Caserta Cinzia
- Cash Tiyonnoh
- Cavalcante Lino Valeria
- Cavdar Tugce Kirbas
- Cavus Hakan
- Charalambous Despoina
- Chaudhry Vinay
- Chilingaryan Amaiak
- Chmelikova Magda
- Cho Eun Bin
- Chopra Manisha
- Cierny Marek
- Cochrane Thomas
- Coelho Erica
- Cooley Anne
- Corse Andrea
- Cortes Vicente Elena
- Costabile Teresa
- Crabtree Brigid
- Cudia Paola
- D&apos
- D&apos
- da Cruz Pacheco Daiane
- da Penha Morita Ananias Maria
- Dada Martineli Torres Debora
- Daniels Kevin
- Darnell Taylor
- David William
- Davies Debbie
- de Baets Marc
- De Bleecker Jan
- de Cassia Santos Aline
- de Koning Kathy
- De Mey Katrien
- De Rosa Anna
- de Visser Marianne
- Decressac Sonia
- Deneve Michel
- Deruelle Fabienne
- Desnuelle Claude
- Dezsi Livia
- Dheel Christina
- Di Pasquale Antonella
- Dias Brockhausen Igor
- Diaz-Manera Jordi
- Dicapua Daniel
- Diez Tejedor Exuperio
- Dimitriou Aikaterini
- Dimitrova Diana
- DiSanzo Beth
- Distad Jane
- Dogan Baki
- Donahue Craig
- Doreen Ho
- Downing Sharon
- Droker Brian
- Duran Gustavo
- Echevarria Laura
- Eduardo Ng
- Efendi Husnu
- Engel Marguerite
- Erä
- Erdem-Ozdamar Sevim
- Eriksson Jaana
- Evoli Amelia (ORCID:0000-0003-0282-8787)
- Fä
- Faber Catherine
- Faigle Casey
- Feder David
- Fernanda Butinhao Cristiani
- Fernandez-Fournier Mireya
- Filla Alessandro
- Fionda Laura
- Frasca Vittorio
- Freimer Miriam
- Fricke Karin
- Fujii Yuko
- Fukuda Yusuke
- Fukudome Takayasu
- Fukui Sachie
- Funaka Soichiro
- Futono Kazumi
- Fyfe Beverly
- Gaboreau Morgane
- Gabriele Maria
- Gallatti Nichole
- Gamez Josep
- Garcia Alejandra Dalila
- Garcia Rebekah
- Garcia Sonia
- Garibaldi Matteo
- Gazioglu Sibel
- Genge Angela
- Gervais-Bernard Helene
- Gheller Friedrich Maurí
- Giacomelli Elena
- Gibson Tamar
- Gilchrist James
- Gingele Stefan
- Goldstein Jonathan
- Gollogly Jakit
- Gomes da Silva Tamires Cristina
- Gonç
- Gondo Yuichiro
- Gori Maria
- Goyal Namita
- Goyal Neelam
- Greenbereg Nelly
- Gross Bella
- Guerreiro Alexandre
- Guidon Amanda
- Guinrich Sandra
- Guptill Jeffrey
- Gutmann Laurie
- Gutmann Ludwig
- Hø
- Haar Laura
- Hafer-Macko Charlene
- Halton Sharon
- Harbo Thomas
- Harrison Tuula
- Hart Adam
- Hartmann J. Edward
- Harvey Brittany
- Hasan Rosa
- Hasuike Tomoya
- Hayashi Takashi
- Hehir Michael
- Henderson Kendrick
- Herbert Carol
- Hewlett Jasmine
- Hietala Albert
- Higuchi Eriko
- Hisahara Shin
- Hobson-Webb Lisa
- Holzberg Shara
- Homedes-Pedret Christian
- Hong Vu
- Hong Yoon-Ho
- Hopkins Steve
- Horvath Melinda
- Hourquin Caroline
- Howard James F
- Hoyle J. Chad
- Huynh Kristin
- Hwang Eun Bi
- HyeJin Ra
- Ikeda Yasuko
- Illa Isabel
- Imai Tomihiro
- Imamura Tomomi
- Inghilleri Maurizio
- Inoue Masashi
- Iorio Raffaele
- Jacob Saiju
- Jacobs Daniel
- Jasinarachchi Mahi
- Jeffery Dennis
- Jia Kelly
- Jingu Maki
- Jones Floyd
- Jones H. James
- Jons Daniel
- Juel Vern
- Junkerova Jana
- Jurajdova Ivana
- Kamakura Sachiko
- Kamegamori Ikuko
- Kaminska Anna
- Kanai Tetsuya
- Kanda Takashi
- Kane Jennifer
- Kaneko Yoko
- Kang Hoo Nam
- Kanzaki Akiko
- Kaplan Lindsay
- Karam Chafic Karam
- Kasioti Eleni
- Kassebaum Nicole
- Katz Jonathan
- Katzberg Hans
- Katzin Lara
- Kaufman Jacob
- Kaur Harpreet
- Kawai Motoharu
- Kawamata Jun
- Kawamura Tomohiro
- Kazamel Mohamed
- Keijzers Maria Johanna
- Keo Roseann
- Keung Benison
- Khan Omar
- Khoury Julie
- Kikutake Keiko
- Kim Byoung Joon
- Kim Byung-Jo
- Kim MiRi
- Kim Seung Min
- Kim Yool-hee
- Kincaid John
- Kissel John T
- Kobashikawa Tomomi
- Kobayashi Eri
- Kobayashi Hisako
- Koga Megumi
- Koga Michiaki
- Koh Da Yoon
- Konno Shingo
- Konyane Monika
- Koo Yong Seo
- Korobko Denis
- Kostera-Pruszczyk Anna
- Kosykh Evgeniya
- Kramer Megan
- Kumar Sriwastava Shitiz
- Kumar Aditya
- Kurkova Barbora
- Kwan Justin
- Kwon JuYoung
- Lö
- Laaksonen Mikko
- Lacour Arnaud
- Lahaut Pauline
- Lai Eugene
- Lamont Phillipa
- Lange Dale
- Lay Luis
- Lazaro Ana
- Le Masson Gwendal
- Lee Chang Nyoung
- Lee HyeLim
- Lee Hyung Seok
- Lee JiEun
- Leong Wai-Kuen
- Levine-Weinberg Mark
- Liang Lu
- Lim Jae-Sung
- Lin Frank
- Lindberg Christopher
- Lindsay Molly
- Lisak Robert
- Liu Ye
- Loor John
- Lopergolo Diego
- Lopez Ruiz Pedro
- Lovas Gabor
- Lucy Shannon
- Macagnan Ana Paula
- Maeda Yasuhiro
- Maeda Yasuko
- Maessen Jos
- Maestri Tassoni Michelangelo
- Maggi Lorenzo
- Mahdi-Rogers Mohamed
- Mahieu Delphine
- Maier Gal
- Makamori Masayuki
- Malekniazi Ali
- Malkova Nadezhda
- Manning Erin
- Mantegazza Renato
- Maqsood Fatima
- Marano Enrico
- Marburger Tessa
- Marsil Angela
- Masaki Katsuhisa
- Massie Rami
- Mathew Veena
- Matolcsi Judit
- Matsuo Hidenori
- Matsuse Dai
- Matsushita Takuya
- Mazia Claudio Gabriel
- McClain Terry
- McKenna Kaitlyn
