Is Plaque Rupture Always Responsible in Acute Coronary Syndrome?

The majority cause of myocardial infarction is the atherothrombotic event, mainly cause by plaque rupture. Since the 20th century, it was found that the plaque rupture was not the solely condition responsible for the acute coronary syndrome. With the invention of more sensitive myocardial biomarker, a series of guideline was written as guideline for the definition of myocardial infarction. This review discuss about the consensus in the Universal Definition of  Myocardial Infarction

LAPORAN INDIVIDU PRAKTEK PENGALAMAN LAPANGAN LOKASI LEMBAGA PENJAMINAN MUTU PENDIDIKAN

Praktik pengalaman lapangan (PPL) merupakan program kegiatan yang bertujuan untuk memberikan pengalaman kepada mahasiswa agar siap masuk dalam dunia kerja. Kegiatan ini mempersyaratkan kemampuan aplikatif dan terpadu seluruh pengalaman belajar kedalam program latihan berupa kinerja dan kompetisi dalam suatu hal yang berkaitan dengan jabatan dan profesionalisme keguruan, baik kegiatan mengajar maupun kegiatan bukan mengajar. Teknologi pendidikan merupakan suatu kajian ataupun praktik dalam meningkatkan kinerja dalam merancang, mengembangkan, memanfaatkan, mengevaluasi, serta mengelola proses dan sumber teknologi yang memadai. Pada program ini, mahasiswa Teknologi Pendidikan memiliki kesempatan untuk mengembangkan potensinya di Lembaga Penjaminan Mutu Pendidikan (LPMP) Daerah Istimewa Yogyakarta sebagai lokasi praktik. Di lembaga tersebut, mahasiswa dapat membahaskan ide-ide dan pemikirannya yang telah dikuasainya, sehingga kehadiran para vii mahasiwa dapat dirasakan manfaatnya oleh seluruh masyarakat. Segala hal yang akan dilakasanakan mahasiswa di LPMP D.I.Yogyakarta sebagaimana telah tercantum di dalam perencanaan program. Kegiatan PPL oleh mahasiswa PPL Teknologi Pendidikan bekerjasama dengan LPMP D.I. Yogyakarta telah dilaksanakan dari tanggal 3 Agustus sampai 4 September 2015 di LPMP D.I.Yogyakarta. Pelaksanaan PPL ini diisi dengan berbagai program kelompok maupun program individu yang telah disetujui oleh pembimbing baik dari UNY dan pembimbing dari LPMP D.I.Yogyakarta. Di dalam pelaksanaan program ini, tentunya terdapat persiapan yang kemudian dilanjutkan dengan pelaksanaan dan disusul dengan analisis hasil dari program yang telah dijalankan. Program kelompok yang telah berhasil dijalankan meliputi program kelompok yaitu kegiatan penataan laboratorium dan kegiatan peringatan HUT RI ke-70, sedangkan program individu yang telah dilaksanakan adalah pendampingan diklat. Dari analisis hasil dan refleksi dapat disimpulkan bahwa program kerja yang dilaksanakan oleh praktikan telah berhasil dengan baik dan memberi manfaat bagi mahasiswa sendiri maupun lembaga

Clinical cardiac manifestations in patients with coronavirus disease 2019 (COVID-19)

The pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than 2 million people worldwide with case fatality rates between 3-15%. The pathophysiology of this newly emerging disease in affecting cardiovascular system is poorly understood. This review aimed to understand from various retrospective studies and case reports that have been published and updated during the pandemic of COVID-19 related to the underlying mechanism and cardiovascular interaction with coronavirus. A literature search was done with Google search, PubMed, European Society of Cardiology (ESC) and Journal of American Medical Association (JAMA) network since the early days of COVID-19 pandemic. Clinical presentation may be asymptomatic or the severe cases will have acute respiratory distress syndrome (ARDS). Protein spikes of SARS-CoV-2 virus use the angiotensin-converting enzyme 2 (ACE2) as viral entry to host cells. Due to the upregulation of ACE2, people with any pre-existing cardiac diseases are more vulnerable to the infection and more likely to have a severe condition of COVID-19 infection with a higher risk of mortality. On the other hand, ACE2 has protective effects against myocardial inflammation and lung injuries. Several cases of COVID-19 infection may have cardiac manifestations as a chief complaint or acute cardiac injury as the complication. Recent case reports show that acute cardiac injury, myocarditis, cardiogenic shock, thromboembolism, and arrhythmias could be the complications of COVID-19 even without history or risk factors of cardiovascular disease. There are several hypotheses related to the mechanism of acute cardiac injury in COVID-19 patients, including damage through ACE2 receptors, hypoxia, cardiac microvascular damage, and inflammatory response.COVID-19 infection can cause many interactions in the cardiovascular system, whether the patients already had chronic heart disease or not. Considering the lack of evidence of the RAS inhibitor in COVID-19, the use of ACE inhibitor/ARB should be continued unless contraindicated and may be beneficial in patients with hypertension, heart failure and diabetes mellitus. Early recognition of cardiac manifestations from COVID-19 infections will be the key to prevent short and long term cardiac adverse events

