34,490 research outputs found

    Simultaneous qualitative and quantitative analysis of Tangkening granule using thin layer chromatography (TLC) and high performance liquid chromatography (HPLC)

    Get PDF
    This study was designed to establish the quality standard of Tangkening granule in order to effectively control the quality of this new Chinese traditional patent medicine in the process of production, in addition to ensure the good clinical application. Fructus gardenia, Herba gynostemmatis, Dioscorea batatas, and Polygonatum odoratum in Tangkening granule were identified by thin layer chromatography (TLC), and the content of geniposide was determined by high performance liquid chromatography (HPLC). A comprehensive validation of the method that included sensitivity, linearity, repeatability and recovery was conducted. The results show that this analytical method was simple and suitable for the original identification and quality control of this new Chinese traditional patent medicine.Key words: Tangkening granule, geniposide, quality standard, thin layer chromatography, high performance liquid chromatography

    Switchable coupling between charge and flux qubits

    Full text link
    We propose a hybrid quantum circuit with both charge and flux qubits connected to a large Josephson junction that gives rise to an effective inter-qubit coupling controlled by the external magnetic flux. This switchable inter-qubit coupling can be used to transfer back and forth an arbitrary superposition state between the charge qubit and the flux qubit working at the optimal point. The proposed hybrid circuit provides a promising quantum memory because the flux qubit at the optimal point can store the tranferred quantum state for a relatively long time.Comment: 5 pages, 1 figur

    Tissue-specific Accumulation of Flavonoids in Grape Berries is Related to Transcriptional Expression of VvF3′H and VvF3′5′H

    Get PDF
    The products and the related gene expression of flavonoid metabolism were examined in the skin and pulpof Yan73 (Vitis vinifera L. cv.) grapes, a teinturier variety cultivated in China, and the data were comparedwith those in the skin and pulp of Cabernet Sauvignon (Vitis vinifera L. cv.) grapes, a well-known redvariety. The results showed that, in comparison with the skins of Cabernet Sauvignon, the skins of Yan73berries were characterised by fewer types of flavonols and anthocyanins, a higher level of flavonoids,and a much lower percentage of 3′-hydroxylated flavonols. Flavonoid metabolism was also present in thepulp of Yan73, and the percentages of 3′-hydroxylated flavonols and 3′-hydroxylated flavan-3-ols weresignificantly higher than the percentages of their corresponding 3′,5′-hydroxylated forms. Only flavan-3-ols were found in the pulp of Cabernet Sauvignon. The expression of VvmybA1 exhibited a co-ordinationwith the accumulation of anthocyanins in the pulp of the teinturier cultivar, which showed great similarityto that in the skin. A good correlation was found between the expression of VvF3′H and 3′-hydroxylatedflavonoids, as well as between the expression of VvF3′5′H and 3′,5′-hydroxylated flavonoids in the skin andpulp of the grape berries. It is suggested that tissue-specific accumulation of flavonoids in grape berries isrelated to the transcriptional expression of VvF3′H and VvF3′5′H

    Position-Based Multi-Agent Dynamics for Real-Time Crowd Simulation (MiG paper)

    Full text link
    Exploiting the efficiency and stability of Position-Based Dynamics (PBD), we introduce a novel crowd simulation method that runs at interactive rates for hundreds of thousands of agents. Our method enables the detailed modeling of per-agent behavior in a Lagrangian formulation. We model short-range and long-range collision avoidance to simulate both sparse and dense crowds. On the particles representing agents, we formulate a set of positional constraints that can be readily integrated into a standard PBD solver. We augment the tentative particle motions with planning velocities to determine the preferred velocities of agents, and project the positions onto the constraint manifold to eliminate colliding configurations. The local short-range interaction is represented with collision and frictional contact between agents, as in the discrete simulation of granular materials. We incorporate a cohesion model for modeling collective behaviors and propose a new constraint for dealing with potential future collisions. Our new method is suitable for use in interactive games.Comment: 9 page

    Dissociation of writing processes: A functional magnetic resonance imaging study on the neural substrates for the handwritten production of Chinese characters

    Get PDF
    Writing is an important way to communicate in everyday life because it can convey information over time and space, but its neural substrates remain poorly known. Although the neural basis of written language production has been investigated in alphabetic scripts, it has rarely been examined in nonalphabetic languages such as Chinese. The present functional magnetic resonance imaging study explored the neural substrates of handwritten word production in Chinese and identified the brain regions sensitive to the psycholinguistic factors of word frequency and syllable frequency. To capture this, we contrasted neural activation in “writing” with “speaking plus drawing” and “watching plus drawing.” Word frequency (high, low) and syllable frequency (high, low) of the picture names were manipulated. Contrasts between the tasks showed that writing Chinese characters was mainly associated with brain activation in the left frontal and parietal cortex, whereas orthographic processing and the motor procedures necessary for handwritten production were also related to activation in the right frontal and parietal cortex as well as right putamen/thalamus. These results demonstrate that writing Chinese characters requires activation in bilateral cortical regions and the right putamen/thalamus. Our results also revealed no brain activation associated with the main effects of word frequency and syllable frequency as well as their interaction, which implies that word frequency and syllable frequency may not affect the writing of Chinese characters on a neural level
    • …
    corecore