- McKinnon Jonathan
- McKinnon Naya
- Meguro Fumie
- Mellion Michelle
- Melnikova Anna
- Melo Ana Paula
- Mercelis Rudy
- Merle Hé
- Messina Silvia
- Micheels Angela
- Michon Sara-Claude
- Miesen Monique
- Miller Robert
- Millois Edouard
- Min Ju-Hong
- Minton Brian
- Miranda Carolina
- Mitazaki Teiichiro
- Mitropoulou Efstathia
- Mitsikostas Dimos-Dimitrios
- Mogensen Anita
- Mohr Henrique
- Moreau Caroline
- Mori Masahiro
- Morikawa Miyuki
- Morino Stefania
- Mosmiller Betsy
- Motomura Masakatsu
- Moutarde Julie
- Mozaffar Tahseen
- Mukaino Akihiro
- Mumfrey-Thomas Sandi
- Muppidi Srikanth
- Murahara Takashi
- Murai Hiroyuki
- Murata Mayumi
- Nagaishi Akiko
- Nagane Yuriko
- Nakamura Yumiko
- Nakane Shunya
- Nakayama Ritsu
- Nakazora Hiroshi
- Narikawa Koichi
- Nations Sharon
- Naunton Kerry
- Nemeth Joanne
- Nesterova Yulia
- Nigro Catherine
- Nogueira Coelho Erica
- Norwood Fiona
- Novakova Iveta
- Nowak Richard J
- Nye Joan
- Nyrhinen Anne
- O&apos
- Ogasawara Junichi
- Ogawa Miki
- Oksaranta Olli
- Okubo Yoshinori
- Okumura Meinoshin
- Olalde Heena
- Omoto Masatoshi
- Onar Musa Kazim
- Onesti Emanuela
- Orrico Daniele
- Ortea Carolina
- Osakada Kaori
- Otavio Maia Gonç
- Outteryck Olivier
- Ozcelik Pinar
- Ozen Aydin Cigdem
- Paiva Gabriel
- Palacios Natalia Julia
- Papadopoulou Nikoletta
- Papagiannopoulos Sotirios
- Park SangAe
- Pascuzzi Robert
- Patrick Kara
- Patti Francesco
- Patwa Huned
- Pazetto Lucas Eduardo
- Pedersen Jane
- Pegoraro Valentina
- Pereira Martins Maurer
- Perez Ele Kim
- Phan Celile
- Piehl Fredrik
- Pillai Rekha
- Pinto Wladimir
- Pinzan Elena
- Pitha Jiri
- Pleitez Milvia
- Plevka Sarah
- Pokhabov Dmitry
- Pozo Marina
- Prando Natalia
- Pulley Michael
- Puorro Giorgia
- Quarles Brandy
- Querol Gutierrez Luis
- Reggio Ester
- Reguliova Katarina
- Renata Cubas Volpe Luciana
- Reyes Eliana
- Richman David
- Rivner Michael
- Roberts Leslie
- Robeson Kimberly
- Rocha Rosana
- Rodriguez de Rivera Francisco Javier
- Roe Kristen
- Rojas Garcia Ricardo
- Rosa Bruno
- Rosenfeld Jeffrey
- Roy Gulmohor
- Rozsa Csilla
- Rugiero Marcelo
- Saba Juliet
- Sacca Francesco
- Sacconi Sabrina
- Sachs George
- Saito Yuka
- Saitoh Masaki
- Sakamuri Sarada
- Saklad Amy
- Salajegheh Mohammed
- Salvado Figueras Maria
- Salvado Maria
- Salvatore Caramma Andrea
- Samukawa Makoto
- Sanjak Mohammad
- Sano Yasuteru
- Sano Yoshiko
- Sathasivam Sivakumar
- Sato Miwako
- Sattar Nadia
- Sazonov Denis
- Scala Stephanie
- Schommer Clara
- Schoser Benedikt
- Seddigh Arshira
- Semiz Cansu
- Sen Sedat
- Sengun Ihsan
- Seok Hung Youl
- Seok Jinmyoung
- Shabbir Yasmeen
- Shah Akshay
- Shah Jaimin
- Sharma Khema
- Shimohama Shun
- Shimose Shigemi
- Shimpo Misa
- Shin Ha Young
- Shin MiJu
- Shin Susan
- Shinozaki Hirokazu
- Shiraishi Hirokazu
- Shirane Maoko
- Siddiqi Zaeem
- Silvestri Nicholas
- Simpson Ericka
- Sivak Mark
- Skripuletz Thomas
- Smalley Nicole
- Smetcoren Charlotte
- Smith Lisa
- Snook Riley
- Sohail Faisal
- Solé
- Soltani Mehran
- Soriani Marie-Hé
- Souza Duca Luciana
- Souza Iandra
- Srinivasan Jayashri
- Stangel Martin
- Steele Julie
- Stevens Olivier
- Strom Susan
- Suehs Kurt-Wolfram
- Suriane Fialho Tomá
- Suzuki Hidekazu
- Suzuki Shuichiro
- Suzuki Yasushi
- Swenson Andrea
- Szabadosne Brigitta
- Szabo Gyorgyi
- Taber Sandra
- Taichi Namie
- Takada Kazumi
- Takada Mihoko Takada
- Takahashi Masanori
- Tandan Rup
- Terzi Murat
- Thompson Lisa
- Tilkin Petra
- Tobon Gonzalez Alejandro
- Toncrova Stanislava
- Toska Shirli
- Tran Anh
- Trebst Corinna
- Trivedi Jaya
- Troili Fernanda
- Tselis Alexandros
- Tsuda Emiko
- Tsuda Tomoko
- Tsukita Kenichi
- Tuan Vu
- Tuga Celal
- Tun Ozlem
- Tyblova Michaela
- Uehara Taira
- Ugur Muzeyyen
- Utsugisawa Kimiaki
- Uzawa Akiyuki
- Van Damme Philip
- Van den Abeele Guy
- van der Kooi Anneke
- Vanderhook Mollie
- Varga Edina
- Varghese Mary
- Vecsei Laszlo
- Veiga Thabata
- Ventura Nicholas
- Verjans Sarah
- Vermersch Patrick
- Vial Christophe
- Vidal Gonzalo
- Vidal Nuria
- Vinge Lotte
- Vissing John
- Vlaikidis Nicholas
- Vohanka Stanislav
- Vytopil Michael
- Wagemaekers Linda
- Waheed Waqar
- Wang Jing-Jing
- Wanschitz Julia
- Watanabe Masanori
- Watling Dave
- Weiner Elaine
- Weiss Michael
- Welsh Lesly Welsh
- Wenninger Stephan
- Wheeler Lauren
- Wielanek-Bachelet Anne-Cé
- Wilken Miguel
- Willlems Natasha
- Wilson Amy
- Witting Nanna
- Wolfe Gil
- Wolfova Marcela
- Woodall Amy
- Yamamoto Daisuke
- Yamashita Yumi
- Yarmoschuk Asya
- Yilmaz Ezgi
- Yoshida Seiko
- Yoshikawa Chieko
- Yoshimura Shunsuke
- Yuen T So
- Zakalik Karen
- Zampaki Martha
- Zapletalova Olga
- Zephir Hé
- Zilliox Lindsay
