86 research outputs found
The influence of care home managers on the implementation of a complex intervention: Findings from the process evaluation of a randomised controlled trial of Dementia Care Mapping
Background: Many people with dementia live in care homes, where staff can struggle to meet their complex needs. Successful practice improvement interventions in these settings require strong managerial support, but little is known about how managers can support implementation in practice, or what factors support or hinder care home managers in providing this support. Using Dementia Care Mapping™ (DCM) as an example, this study explored how care home managers can support the implementation of complex interventions, and identified factors affecting their ability to provide this support. Methods: We undertook interviews with 48 staff members (managers and intervention leads) from care homes participating in the intervention arm of the DCM EPIC trial of DCM implementation. Results: Managerial support played a key role in facilitating the implementation of a complex intervention in care home settings. Managers could provide practical and financial support in many forms. However, managerial support and leadership approaches towards implementation were highly variable in practice, and implementation was easily de-stabilised by management changes or competing managerial priorities. How well managers understood, valued and engaged with the intervention, alongside the leadership style they adopted to support implementation, were key influences on implementation success. Conclusions: For care home managers to effectively support interventions they must fully understand the proposed intervention and its potential value. This is especially important during times of managerial or practice changes, when managers lack the skills required to effectively support implementation, or when the intervention is complex. It may be unfeasible to successfully implement new interventions during times of managerial or practice instability
Total Synthesis of Oxidized Welwitindolinones and (−)-<i>N</i>-Methylwelwitindolinone C Isonitrile
We report the total synthesis of (−)-<i>N</i>-methylwelwitindolinone
C isonitrile, in addition to the total syntheses of the 3-hydroxylated
welwitindolinones. Our routes to these elusive natural products feature
the strategic use of a deuterium kinetic isotope effect to improve
the efficiency of a late-stage nitrene insertion reaction. We also
provide a computational prediction for the stereochemical configuration
at C3 of the hydroxylated welwitindolinones, which was confirmed by
experimental studies
Nickel-Catalyzed Suzuki–Miyaura Cross-Coupling in a Green Alcohol Solvent for an Undergraduate Organic Chemistry Laboratory
A modern undergraduate organic chemistry
laboratory experiment
involving the Suzuki–Miyaura coupling is reported. Although
Suzuki–Miyaura couplings typically employ palladium catalysts
in environmentally harmful solvents, this experiment features the
use of inexpensive nickel catalysis, in addition to a “green”
alcohol solvent. The experiment employs heterocyclic substrates, which
are important pharmaceutical building blocks. Thus, this laboratory
procedure exposes students to a variety of contemporary topics in
organic chemistry, including transition metal-catalyzed cross-couplings,
green chemistry, and the importance of heterocycles in drug discovery,
none of which are well represented in typical undergraduate organic
chemistry curricula. The experimental protocol uses commercially available
reagents and is useful in both organic and inorganic instructional
laboratories
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