Partially carbonized wastepaper with excellent mechanical strength for oil-water and emulsion separation

Background Taking the treatment of oily sewage and the recycling of wastepaper as the starting point, the idea of using waste to treat waste was used to treat the swage with aerogels made of wastepaper. Methods Porous ultralight Fe-functionalized cellulose carbon aerogels (CPFe) were synthesized using wastepaper as raw material through FeCl3 impregnation and low-temperature carbonization. Findings CPFe aerogels exhibit excellent physicochemical properties, such as: low density (0.0284 g/cm3), high porosity (97.32%), and selective absorption capacity for various oil products. The absorption capacity of chloroform reached 62.8 g/g. In addition, it exhibits excellent capacity in emulsion separation for both o/w and w/o types. Droplet size of w/o emulsion reduced by two orders of magnitude. CPFe aerogel is a low-cost, renewable, environmentally friendly material and suitable for large-scale production. It is expected to have broad applications in pollution remediation.publishedVersio

Chitinase-3 like-protein-1, matrix metalloproteinase -9 and positive intracranial arterial remodelling

IntroductionPositive intracranial arterial remodelling is a dilated lesion of the large intracranial vessels; however, its pathogenesis is currently unknown. Some studies have identified chitinase-3 like-protein-1 (YKL-40) and matrix metalloproteinase (MMP)-9 as circulating inflammatory factors involved in positive vascular remodelling. Herein, we aimed to investigate the relationship between changes in serum YKL-40 and MMP-9 levels and positive intracranial arterial remodelling in patients with cerebral small vessel disease (CSVD).MethodsA total of 110 patients with CSVD were selected. Patients with brain arterial remodelling (BAR) scores >1 times the standard deviation were defined as the positive intracranial artery remodelling group (n = 21 cases), and those with BAR scores ≤1 times the standard deviation were defined as the non-positive intracranial artery remodelling group (n = 89 cases). Serum YKL-40 and MMP-9 levels were measured using an enzyme-linked immunosorbent assay kit. Factors influencing positive intracranial artery remodelling using binary logistic regression analysis and predictive value of YKL-40 and MMP-9 for positive intracranial arterial remodelling in patients with CSVD were assessed by a subject receiver operating characteristic curve.ResultsStatistically significant differences in serum YKL-40 and MMP-9 levels were observed between the positive and non-positive remodelling groups (p < 0.05). The integrated indicator (OR = 9.410, 95% CI: 3.156 ~ 28.054, P<0.01) of YKL-40 and MMP-9 levels were independent risk factors for positive intracranial arterial remodelling. The integrated indicator (OR = 3.763, 95% CI: 1.884 ~ 7.517, p < 0.01) of YKL-40 and MMP-9 were independent risk factors for positive arterial remodelling in posterior circulation, but were not significantly associated with positive arterial remodelling in anterior circulation (p > 0.05). The area under the curve for YKL-40 and MMP-9 diagnostic positive remodelling was 0.778 (95% CI: 0.692–0.865, p < 0.01) and 0.736 (95% CI: 0.636–0.837, p < 0.01), respectively.DiscussionElevated serum YKL-40 and MMP-9 levels are independent risk factors for positive intracranial arterial remodelling in patients with CSVD and may predict the presence of positive intracranial arterial remodelling, providing new ideas for the mechanism of its occurrence and development and the direction of treatment

Graphene-Based Flexible Sensors for Respiratory and Airflow Monitoring

Flexible devices have been rapidly developed and applied in various applications. However, there have been few reports on printable graphene-based sensors with customized structures and properties capable of respiratory and airflow monitoring. In this study, a graphene-based flexible sensor with a conical microdot array (GSCA) made by the direct-ink writing 3D printing method for real-time personal signals and air-coupled detection is reported. GSCA 3D structures with microdot features on the sensing layer can deliver a fast response of below 60 ms and improve the sensitivity by 32.4% (26–78 kPa), 800% (78–102 kPa), and 600% (102–160 kPa) by adjusting the printing parameters. The sensor exhibits a low detection limit of 11.4 Pa and a large detection range with a linear sensitivity of 1.4–509 kPa. The spider leg-like micro-/nanofibers between two adjacent microdots contribute to electron transport and airflow sensing. The results show the feasibility of the graphene-based sensor with dots to recognize air strength and direction for respiration and airflow. Further validation of the GSCA in real-time personal monitoring demonstrates the potential for multitasking wearable sensors