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Background Complement is likely to have a role in refractory generalised myasthenia gravis, but no approved therapies specifically target this system. Results from a phase 2 study suggested that eculizumab, a terminal complement inhibitor, produced clinically meaningful improvements in patients with anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis. We further assessed the efficacy and safety of eculizumab in this patient population in a phase 3 trial. Methods We did a phase 3, randomised, double-blind, placebo-controlled, multicentre study (REGAIN) in 76 hospitals and specialised clinics in 17 countries across North America, Latin America, Europe, and Asia. Eligible patients were aged at least 18 years, with a Myasthenia Gravis-Activities of Daily Living (MG-ADL) score of 6 or more, Myasthenia Gravis Foundation of America (MGFA) class II\ue2\u80\u93IV disease, vaccination against Neisseria meningitides, and previous treatment with at least two immunosuppressive therapies or one immunosuppressive therapy and chronic intravenous immunoglobulin or plasma exchange for 12 months without symptom control. Patients with a history of thymoma or thymic neoplasms, thymectomy within 12 months before screening, or use of intravenous immunoglobulin or plasma exchange within 4 weeks before randomisation, or rituximab within 6 months before screening, were excluded. We randomly assigned participants (1:1) to either intravenous eculizumab or intravenous matched placebo for 26 weeks. Dosing for eculizumab was 900 mg on day 1 and at weeks 1, 2, and 3; 1200 mg at week 4; and 1200 mg given every second week thereafter as maintenance dosing. Randomisation was done centrally with an interactive voice or web-response system with patients stratified to one of four groups based on MGFA disease classification. Where possible, patients were maintained on existing myasthenia gravis therapies and rescue medication was allowed at the study physician's discretion. Patients, investigators, staff, and outcome assessors were masked to treatment assignment. The primary efficacy endpoint was the change from baseline to week 26 in MG-ADL total score measured by worst-rank ANCOVA. The efficacy population set was defined as all patients randomly assigned to treatment groups who received at least one dose of study drug, had a valid baseline MG-ADL assessment, and at least one post-baseline MG-ADL assessment. The safety analyses included all randomly assigned patients who received eculizumab or placebo. This trial is registered with ClinicalTrials.gov, number NCT01997229. Findings Between April 30, 2014, and Feb 19, 2016, we randomly assigned and treated 125 patients, 62 with eculizumab and 63 with placebo. The primary analysis showed no significant difference between eculizumab and placebo (least-squares mean rank 56\uc2\ub76 [SEM 4\uc2\ub75] vs 68\uc2\ub73 [4\uc2\ub75]; rank-based treatment difference \ue2\u88\u9211\uc2\ub77, 95% CI \ue2\u88\u9224\uc2\ub73 to 0\uc2\ub796; p=0\uc2\ub70698). No deaths or cases of meningococcal infection occurred during the study. The most common adverse events in both groups were headache and upper respiratory tract infection (ten [16%] for both events in the eculizumab group and 12 [19%] for both in the placebo group). Myasthenia gravis exacerbations were reported by six (10%) patients in the eculizumab group and 15 (24%) in the placebo group. Six (10%) patients in the eculizumab group and 12 (19%) in the placebo group required rescue therapy. Interpretation The change in the MG-ADL score was not statistically significant between eculizumab and placebo, as measured by the worst-rank analysis. Eculizumab was well tolerated. The use of a worst-rank analytical approach proved to be an important limitation of this study since the secondary and sensitivity analyses results were inconsistent with the primary endpoint result; further research into the role of complement is needed. Funding Alexion Pharmaceuticals
Long-term safety and efficacy of eculizumab in generalized myasthenia gravis
- Author
- Acar Nazire Pinar
- Agrawal Brajesh
- Agriesti Julie
- Ahn So-Hyun
- Akhter Salma
- Akiyama Tetsuya
- Alam Sharmeen
- Alberti Aguilo Maria Antonia
- Alboini Paolo Emilio
- Alcon Karan
- Alsharabati Mohammad
- Alves de Siqueira Carvalho Alzira
- Amamoto Shoko
- Amaral Andrade Ana Carolina
- Amato Anthony
- Amato Katherine
- Ambrosio Daniel
- Ananias Morita Maria da Penha
- Andersen Henning
- Anderson Amanda
- Andoin Angela
- Annes Marcelo
- Antonini Giovanni
- Antozzi Carlo
- Aranke Shachie
- Arndt Heike
- Arnold Thomas
- Arribas-Ibar Elisabet
- Asada Shizuka
- Assis NatĂĄlia
- Aydinlik Seda
- Balkan Bengu
- Barohn Richard J.
