35 research outputs found
Using Real-World Data to Guide Ustekinumab Dosing Strategies for Psoriasis: A Prospective Pharmacokinetic-Pharmacodynamic Study.
- Author
- Alsharqi Ali
- Barker Jonathan
- Barnes Michael R.
- Baudry David
- Becher Gabrielle
- Benham Marilyn
- Bloem Karien
- Consortium PSORT
- Dand Nick
- David Burden A.
- de Vries Annick
- Di Meglio Paola
- Duckworth Michael
- Emsley Richard
- Evans Andrea
- Evans Ian
- Griffiths Christopher E.M.
- Hussain Sagair
- Kirby Brian
- Lawson Linda
- Loeff Floris C.
- Lonsdale Dagan O.
- Mahil Satveer
- Mason Kayleigh
- McElhone Kathleen
- Murphy Ruth
- Ormerod Anthony
- Owen Caroline
- Pan Shan
- Payne Katherine
- Pushpa-Rajah Angela
- Reynolds Nick J.
- Rispens Theo
- Russell Alice
- Smith Catherine H.
- Standing Joseph F.
- Study Group BADBIR
- Study Group BSTOP
- Tsakok Teresa
- Wahie Shyamal
- Warren Richard B.
- Wright Andrew
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
Variation in response to biologic therapy for inflammatory diseases, such as psoriasis, is partly driven by variation in drug exposure. Real-world psoriasis data were used to develop a pharmacokinetic/pharmacodynamic (PK/PD) model for the first-line therapeutic antibody ustekinumab. The impact of differing dosing strategies on response was explored. Data were collected from a UK prospective multicenter observational cohort (491 patients on ustekinumab monotherapy, drug levels, and anti-drug antibody measurements on 797 serum samples, 1,590 measurements of Psoriasis Area Severity Index (PASI)). Ustekinumab PKs were described with a linear one-compartment model. A maximum effect (Emax ) model inhibited progression of psoriatic skin lesions in the turnover PD mechanism describing PASI evolution while on treatment. A mixture model on half-maximal effective concentration identified a potential nonresponder group, with simulations suggesting that, in future, the model could be incorporated into a Bayesian therapeutic drug monitoring "dashboard" to individualize dosing and improve treatment outcomes
Genetic effects on gene expression across human tissues
- Author
- Abell Nathan S.
- Abell Nathan S.
- Addington Anjene
- Addington Anjene M.
- Aguet François
- Aguet François
- Akey Joshua M.
- Ardlie Kristin G.
- Ardlie Kristin G.
- Balliu Brunilda
- Balliu Brunilda
- Barcus Mary E.
- Barcus Mary E.
- Barker Laura K.
- Barshir Ruth
- Basha Omer
- Bates Daniel
- Battle Alexis
- Billy Li Jin
- Bogu Gireesh K.
- Branton Philip A.
- Branton Philip A.
- Bridge Jason
- Bridge Jason
- Brigham Lori E.
- Brigham Lori E.
- Brown Andrew
- Brown Andrew A.
- Brown Christopher D.
- Bustamante Carlos D.
- Carithers Latarsha J.
- Castel Stephane E.
- Castel Stephane E.
- Chan Joanne
- Chen Lin S.
- Chen Lin S.
- Chiang Colby
- Claussnitzer Melina
- Conrad Donald F.
- Conrad Donald F.
- Cox Nancy J.
- Cox Nancy J.
- Craft Brian
- Cummings Beryl B.
- Cummings Beryl B.
- Damani Farhan N.
- Davis David A.
- Davis David A.
- Davis Joe R.
- Davis Joe R.
- Delaneau Olivier
- Delaneau Olivier
- Demanelis Kathryn
- Dermitzakis Emmanouil T.
- Dermitzakis Emmanouil T.
- Diegel Morgan
- Doherty Jennifer A.
- Engelhardt Barbara E.
- Eskin Eleazar
- Eskin Eleazar
- Feinberg Andrew P.
