Dairy Farm Business Summary: Southeastern New York Region 1990

A.E. Ext. 91-17Dairy farmers throughout New York State have been participating in Cornell Cooperative Extension's farm business summary and analysis program since the early 1950's. Each participating farmer receives a comprehensive business summary and analysis of his or her farm business. The information in this report represents an average of the data submitted from farms in the Southeastern New York region

Evolution of the Rate and Mode of Star Formation in Galaxies since z=0.7

We present the star formation rate (SFR) and starburst fraction (SBF) for a sample of field galaxies from the ICBS intermediate-redshift cluster survey. We use [O II] and Spitzer 24 micron fluxes to measure SFRs, and 24 micron fluxes and H-delta absorption to measure of SBFs, for both our sample and a present-epoch field sample from the Sloan Digital Sky Survey (SDSS) and Spitzer Wide-area Infrared Extragalactic (SWIRE) survey. We find a precipitous decline in the SFR since z=1, in agreement with other studies, as well as a corresponding rapid decline in the fraction of galaxies undergoing long-duration moderate-amplitude starbursts. We suggest that the change in both the rate and mode of star formation could result from the strong decrease since z=1 of gas available for star formation.Comment: ApJ Letters in pres

The provision of NHS health checks in a community setting: an ethnographic account

Background: The UK National Health Service Health Checks programme aims to reduce avoidable cardiovascular deaths, disability and health inequalities in England. However, due to the reported lower uptake of screening in specific black and minority ethnic communities who are recognised as being more at risk of cardiovascular disease, there are concerns that NHS Health Checks may increase inequalities in health. This study aimed to examine the feasibility and acceptability of community outreach NHS Health Checks targeted at the Afro-Caribbean community. Methods: This paper reports findings from an ethnographic study including direct observation of four outreach events in four different community venues in inner-city Bristol, England and follow up semi-structured interviews with attendees (n = 16) and staff (n = 4). Interviews and field notes were transcribed, anonymized and analysed thematically using a process of constant comparison. Results: Analysis revealed the value of community assets (community engagement workers, churches, and community centres) to publicise the event and engage community members. People were motivated to attend for preventative reasons, often prompted by familial experience of cardiovascular disease. Attendees valued outreach NHS Health Checks, reinforcing or prompting some to make healthy lifestyle changes. The NHS Health Check provided an opportunity for attendees to raise other health concerns with health staff and to discuss their test results with peers. For some participants, the communication of test results, risk and lifestyle information was confusing and unwelcome. The findings additionally highlight the need to ensure community venues are fit for purpose in terms of assuring confidentiality. Conclusions: Outreach events provide evidence of how local health partnerships (family practice staff and health trainers) and community assets, including informal networks, can enhance the delivery of outreach NHS Health Checks and in promoting the health of targeted communities. To deliver NHS Health Checks effectively, the location and timing of events needs to be carefully considered and staff need to be provided with the appropriate training to ensure patients are supported and enabled to make lifestyle changes

Reprogramming human T cell function and specificity with non-viral genome targeting.

Decades of work have aimed to genetically reprogram T cells for therapeutic purposes1,2 using recombinant viral vectors, which do not target transgenes to specific genomic sites3,4. The need for viral vectors has slowed down research and clinical use as their manufacturing and testing is lengthy and expensive. Genome editing brought the promise of specific and efficient insertion of large transgenes into target cells using homology-directed repair5,6. Here we developed a CRISPR-Cas9 genome-targeting system that does not require viral vectors, allowing rapid and efficient insertion of large DNA sequences (greater than one kilobase) at specific sites in the genomes of primary human T cells, while preserving cell viability and function. This permits individual or multiplexed modification of endogenous genes. First, we applied this strategy to correct a pathogenic IL2RA mutation in cells from patients with monogenic autoimmune disease, and demonstrate improved signalling function. Second, we replaced the endogenous T cell receptor (TCR) locus with a new TCR that redirected T cells to a cancer antigen. The resulting TCR-engineered T cells specifically recognized tumour antigens and mounted productive anti-tumour cell responses in vitro and in vivo. Together, these studies provide preclinical evidence that non-viral genome targeting can enable rapid and flexible experimental manipulation and therapeutic engineering of primary human immune cells

Spatial capital as a tool for planning practice

This purpose of this article is to look at the potential benefit to planning practice of engaging with spatial capital – a concept derived from the social theory of Bourdieu. Doubt is expressed about the theoretical basis for spatial capital; nevertheless, it is argued that it may have merit as a trope for planning practitioners. Spatial capital has a strong empirical basis, making it accessible to planning practice and offering a new means for interpreting and communicating the combined effects of a range of individual urban events such as the gating of communities, differing mobilities and schooling tactics. By focussing on the interplay of social positioning within place, it emphasises the joined-up nature of disadvantage and highlights the limits of environmental determinism. However, its use is not without possible drawbacks. Here, the experience of social capital is informative, as this has been appropriated by groups with quite different readings of its implications for policy

Enabling and Enhancing Science Exploration Across the Solar System: Aerocapture Technology for SmallSat to Flagship Missions

n/