Advances in myopia prevention strategies for school-aged children: a comprehensive review

Myopia has significantly risen in East and Southeast Asia, and the pathological outcomes of this condition, such as myopic maculopathy and optic neuropathy linked to high myopia, have emerged as leading causes of irreversible vision loss. Addressing this issue requires strategies to reduce myopia prevalence and prevent progression to high myopia. Encouraging outdoor activities for schoolchildren and reducing near-work and screen time can effectively prevent myopia development, offering a safe intervention that promotes healthier habits. Several clinical approaches can be employed to decelerate myopia progression, such as administering low-dose atropine eye drops (0.05%), utilizing orthokeratology lenses, implementing soft contact lenses equipped with myopia control features, and incorporating spectacle lenses with aspherical lenslets. When choosing an appropriate strategy, factors such as age, ethnicity, and the rate of myopia progression should be considered. However, some treatments may encounter obstacles such as adverse side effects, high costs, complex procedures, or limited effectiveness. Presently, low-dose atropine (0.05%), soft contact lenses with myopia control features, and orthokeratology lenses appear as promising options for managing myopia. The measures mentioned above are not necessarily mutually exclusive, and researchers are increasingly exploring their combined effects. By advocating for a personalized approach based on individual risk factors and the unique needs of each child, this review aims to contribute to the development of targeted and effective myopia prevention strategies, thereby minimizing the impact of myopia and its related complications among school-aged children in affected regions

Negative reflection of nanoscale-confined polaritons in a low-loss natural medium

7 pags., 4 figs.Negative reflection occurs when light is reflected toward the same side of the normal to the boundary from which it is incident. This exotic optical phenomenon is not only yet to be visualized in real space but also remains unexplored, both at the nanoscale and in natural media. Here, we directly visualize nanoscale-confined polaritons negatively reflecting on subwavelength mirrors fabricated in a low-loss van der Waals crystal. Our near-field nanoimaging results unveil an unconventional and broad tunability of both the polaritonic wavelength and direction of propagation upon negative reflection. On the basis of these findings, we introduce a device in nano-optics: a hyperbolic nanoresonator, in which hyperbolic polaritons with different momenta reflect back to a common point source, enhancing the intensity. These results pave way to realize nanophotonics in low-loss natural media, providing an efficient route to control nanolight, a key for future on-chip optical nanotechnologies.G.Á.-P. and J.T.-G. acknowledge support through the Severo Ochoa Program from the Government of the Principality of Asturias (grant numbers PA-20-PF-BP19-053 and PA-18-PF-BP17-126, respectively). Q.O. acknowledges support from the Australian Research Council (ARC; CE170100039 and DE220100154). This work was performed in part at the Melbourne Centre for Nanofabrication (MCN) in the Victorian Node of the Australian National Fabrication Facility (ANFF). hBN crystal growth was supported by the National Science Foundation award number CMMI 1538127. V.G. acknowledges the Ministerio de Ciencia, Innovación y Universidades through the grant MELODIA (PGC2018-095777-B-C21). V.G. thanks the “ENSEMBLE 3–Centre of Excellence for nanophotonics, advanced materials and novel crystal growth-based technologies” project (GA no. MAB/2020/14) carried out within the International Research Agendas program of the Foundation for Polish Science cofinanced by the European Union under the European Regional Development Fund and the European Union’s Horizon 2020 research and innovation programme Teaming for Excellence (GA no. 857543) for support of this work. R.H. acknowledges financial support from the Spanish Ministry of Science, Innovation and Universities (national project RTI2018-094830-B-100 and the project MDM-2016-0618 of the María de Maeztu Units of Excellence Program) and the Basque Government (grant no. IT1164-19). J.M.-S. acknowledges financial support from the Ramón y Cajal Program of the Government of Spain and FSE (RYC2018-026196-I) and the Spanish Ministry of Science and Innovation (State Plan for Scientific and Technical Research and Innovation grant number PID2019-110308GA-I00). A.Y.N. acknowledges the Spanish Ministry of Science and Innovation (grants MAT201788358-C3-3-R and PID2020-115221GB-C42) and the Basque Department of Education (grant PIBA-2020-1-0014). P.A.-G. acknowledges support from the European Research Council under starting grant no. 715496, 2DNANOPTICA and the Spanish Ministry of Science and Innovation (State Plan for Scientific and Technical Research and Innovation grant number PID2019-111156GB-I00). Q.B. acknowledges the support from Shenzhen Nanshan District Pilotage Team Program (LHTD20170006)

