Fault Diagnosis of Supervision and Homogenization Distance Based on Local Linear Embedding Algorithm

In view of the problems of uneven distribution of reality fault samples and dimension reduction effect of locally linear embedding (LLE) algorithm which is easily affected by neighboring points, an improved local linear embedding algorithm of homogenization distance (HLLE) is developed. The method makes the overall distribution of sample points tend to be homogenization and reduces the influence of neighboring points using homogenization distance instead of the traditional Euclidean distance. It is helpful to choose effective neighboring points to construct weight matrix for dimension reduction. Because the fault recognition performance improvement of HLLE is limited and unstable, the paper further proposes a new local linear embedding algorithm of supervision and homogenization distance (SHLLE) by adding the supervised learning mechanism. On the basis of homogenization distance, supervised learning increases the category information of sample points so that the same category of sample points will be gathered and the heterogeneous category of sample points will be scattered. It effectively improves the performance of fault diagnosis and maintains stability at the same time. A comparison of the methods mentioned above was made by simulation experiment with rotor system fault diagnosis, and the results show that SHLLE algorithm has superior fault recognition performance

Raising interest in master of physical education during the COVID-19 pandemic: An analysis of Baidu Index data

Objective: Current evidence shows the master of physical education has attracted attention since its opening. The study aims to quantify recent trends in the public interest and related online search behavior for master of physical education, and “nowcast” future scenarios with respect to the master of physical education. Methods: Baidu Index, a database of search engines with massive information, was employed. By searching for the keyword master of physical education, and using content analysis to understand the data information related to master of physical education. It extracted the search trend data regarding Chinese interest in the master of physical education from November 21, 2016, to November 21, 2022. Finally, it compares the search trend of search interests in the master of physical education with related terms. Results: It found that the search trend of master of physical education was on the rise overall. Specifically, the peak value appeared in September 2019, the valley value appeared around the Spring Festival each year, and the search trend in other periods was stable. Conclusion: The raise in public interest in a master of physical education will likely result in an increase in the number of candidates who are going to attend the National Graduate Entrance Exam to pursue a master of physical education. In the coming months or more, the competition for the employment of sports professionals in China will become more intense. Affected by the COVID-19, more people are interested in health and physical exercise, and then pay attention to the Master of Physical Education. The Sports Law of the People's Republic of China has been revised recently, which has led to more people interested in the master of physical education

Increasing Interest in Inclusive Education in the Context of Action Plan for the Development and Enhancement of Special Education during the Fourteenth Five-Year Period in China: An Analysis of Baidu Index Data

Objective: Current evidence shows that public interest in inclusive education has been rising since the implementation of Action Plan for the development and enhancement of special education during the Fourteenth Five-Year period in China. The aim of this study was to quantify recent trends in public interest and related online search behavior for inclusive education in the context of this Action Plan. Methods: Baidu Index, a database of search engines with massive information, was employed. By searching for the keyword inclusive education, and using content analysis to understand the data information related to inclusive education. This study also extracted the search trend data of Chinese netizens on the related terms "Law on the Protection of Persons with Disabilities " and "Regulation on the Education of Persons with Disabilities" from January 1, 2022 to October 27, 2022. Finally, it compares the search trend of public search interests of inclusive education with related terms. Results: The public's interest in "inclusive education" and the related terms "Law on the Protection of Persons with Disabilities " and "Regulation on the Education of Persons with Disabilities" has been on the rise since the implementation of the Action Plan. The search trend reached its peak in February and May 2022, the valley in January 2022, and the search volume in other time periods tended to be stable. Conclusion: Baidu Index can understand the public's interest in inclusive education. The study shows that the rising search trend of inclusive education is closely related to the implementation of the Action Plan. The search volume of the "Law on the Protection of Persons with Disabilities " and "Regulation on the Education of Persons with Disabilities" is basically the same as that of "inclusive education", but the average search volume daily of "inclusive education" is slightly higher than that of "Regulation on the Education of Persons with Disabilities"

Application of statins in management of glioma: Recent advances

Gliomas are common primary intra-cerebral tumors in adults, and seriously threaten the health and life of affected patients, especially highly-malignant gliomas, such as glioblastoma multiforme. The clinical prognosis of glioma patients is poor, even for those who have received comprehensive treatment including surgery and concurrent chemo- and/or radio-therapy. As a structural analog of β-hydroxy-β- methylglutaryl coenzyme A (HMG CoA) reductase, statins are a restrictive enzyme in the metabolism of cholesterol. Recent laboratory studies and clinical trials have demonstrated that statins can exert antitumor effect, improve clinical prognosis and significantly prolong the survival time of glioma patients. This article is aimed to highlight the mechanisms of the anti-glioma effect of statins and review recent advances in the management of the disease.Keywords: Glioma, Glioblastoma multiforme, Intra-cerebral tumors, Statins, Prognosis, Survival time, β-Hydroxy-β-methylglutaryl coenzyme A (HMG CoA) reductas