- Barroso Fabio
- Becerikli Gulsar
- Beck Kate
- Bednarik Josef
- Bekircan-Kurt Can Ebru
- Benatar Michael
- Berger Alan Ross
- Bertorini Tulio
- Bettini Mariela
- Beydoun Said
- Bezerra Rosa Bruno
- Bhavaraju-Sanka Ratna
- Bilsker Martin
- Bjarbo Lena
- Blackmore Derrick
- Bodkin Cynthia
- Bonanno Silvia
- Bravver Elena
- Brooks Benjamin
- Brown Claire
- Burdette Maryanne
- Burns Ted M.
- Butinhao Cristiani Fernanda
- Caliskan Yagmur
- Callison Karen
- Camera Giorgia
- Campanella Angela
- Carnes Donna
- Carrara Fernanda
- Carter Cynthia
- Casasnovas Carlos
- Cash Tiyonnoh
- Cavalcante Lino Valeria
- Cavus Hakan
- Chaudhry Vinay
- Chaves Marcelo
- Chelnick Sharon
- Chilingaryan Amaiak
- Chmelikova Magda
- Cho Eun Bin
- Choi Eun Hwa
- Choi MiSong
- Chopra Manisha
- Cierny Marek
- Cochrane Thomas
- Cooley Anne
- Corse Andrea
- Cortes Vicente Elena
- Costabile Teresa
- Cunningham Scott
- CĂ©sar Pamela
- D'Amato Valentina
- D'Hondt Ann
- da Cruz Pacheco Daiane
- da Silva Luiz Augusto
- Daniels Kevin
- Darnell Taylor
- Davies Debbie
- de Bleecker Jan L.
- de Cassia Santos Aline
- de Koning Kathy
- de Mey Katrien
- de Visser Marianne
- Depreitere Annelies
- Dezsi Livia
- di Pasquale Antonella
- Dias Brockhausen Igor
- Diaz-Manera Jordi
- Dicapua Daniel
- Diez Porras Laura
- Diez Tejedor Exuperio
- Dimachkie Mazen
- Dimitriou Aikaterini
- Dimitrova Diana
- DiSanzo Beth
- Dishman Lorraine
- Distad Jane
- Doan Victor
- Dogan Baki
- Donahue Craig
- Downing Sharon
- Droker Brian
- Duarte Silva Liene
- Duran Gustavo
- Echevarria Laura
- Efendi Husnu
- Elsayed Mona
- Emmons Kelley
- Engel Marguerite
- Eralinna Juha-Pekka
- Erdem-Ozdamar Sevim
- Eriksson Jaana
- Evoli Amelia
- Fasanaro Angiola
- Feder David
- Fernandes Patricia
- Fernandez-Fournier Mireya
- Ferreira Luciana
- Fialho TomĂĄs Augusto Suriane
- Filla Allessandro
- Fionda Laura
- Fionda Laura
- Fondaw Alex
- Forshew Dallas
- Frasca Vittorio
- Frasca Vittorio
- Freimer Miriam
- Fujii Yuko
- Fujita Kenji P.
- Fukuda Yusuke
- Funaka Soichiro
- Futono Kazumi
- Gabriele Maria
- Gamez Josep
- Garcia Alejandra Dalila
- Garcia Rebekah
- Garcia Sonia
- Garibaldi Matteo
- Gheller Friedrich MaurĂcio AndrĂ©
- Giacomelli Elena
- Gibson Tamar
- Gilchrist James
- Gili Gisela
- Glenn Melanie
- Golden Laura
- Gollogly Jakit
- Gomes da Silva Tamires Cristina
- Gomez Salcedo Pilar
- Gong Hui
- Gonzalez Anna
- Gonçalves Geraldo Jordana
- Gori Maria
- Goyal Namita
- Goyal Neelam
- Guerreiro Alexandre
- Guingrich Sandra
- Guptill Jeffrey
- Gutmann Laurie
- Gutmann Ludwig
- Haar Laura
- Hafer-Macko Charlene
- Harbo Thomas
- Harrison Tuula
- Hart Adam
- Harvey Brittany
- Hasuike Tomoya
- Hayashi Takashi
- Hehir Michael
- Hendersen Kendrick
- Herbelin Laura
- Herbert Carol
- Hewlett Jasmine
- Hietala Albert
- Higuchi Eriko
- Hisahara Shin
- Ho Doreen
- Hobson-Webb Lisa
- Homedes-Pedret Christian
- Hong Yoon-Ho
- Hopkins Steve
- Horvath Melinda
- Howard James F.
- Hoyle Joseph Chad
- Huynh Kristin
- Hwang Eun Bi
- Hwang Ji Ye
- HĂžjgaard Joan
- Illa Isabel
- Imai Tomihiro
- Inghilleri Maurizio
- Iorio Raffaele
- Ishiyama Naoko
- Ishiyama Yoko
- Jacob Saiju
- Jakab Gedeonne
- Jara Jordan
- Jeffery Dennis
- Jenci Nicole
- Jeong Ha-Neul
- Jerath Nivedita
- Jingu Maki
- Johns Kathryn
- Jones Floyd
- Jones H. James
- Juel Vern
- Julia Palacios Natalia
- Jung JinWoo
- Junkerova Jana
- Jurajdova Ivana
- Kamakura Sachiko
- Kamegamori Ikuko
- Kanai Tetsuya
- Kaneko Yoko
- Kang Hoo Nam
- Kanzaki Akiko
- Karam Chafic
- Karam Chafic
- Karimi Sanaz
- Katz Jonathan
- Katzin Lara
- Kaur Harpreet
- Kawaguchi Naoki
- Kawamata Jun
- Kawamura Tomohiro
- Kazamel Mohamed
- Kelley Andrea
- Keung Benison
- Khoury Julie
- Kikutake Keiko
- Kim Bryan
- Kim Byoung Joon
- Kim Byung-Jo
- Kim Miri
- Kim Seung Min
- Kim Yool-hee
- Kincaid John
- Kirbas Cavdar Tugce
- Kissel John T.
