75 research outputs found

    Estimation of swell height using spaceborne GNSS-R data from eight CYGNSS satellites

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    Global Navigation Satellite System (GNSS)-Reflectometry (GNSS-R) technology has opened a new window for ocean remote sensing because of its unique advantages, including short revisit period, low observation cost, and high spatial-temporal resolution. In this article, we investigated the potential of estimating swell height from delay-Doppler maps (DDMs) data generated by spaceborne GNSS-R. Three observables extracted from the DDM are introduced for swell height estimation, including delay-Doppler map average (DDMA), the leading edge slope (LES) of the integrated delay waveform (IDW), and trailing edge slope (TES) of the IDW. We propose one modeling scheme for each observable. To improve the swell height estimation performance of a single observable-based method, we present a data fusion approach based on particle swarm optimization (PSO). Furthermore, a simulated annealing aided PSO (SA-PSO) algorithm is proposed to handle the problem of local optimal solution for the PSO algorithm. Extensive testing has been performed and the results show that the swell height estimated by the proposed methods is highly consistent with reference data, i.e., the ERA5 swell height. The correlation coefficient (CC) is 0.86 and the root mean square error (RMSE) is 0.56 m. Particularly, the SA-PSO method achieved the best performance, with RMSE, CC, and mean absolute percentage error (MAPE) being 0.39 m, 0.92, and 18.98%, respectively. Compared with the DDMA, LES, TES, and PSO methods, the RMSE of the SA-PSO method is improved by 23.53%, 26.42%, 30.36%, and 7.14%, respectively.This work was supported in part by the National Natural Science Foundation of China under Grant 42174022, in part by the Future Scientists Program of China University of Mining and Technology under Grant 2020WLKXJ049, in part by the Postgraduate Research & Practice Innovation Program of Jiangsu Province under Grant KYCX20_2003, in part by the Programme of Introducing Talents of Discipline to Universities, Plan 111, Grant No. B20046, and in part by the China Scholarship Council (CSC) through a State Scholarship Fund (No. 202106420009).Peer ReviewedPostprint (published version

    Тантризм в контексте теории мистического опыта просветления

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    У статті досліджується індійський тантризм і робиться висновок, що він постає іманентним містичним напрямом, який стверджує тотожність індивідуального та абсолютного духовного начал. Він відноситься до холічного містицизму, що закликає до прийняття матеріального буття у всіх його аспектах. Основними методами просвітлення у тантризмі є медитація і різноманітні види йоги тіла (пранаяма, асана, сексуальна йога). Не використовується в цій формі містичного досвіду такий метод як бхакті, почуттєво-емоційне служіння Абсолюту шляхом віри та любові.В статье исследуется индийский тантризм и делается вывод, что он является имманентным мистическим направлением, которое утверждает тождественность индивидуального и абсолютного духовного начал. Он относится к холическому мистицизму, который призывает к приятию всех аспектов материального бытия. В качестве основных методов просветления в тантризме используется медитация и разнообразные виды йоги тела (пранаяма, асана, сексуальная йога). Практически не используется в данной форме мистического опыта такой метод как бхакти, чувственно-эмоциональное служение Абсолюту путем любви и веры.The article studies Indian tantrism and the conclusion can be made that it is an immanent mystical policy which affirms the identity of individual and absolute origins. It has to do with the whole mysticism which appeals to accept all the aspects of the material being. As the main methods of enlightening tantrism uses meditation and different kinds of body yoga (pranayama, asana, sexual yoga). Such method as bhakti, the sensual and emotional service to the Absolute by means of love and faith, is not practically used in this form of the mystical experience

    Exploring the relationship between abnormally high expression of NUP205 and the clinicopathological characteristics, immune microenvironment, and prognostic value of lower-grade glioma