Polypharmacology of Berberine Based on Multi-Target Binding Motifs

Background: Polypharmacology is emerging as the next paradigm in drug discovery. However, considerable challenges still exist for polypharmacology modeling. In this study, we developed a rational design to identify highly potential targets (HPTs) for polypharmacological drugs, such as berberine.Methods and Results: All the proven co-crystal structures locate berberine in the active cavities of a redundancy of aromatic, aliphatic, and acidic residues. The side chains from residues provide hydrophobic and electronic interactions to aid in neutralization for the positive charge of berberine. Accordingly, we generated multi-target binding motifs (MBM) for berberine, and established a new mathematical model to identify HPTs based on MBM. Remarkably, the berberine MBM was embodied in 13 HPTs, including beta-secretase 1 (BACE1) and amyloid-β1-42 (Aβ1-42). Further study indicated that berberine acted as a high-affinity BACE1 inhibitor and prevented Aβ1-42 aggregation to delay the pathological process of Alzheimer’s disease.Conclusion: Here, we proposed a MBM-based drug-target space model to analyze the underlying mechanism of multi-target drugs against polypharmacological profiles, and demonstrated the role of berberine in Alzheimer’s disease. This approach can be useful in derivation of rules, which will illuminate our understanding of drug action in diseases

The Bioavailability, Biodistribution, and Toxic Effects of Silica-Coated Upconversion Nanoparticles in vivo

Lanthanide-doped upconversion nanoparticles can convert long wavelength excitation radiation to short wavelength emission. They have great potential in biomedical applications, such as bioimaging, biodetection, drug delivery, and theranostics. However, there is little information available on their bioavailability and biological effects after oral administration. In this study, we systematically investigated the bioavailability, biodistribution, and toxicity of silica-coated upconversion nanoparticles administrated by gavage. Our results demonstrate that these nanoparticles can permeate intestinal barrier and enter blood circulation by microstructure observation of Peyer's patch in the intestine. Comparing the bioavailability and the biodistribution of silica-coated upconversion nanoparticles with oral and intravenous administration routes, we found that the bioavailability and biodistribution are particularly dependent on the administration routes. After consecutive gavage for 14 days, the body weight, pathology, Zn and Cu level, serum biochemical analysis, oxidative stress, and inflammatory cytokines were studied to further evaluate the potential toxicity of the silica-coated upconversion nanoparticles. The results suggest that these nanoparticles do not show overt toxicity in mice even at a high dose of 100 mg/kg body weight

Genotype-phenotype features of germline variants of the TMEM127 pheochromocytoma susceptibility gene: A 10-year update