- Kobashikawa Tomomi
- Kobayashi Eri
- Kobayashi Hisako
- Koga Megumi
- Koh Da Yoon
- Kohlrus Stephanie
- Konyane Monika
- Koo Dae Lim
- Koo Yong Seo
- Kramer Megan
- Kressin Nicole
- Krogh Susanne
- Kumar Aditya
- Kurihara Rikako
- Kurkova Barbora
- Kutlu Ayse
- Kwan Justin
- Kwon JuYoung
- Laaksonen Mikko
- Lazaro Ana
- Lee Chang Nyoung
- Lee HyeLim
- Lee Hyung Seok
- Lee JiEun
- Lim Jae-Sung
- Lin Frank
- Liu Tina
- Liu Ye
- Locatelli Alberta
- Locheke Jerry
- Lokaitis Barbara
- Loor John
- Lopergolo Diego
- Lopez Ruiz Pedro
- Lovas Gabor
- Lu Liang
- Lucy Shannon
- Macagnan Ana Paula
- Maeda Yasuko
- Maggi Lorenzo
- Mahdi-Rogers Mohamed
- Mahieu D. lphine
- Maier Gal
- Makamori Masayuki
- Malekniazi Ali
- Mallon Ashley
- Mantegazza Renato
- Maqsood Fatima
- Marano Enrico
- Marburger Tessa
- Marsili Angela
- Martineli Torres Debora Dada
- Martins Ribeiro Renata
- Masaki Katsuhisa
- Massey Janice
- Mathew Veena
- Matolcsi Judit
- Matsuse Dai
- Matsushita Takuya
- Mazia Claudio Gabriel
- Mazuela Gonzalo
- McClain Terry
- McClain Terry
- McKenna Kaitlyn
- McKinnon Jonathan
- McKinnon Naya
- McVey April
- Meguro Fumie
- Meherremova Arzu
- Melo Ana Paula
- Mercelis Rudy
- Mezache Louisa
- Micheels Angela
- Michon Sara-Claude
- Miller Robert
- Min Ju-Hong
- Minton Brian
- Miranda Carolina
- Mitazaki Teiichiro
- Miyawaki Eriko
- Mizugami Aya
- Mogensen Anita
- Mohr Henrique
- Mori Masahiro
- Morikawa Miyuki
- Morino Stefania
- Mosmiller Betsy
- Motomura Masakatsu
- Mozaffar Tahseen
- Muharrem Filiz
- Mukaino Akihiro
- Mumfrey-Thomas Sandi
- Muppidi Srikanth
- Murahara Takashi
- Murai Hiroyuki
- Nagane Yuriko
- Nakamura Yumiko
- Nance Christopher
- Narayan Jeffrey
- Narikawa Koichi
- Nations Sharon
- Naunton Kerry
- Nemeth Joanne
- Nogueira Coelho Erica
- Norwood Fiona
- Noshiro Mayuko
- Novakova Iveta
- Nowak Richard J.
- Nozaki Kenkichi
- Nye Joan
- O'Brien Fanny L.
- Oksaranta Olli
- Okumura Meinoshin
- Olalde Heena
- Onar Musa Kazim
- Onesti Emanuela
- Orsel Gulsah
- Osakada Kaori
- Ostergaard Autzen Anne
- Otavio Maia Gonçalves Luiz
- Ozawa Yukiko
- Ozcelik Pinar
- Padilla Patricia
- Paiva Gabriel
- Park SangAe
- Pasanisi Maria
- Pascuzzi Robert
- Pasnoor Mamatha
- Patrick Kara
- Patwa Huned
- Paulose Shirley
- Pazetto Lucas Eduardo
- Pedersen Jane
- Pereira Martins Maurer
- Phan Cecile
- Piehl Fredrik
- Pillai Rekha
- Pineda Colleen
- Pinto Graziela
- Pinto Wladimir
- Pitha Jiri
- Plevka Sarah
- Pokala Krishna
- Pol Sabrina
- Pozo Marina
- Prando Natalia
- Pulley Michael
- Puorro Giorgia
- Querol Gutierrez Luis Antonio
- Ra HyeJin
- Reguliova Katarina
- Renata Cubas Volpe Luciana
- Reyes Eliana
- Rico Gabrielle
- Robeson Kimberly
- Rocha Rosana
- Roderus Rikki
- Rodriguez de Rivera Francisco Javier
- Roe Kristen
- Rojas Garcia Ricardo
- Rosenfeld Jeffrey
- Roy Gulmohor
- Rozsa Csilla
- Rugiero Marcelo
- Saba Juliet
- SaccĂ Francesco
- Sadalage Girija
- Saito Yuka
- Saitoh Masaki
- Sakamuri Sarada
- Saklad Amy
- Salajegheh Mohammed
- Salvado Maria
- Samukawa Makoto
- Sanjak Mohammad
- Sano Yoshiko
- Santos Engel Murilo
- Sastre Maria
- Sathasivam Sivakumar
- Sato Miwako
- Sattar Nadia
- Scala Stephanie
- Schommer Clara
- Schotte Caroline
- Seddigh Arshira
- Seelback Jenna
- Semiz Cansu
- Sen Sedat
- Sengun Ihsan
- Seok Hung Youl
- Seok Jinmyoung
- Shabbir Yasmeen
- Shah Akshay
- Shah Amna
- Shah Jaimin
- Sharma Khema
- Sheldon Danielle
- Shimohama Shun
- Shimpo Misa
- Shin Chae Won
- Shin Ha Young
- Shin Miju
- Shiraishi Hirokazu
- Siddiqi Zaeem
- Sieren Jeri
- Silva Marcela
- Silvestri Nicholas
- Smetcoren Charlotte
- Smith Lisa
- Snook Riley
- So Yuen T.
