UniKG: A Benchmark and Universal Embedding for Large-Scale Knowledge Graphs

Irregular data in real-world are usually organized as heterogeneous graphs (HGs) consisting of multiple types of nodes and edges. To explore useful knowledge from real-world data, both the large-scale encyclopedic HG datasets and corresponding effective learning methods are crucial, but haven't been well investigated. In this paper, we construct a large-scale HG benchmark dataset named UniKG from Wikidata to facilitate knowledge mining and heterogeneous graph representation learning. Overall, UniKG contains more than 77 million multi-attribute entities and 2000 diverse association types, which significantly surpasses the scale of existing HG datasets. To perform effective learning on the large-scale UniKG, two key measures are taken, including (i) the semantic alignment strategy for multi-attribute entities, which projects the feature description of multi-attribute nodes into a common embedding space to facilitate node aggregation in a large receptive field; (ii) proposing a novel plug-and-play anisotropy propagation module (APM) to learn effective multi-hop anisotropy propagation kernels, which extends methods of large-scale homogeneous graphs to heterogeneous graphs. These two strategies enable efficient information propagation among a tremendous number of multi-attribute entities and meantimes adaptively mine multi-attribute association through the multi-hop aggregation in large-scale HGs. We set up a node classification task on our UniKG dataset, and evaluate multiple baseline methods which are constructed by embedding our APM into large-scale homogenous graph learning methods. Our UniKG dataset and the baseline codes have been released at https://github.com/Yide-Qiu/UniKG.Comment: 9 pages, 4 figure

Time-delay Estimation based on an Enhanced Modified MUSIC with Co-prime Frequency Sampling for Rough Pavement

International audienceIn cases involving a rough interface, the echo fre-quency behavior of ultrawideband GPR approximates a non-linear Gaussian function. This characteristic leads to poor ro-bustness and high computational complexity in existing modifiedMUSIC (Mod-MUSIC) methods. To address this challenge, thisletter proposes an enhanced modified MUSIC (E-Mod-MUSIC)approach to mitigate the interference of false peaks, thus enhanc-ing robustness. Furthermore, to reduce computational complexitywhile maintaining high estimation accuracy comparable to denseuniform frequency sampling structures, a distributed co-primefrequency sampling structure is employed with E-Mod-MUSIC.Numerical simulations with different scenarios show the effec-tiveness of the proposed method

Efficacy and safety of US-guided thermal ablation for primary hyperparathyroidism: a systematic review and meta-analysis

Purpose To summarize the published literature on thermal ablation for primary hyperparathyroidism (PHPT) and to evaluate the effectiveness and safety of thermal ablation as a novel treatment strategy. Materials and methods Two authors carried out the literature search using four databases independently, including PubMed, Embase, Cochrane, and Web of Science. The meta-analysis included prospective and retrospective data that compared post-ablative outcomes to pre-ablative values. The primary outcomes were parathyroid hormone (PTH), serum calcium and volume of the parathyroid gland (VPG). Results From the 184 original articles, five studies (4 retrospective studies and 1 prospective study) examining 84 patients met the inclusion criteria. The meta-analysis showed significant reduction of PTH at 3 (standardized mean difference (SMD) =  −1.09, 95% confidence index (CI) =  −1.42 to −0.76, p < 0.001) and 6 months (SMD =  −1.13, 95% CI =  −1.46 to −0.80, p < 0.001) after thermal ablation. Serum calcium level was significantly reduced at 3 (mean difference (MD) =  −0.31, 95% CI =  −0.50 to −0.12, p  =  0.001) and 6 months (MD =  −0.31, 95% CI =  −0.46 to −0.17, p < 0.001) after thermal ablation. There was no significant difference between pre-ablative VPG and that of 6 months after ablation (MD =  −0.30, 95% CI =  −0.70 to 0.09, p  =  0.13). The most common complications were transient dysphonia and subcutaneous edema. No major complications or death occurred. Conclusion Thermal ablation is effective and safe for treatment of PHPT. PTH and calcium levels were reduced significantly at 3 and 6 months after thermal ablation

A Novel Molecular Mechanism of IKKε-Mediated Akt/mTOR Inhibition in the Cardiomyocyte Autophagy after Myocardial Infarction

Autophagy of cardiomyocytes after myocardial infarction (MI) is an important factor affecting the prognosis of MI. Excessive autophagy can lead to massive death of cardiomyocytes, which will seriously affect cardiac function. IKKε plays a crucial role in the occurrence of autophagy, but the functional role in MI remains largely unknown. To evaluate the impact of IKKε on the autophagy of cardiomyocytes after MI, MI was induced by surgical left anterior descending coronary artery ligation in IKKε knockout (KO) mice and wild-type (WT) mice. Starvation of H9c2 cells with IKKε siRNA and rescued with IKKε overexpressed afterwards to test the mechanism of IKKε in autophagy in vitro. Our results demonstrated that the expression of IKKε was upregulated in mice myocardial tissues which were consistent with cardiomyocyte autophagy after MI. Significantly, the IKKε KO mice showed increased infarct size, decreased viable cardiomyocytes, and exacerbated cardiac dysfunction when compared with the wild-type mice. Western blot and electron micrography analysis also revealed that loss of IKKε induces excessive cardiomyocyte autophagy and reduced the expression of p-Akt and p-mTOR. Similar results were observed in IKKε siRNA H9c2 cells in vitro which were under starvation injury. Notably, the levels of p-Akt and p-mTOR can restore in IKKε rescued cells. In conclusion, our results indicated that IKKε protects cardiomyocyte survival by reduced autophagy following MI via regulation of the Akt/mTOR signaling pathway. Thus, our study suggests that IKKε might represent a potential therapeutic target for the treatment of MI

Effects of canopy gaps on N2O fluxes in a tropical montane rainforest in Hainan of China

Background and aims: Tropical montane rainforests play an important role in increasing atmospheric N2O concentration. Although accurate estimations of N2O fluxes in tropical montane rainforests are critical for predicting global climate change, there are still considerable uncertainties about the spatial and temporal variability of the emissions. This study aims to investigate the effects of canopy gap caused by typhoons on N2O emissions, a key factor for understanding the spatial heterogeneity and supporting environmental regulations. Methods: N2O fluxes were measured monthly using static chambers both inside and outside two large canopy gaps in the tropical montane rainforest of the Jianfengling National Natural Reserve on Hainan Island, south of China, from August 2012 to July 2013. Results: Mean annual N2O emissions were 2.19 +/- 0.43 kg N2O-N ha(-1) yr(-1) inside canopy gaps, and 1.19 +/- 0.29 kg N2O-N ha(-1) yr(-1) outside canopy gaps, revealing substantial differences in N2O emissions resulting from forest structure. Moreover, N2O emission rates within canopy gaps during the wet season (2.89 kg N2O-N ha(-1) yr(-1)) were significantly higher than those during the dry season (1.34 kg N2O-N ha(-1) yr(-1)), suggesting strong regulation of soil moisture and precipitation in controlling soil N dynamics. However, there were significant nonlinear relationships between N2O fluxes and water filled pore space, and soil temperature within canopy gaps, but no significant relationships were found under the closed canopy. Conclusions: Contribution of canopy gaps should be considered to avoid underestimation of N2O emission rates from disturbed forests. Interestingly, emissions from gaps are more strongly coupled with climate drivers (moisture and temperature), with important implications for climate change projections. Therefore, the further research is needed to study the biogeochemical processes and mechanisms behind such phenomenon. (C) 2017 Elsevier B.V. All rights reserved

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

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