STUDY ON THE DRIVING GAZE SHIFT CHARACTERISTICS OF VISION INTERESTING AREA ON MOUNTAINOUS ROAD

Mountainous road landscape is the main source of driving information. The characteristics of two-lane mountainous road result in real-time dynamic changes in the driver's vision interesting areas. In order to explore the dynamic gaze characteristics, a driving experiment is conducted, and the gaze data of 10 drivers are collected. Markov chain is used to analyze the change process of gaze. The results show that: (1) when the current gaze point is in the straight front area, different road landscape has no significant impact on the gaze shift probability; (2) when the current gaze point is in the near left area, next gaze will expand the search scope to obtain much more driving information; (3) when the current gaze point is in the near right area, there is a high probability that the driver's next gaze will return to the front area; (4) when the current gaze point is in the far right area, the gaze will move back and forth between the near right and the far right areas; (5) when the current gaze point is in the far left area, there is a high probability that the gaze will remain in current area; (6) the main source of traffic information obtained by the driver in mountainous road landscape is the straight front area in the vision field, and the gaze point constantly shifts between the far ahead and the near ahead. The research results can provide technical reference for the construction of landscape in mountainous two-lane road

Research on spatiotemporal characteristics of urban crowd gathering based on Baidu map heat map

With the rapid development of urban transportation and the increase in per capita car ownership, the problem of urban traffic congestion is becoming increasingly prominent. Due to the uneven distribution of crowd in different regions of the city, it is difficult to determine and solve the traffic dynamics congestion. In order to solve the problem that it is difficult to determine the dynamics of traffic congestion areas caused by uneven distribution of vitality in different regions of mountainous cities, a crowded mega mountainous city is selected as research object and it proposes a model to calculate the change characteristics of regional crowd gathering. Baidu Heatmap is used as it could distinguish crowd gathering in certain urban core area. The heat map pictures in dozens of consecutive days is extracted and researchers conducted pixel statistical classification on thermal map images. Based on the pixel data of different levels of the pictures, the calculation model is established and an algorithm based on particle swarm optimization is proposed. The calibration of the relative active population equivalent density is conducted, and the distribution characteristics of crowd gathering in time and space are analyzed. The results show that there are obvious spatiotemporal characteristics for this selected city. In time, holidays have an important impact on crowd gathering. The peak time of crowd gathering on weekdays is different from that on rest days. The research in this paper has a direct practical value for the identification of traffic congestion areas and the corresponding governance measures. The dynamic identification of population gathering areas in mountainous mega cities, demand prediction for various transportation regions, and future population OD(Origin—Destination) planning are of great significance.

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

cAMP-modulated biomimetic ionic nanochannels based on a smart polymer

The flow of ions across the cell membrane is essential to many life processes. Cyclic 30,50-adenosine monophosphate (cAMP) binds to and regulates the function of cyclic nucleotide-gating channel proteins, which directly mediate the Na+/ Ca2+ transmembrane behaviours. This inspires us to develop a biomimetic cAMP-modulated ionic nanochannel based on a cAMP-responsive polymer design. Driven by specific hydrogen bonding interactions with cAMP, an arginine-based smart copolymer film displays remarkable adsorption toward cAMP and can clearly discriminate cAMP from other nucleotides, accompanied with reversible conformational transition of the polymer chain from a contracted state to a swollen one. Benefiting from these features, dynamic gating behaviours of the nanochannels located on the copolymer-modified anodic aluminum oxide (AAO) membrane could be precisely manipulated by cAMP. Sensitive responsiveness (10 pmol L 1) and high specificity toward cAMP, high controllability and satisfactory reversibility reveal the great potential of biomolecule responsive polymers in biomimetic nanochannels and nanodevices

Hierarchically engineered nanochannel systems with pore-in/on-pore structures

The exquisite structures of biological ion channels provide inspiration for designing and constructing artificial ion channels to achieve analogous functions. Hierarchically engineered heterogeneous nanochannels with excellent ion rectification, selectivity, and gating properties have attracted more and more attention. In this review, we briefly review the recent advances of hierarchically engineered nanochannel systems in terms of pore-on-pore and pore-in-pore structures, with an emphasis on the promising applications, including ion-selective transport, osmotic energy harvesting, separation, and biosensing

Stimuli-Directed Helical Chirality Inversion and Bio-Applications

Helical structure is a sophisticated ubiquitous motif found in nature, in artificial polymers, and in supramolecular assemblies from microscopic to macroscopic points of view. Significant progress has been made in the synthesis and structural elucidation of helical polymers, nevertheless, a new direction for helical polymeric materials, is how to design smart systems with controllable helical chirality, and further use them to develop chiral functional materials and promote their applications in biology, biochemistry, medicine, and nanotechnology fields. This review summarizes the recent progress in the development of high-performance systems with tunable helical chirality on receiving external stimuli and discusses advances in their applications as drug delivery vesicles, sensors, molecular switches, and liquid crystals. Challenges and opportunities in this emerging area are also presented in the conclusion

Protein/Peptide Aggregation and Amyloidosis on Biointerfaces

Recently, studies of protein/peptide aggregation, particularly the amyloidosis, have attracted considerable attention in discussions of the pathological mechanisms of most neurodegenerative diseases. The protein/peptide aggregation processes often occur at the membrane–cytochylema interface in vivo and behave differently from those occurring in bulk solution, which raises great interest to investigate how the interfacial properties of artificial biomaterials impact on protein aggregation. From the perspective of bionics, current progress in this field has been obtained mainly from four aspects: (1) hydrophobic–hydrophilic interfaces; (2) charged surface; (3) chiral surface; and (4) biomolecule-related interfaces. The specific physical and chemical environment provided by these interfaces is reported to strongly affect the adsorption of proteins, transition of protein conformation, and diffusion of proteins on the biointerface, all of which are ultimately related to protein assembly. Meanwhile, these compelling results of in vitro experiments can greatly promote the development of early diagnostics and therapeutics for the relevant neurodegenerative diseases. This paper presents a brief review of these appealing studies, and particular interests are placed on weak interactions (i.e., hydrogen bonding and stereoselective interactions) that are also non-negligible in driving amyloid aggregation at the interfaces. Moreover, this paper also proposes the future perspectives, including the great opportunities and challenges in this field as well