- Sohail Faisal
- Sokratous Giannis
- Souza Bulle Oliveira Acary
- Souza Duca Luciana
- Souza Iandra
- Srinivasan Jayashri
- Statland Jeffery
- Steele Julie
- Stevens Olivier
- Strom Susan
- Sune Pilar
- Suzuki Hidekazu
- Suzuki Shuichiro
- Suzuki Yasushi
- Swenson Andrea
- Szabadosne Brigitta
- Szabo Gyorgyi
- Taichi Namie
- Takada Kazumi
- Takada Mihoko
- Takahashi Masanori
- Takeyama Rumi
- Tandan Rup
- Tano Ohito
- Terzi Murat
- Tierney Scott
- Tilkin Petra
- Tobon Gonzales Alejandro
- Toncrova Stanislava
- Torane Pravin
- Toska Shirli
- Tran Anh
- Traub Rebecca
- Trivedi Jaya
- Troili Fernanda
- Tsuda Emiko
- Tsuda Tomoko
- Tsukita Kenichi
- Tsurumaru Masako
- Tuga Celal
- Tun Ozlem
- Tyblova Michaela
- Uehara Taira
- Ugur Muzeyyen
- Utsugisawa Kimiaki
- Uwasa Kaori
- Uzawa Akiyuki
- van Daele Sien
- van Damme Philip
- van den Abeele Guy
- van der Kooi Anneke
- Vandenbussche Nicolas
- Vanderhook Mollie
- Vanhee Annelies
- Varga Edina
- Varghese Mary
- Vecsei Laszlo
- Veiga Thabata
- Velez Santamaria Valentina
- Ventura Nicholas
- Verjans Sarah
- Veske Adife
- Vidal Gonzalo
- Vidal Nuria
- Vinge Lotte
- Vissing John
- Vohanka Stanislav
- Vu Hong
- Vu Tuan H.
- Vynckier Jan
- Vytopil Michal
- Wagemaekers Linda
- Waheed Waqar
- Walsh Maureen
- Wang Jing Jing
- Wang Yunxia
- Watling Dave
- Watt Elizabeth
- Weiner Elaine
- Weiss Michael
- Welsh Lesly
- Wheeler Lauren
- Wilken Miguel
- Witting Nanna
- Wolfe Gil
- Wolfova Marcela
- Woodall Amy
- Yamamoto Daisuke
- Yamashita Yumi
- Yang Irene
- Yasuda Ikuko
- Yilmaz Ezgi
- Yoshida Seiko
- Yoshimura Shunsuke
- Young Valerie
- Zakalik Karen
- Zapletalova Olga
- Zilliox Lindsay
- Publication venue
- 'Wiley'
- Publication date
- 01/07/2019
- Field of study
Introduction: Eculizumab is effective and well tolerated in patients with antiacetylcholine receptor antibody-positive refractory generalized myasthenia gravis (gMG; REGAIN; NCT01997229). We report an interim analysis of an open-label extension of REGAIN, evaluating eculizumab's long-term safety and efficacy. Methods: Eculizumab (1,200 mg every 2 weeks for 22.7 months [median]) was administered to 117 patients. Results: The safety profile of eculizumab was consistent with REGAIN; no cases of meningococcal infection were reported during the interim analysis period. Myasthenia gravis exacerbation rate was reduced by 75% from the year before REGAIN (P < 0.0001). Improvements with eculizumab in activities of daily living, muscle strength, functional ability, and quality of life in REGAIN were maintained through 3 years; 56% of patients achieved minimal manifestations or pharmacological remission. Patients who had received placebo during REGAIN experienced rapid and sustained improvements during open-label eculizumab (P < 0.0001). Discussion: These findings provide evidence for the long-term safety and sustained efficacy of eculizumab for refractory gMG. Muscle Nerve 2019
Correction to: Eculizumab improves fatigue in refractory generalized myasthenia gravis (Quality of Life Research, (2019), 28, 8, (2247-2254), 10.1007/s11136-019-02148-2)
- Author
- Acar Nazire Pinar
- Agrawal Brajesh
- Agriesti Julie
- Ahn So-Hyun
- Akhter Salma
- Akiyama Tetsuya
- Alam Sharmeen
- Alberti Aguilo Maria Antonia
- Alboini Paolo Emilio
- Alcon Karan
- Alsharabati Mohammad
- Alves de Siqueira Carvalho Alzira
- Amamoto Shoko
- Amaral Andrade Ana Carolina
- Amato Anthony
- Amato Katherine
- Ambrosio Daniel
- Andersen Henning
- Anderson Amanda
- Andoin Angela
- Annes Marcelo
- Antonini Giovanni
- Antozzi Carlo
- Aranke Shachie
- Arndt Heike
- Arnold Thomas
- Arribas-Ibar Elisabet
- Asada Shizuka
- Assis NatĂĄlia
- Aydinlik Seda
- Balkan Bengu
- Barohn Richard
- Barroso Fabio
- Becerikli Gulsar
- Beck Kate
- Bednarik Josef
- Bekircan-Kurt Can Ebru
- Benatar Michael
- Berger Alan Ross
- Bertorini Tulio
- Bettini Mariela
- Beydoun Said
- Bezerra Rosa Bruno
- Bhavaraju-Sanka Ratna
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- Yilmaz Ezgi
- Yoshida Seiko
- Yoshimura Shunsuke
- Young Valerie
- Zakalik Karen
- Zapletalova Olga
- Zilliox Lindsay
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 15/08/2019
- Field of study
The article âEculizumab improves fatigue in refractory generalized myasthenia gravisâ, written by âHenning Andersen, Renato Mantegazza, Jing Jing Wang, Fanny OâBrien, Kaushik Patra, James F. Howard Jr. and The REGAIN Study Groupâ was originally published electronically on the publisherâs internet portal (currently SpringerLink) on 23 March 2019 without open access
Long-term efficacy and safety of eculizumab in Japanese patients with generalized myasthenia gravis: A subgroup analysis of the REGAIN open-label extension study