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    Nuclear pore complex (NPC) is a major transport pivot for nucleocytoplasmic molecule exchange. Nucleoporin 205 (NUP205)—a main component of NPC—plays a key regulatory role in tumor cell proliferation; however, few reports document its effect on the pathological progression of lower-grade glioma (LGG). Therefore, we conducted an integrated analysis using 906 samples from multiple public databases to explore the effects of NUP205 on the prognosis, clinicopathological characteristics, regulatory mechanism, and tumor immune microenvironment (TIME) formation in LGG. First, multiple methods consistently showed that the mRNA and protein expression levels of NUP205 were higher in LGG tumor tissue than in normal brain tissue. This increased expression was mainly noted in the higher WHO Grade, IDH-wild type, and 1p19q non-codeleted type. Second, various survival analysis methods showed that the highly expressed NUP205 was an independent risk indicator that led to reduced survival time of patients with LGG. Third, GSEA analysis showed that NUP205 regulated the pathological progress of LGG via the cell cycle, notch signaling pathway, and aminoacyl-tRNA biosynthesis. Ultimately, immune correlation analysis suggested that high NUP205 expression was positively correlated with the infiltration of multiple immune cells, particularly M2 macrophages, and was positively correlated with eight immune checkpoints, particularly PD-L1. Collectively, this study documented the pathogenicity of NUP205 in LGG for the first time, expanding our understanding of its molecular function. Furthermore, this study highlighted the potential value of NUP205 as a target of anti-LGG immunotherapy

    Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages

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    Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.We thank S. Lecher, S. Li and J. Zallet for technical support. Calculations were performed at the sciCORE scientific computing core facility at the University of Basel. This work was supported by the Swiss National Science Foundation (grants 310030_166687 (S.G.) and 320030_153442 (M.E.) and Swiss HIV Cohort Study grant 740 to L.F.), the European Research Council (309540-EVODRTB to S.G.), TB-PAN-NET (FP7-223681 to S.N.), PathoNgenTrace projects (FP7-278864-2 to S.N.), SystemsX.ch (S.G.), the German Center for Infection Research (DZIF; S.N.), the Novartis Foundation (S.G.), the Natural Science Foundation of China (91631301 to Q.G.), and the National Institute of Allergy and Infectious Diseases (5U01-AI069924-05) of the US National Institutes of Health (M.E.)

    The bounds estimate of sub-band operators for multi-band wavelets

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    Abstract A concept of the sub-band operator of multi-band wavelets is introduced, the theory of d-circular matrices is developed and the upper bound and the lower bound of the norm of the sub-band operator are obtained. Examples are provided to illustrate the results proposed in this paper

    Sustainability of Land Use Promoted by Construction-to-Ecological Land Conversion: A Case Study of Shenzhen City, China

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    Rapid urbanization and rapid urban growth present great challenges to the sustainable utilization of land resources. This paper discusses the on-going process of construction-to-ecological land conversion (CELC) in terms of three aspects: land use, environmental effects, and system responses. CELC is compared to other current land conversion strategies in China. Taking Shenzhen City as an example, this paper introduces five areas in which CELC has been implemented since 2009, including basic farmland protection zones, mining areas, ecological corridors, inefficient industrial zones, and urban villages. This paper argues that Shenzhen’s CELC model can improve the ecological environment, control urban sprawl, and promote sustainable land use and, thus, serve as an example for other cities in China

    Urban Land Expansion and Sustainable Land Use Policy in Shenzhen: A Case Study of China’s Rapid Urbanization

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    Shenzhen is a city that is highly representative of China’s rapid urbanization process. As the city rapidly expands, there are enormous challenges to the sustainable use of land resources. This paper introduces the evolution of urban land expansion and the sustainable land use policy of the Shenzhen Government since 2005. The policy covers the reduction in rural-to-urban land conversion, the delineation of urban growth boundaries, arable land reclamation and the establishment of farmland protection areas, urban redevelopment, and the investigation and prosecution of illegal construction. This paper considers the aspects of urbanization and land management systems that are unique to China. The current top-down indicative and mandatory mode of control, which relies on the central government, has very limited effects. Good results were achieved in Shenzhen for the following elements: governmental self-restraint, governmental identity change, and policy innovation. Shenzhen’s sustainable land use practices can provide a reference for other cities in China
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