TREES PHYSIOLOGICAL RESPONSES TO AIR POLLUTION IN TAMAN MARGASATWA RAGUNAN AND UI DEPOK CAMPUS

 Air pollution is a common environmental problem. Planting trees can minimize the adverse effects of air pollution. Plants can absorb and accumulate air pollutants through stomata. Biochemical changes in the leaves will appear as a physiological response of plants to air pollution that can be known by calculating the APTI (Air Pollution Tolerance Index) value. This study aimed to analyze the differences in physiological responses of five tree species in Taman Margasatwa Ragunan (TMR) South Jakarta and Universitas Indonesia (UI) Depok Campus as well as to find out the proper tree species planted in areas with high levels of air pollution. The leaves of five species (Hevea brasiliensis, Manilkara kauki, Artocarpus heterophyllus, Ficus septica, and Mangifera indica) were used to examine the effect of air pollution. Biochemical parameters (relative water content, leaf extract pH, total chlorophyll content, and ascorbic acid content) were observed from each species. The value of each parameter was calculated into the APTI equation. H. brasiliensis, F. septica, and M. indica were categorized as moderately tolerant plants, M. kauki were included as intermediate plants, and A. heterophyllus was a sensitive plant to air pollution in both locations. The highest APTI values were observed in M. indica in both locations. Thus, the recommended species planted in a polluted area was M. indica

Fungsi Kuasa untuk Uji Hipotesis Satu Arah pada Parameter Distribusi Beta

Penelitian ini membahas fungsi kuasa untuk uji hipotesis arah kanan pada distribusi beta. Metode yang digunakan untuk menentukan daerah penolakan dari uji parameter arah kanan adalah UMP test. Selanjutnya, fungsi kuasa ditentukan berdasarkan daerah penolakan tersebut. Grafik fungsi kuasa disimulasikan dengan menggunakan software R versi 4.0.3. Hasil simulasi menunjukkan bahwa batas daerah penolakan k berpengaruh terhadap ukuran uji. Semakin besar k, maka ukuran uji akan semakin kecil. Selain itu, parameter b juga berpengaruh terhadap ukuran uji, semakin besar nilai parameter b, maka ukuran uji akan semakin kecil

Isolated Persistent Left Superior Vena Cava, Role of Echocardiography Screening and CT angiography

Background: An isolated persistent left SVC with concomittant agenesis of right SVC in adult patients is a very rare abnormality. Physician should consider it particularly in patients, in which venous acces will be performed. Our rare case deals with the importance of detailed echocardiographic examination with screening of coronary sinus dilatation before the electrophysiology study.Case: A 65-year-old woman came to outpatient clinic for a chief complaint of palpitations. Her ECG showed paroxysmal SVT with WPW syndrome. She underwent echocardiography examination before electrophysiology study and it was found that she had a dilated coronary sinus. Therefore we performed cardiac CT. It was found that she had a persistent left superior vena cava (SVC) and an absence of a right SVC with no other congenital anomaly.Conclusion: A comprehensive echocardiography examination to look for a dilation of coronary sinus is a first suggestion to screen this anomaly, eventually followed by echocardiography with agitated saline injection and/or computed tomography can help physician to anticipate the anomaly before the invasive procedure involving the thoracic vein.Keywords: echocardiography, cardiac CT angiography, vascular malformation, superiorvena cav

Relationship of P Terminal Force V1 on Electrocardiogram with Left Atrial Function in Chronic Kidney Failure Patients on Hemodialysis

Background: Chronic kidney failure is a worldwide public health problem.Cardiovascular disease is a common complication and the main cause of mortality in this population.Impaired left atrial function is an early marker of cardiovascular involvement and a prognostic factor that correlated with mortality in chronic kidney disease patients. We aimto investigate the relationship between P terminal force V1 (PTFV1), an ECG parameter, with left atrial function in chronic kidney failure patients on hemodialysis.Method: This cross sectional study was done in chronic kidney failure patients on hemodialysis in Dr. Sardjito General Hospital Jogjakarta. Electrocardiogram and echocardiography were done after hemodialysis procedure. P terminal force V1 was measured by multiplying amplitude and duration of negative deflection of terminal P wave in V1. Abnormal PTFV1 was defined as PTFV1 value ≥ 40 mm.msec. Left atrial function was measured using left atrial peak global longitudinal strain (LA PGLS).Results: This study was done in 71 patients with mean age 50 years old. Forty three subjects (61%) were men. Sixty four subjects (90%) had hypertension. Forty four subjects (62%) had abnormal PTFV1 on ECG. Mean LA PGLS was 24.89 ± 8.23%. No significant correlation was found between PTFV1 value with LA PGLS (r= -0.178; p=0.138). By multivariate analysis, left ventricular ejection fraction, left atrial diameter and hemodialysis duration (in months) were variables that independently correlated with LA PGLS. In subanalysis, amplitude of negative deflection of terminal P wave in V1 was significantly correlated with LA PGLS(r= -0.257, p= 0.031).Conclusions: This study reveals no correlation between P terminal force V1 and left atrial function in chronic kidney failure patients on routine hemodialysis. There is significant correlation between amplitude of negative deflection of terminal P wave in V1 with LA PGLS

PENGARUH KINERJA PERUSAHAAN TERHADAP PERGANTIAN CHIEF EXECUTIVE OFFICER (CEO) PADA PERUSAHAAN BUMN YANG TERDAFTAR DI BEI

This study aims to predict the influence of total assets, sales, ROA, ROE, tobin’s q, earnings, current ratio, and debt ratio on CEO turnover. The samples in this study are BUMN companies listed on the Indonesia Stock Exchange (BEI) in 2007-2011. 55 companies are collected as the number of observations which being obtained by the method of purposive sampling. Analytical techniques employed in this study were logistic regression analysis. According to the result of this research, it’s found that total assets, sales, ROA, ROE, tobin’s q, earnings, current ratio, and debt ratio have no significant effects on CEO turnover. Keywords: CEO turnover, firm performance