UGC-HRDC Academic Staff College Websites and Naive Users

Indian Government promoting for the Quality Education and Research & Development by through the Universities and Colleges. The University Grants Commission (UGC)-Human Resource Development Center (HRDC) establishes the Academic Staff College (ASC) for this purpose to train the faculties of university and colleges by taking Orientation course, Refresher courses, Short term courses etc. In this paper I have studied the 66 Academic Staff College websites who conducting the said course by through the UGC guidelines. I have access these websites by using different browsers such as Internet Explorer, Mozilla Firefox and Google Chrome. I found many different structure of websites and there problems for newly searching person. By through this paper I try to show how the uniformity of web structure is design and easy to access Academic Staff College for newly user or naive user

The Hierarchy Principle and the Large Mass Limit of the Linear Sigma Model

In perturbation theory we study the matching in four dimensions between the linear sigma model in the large mass limit and the renormalized nonlinear sigma model in the recently proposed flat connection formalism. We consider both the chiral limit and the strong coupling limit of the linear sigma model. Our formalism extends to Green functions with an arbitrary number of pion legs,at one loop level,on the basis of the hierarchy as an efficient unifying principle that governs both limits. While the chiral limit is straightforward, the matching in the strong coupling limit requires careful use of the normalization conditions of the linear theory, in order to exploit the functional equation and the complete set of local solutions of its linearized form.Comment: Latex, 41 pages, corrected typos, final version accepted by IJT

Complications in surgical management of calcaneal fractures with anatomical plates

Calcaneal fractures, irrespective of their types, are treated non-operatively, one of the reasons being fear of complications. But conservatively managed fractures can result in equally problematic complications. Incidence of subtalar arthritis in such cases is reported to be 16.9% compared 3.3% in cases treated surgically. With surgical treatment aimed at achieving anatomical joint reduction, regaining calcaneal height, its length and width, successful attempts at curtailing the long-term complications can be made. This was a prospective study of 20 cases of calcaneal fractures, admitted to MNR Medical College and Hospital, Sangareddy from August 2020 to September 2021 were treated with ORIF with non-locking anatomical calcaneal plates using Fernandez’s approach, without use of bone graft. Essex Lopresti and Sander’s classification were used. Intra-operative assessment of reduction and articular surface reconstruction was done under fluoroscopic guidance. Regular follow up was done for assessment of fracture union and complications, assessment of late collapse. Among the 20 cases, 73% were men and 27% women. On typing the fractures based on Essex-Lopresti classification, intra-articular tongue type constituted 13% and 87% were of joint depression. Near normal anatomical reduction was obtained in all cases except in one where it was difficult due to comminution noted during surgery. 2 cases developed superficial skin necrosis at the surgical site, 1 case of deep infection and abscess formation and 3 cases of subtalar arthritis. This study showed that the incidence of long-term complications can probably be minimized by restoring the altered anatomy through surgical means; hence we advocate surgical management and accurate anatomical reduction in cases of displaced and comminuted calcaneal fractures with proper surgical principles

Comments on the Equivalence between Chern-Simons Theory and Topological Massive Yang-Mills Theory in 3D

The classical formal equivalence upon a redefinition of the gauge connection between Chern-Simons theory and topological massive Yang-Mills theory in three-dimensional Euclidean space-time is analyzed at the quantum level within the BRST formulation of the Equivalence Theorem. The parameter controlling the change in the gauge connection is the inverse $\lambda$ of the topological mass. The BRST differential associated with the gauge connection redefinition is derived and the corresponding Slavnov-Taylor (ST) identities are proven to be anomaly-free. The Green functions of local operators constructed only from the ($\lambda$-dependent) transformed gauge connection, as well as those of BRST invariant operators, are shown to be independent of the parameter $\lambda$, as a consequence of the validity of the ST identities. The relevance of the antighost-ghost fields, needed to take into account at the quantum level the Jacobian of the change in the gauge connection, is analyzed. Their role in the identification of the physical states of the model within conventional perturbative gauge theory is discussed.Comment: 19 pages, LATEX, to appear in Journal of High Energy Physic