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study

Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe

Vegetation differentiation characteristics and control mechanisms in the Altay region based on topographic gradients

Among numerous vegetation studies, there are few studies on the elevation gradient distribution control mechanism and horizontal law of small-scale vegetation. In the same climate zone, topography is one of the most important factors affecting vegetation pattern. Here, we used the geo-informatic Tupu theory to construct topographic gradient-vegetation distribution information Tupu (TG-VDI Tupu) to display the topographical differentiation characteristics of vegetation. Moreover, an improved evaluation of topographical differentiation characteristics of vegetation was proposed based on topographic gradients, and the topographic composite index (TCI) was constructed to analyse the topographic variation in vegetation distribution. Meanwhile, the dominant factors and limiting factors affecting vegetation distribution under different topographic gradients were determined through statistical analysis. Combined with field surveys, Gaofen-1 (GF-1) satellite images were used to extract vegetation types, and the solar radiation value (SRV), topographic wetness index (TWI) and topographic variables were extracted from DEM data. The results indicate that TG-VDI Tupu can visually display topographic differentiation characteristics of vegetation on an elevation gradient. Elevation controls the horizontal distribution of vegetation on a small scale by changing ecological factors. At the same elevation, slope affects vegetation distribution by changing the SRV and TWI, while aspect changes the TWI. Coniferous forest is separated along a slope gradient and is more abundant on steep slopes. The percentage of broadleaf forest is negatively correlated with SRV and positively correlated with TWI, and the proportion is higher on the leeward slope facing north. The distribution of shrubs is more abundant on more xeric aspects and on steeper and more xeric slope configurations. In alpine areas above 2800 m, the abundance of vegetation types declines. This decline may be related to the weak solar radiation and widespread glacial landforms, exposed rocks and strong weathering. The methodology in our study can be applied to other regions and is expected to provide useful information for ecological conservation policy making

Hybridized Hyperbolic Surface Phonon Polaritons at α-MoO3 and Polar Dielectric Interfaces

10.1021/acs.nanolett.1c00281Nano Letter

Manipulating polaritons at the extreme scale in van der Waals materials

Polaritons, originating from the interactions between photons and material excitations, have attracted attention because of their strong field compression and deeply subdiffractional scales. For practical applications, it is crucial to manipulate polaritons efficiently, but doing so has remained challenging because of the relatively poor tunability of traditional polaritonic media. Fortunately, in the past decade, polaritons hosted by van der Waals (vdW) materials have allowed new opportunities to tackle this difficulty. We review the state of the art in the manipulation of polaritons at the extreme scale in vdW materials. Benefiting from the large and expanding catalogue of vdW materials and associated architectures and techniques, more accessible manipulation strategies are expected, not only offering control of light at the nanoscale with new degrees of freedom, but also offering insight into nanophotonics, meta-optics, topological physics and quantum materials.This work was supported by the Australian Research Council (ARC, CE170100039 and DE220100154) and Shenzhen Nanshan District Pilotage Team Program (LHTD20170006). P.L. acknowledges support from the National Natural Science Foundation of China (grant no. 62075070) and the Innovation Fund of WNLO. P.A.-G. acknowledges support from the European Research Council under starting grant no. 715496, 2DNANOPTICA and the Spanish Ministry of Science and Innovation (State Plan for Scientific and Technical Research and Innovation grant no. PID2019-111156GB-I00). J.D.C. acknowledges support from the Office of Naval Research, grant no. N000142212035.Peer reviewe

Artificial Metaphotonics Born Naturally in Two Dimensions

10.1021/acs.chemrev.9b00592Chemical Review