The effect of torsion on the distribution of Ш among quadratic twists of an elliptic curve

AbstractLet E be an elliptic curve of rank zero defined over Q and ℓ an odd prime number. For E of prime conductor N, in Quattrini (2006) [Qua06], we remarked that when ℓ||E(Q)Tor|, there is a congruence modulo ℓ among a modular form of weight 3/2 corresponding to E and an Eisenstein series. In this work we relate this congruence in weight 3/2, to a well-known one occurring in weight 2, which arises when E(Q) has an ℓ torsion point. For N prime, we prove that this last congruence can be lifted to one involving eigenvectors of Brandt matrices Bp(N) in the quaternion algebra ramified at N and infinity. From this follows the congruence in weight 3/2. For N square free we conjecture on the coefficients of a weight 3/2 Cohen–Eisenstein series of level N, which we expect to be congruent to the weight 3/2 modular form corresponding to E

A Case Study and Semi-Intervention of Best Practices at AIDS Rochester, Inc.

Mentoring programs can provide a foundation so that employees can improve their overall career development and satisfaction. When an organization has even an informal mentoring program, it encourages employees to support one another by learning from each other. When an organization has a formalized and structured mentoring program that is designed to fit the needs of their employees, it can enhance overall productivity and reduce employee stagnation and burn-out. This study examined the importance of mentoring in for-profit and non-profit organizations. This study has taken relevant literature, benchmarking, and focus group data and adapted the information to make a Mentoring Program Implementation Plan for AIDS Rochester, Inc. The findings from this study suggest that mentoring can lead to positive impacts in organizations if the customer requirements are taken into consideration. This study has also presented the benefits and challenges of mentoring, roles and characteristics of successful mentors and mentees, and some key areas of significance for mentoring. Finally, this case study and semi-intervention has provided ARI with an implementation plan that should increase retention and employee satisfaction and decrease turnover and stagnation. This study is extremely important for ARl to consider and implement in order to increase overall productivity. Since mentoring can encourage employees to solve their own problems, find valuable resources, and become more independent, ARI would also be assisting many individuals to reach their highest potential, both personally and professionally

Anguilliform larvae collected off North Carolina

The distinctive larval stage of eels (leptocephalus) facilitates dispersal through prolonged life in the open ocean. Leptocephali are abundant and diverse off North Carolina, yet data on distributions and biology are lacking. The water column (from surface to 1,293 m) was sampled in or near the Gulf Stream off Cape Hatteras, Cape Lookout, and Cape Fear, North Carolina during summer through fall of 1999–2005, and leptocephali were collected by neuston net, plankton net, Tucker trawl, and dip net. Additional samples were collected nearly monthly from a transect across southern Onslow Bay, North Carolina (from surface to 91 m) from April 2000 to December 2001 by bongo and neuston nets, Methot frame trawl, and Tucker trawl. Overall, 584 tows were completed, and 224 of these yielded larval eels. The 1,295 eel leptocephali collected (combining all methods and areas) represented at least 63 species (nine families). Thirteen species were not known previously from the area. Dominant families for all areas were Congridae (44% of individuals, 11 species), Ophichthidae (30% of individuals, 27 species), and Muraenidae (22% of individuals, ten species). Nine taxa accounted for 70% of the overall leptocephalus catches (in order of decreasing abundance): Paraconger caudilimbatus (Poey), Gymnothorax ocellatus Agassiz complex, Ariosoma balearicum (Delaroche), Ophichthus gomesii (Castelnau), Callechelys muraena Jordan and Evermann, Letharchus aliculatus McCosker, Rhynchoconger flavus (Goode and Bean), Ophichthus cruentifer (Goode and Bean), Rhynchoconger gracilior (Ginsburg). The top three species represented 52% of the total eel larvae collected. Most leptocephali were collected at night (79%) and at depths \u3e 45 m. Eighty percent of the eels collected in discrete depth Tucker trawls at night ranged from mean depths of 59–353 m. A substantial number (38% of discrete depth sample total) of larval eels were also collected at the surface (neuston net) at night. Daytime leptocephalus distributions were less clear partly due to low catches and lower Tucker trawl sampling effort. While net avoidance may account for some of the low daytime catches, an alternative explanation is that many species of larval eels occur during the day at depths \u3e 350 m. Larvae of 21 taxa of typically shallow water eels were collected at depths \u3e 350 m, but additional discrete depth diel sampling is needed to resolve leptocephalus vertical distributions. The North Carolina adult eel fauna (estuary to at least 2,000 m) consists of 51 species, 41% of which were represented in these collections. Many species of leptocephali collected are not yet known to have juveniles or adults established in the South Atlantic Bight or north of Cape Hatteras. Despite Gulf Stream transport and a prolonged larval stage, many of these eel leptocephali may not contribute to their respective populations

La concimazione del rosmarino

Nell\u2019accertare le asportazioni di azoto, fosforo e potassio, si osserva che la concimazione influenzerebbe la qualit\ue0 dell\u2019olio essenziale

AMPK Activators as Novel Drug Candidates for the Treatment of Inflammatory Bowel Diseases