Purpose: This work aimed to evaluate genotype-phenotype associations in individuals carrying germline variants of transmembrane protein 127 gene (TMEM127), a poorly known gene that confers susceptibility to pheochromocytoma (PHEO) and paraganglioma (PGL). Design: Data were collected from a registry of probands with TMEM127 variants, published reports, and public databases. Main Outcome Analysis: Clinical, genetic, and functional associations were determined. Results: The cohort comprised 110 index patients (111 variants) with a mean age of 45 years (range, 21-84 years). Females were predominant (76 vs 34, P <. 001). Most patients had PHEO (n = 94; 85.5%), although PGL (n = 10; 9%) and renal cell carcinoma (RCC, n = 6; 5.4%) were also detected, either alone or in combination with PHEO. One-third of the cases had multiple tumors, and known family history was reported in 15.4%. Metastatic PHEO/PGL was rare (2.8%). Epinephrine alone, or combined with norepinephrine, accounted for 82% of the catecholamine profiles of PHEO/PGLs. Most variants (n = 63) occurred only once and 13 were recurrent (2-12 times). Although nontruncating variants were less frequent than truncating changes overall, they were predominant in non-PHEO clinical presentations (36% PHEO-only vs 69% other, P <. 001) and clustered disproportionately within transmembrane regions (P <. 01), underscoring the relevance of these domains for TMEM127 function. Integration of clinical and previous experimental data supported classification of variants into 4 groups based on mutation type, localization, and predicted disruption. Conclusions: Patients with TMEM127 variants often resemble sporadic nonmetastatic PHEOs. PGL and RCC may also co-occur, although their causal link requires further evaluation. We propose a new classification to predict variant pathogenicity and assist with carrier surveillance.Fil: Armaiz Pena, Gustavo. University Of Texas Health Science Center At San Antonio;; Estados UnidosFil: Flores, Shahida K.. No especifíca;Fil: Cheng, Zi Ming. No especifíca;Fil: Zhang, Xhingyu. No especifíca;Fil: Esquivel, Emmanuel. No especifíca;Fil: Poullard, Natalie. No especifíca;Fil: Vaidyanathan, Anusha. No especifíca;Fil: Liu, Qianqian. No especifíca;Fil: Michalek, Joel. No especifíca;Fil: Santillan Gomez, Alfredo A.. No especifíca;Fil: Liss, Michael. No especifíca;Fil: Ahmadi, Sara. No especifíca;Fil: Katselnik, Daniel. No especifíca;Fil: Maldonado, Enrique. No especifíca;Fil: Salgado, Sarimar Agosto. No especifíca;Fil: Jimenez, Camilo. No especifíca;Fil: Fishbein, Lauren. No especifíca;Fil: Hamidi, Oksana. No especifíca;Fil: Else, Tobias. No especifíca;Fil: Lechan, Ron. Tufts Medical Center; Estados UnidosFil: Tischler, Art S.. Tufts Medical Center; Estados UnidosFil: Benn, Diana E.. No especifíca;Fil: Dwight, Trisha. University of Technology Sydney; AustraliaFil: Clifton Bligh, Rory. University of Technology Sydney; AustraliaFil: Sanso, Elsa Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; ArgentinaFil: Barontini, Marta Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; ArgentinaFil: Vincent, Deepa. Massachusetts Institute of Technology; Estados UnidosFil: Aronin, Neil. Massachusetts Institute of Technology; Estados UnidosFil: Biondi, Bernadette. University of Naples Federico II; ItaliaFil: Koops, Maureen. University of Texas Health San Antonio; Estados UnidosFil: Bowhay Carnes, Elizabeth. No especifíca;Fil: Gimenez Roqueplo, Anne Paule. No especifíca;Fil: Alvarez Eslava, Andrea. No especifíca;Fil: Bruder, Jan M.. No especifíca;Fil: Kitano, Mio. No especifíca;Fil: Burnichon, Nelly. No especifíca;Fil: Ding, Yanli. No especifíca;Fil: Dahia, Patricia L. M.. No especifíca

The Association Between Diabetic Retinopathy and the Prevalence of Age-Related Macular Degeneration—The Kailuan Eye Study

This study aimed to investigate the prevalence of age-related macular degeneration (AMD) in patients with diabetes mellitus (DM) and diabetic retinopathy (DR) and analyze whether DR is a risk factor for AMD. This population-based epidemiological study included 14,440 people from the Kailuan Eye Study in 2016, of whom 1,618 were patients with type 2 DM aged over 50 years, and 409 had DM with DR. We analyzed whether there were differences in the prevalence of AMD between DM with DR and DM without DR, and conducted a hierarchical statistical analysis according to different stages of DR. Using variable regression analysis, we explored whether DR constituted a risk factor for AMD. In the DM population, the prevalence of wet AMD in patients with DM with and without DR was 0. 3 and 0.2%, respectively, with no significant difference (P = 0.607). Meanwhile, the prevalence of dry AMD in patients with DM with and without DR was 20.8 and 16.0%, respectively, with a significant difference. In the subgroup analysis of dry AMD, the prevalence of early, middle, and late dry AMD in DM with DR was 14.4, 5.9, and 0.5%, respectively. In DM without DR, the prevalence of early, middle, and late dry AMD was 10.5, 4.8, and 0.7%, respectively (P = 0.031). In the subgroup analysis of DR staging, statistical analysis could not be performed because of the limited number of patients with PDR. In the variable regression analysis of risk factors for dry AMD, after adjusting for age, sex, body mass index, hypertension, and dyslipidemia, DR constituted the risk factor for dry AMD. In conclusion, DM did not constitute a risk factor for AMD, and the prevalence of wet AMD and dry AMD in patients with DM and DR was higher than that in patients with DM without DR (among which dry AMD was statistically significant). Multivariate regression analysis confirmed that DR is an independent risk factor for dry AMD. Reasonable control of DM and slowing down the occurrence and development of DR may effectively reduce the prevalence of AMD in patients with DM