Preliminary studies of the tardigrada communities from a polymetallic nodule area of the deep South China Sea

Knowledge about marine tardigrades from the South China Sea is very scarce, with only four species from shallow waters recorded to date. The present study investigated the structure and diversity of tardigrade communities from the deep sea (1517-1725 m) at 8 stations in a polymetallic nodule area of the northern South China Sea. A total of 151 arthrotardigrades were collected belonging to 11 genera (Angursa, Batillipes, Coronarctus, Euclavarctus, Exoclavarctus, Halechiniscus, Moebjergarctus, Raiarctus, Rhomboarctus, Tanarctus and Tholoarctus), representing 17 species. Two Angursa species (Angursa sp. 4 and Angursa sp. 3) were the most abundant (25.2% and 14.6%, respectively), followed by Moebjergarctus sp. (13.9%). Specimens were mostly (90.7%) distributed in the upper layer of the sandy-mud sediment (0-1 cm). The SIMPROF test showed that the composition of tardigrade communities at all stations was not significantly different. At different stations, the number of species, Shannon-Wiener diversity index and Pielou’s evenness index ranged from 4 to 10, 1.94 to 2.87, and 0.75 to 1.00, respectively. The average taxonomic distinctness (D+) ranged from 72.50 to 90.00, and the variation in taxonomic distinctness (L+) ranged from 316.67 to 1181.25. This study provides some basic information about the biodiversity of the marine tardigrade community in the South China Sea.info:eu-repo/semantics/publishedVersio

Observations of nitryl chloride and modeling its source and effect on ozone in the planetary boundary layer of southern China

Nitryl chloride (ClNO2) plays potentially important roles in atmospheric chemistry, but its abundance and effect are not fully understood due to the small number of ambient observations of ClNO2 to date. In late autumn 2013, ClNO2 was measured with a chemical ionization mass spectrometer (CIMS) at a mountain top (957 m above sea level) in Hong Kong. During 12 nights with continuous CIMS data, elevated mixing ratios of ClNO2 (>400 parts per trillion by volume) or its precursor N2O5 (>1000 pptv) were observed on six nights, with the highest ever reported ClNO2 (4.7 ppbv, 1 min average) and N2O5 (7.7 ppbv, 1 min average) in one case. Backward particle dispersion calculations driven by winds simulated with a mesoscale meteorological model show that the ClNO2/N2O5-laden air at the high-elevation site was due to transport of urban/industrial pollution north of the site. The highest ClNO2/N2O5 case was observed in a later period of the night and was characterized with extensively processed air and with the presence of nonoceanic chloride. A chemical box model with detailed chlorine chemistry was used to assess the possible impact of the ClNO2 in the well-processed regional plume on next day ozone, as the air mass continued to downwind locations. The results show that the ClNO2 could enhance ozone by 5-16% at the ozone peak or 11-41% daytime ozone production in the following day. This study highlights varying importance of the ClNO2 chemistry in polluted environments and the need to consider this process in photochemical models for prediction of ground-level ozone and haze. Key Points First observation of ClNO2 in the planetary boundary layer of China Combined high-resolution meteorological and measurement-constrained chemical models in data analysis ClNO2 enhances daytime ozone peak by 5-16% in well-processed PRD air.Department of Civil and Environmental Engineerin

Ambra1 is an essential regulator of autophagy and apoptosis in SW620 cells: Pro-survival role of Ambra1