A Quick Review of On-Disk Layout of Some Popular Disk File Systems

Disk file systems are being researched since the inception of first magnetic disk in 1956 by IBM. As such, many good disk file system designs have been drafted and implemented. Every file system design addressed a problem at the time of its development and efficiently mitigated it. The augmented or new designs rectified the flaws in previous designs or provided a new concept in file system design. As such, there are many file systems that have been successfully d in operating systems. Among these designs, some file systems have made an influential impact on the file system design because of their capability to cope up with change in hardware technology and/or user requirements or because of their innovation in file system ign or because time favored them which allowed them to find space in popular operating systems. In this paper, we vide a quick review of on-disk layout of some popular disk file systems across many popular platforms like Windows, Linu

IO Bound Property: A System Perspective Evaluation

File systems have been mostly benchmarked as per the application perspective. This approach hides all the underlying complexities of the system including the actual I/O being done with the secondary storage device like magnetic disk. The IO bound property of a file system is necessarily to be evaluated because the most dominant performance limiting factor of a file system is its I/O operation with secondary storage device. This IO bound property of file system dictates the quantity and frequency of IO that a file system does with secondary storage device. In this paper, we argue system perspective of file system benchmarks and develop a benchmark to evaluate some common disk file systems for IO bound property. The goal of this paper is to better understand the behavior of file systems and unveil the low level complexities faced by file systems

INVESTIGATION OF THE ROLE OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS IN INFLAMMATORY DISEASES THROUGH THE DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW HETEROCYCLIC DERIVATIVES

