The role of long non-coding RNA in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is a prevalent liver malignancy with complex etiology and generally poor prognosis. Recently, long non-coding RNAs (lncRNAs), non-protein-coding RNA molecules exceeding 200 nucleotides, have emerged as pivotal players in HCC, influencing its initiation, progression, invasion, and metastasis. These lncRNAs modulate gene expression at epigenetic, transcriptional, and post-transcriptional levels, actively participating in the pathological and physiological processes of HCC. Understanding the intricate relationship between lncRNAs and HCC is important for improving prognosis and reducing mortality. This review summarizes advancements in elucidating the role of lncRNAs in HCC pathogenesis

Comparative study of two rolling bond process for super-thick Q235B

In paper, two rolling bond processes for heavy-gauge steel plate Q235B were studied and the processes were simulated by MARC software. The mechanical properties and microstructure at the interface were comparative analyzed for the two bonded plates using different rolling process. Using MARC software analysis for two rolling process, the ratio of equivalent stress in rolling process /yield stress in current temperature from surface to center portion was relatively uniform for rolling bonded

Numerical Simulation of One-Dimensional Fractional Nonsteady Heat Transfer Model Based on the Second Kind Chebyshev Wavelet

In the current study, a numerical technique for solving one-dimensional fractional nonsteady heat transfer model is presented. We construct the second kind Chebyshev wavelet and then derive the operational matrix of fractional-order integration. The operational matrix of fractional-order integration is utilized to reduce the original problem to a system of linear algebraic equations, and then the numerical solutions obtained by our method are compared with those obtained by CAS wavelet method. Lastly, illustrated examples are included to demonstrate the validity and applicability of the technique

Exploration of An Open Online Learning Platform Based on Google Cloud Computing

With the progress of society, traditional online learning platforms have demonstrated the uneven distribution of information resources, and teacher–student communication exhibits a certain delay. At present, cloud computing, which is a new product of information technology, has been favored in many areas because of its superior feedback mechanism and storage space. Therefore, to improve the integration of online learning information resources and facilitate interaction between teachers and students, we designed our own online learning system based on the Google cloud computing platform. We used Google’s cloud computing platform and the Google App Engine to develop a unified and open online learning platform that is capable of storing large amounts of data, integrating considerable amounts of learning resources, and storing them on cloud. Through a test, we determined that the designed online learning platform for sharing information resources and integrating teacher–student exchanges is highly beneficial. The platform helps the classroom learning atmosphere become active, and has a positive effect on teaching methods. The proposed platform can promote further development of online learning

The effects of vacuum annealing temperatures on the microstructure, mechanical properties and electrical resistivity of Mg-3Al-1Zn alloy ribbons

This paper investigates the influence of vacuum annealing temperature on the microstructure, mechanical properties and electrical resistivity of Mg-3Al-1Zn rapid solidification (RS) magnesium ribbons. The results indicate that when the annealing temperature is increased, the grain size of the ribbons is dramatically reduced from 10 to 1 μm. The highest break stress and micro-hardness is obtained at 673 K. These effects are ascribed to the dispersion strengthening caused by the high amount of fine nanoparticles distributed in the material. Electrical resistivity-temperature (ρ-T) curves have been used to provide useful information about the effects of the annealing temperature on the grain size, grain orientation and crystal structure of the ribbons. In this way, a new lightweight electric wire or connection cable line could be produced which would have good electromagnetic interference (EMI)

Effects of grain boundaries in oxide scale on tribological properties of nanoparticles lubrication

The characters of grain boundaries in oxide layers formed on substrates influence adhesion and friction behaviour, surface fracture and wear during high temperature steel processing. In this work, an electron backscattered diffraction (EBSD) analysis was conducted to investigate the role of surface grain boundary and orientation in magnetite (Fe3O4)/haematite (α-Fe2O3) scale during hot rolling, and further evaluate their effects on tribological properties of water-based nanoparticles lubrication. The results demonstrate that Fe3O4 (100) plane is strongly sensitive to the surface characteristics as the minimisation of surface energy. Coincident site lattice (CSL) boundaries in microstructure is in presence of Σ3 in the Fe3O4 and Σ13b in the Fe2O3 of the substrates subjected to a thickness reduction of 28% and cooling rate of 28 ° C/s. This is due in great part to the changes in crystal slip systems. These low-Σ CSL boundaries in oxide scale offer obstacles to the propagation of cracks, where some of nanoparticles collected would be trapped at the interface and thereby may cause high wear rates. A lubrication mechanism is proposed to explain the grain boundary effect on nanoparticles lubrication, and further to determine the dependence of frictional behaviour on surface energy, crystallographic preferred orientation (microtexture) and crystal structure. These results provide an intriguing new insight into the application of water-based lubricant with graphite nanoparticles

Local strain analysis of the tertiary oxide scale formed on a hot-rolled steel strip via EBSD

This work presents a fine microstructure and local misorientation study of various oxide phases in the tertiary oxide scale formed on a hot-rolled steel strip via electron back-scattering diffraction (EBSD). Local strain in individual grains of four phases, ferrite (α-Fe), wustite (FeO), magnetite (Fe3O4) and hematite (α-Fe2O3), has been systematically analysed. The results reveal that Fe3O4 has a lower local strain than α-Fe2O3, in particular, on the surface and inner layers of the oxide scale. The multiphase oxides along the cracking or α-Fe2O3 penetration generally develop a high local misorientation. Localised stain along the cracks demonstrates that the misorientation tends to be strong near grain boundaries. The high fraction of small Fe3O4 grains accumulate at the oxide-substrate interface, which leads to a dramatic increase in the intensity of local stain. This variation is due mainly to the phase transformation among the oxide phases, i.e., the Fe3O4 particles during their nucleation and growth. The combined action of stress relief and re-oxidisation is proposed to explain the formation of Fe3O4 seam at the oxide-steel interface. The present study offers an intriguing insight into the deformation behaviour of the tertiary oxide scale formed on steels, and may help with understanding the stress-aided oxidation effect of metal alloys

Tribological analysis of oxide scales during cooling process of rolled microalloyed steel

The composition and phase transformation of oxide scale in cooling process (after hot rolling) of rolled microalloyed steels affect tribological features of rolled strip and downstream process, and the produced steel surface quality. In this study, physical simulation of surface roughness transfer during cooling process with consideration of ultra fast cooling (UFC) was carried out in Hille 100 experimental rolling mill, the obtained oxide scale was examined with SEM to show its surface and phase features. The results indicate that the surface roughness of the oxide scale increases as the final cooling (coiling) temperature increases, and the flow rate of the introduced air decreases. The cracking of the surface oxide scale can be improved when the cooling rate is 20 °C/s, the strip reduction is less than 12%, and the thickness of oxide scale is less than 15 μm, independent of the surface roughness. A cooling rate of more than 70 °C/s can increase the formation of retained wustite and primary magnetite precipitates other than the precipitation of α-iron. This study is helpful in optimising the cooling process after hot rolling of microalloyed steels to obtain quality surface products