Inflammatory bowel diseases (IBDs), mainly represented by ulcerative colitis and Crohn’s disease, are chronic and idiopathic diseases of the digestive tract. They incidence and prevalence is raising significantly in both developed and developing countries, thus representing a major challenge for the worldwide healthcare systems. The pharmacological armamentarium for the treatment of IBDs is far from being satisfactory, as the therapeutic success of the available drugs is still limited. Accordingly, the development of novel and effective compounds is highly requested. In this context, the serine/threonine heterotrimeric kinase AMPK (adenosine monophosphate-activated protein kinase) seems a sound target to strike. Known as the central hub of energy homeostasis in eukaryotic cells, AMPK contributes also to the modulation of immune/inflammatory cell functions. Actually, alterations in AMPK expression and/or activity play a key role in the pathophysiology of immune-mediated inflammatory diseases characterized by abnormal immune cell functions, like IBDs. Moreover, AMPK is able to improve intestinal health by enhancing para-cellular junctions, nutrient transporters, autophagy and apoptosis. Accordingly, AMPK activation represents a promising therapeutic strategy for the treatment of intestinal inflammatory disorders. Here we describe a novel heterocyclic derivative, developed as AMPK activator. Tested in C2C12 myoblast cell lines, our compound significantly increased AMPK activity, in a concentration-dependent manner, turning out to be more effective than the well-known activator acadesine (ACA). Moreover, assayed in a mouse model of acute DNBS-induced colitis, the novel heterocycle displayed a relevant anti-inflammatory efficacy, proving to ameliorate both systemic- and tissue-related inflammatory parameters like body and spleen weight, colon length, macroscopic damage, TNF and MDA levels. Also in this case, our compound turned out to be significantly more active that the known reference ACA, thus imposing itself as a novel and valuable drug candidate for the treatment of IBDs

The use of skin traction in the adult patients with proximal femur fracture. What are the effects, advantages and disadvantages? A scoping review

Background: Hip surgery is normally the chosen therapy for proximal femur fractures. Surgery within 24–48 h after hip fracture is recommended, but surgery may not always be performed promptly. Consequently, skin-traction is applied to reduce complications. The purpose of this review is to assess both advantages and disadvantages of skin traction. Methods: A scoping review was conducted. The research question was: which are the effects of skin traction, its advantages and disadvantages in adult patients with proximal femur fractures hospitalised in orthopaedic wards? The search was done in the databases PubMed, CINAHL, Cochrane, Embase, DOAJ, ClinicalTrials.gov and OpenDissertation. Results: 9 records were included, skin traction effects were summarised in 7 categories: pain, pressure sores, comfort and relaxation, thromboembolism, damage from adhesive, complications and quality of care. The possible advantage is pain reduction between 24 and 60 h, the possible disadvantage is skin damage. Discussion and conclusion: The routine use of skin traction does not appear recommended, but more consistent evidence is necessary to make clinic decisions. Future RCTs could focus on the effects of skin traction 24–60 h after hospitalisation and before surgery

PO-485 Low abundance circulating proteins in giant cell tumours of bone

Introduction Circulating low-abundance proteins/fragments generating from tumour cells and tissues, represent the most important source of cancer biomarkers useful for early diagnosis and prognosis. Giant cell tumour of bone (GCT) is a benign neoplasm occurring in the long bone and in the axial skeleton of young adults. Approximately 5% of GCT develop pulmonary metastases. Although many biomarkers have been proposed, identification of circulating low abundance molecules may be useful to predict metastasis with a non invasive method. Material and methods The hydrogel nanoparticles technique followed by mass spectrometry was used to detect low molecular weight serum proteins or protein fragments in serum of 20 GCT patients with different clinical course and in 10 healthy sera used as control. The most representative low-abundant de novo or differentially abundant proteins were submitted to String database in order to define protein-protein interaction network. Cluster analysis was performed to identify prognostic groups of patients with similar abundance of proteins that significantly discriminate between the groups. Results and discussions For the 25 low-abundant de novo or differentially abundant proteins identified, we recognised that the top interconnected pathways included protein activation cascade, wound healing, blood coagulation, cell-substrate adhesion. Proteoma cluster analysis separated metastasis-free from metastatic GCT patients in two well-defined groups where serum levels of signalling transduction mediators and regulators of kinase activity presented a high discriminatory power. Increased expression of proteins STAT5B, GRB2 and OXSR1 was related to a higher probability of metastasis. Conclusion In conclusion, using a no invasive technique, we identified differentially abundant serum biomarkers, also providing prognostic information in patients with GCT of bone. Future studies are ongoing to establish the interplay between these biomarkers in order to fully understand the mechanism involved in tumour development and to focus on the planning of tailored therapies that should be more effective and less toxic

KNOWLEDGE-BASED MODELLING FOR AUTOMATIZING HBIM OBJECTS. THE VAULTED CEILINGS OF PALAZZO DUCALE IN URBINO

Vault modelling in HBIM poses a significant challenge due to the geometrical complexity and lack of standardization of those elements. Starting from the definition of an ontology able to describe and manage different typologies of Italian Renaissance vaults, this paper presents two methods for their representation in the context of Ducal Palace of Urbino HBIM implementation. The first method is a simplified semi-automated scan-to-BIM procedure relying on Revit adaptive families; the second is a more complex parametric scripting in Dynamo VPL. The paper proposes a library of suitable vault families for the parametric modelling of Renaissance architecture and offers a comparison between the models generated and their respective surveyed point-clouds, with the aim of assessing the procedure. Revit adaptive families appeared to be the easiest to implement and the most efficient solution, while Dynamo allowed for greatest complexity thought showing limitations and implementation difficulties