Recent research has revealed a role for Ambra1, an autophagy-related gene-related (ATG) protein, in the autophagic pro-survival response, and Ambra1 has been shown to regulate Beclin1 and Beclin1-dependent autophagy in embryonic stem cells. However, whether Ambra1 plays an important role in the autophagy pathway in colorectal cancer cells is unknown. In this study, we hypothesized that Ambra1 is an important regulator of autophagy and apoptosis in CRC cell lines. To test this hypothesis, we confirmed autophagic activity in serum-starved SW620 CRC cells by assessing endogenous microtubule-associated protein 1 light chain 3 (LC3) localization, the presence of autophagosomes (transmission electron microscopy) and LC3 protein levels (Western blotting). Ambra1 expression was detected by Western blot in SW620 cells treated with staurosporine or etoposide. Calpain and caspase inhibitors were employed to verify whether calpains and caspases were responsible for Ambra1 cleavage. To examine the role of Ambra1 in apoptosis, Ambra1 knockdown cells were treated with staurosporine and etoposide. Cell apoptosis and viability were measured by annexin-V and PI staining and MTT assays. We determined that serum deprivation-induced autophagy was associated with Ambra1 upregulation in colorectal cancer cell lines. Ambra1 expression decreased during staurosporine- or etoposide-induced apoptosis. Calpains and caspases may be responsible for Ambra1 degradation. When Ambra1 expression was reduced by siRNA, SW620 cells were more sensitive to staurosporine- or etoposide-induced apoptosis. In addition, starvation-induced autophagy decreased. Finally, Co-immunoprecipitation of Ambra1 and Beclin1 demonstrated that Ambra1 and Beclin1 interact in serum-starved or rapamycin-treated SW620 cells, suggesting that Ambra1 regulates autophagy in CRC cells by interacting with Beclin1. In conclusion, Ambra1 is a crucial regulator of autophagy and apoptosis in CRC cells that maintains the balance between autophagy and apoptosis

Cost-effective priorities for the expansion of global terrestrial protected areas: Setting 2 post-2020 global and national targets

Biodiversity loss is a social and ecological emergency, and calls have been made for the global expansion of protected areas (PAs) to tackle this crisis. It is unclear, however, where best to locate new PAs to protect biodiversity cost-effectively. To answer this question, we conducted a spatial meta-analysis by overlaying seven global biodiversity templates to identify Conservation Priority Zones (CPZs). These are then combined with Low Human Impact Areas (LIAs) to identify Cost-Effective Zones for PA designation (CEZs). CEZs cover around 38% of global terrestrial area, of which only 24% is currently covered by existing PAs. To protect more CEZs, we propose three scenarios with conservative, moderate and ambitious targets, which aim to protect 19%, 26% and 43% of global terrestrial area, respectively. These three targets are set for each Convention on Biological Diversity (CBD) party with spatially-explicit CEZs identified, providing valuable decision support for the post-2020 global biodiversity framework

Chemical interactions between ship-originated air pollutants and ocean-emitted halogens

Ocean-going ships supply products from one region to another and contribute to the world's economy. Ship exhaust contains many air pollutants and results in significant changes in marine atmospheric composition. The role of Reactive Halogen Species (RHS) in the troposphere has received increasing recognition and oceans are the largest contributors to their atmospheric burden. However, the impact of shipping emissions on RHS and that of RHS on ship-originated air pollutants have not been studied in detail. Here, an updated WRF-Chem model is utilized to explore the chemical interactions between ship emissions and oceanic RHS over the East Asia seas in summer. The emissions and resulting chemical transformations from shipping activities increase the level of NO and NO2 at the surface, increase O3 in the South China Sea, but decrease O3 in the East China Sea. Such changes in pollutants result in remarkable changes in the levels of RHS as well as in their partitioning. The abundant RHS, in turn, reshape the loadings of air pollutants and those of the oxidants with marked patterns along the ship tracks. We, therefore, suggest that these important chemical interactions of ship-originated emissions with RHS should be considered in the environmental policy assessments of the role of shipping emissions in air quality and climate.Fil: Li, Qinyi. Consejo Superior de Investigaciones Científicas. Instituto de Química Física; EspañaFil: Fernandez, Rafael P.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Interdisciplinario de Ciencias Básicas. - Universidad Nacional de Cuyo. Instituto Interdisciplinario de Ciencias Básicas; ArgentinaFil: Mahan, Anoop. No especifíca;Fil: Lopez, Ana Isabel. Universidad Tecnológica Nacional. Facultad Regional de Mendoza; ArgentinaFil: Shanshan, Wang. Key Laboratory Atmospheric Particle Pollution Research; ChinaFil: Puliafito, Salvador Enrique. Universidad Tecnológica Nacional. Facultad Regional de Mendoza; ArgentinaFil: Cuevas, Carlos A.. Consejo Superior de Investigaciones Científicas. Instituto de Química Física; EspañaFil: Saiz Lopez, Alfonso. Consejo Superior de Investigaciones Científicas. Instituto de Química Física; EspañaEGU General Assembly 2021AustriaEuropean Geosciences Unio