La ricerca sviluppata con il presente progetto di Dottorato \ue8 rivolta all\u2019approfondimento del ruolo del recettore nicotinico alfa7 nella cascata infiammatoria colinergica attraverso la progettazione, la sintesi e la valutazione farmacologica di nuovi derivati eterociclici in grado di interagire e attivare selettivamente questo sottotipo recettoriale. A tale scopo, sono stati progettati nuovi modulatori allosterici positivi (PAMs) o agonisti silenti del recettore nicotinico alfa7. Per ottenere i nuovi PAMs, caratterizzati da migliore potenza e selettivit\ue0, \ue8 stato applicato l\u2019approccio di ibridizzazione molecolare ai due PAMs di tipo I, il 5-idrossindolo (5-HI) e la genisteina. Il nucleo eteroaromatico del 5-HI \ue8 stato connesso a un anello benzenico variamente funzionalizzato sfruttando due diversi posizioni di connessione, l\u2019azoto indolico e il carbonio in posizione 2, e sono state pertanto ottenute due serie parallele di composti. Inoltre, l\u2019attivazione del recettore alfa7 \ue8 stata studiata attraverso la preparazione di agonisti silenti, in grado di trasmettere il segnale recettoriale con un meccanismo indipendente dall\u2019apertura del canale e dal passaggio della corrente ionica. Con l\u2019intento di chiarire il modello farmacoforico di tali nuovi agonisti alfa7 e di approfondirne il profilo farmacologico, tre serie di derivati sono state progettate e sintetizzate. La prima comprende derivati strutturalmente correlati al diEPP, recentemente emerso come agonista silente del recettore alfa7. Le altre due serie di composti sono state progettate inserendo il nucleo azabiciclico chinuclidinico, legato in forma spirociclica all\u2019anello Delta2-isossazolinico o connesso a un eterociclo 1,2,4-ossadiazolico, per valutare l\u2019importanza del centro basico quale requisito fondamentale nel modello farmacoforico noto. Il profilo farmacologico dei nuovi derivati \ue8 stato studiato in saggi elettrofisiologici su oociti di Xenopus che esprimono il recettore umano alfa7. Nella serie dei derivati del 5-idrossindolo, tre composti hanno mostrato un\u2019attivit\ue0 allosterica positiva migliore rispetto al composto di riferimento. L\u2019indagine farmacologica sui potenziali agonisti silenti \ue8 tuttora in corso. Attualmente sono disponibili i dati preliminari solo per la serie dei diEPP derivati e quattro composti si sono rivelati caratterizzati da un agonismo silente fino a 46 volte maggiore rispetto al composto parente.The current PhD research project aimed at investigating the role of the alpha7 nAChRs in the cholinergic inflammatory cascade through the design, synthesis and pharmacological evaluation of novel heterocyclic ligands targeting and selectively activating this receptor subtype. To this purpose, new sets of compounds acting as positive allosteric modulators (PAMs) or silent agonists were planned. In order to achieve new alpha7 PAMs endowed with enhanced allosteric activity and selectivity, the molecular hybridization approach was applied to the type I PAMs, 5-hydroxyindole (5-HI) and genistein. Therefore, the heteroaromatic nucleus of 5-HI was connected to a variable substituted phenyl ring by exploring two different positions of linking, the nitrogen and the adjacent carbon atom in position 2, thus obtaining two parallel series of target compounds. In addition, the alpha7 nAChR activation was investigated through compounds characterized by the silent agonism profile, an emerging mode of signal transduction of the alpha7 receptor not involving ion-channel current signaling. To shed light on this new mechanism of alpha7 receptor activation and to clarify the peculiar pharmacological profile of silent agonism in the modulation of inflammatory conditions, three different series of new potential silent derivatives were designed and synthesized. Moreover, the new compounds aimed at elucidating the pharmacophoric requirements for alpha7 nAChR silent agonism. In particular, a first series was obtained by modifying the diEPP compound, a recently emerged alpha7 silent agonist, whereas the other two sets of derivatives were planned to evaluate the pharmacophoric positive center by selecting the azabicyclic quinuclidine nucleus which was inserted as a spirocyclic-Delta2-isoxazoline scaffold or connected to a 1,2,4-oxadiazole heterocyclic system. Electrophysiological assays in Xenopus oocytes expressing human alpha7 nAChRs were performed to investigate the pharmacological profile of the novel derivatives. Within the 5-HI series, three compounds displayed enhanced alpha7 PAM activity compared to the parent compound. As far as concern the alpha7 nAChR silent signaling transduction, many target derivatives are still under investigation. The data so far available highlighted four diEPP analogues endowed with a very promising silent agonism profile which appear to be up to 46-fold greater compared to the reference compound

EOAODV: Routing Protocol for Cognitive Radio Network

Cognitive Radio (CR) technology provides promising and a new solution to improve the spectrum utilization. In recent years, cognitive radio technology (CR) has been proposed to allow unlicensed secondary users (SUs) to opportunistically access the channels unused by primary users (PU). This paper focuses on designing Enhancement of Opportunistic Ad-hoc On Demand Distance Vector (EOAODV) routing protocol that uses shortest distance, Expected Transmissions Count (ETC) and residual energy as a parameter to select the most reliable link and the next forwarding node. The selection of route in the network by the traditional AODV is based on hop count. It is proposed to achieve a gain of Opportunistic Routing (OR) with AODV for cognitive radio wireless sensor networks (CRWSN) to improve its efficiency. In the OR work the nexthop node selection was based on only Expected Transmission Count (ETC). In this case if the same node is selected as nexthop for many times, energy of that node is drained and node may be dead. To overcome this problem, a technique is contributed that is energy based nexthop selection ie. EOAODV. The ETC is computed based on the quantized value of RSSI of the links with residue energy in the forwarding node. Using ETC the reliable link is computed and stored in routing table. The packets are tranmitted to the destination using channel details and the next hop, available in the routing table. The next hop selection is based on high energy in the nodes, shortest distance and least ETC