Key contribution of eIF4H-mediated translational control in tumor promotion.

Dysregulated expression of translation initiation factors has been associated with carcinogenesis, but underlying mechanisms remains to be fully understood. Here we show that eIF4H (eukaryotic translation initiation factor 4H), an activator of the RNA helicase eIF4A, is overexpressed in lung carcinomas and predictive of response to chemotherapy. In lung cancer cells, depletion of eIF4H enhances sensitization to chemotherapy, decreases cell migration and inhibits tumor growth in vivo, in association with reduced translation of mRNA encoding cell-proliferation (c-Myc, cyclin D1) angiogenic (FGF-2) and anti-apoptotic factors (CIAP-1, BCL-xL). Conversely, each isoform of eIF4H acts as an oncogene in NIH3T3 cells by stimulating transformation, invasion, tumor growth and resistance to drug-induced apoptosis together with increased translation of IRES-containing or structured 5'UTR mRNAs. These results demonstrate that eIF4H plays a crucial role in translational control and can promote cellular transformation by preferentially regulating the translation of potent growth and survival factor mRNAs, indicating that eIF4H is a promising new molecular target for cancer therapy

Anesthesia of Epinephelus marginatus with essential oil of Aloysia polystachya: an approach on blood parameters

This study investigated the anesthetic potential of the essential oil (EO) of Aloysia polystachya in juveniles of dusky grouper (Epinephelus marginatus). Fish were exposed to different concentrations of EO of A. polystachya to evaluate time of induction and recovery from anesthesia. In the second experiment, fish were divided into four groups: control, ethanol and 50 or 300 mu L L-1 EO of A. polystachya, and each group was submitted to induction for 3.5 min and recovery for 5 or 10 min. The blood gases and glucose levels showed alterations as a function of the recovery times, but Na+ and K+ levels did not show any alteration. In conclusion, the EO from leaves of A. polystachya is an effective anesthetic for dusky grouper, because anesthesia was reached within the recommended time at EO concentrations of 300 and 400 mu L L-1. However, most evaluated blood parameters showed compensatory responses due to EO exposure.Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul/Programa de Apoio a Nucleos de Excelencia (FAPERGS/PRONEX) [10/0016-8]; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [470964/2009-0]; Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior, Brazil (CAPES)info:eu-repo/semantics/publishedVersio

Acute basophilic leukemia - t(X;6)(p11;q23)

Review on Acute basophilic leukemia - t(X;6)(p11;q23), with data on clinics, and the genes involved

Epidemiologie et nuisibilite du virus de la mosaique du chou-fleur en Bretagne

National audienc

Editor's Choice – Thirty day Outcomes and Costs of Fenestrated and Branched Stent Grafts versus Open Repair for Complex Aortic Aneurysms

ObjectiveTo compare 30 day outcomes and costs of fenestrated and branched stent grafts (f/b EVAR) and open surgery (OSR) for the treatment of complex abdominal aortic aneurysms (AAA) and thoraco-abdominal aortic aneurysms (TAAA).MethodsThe multicenter prospective registry WINDOW was set up to evaluate f/b EVAR in high risk patients with para/juxtarenal AAA, and infradiaphragmatic and supradiaphragmatic TAAA. A control group of patients treated by OSR was extracted from the national hospital discharge database. The primary endpoint was 30 day mortality. Secondary endpoints included severe complications, length of stay, and costs. Mortality was assessed by survival analysis and uni/multivariate Cox regression analyses using pre- and post-operative characteristics. Bootstrap methods were used to estimate the cost-effectiveness of f/b EVAR versus OSR.ResultsTwo hundred and sixty eight cases and 1,678 controls were included. There was no difference in 30 day mortality (6.7% vs. 5.4%, p = 0.40), but costs were higher with f/b EVAR (€38,212 vs. €16,497, p < .001). After group stratification, mortality was similar with both treatments for para/juxtarenal AAA (4.3% vs. 5.8%, p = .26) and supradiaphragmatic TAAA (11.9% vs. 19.7%, p = .70), and higher with f/b EVAR for infradiaphragmatic TAAA (11.9% vs. 4.0%, p = .010). Costs were higher with f/b EVAR for para/juxtarenal AAA (€34,425 vs. €14,907, p < .0001) and infradiaphragmatic TAAA (€37,927 vs. €17,530, p < .0001), but not different for supradiaphragmatic TAAA (€54,710 vs. €44,163, p = .18).Conclusionf/b EVAR does not appear justified for patients with para/juxtarenal AAA and infradiaphragmatic TAAA fit for OSR but may be an attractive option for patients with para/juxtarenal AAA not eligible for surgery and patients with supradiaphragmatic TAAA. Clinical Trial Registration: http://www.clinicaltrials.gov/ct2/show/NCT01168037; identifier: NCT01168037 (WINDOW registry)

Fast-Convergence Self-Adjusting SECE Circuit With Tunable Short-Circuit Duration Exhibiting 368% Bandwidth Improvement

International audienceThe harvesting frequency bandwidth (HBW) of a resonant-based electromechanical harvester is inherently limited by its quality factor. Electrical tuning of the resonant frequency leveraged by a significant electromechanical coupling is a promising approach to enhance the HBW and paves the way toward industrialization of robust vibration energy harvesting system. However, it remains challenging to design a self-powered harvesting IC that includes self-tuning capabilities, especially at low vibration amplitude. This paper describes the shorted synchronous electrical charge extraction (SSECE) strategy and proposes a dedicated self-powered integrated circuit including power stage, sensors to sequence the harvesting phases and power sensing. An on-chip tracker dynamically maximizes the harvesting power when the piezoelectric-based harvester characteristics or excitation frequency shifts. The experimental results show a 368% HBW enlargement with the highest convergence FoM (0.213) and the lowest power-peak frequency compared to prior art

APIVALE scientific consortium: integrated approach for organic effluent recycling and valorisation

International audienceAbout 400 million tons of organic waste is produced each year in France with a major contribution of animal production (300 million tons) and agroindustry (45 million tons). Agriculture is thus at the heart of organic waste recycling and valorisation (organic matter, energy, nutrients, etc.). This challenge requires the production of scientific knowledge, the development of technical or organizational innovation and a more holistic approach to better consider the possible synergies on the territories. Organic effluents are subjected to numerous biological, chemical and physical processes that modify their composition, generate emissions to the environment and finally affect the availability of nutrient to plants and soil fertility. An improved knowledge of these different processes is thus required to quantify more precisely the emissions (for environmental evaluation) as well as for their reduction (for mitigation strategies). Different research institutes located in Western France including INRAE, ANSES, CNRS, UBS, Institut Agro, Université de Rennes and ENSCR, have decided to share their skills, experimental facilities and equipment in a scientific consortium named ‘APIVALE’ in order to develop an integrated approach of organic effluent recycling and valorisation. The scientific consortium provides skills and facilities to perform integrated studies over the whole chain of production and valorisation of organic effluent, possibly in combination with other sources of organic waste (urban or agro-industrial)