- Author
- Acary Souza Bulle Oliveira
- Adam Hart
- Adife Veske
- Aditya Kumar
- Aikaterini Dimitriou
- Akihiro Mukaino
- Akiko Kanzaki
- Akiyuki Uzawa
- Akshay Shah
- Alan Ross Berger
- Albert Hietala
- Alberta Locatelli
- Alejandra Dalila Garcia
- Alejandro Tobon Gonzales
- Alex Fondaw
- Ali Malekniazi
- Allessandro Filla
- Alzira Alves de Siqueira Carvalho
- Amaiak Chilingaryan
- Amanda Anderson
- Amelia Evoli
- Amna Shah
- Amy Saklad
- Amy Woodall
- Ana Carolina Amaral Andrade
- Ana Lazaro
- Ana Paula Melo
- Andrea Corse
- Andrea Kelley
- Andrea Swenson
- Angela Andoin
- Angela Campanella
- Angela Marsili
- Angela Micheels
- Angiola Fasanaro
- Anh Tran
- Anita Mogensen
- Ann D'Hondt
- Anna Gonzalez
- Anne Cooley
- Anne Mette Ostergaard Autzen
- Anneke van der Kooi
- Annelies Depreitere
- Annelies Vanhee
- Anthony Amato
- Antonella Di Pasquale
- April McVey
- Arshira Seddigh
- Arzu Meherremova
- Ashley Mallon
- Aya Mizugami
- Ayse Kutlu
- Baki Dogan
- Barbara Lokaitis
- Barbora Kurkova
- Barohn
- Bengu Balkan
- Benison Keung
- Benjamin Brooks
- Beth DiSanzo
- Betsy Mosmiller
- Boscoe
- Brajesh Agrawal
- Brian Droker
- Brian Minton
- Brigitta Szabadosne
- Brittany Harvey
- Bruno Bezerra Rosa
- Bryan Kim
- Burns
- Burns
- Buzzard
- Can Ebru Bekircan-Kurt
- Cansu Semiz
- Carlo Antozzi
- Carlos Casasnovas
- Carol Herbert
- Carolina Miranda
- Caroline Schotte
- Cecile Phan
- Celal Tuga
- Chafic Karam
- Chafic Karam
- Charlene Hafer-Macko
- Charlotte Smetcoren
- Christian Homedes-Pedret
- Christopher Nance
- Claire Brown
- Clara Schommer
- Claudio Gabriel Mazia
- Colleen Pineda
- Conti-Fine
- Craig Donahue
- Cristiani Fernanda Butinhao
- Csilla Rozsa
- Cynthia Bodkin
- Cynthia Carter
- Dai Matsuse
- Daisuke Yamamoto
- Dallas Forshew
- Daniel Ambrosio
- Daniel Dicapua
- Danielle Sheldon
- Dave Watling
- David Feder
- Debbie Davies
- Debora Dada Martineli Torres
- Dennis Jeffery
- Derrick Blackmore
- Diana Dimitrova
- Donna Carnes
- Doreen Ho
- DĂ©lphine Mahieu
- Elaine Weiner
- Elena Bravver
- Elena Cortes Vicente
- Eliana Reyes
- Elisabet Arribas-Ibar
- Elizabeth Watt
- Emiko Tsuda
- Engel-Nitz
- Enrico Marano
- Eri Kobayashi
- Erica Nogueira Coelho
- Eriko Higuchi
- Eriko Miyawaki
- Exuperio Diez Tejedor
- Ezgi Yilmaz
- Fabio Barroso
- Faisal Sohail
- Fanny OâBrien
- Fatima Maqsood
- Fernanda Carrara
- Fernanda Troili
- Filiz Muharrem
- Fiona Norwood
- Floyd Jones
- Francesco SaccĂ
- Francisco Javier Rodriguez de Rivera
- Frank Lin
- Fredrik Piehl
- Fumie Meguro
- Gabor Lovas
- Gabriel Paiva
- Gabrielle Rico
- Gal Maier
- Gedeonne Jakab
- Giannis Sokratous
- Gil Wolfe
- Giorgia Camera
- Giorgia Puorro
- Giovanni Antonini
- Girija Sadalage
- Gisela Gili
- Gonzalo Mazuela
- Gonzalo Vidal
- Gulmohor Roy
- Gulsah Becerikli
- Gulsah Orsel
- Gustavo Duran
- Guy Van den Abeele
- Gyorgyi Szabo
- H. James Jones
- Hakan Cavus
- Harpreet Kaur
- Heena Olalde
- Heike Arndt
- Henning Andersen
- Hidekazu Suzuki
- Hillmen
- Hirokazu Shiraishi
- Hiroyuki Murai
- Hisako Kobayashi
- Hong Vu
- Howard
- Howard
- Hui Gong
- Huned Patwa
- Husnu Efendi
- Iandra Souza
- Igor Dias Brockhausen
- Ihsan Sengun
- Ikuko Kamegamori
- Ikuko Yasuda
- Irene Yang
- Isabel Illa
- Ivana Jurajdova
- Iveta Novakova
- Jaana Eriksson
- Jaimin Shah
- Jakit Gollogly
- James Gilchrist
- James Howard Jr
- Jan De Bleecker
- Jan Vynckier
- Jana Junkerova
- Jane Distad
- Jane Pedersen
- Janice Massey
- Jaretzki
- Jayashri Srinivasan
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- Jeffrey Narayan
- Jeffrey Rosenfeld
- Jenna Seelback
- Jeri Sieren
- Jerry Locheke
- Jing-Jing Wang
- Jiri Pitha
- Joan HĂžjgaard
- Joan Nye
- Joanne Nemeth
- John Kincaid
- John Kissel
- John Loor
- John Vissing
- Jonathan Katz
- Jonathan McKinnon
- Jordan Jara
- Jordana Gonçalves Geraldo
- Jordi Diaz-Manera
- Josep Gamez
- Joseph Chad Hoyle
- Judit Matolcsi
- Juha-Pekka Eralinna
- Julie Agriesti
- Julie Khoury
- Julie Steele
- Juliet Saba
- Jun Kawamata
- Justin Kwan
- Kaitlyn McKenna
- Kaori Osakada
- Kaori Uwasa
- Kara Patrick
- Karan Alcon
- Karen Callison
- Karen Zakalik
- Katarina Reguliova
- Kate Beck
- Katherine Amato
- Kathryn Johns
- Kathy de Koning
- Katrien De Mey
- Katsuhisa Masaki
- Kawaguchi
- Kazumi Futono
- Kazumi Takada
- Keiko Kikutake
- Kelley Emmons
- Kenichi Tsukita
- Kenji P. Fujita
- Kenkichi Nozaki
- Kerry Naunton
- Kevin Daniels
- Khema Sharma
- Kida
- Kimberly Robeson
- Kimiaki Utsugisawa
- Koichi Narikawa
- Krishna Pokala
- Kristen Roe
- Kristin Huynh
- Lara Katzin
- Laura Diez Porras
- Laura Echevarria
