Non-Reciprocal MEMS Periodic Structure

In recent years, active periodic structures with in-time modulated parameters have drawn ever-increasing attention due to their peculiar (and sometimes exotic) wave propagation properties. Although many experimental works have shown the efficacy of time-modulation strategies, the benchmarks proposed until now have been mostly proof-of-concept demonstrators, with little attention to the feasibility of the solution for practical purposes. In this work, we propose a micro electro-mechanical system (MEMS) periodic structure with modulated electromechanical stiffness featuring non-reciprocal band-gaps that are frequency bands where elastic waves are allowed to travel only in one direction. To this aim, we derive a simplified analytical lumped-parameter model, which is then verified through numerical simulations of both the lumped-parameter system and the high-fidelity multiphysics finite element model including electrostatic effects. We envision that this system, which can easily be manufactured through standard MEMS production processes, may be used as a directional filter in MEMS devices such as insulators and circulators

Adaptive Multi-Functional Space Systems for Micro-Climate Control

This report summarizes the work done during the Adaptive Multifunctional Systems for Microclimate Control Study held at the Caltech Keck Institute for Space Studies (KISS) in 2014-2015. Dr. Marco Quadrelli (JPL), Dr. James Lyke (AFRL), and Prof. Sergio Pellegrino (Caltech) led the Study, which included two workshops: the first in May of 2014, and another in February of 2015. The Final Report of the Study presented here describes the potential relevance of adaptive multifunctional systems for microclimate control to the missions outlined in the 2010 NRC Decadal Survey. The objective of the Study was to adapt the most recent advances in multifunctional reconfigurable and adaptive structures to enable a microenvironment control to support space exploration in extreme environments (EE). The technical goal was to identify the most efficient materials, architectures, structures and means of deployment/reconfiguration, system autonomy and energy management solutions needed to optimally project/generate a micro-environment around space assets. For example, compact packed thin-layer reflective structures unfolding to large areas can reflect solar energy, warming and illuminating assets such as exploration rovers on Mars or human habitats on the Moon. This novel solution is called an energy-projecting multifunctional system (EPMFS), which are composed of Multifunctional Systems (MFS) and Energy-Projecting Systems (EPS)

Rational Design of Allosteric and Selective Inhibitors of the Molecular Chaperone TRAP1

The molecular chaperone TRAP1 regulates energy metabolism, and its activity is relevant in cancer and degenerative diseases. Here, Sanchez-Martin et al. identify highly selective allosteric inhibitors of TRAP1. These compounds revert biochemical and pro-neoplastic effects of TRAP1 and could both enlighten its mode of action and disclose novel therapeutic strategies

4U 1344-60: a bright intermediate Seyfert galaxy at z=0.012 with a relativistic Fe Kalpha emission line

We present analysis of the optical and X-ray spectra of the low Galactic latitude bright (F(2-10) = 3.6 10^{-11} erg/cm2/s) source 4U 1344-60. On the basis of the optical data we propose to classify 4U 1344-60 as an intermediate type Seyfert galaxy and we measure a value of z=0.012+/-0.001 for its redshift. From the XMM-Newton observation we find that the overall X-ray spectral shape of 4U 1344-60 is complex and can be described by a power-law continuum (Gamma ~ 1.55) obscured by two neutral absorption components (Nh(f) ~ 10^{22} cm^{-2} and Nh(p) ~ 4 10^{22} cm^{-2}), the latter covering only the ~50% of the primary X-ray source. The X-ray data therefore lend support to our classification of 4U 1344-60. It exhibits a broad and skewed Fe Kalpha line at 6.4 keV, which suggests the existence of an accretion disk that is able to reprocess the primary continuum down to a few gravitational radii. Such a line represents one of the clearest examples of a relativistic line observed by XMM-Newton so far. Our analysis has also revealed the marginal presence of two narrow line-like emission features at ~4.9 and ~5.2 keV.Comment: Accepted for publication in Astronomy & Astrophysic

Cytokinin response factors integrate auxin and cytokinin pathways for female reproductive organ development

The developmental programme of the pistil is under the control of both auxin and cytokinin. Crosstalk between these factors converges on regulation of the auxin carrier PIN-FORMED 1 (PIN1). Here, we show that in the triple transcription factor mutant cytokinin response factor 2 (crf2) crf3 crf6 both pistil length and ovule number were reduced. PIN1 expression was also lower in the triple mutant and the phenotypes could not be rescued by exogenous cytokinin application. pin1 complementation studies using genomic PIN1 constructs showed that the pistil phenotypes were only rescued when the PCRE1 domain, to which CRFs bind, was present. Without this domain, pin mutants resemble the crf2 crf3 crf6 triple mutant, indicating the pivotal role of CRFs in auxin-cytokinin crosstalk

BCR-ABL-specific cytotoxic T cells in the bone marrow of patients with Ph(+) acute lymphoblastic leukemia during second-generation tyrosine-kinase inhibitor therapy.

BCR-ABL-specific cytotoxic T cells in the bone marrow of patients with Ph+ acute lymphoblastic leukemia during second-generation tyrosine-kinase inhibitor therap

U-PHOS Project: Development of a Large Diameter Pulsating Heat Pipe Experiment on board REXUS 22

U-PHOS Project aims to analyse and characterise the behaviour of a large diameter Pulsating Heat Pipe (PHP) on board REXUS 22 sounding rocket. A PHP is a passive thermal control device consisting of a serpentine capillary tube, evacuated, partially filled with a working fluid and finally sealed. In this configuration, the liquid and vapour phases are randomly distributed in the form of liquid slugs and vapour plugs. The heat is efficiently transported by means of the self-sustained oscillatory fluid motion driven by the phase change phenomena. On ground conditions, a small diameter is required in order to obtain a confined slug flow regime. In milli-gravity conditions, buoyancy forces become less intense and the PHP diameter may be increased still maintaining the slug/plug flow configuration typical of the PHP operation. Consequently, the PHP heat power capability may be increased too. U-PHOS aims at proving that a Large Diameter PHP effectively works in milli-g conditions by characterizing its thermal response during a sounding rocket flight. The actual PHP tube is made of aluminum (3 mm inner diameter, filled with FC-72), heated at the evaporator by a compact electrical resistance, cooled at the condenser by a Phase Change Material (PCM) embedded in a metallic foam. The tube wall temperatures are recorded by means of Fibre Bragg Grating (FBG) sensors; the local fluid pressure is acquired by means of a pressure transducer. The present work intends to report the actual status of the project, focusing in particular on the experiment improvements with respect to the previous campaign