Morphological changes of Microcystis aeruginosa colonies in culture

<p>We investigated the changes in the morphology, genetics and photosynthetic characteristics of <em>Microcystis aeruginosa</em> colonies during two months of cultivation. The colonies were collected in Lake Taihu, kept under 25°C on a 12h:12h light/dark cycle at a light density of about 45 μmol m^-2 s^-1. <em>M. novacekii</em>-type colonies were detected on the 10^th day and their percentage of the population tended to increase until the 60^th day. With <em>M. novacekii</em>-like colonies<em> </em>increased, the proportion of <em>M. aeruginosa</em> colonies decreased and reached almost zero by the end of the experiment. <em>M. novacekii</em>-like colony size (D₅₀; this value indicates that particles below D₅₀ accounts for 50%) was greater than 500 μm when<em> </em>these colonies<em> </em>first appeared and was similar to that of <em>M. aeruginosa</em> in the experiment. No differences in cell size were found between these two <em>Microcystis</em> morphotypes either collected from Lake Taihu or cultured in the laboratory. Through molecular tools (16S rDNA, 16S-23S ITS and <em>cpc</em>BA-IGS), there were strong evidences to claim that the original <em>M. aeruginosa</em> colonies isolated from Lake Taihu and the later <em>M. novacekii</em>-like colonies in our cultures were the same species. We suggest that <em>M. aeruginosa </em>colonies consistently changed their colonial morphology to that of a typical <em>M. novacekii</em>.</p

Evaluation of Downward Shortwave Radiation Products Over the Loess Plateau

Downward shortwave radiation (DSR) is a key component of the surface energy budget, influencing atmospheric circulation and climate change. DSR products derived from remote sensing observations or generated from reanalysis systems are commonly used as inputs for ecohydrological and climate models. The Loess Plateau is severely affected by soil erosion and has experienced frequent extreme weather events in recent years. Therefore, an accurate DSR product is crucial for accurately simulating climate change and surface-atmosphere processes on the Loess Plateau. In this study, newly released satellite DSR products CLouds, Albedo and Radiation Edition 3 data (CLARA-A3) and Moderate Resolution Imaging Spectroradiometer land surface Downward Shortwave Radiation Version 6.1 data (MCD18A1 V6.1), along with the reanalysis product Land component of the Fifth Generation European Centre for Medium-Range Weather Forecasts Reanalysis (ERA5-Land), were evaluated over the Loess Plateau and its surrounding areas. Intraday, daily, monthly, and seasonal DSR were evaluated against ground measurements which were collected from five observation networks. CLARA-A3 outperformed MCD18A1 and ERA5-Land on both monthly and daily scales. The root-mean-square error for monthly (daily) DSR from CLARA-A3, ERA5-Land, and MCD18A1 were 19.31 (31.3) W&#x002F;m2, 25.36 (39.74) W&#x002F;m2, and 25.03 (46.14) W&#x002F;m2, respectively. The study explored potential factors contributing to significant errors in DSR products. Results indicated that snow cover was one possible factor influencing the error in MCD18A1, and CLARA-A3 exhibited greater sensitivity to terrain influence compared to ERA5-Land and MCD18A1. The findings can be the reference for selecting DSR products over the Loess Plateau