- Laura Fionda
- Laura Golden
- Laura Haar
- Laura Herbelin
- Laurie Gutmann
- Legendre
- Lena Bjarbo
- Lesly Welsh
- Liang Lu
- Licht
- Liene Duarte Silva
- Linda Wagemaekers
- Lindsay Zilliox
- Lisa Hobson-Webb
- Lisa Smith
- Lorenzo Maggi
- Lorraine Dishman
- Lotte Vinge
- Louisa Mezache
- Lucas Eduardo Pazetto
- Luciana Renata Cubas Volpe
- Luciana Souza Duca
- Ludwig Gutmann
- Luis Antonio Querol Gutierrez
- Luiz Augusto da Silva
- Luiz Otavio Maia Gonçalves
- Maki Jingu
- Makoto Samukawa
- Mamatha Pasnoor
- Manisha Chopra
- Marcela Silva
- Marcela Wolfova
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- Marcelo Rugiero
- Marguerite Engel
- Maria Antonia Alberti Aguilo
- Maria da Penha Ananias Morita
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- Maria Salvado
- Maria Sastre
- Marianne de Visser
- Mariela Bettini
- Marina Pozo
- Martin Bilsker
- Mary Varghese
- Maryanne Burdette
- Masahiro Mori
- Masakatsu Motomura
- Masaki Saitoh
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- Masanori Takahashi
- Masayuki Makamori
- Matsuki
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- Maureen Walsh
- Mayuko Noshiro
- Mazen Dimachkie
- Megan Kramer
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- Melinda Horvath
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- Michael Hehir
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- Michaela Tyblova
- Michal Vytopil
- Miguel Wilken
- Mihoko Takada
- Mikko Laaksonen
- Mireya Fernandez-Fournier
- Miriam Freimer
- Misa Shimpo
- Miwako Sato
- Miyuki Morikawa
- Mohamed Kazamel
- Mohamed Mahdi-Rogers
- Mohammad Alsharabati
- Mohammad Sanjak
- Mohammed Salajegheh
- Mona Elsayed
- Muppidi
- Muppidi
- Murai
- Murai
- Murai
- Murat Terzi
- Murilo Santos Engel
- Musa Kazim Onar
- Muzeyyen Ugur
- Nadia Sattar
- Namie Taichi
- Namita Goyal
- Nanna Witting
- Naoki Kawaguchi
- Naoko Ishiyama
- Natalia Julia Palacios
- Natalia Prando
- NatĂĄlia Assis
- Naya McKinnon
- Nazire Pinar Acar
- Neelam Goyal
- Nicholas Silvestri
- Nicholas Ventura
- Nicolas Vandenbussche
- Nicole Jenci
- Nicole Kressin
- Nivedita Jerath
- Nuria Vidal
- Ohito Tano
- Olga Zapletalova
- Olivier Stevens
- Olli Oksaranta
- Ozlem Tun
- Pamela CĂ©sar
- Paolo Emilio Alboini
- Patricia Fernandes
- Patricia Padilla
- Pedro Lopez Ruiz
- Petra Tilkin
- Pharmaceuticals and Medical Devices Agency Japan
- Philip Van Damme
- Pilar Gomez Salcedo
- Pilar Sune
- Pinar Ozcelik
- Pravin Torane
- Raffaele Iorio
- Ratna Bhavaraju-Sanka
- Rebecca Traub
- Rebekah Garcia
- Renata Martins Ribeiro
- Renato Mantegazza
- Ricardo Rojas Garcia
- Richard Barohn
- Richard Nowak
- Rikako Kurihara
- Rikki Roderus
- Riley Snook
- Robert Miller
- Robert Pascuzzi
- Rosana Rocha
- Rother
- Rudy Mercelis
- Rumi Takeyama
- Rup Tandan
- Sabrina Pol
- Sachiko Kamakura
- Said Beydoun
- Saiju Jacob
- Salma Akhter
- Sanaz Karimi
- Sanders
- Sandi Mumfrey-Thomas
- Sandra Guingrich
- Santos
- Sara-Claude Michon
- Sarada Sakamuri
- Sarah Plevka
- Sarah Verjans
- Scott Cunningham
- Scott Tierney
- Seda Aydinlik
- Sedat Sen
- Seiko Yoshida
- Sevim Erdem-Ozdamar
- Shachie Aranke
- Shannon Lucy
- Sharmeen Alam
- Sharon Chelnick
- Sharon Downing
- Shin Hisahara
- Shirley Paulose
- Shirli Toska
- Shizuka Asada
- Shoko Amamoto
- Shuichiro Suzuki
- Shun Shimohama
- Shunsuke Yoshimura
- Sien Van Daele
- Silvia Bonanno
- Sivakumar Sathasivam
- Soichiro Funaka
- Sonia Garcia
- Srikanth Muppidi
- Stefania Morino
- Stephanie Kohlrus
- Stephanie Scala
- Suh
- Susan Strom
- Susanne Krogh
- Tahseen Mozaffar
- Taira Uehara
- Takashi Hayashi
- Takashi Murahara
- Takuya Matsushita
- Tamar Gibson
- Tamires Cristina Gomes da Silva
- Taylor Darnell
- Teiichiro Mitazaki
- Teresa Costabile
- Terry McClain
- Terry McClain
- Tessa Marburger
- Tetsuya Akiyama
- Tetsuya Kanai
- Thabata Veiga
- Thomas Cochrane
- Thomas Harbo
- Tina Liu
- Tiyonnoh Cash
- Tomihiro Imai
- Tomohiro Kawamura
- Tomoko Tsuda
- Tomomi Kobashikawa
- Tomoya Hasuike
- TomĂĄs Augusto Suriane Fialho
- Tuan Vu
- Tugce Kirbas Cavdar
- Tuula Harrison
- Tuzun
- Utsugisawa
- Utsugisawa
- Valentina D'Amato
- Valentina Velez Santamaria
- Valeria Cavalcante Lino
- Valerie Young
- Veena Mathew
- Vern Juel
- Victor Doan
- Vinay Chaudhry
- Waqar Waheed
- Wladimir Pinto
- Yagmur Caliskan
- Yasmeen Shabbir
- Yasuko Maeda
- Yasushi Suzuki
- Yoko Ishiyama
- Yoko Kaneko
- Yoshiko Sano
- Yuen T. So
- Yuka Saito
- Yukiko Ozawa
- Yuko Fujii
- Yumi Yamashita
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- Yunxia Wang
- Yuriko Nagane
- Yusuke Fukuda
- Zaeem Siddiqi
- Zhang
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study