- Fernando Marian S.
- Ferreira Pedro G.
- Flicek Paul
- Foster Barbara A.
- Foster Barbara A.
- Frésard Laure
- Frésard Laure
- Gamazon Eric R.
- Gamazon Eric R.
- Garrido-Martín Diego
- Garrido-Martín Diego
- Gelfand Ellen T.
- Gelfand Ellen T.
- Getz Gad
- Getz Gad
- Gewirtz Ariel D.H.
- Gewirtz Ariel D.H.
- Gillard Bryan M.
- Gillard Bryan M.
- Gliner Genna
- Gliner Genna
- Gloudemans Michael J.
- Gloudemans Michael J.
- Goldman Mary
- Gould Sarah E.
- Guan Ping
- Guan Ping
- Guigo Roderic
- Guigó Roderic
- Hadley Kane
- Hadley Kane
- Haeussler Maximilian
- Hall Ira M.
- Halow Jessica
- Han Buhm
- Han Buhm
- Handsaker Robert E.
- Hansen Kasper D.
- Hariharan Pushpa
- Hasz Richard
- Hasz Richard
- Haugen Eric
- He Amy Z.
- He Yuan
- He Yuan
- Hickey Peter F.
- Hormozdiari Farhad
- Hormozdiari Farhad
- Hou Lei
- Howald Cedric
- Huang Katherine H.
- Huang Katherine H.
- Hunter Marcus
- Hunter Marcus
- Hunter Steven
- Jasmine Farzana
- Jewell Scott D.
- Jewell Scott D.
- Jian Ruiqi
- Jiang Lihua
- Jo Brian
- Jo Brian
- Johns Christopher
- Johns Christopher
- Johnson Audra
- Johnson Mark
- Johnson Mark
- Juettemann Thomas
- Kang Eun Yong
- Karasik Ellen
- Karasik Ellen
- Karczewski Konrad J.
- Kashin Seva
- Kaul Rajinder
- Kellis Manolis
- Kellis Manolis
- Kent W. James
- Kibriya Muhammad G.
- Kim Yungil
- Kim-Hellmuth Sarah
- Koester Susan
- Koester Susan E.
- Kopen Gene
- Kopen Gene
- Kumar Rachna
- Kumar Rachna
- Kyung Im Hae
- Lappalainen Tuuli
- Lappalainen Tuuli
- Lee Christopher M.
- Lee Kristen
- Leinweber William F.
- Leinweber William F.
- Lek Monkol
- Lek Monkol
- Li Gen
- Li Gen
- Li Qin
- Li Xiao
- Li Xiao
- Li Xiao
- Li Xin
- Li Xin
- Lin Jessica
- Lin Shin
- Linder Sandra
- Linke Caroline
- Little A. Roger
- Little A. Roger
- Liu Boxiang
- Liu Boxiang
- Liu Yaping
- Lockart Nicole C.
- Lockhart Nicole C.
- Lonsdale John T.
- Lonsdale John T.
- MacArthur Daniel G.
- MacArthur Daniel G.
- Mangul Serghei
- Martin Casey
- Mash Deborah C.
- Mash Deborah C.
- Matose Takunda
- Maurano Matthew T.
- McCarthy Mark I.
- McCarthy Mark I.
- McDonald Alisa
- McDonald Alisa
- McDowell Ian C.
- McDowell Ian C.
- McLean Jeffrey A.
- Mestichelli Bernadette
- Mestichelli Bernadette
- Miklos Mark
- Miklos Mark
- Mohammadi Pejman
- Mohammadi Pejman
- Molinie Benoit
- Monlong Jean
- Montgomery Stephen B.
- Montgomery Stephen B.
- Montroy Robert G.
- Montroy Robert G.
- Moore Helen M.
- Moore Helen M.
- Mosavel Maghboeba
- Moser Michael T.
- Moser Michael T.
- Muñoz-Aguirre Manuel
- Myer Kevin
- Myer Kevin
- Ndungu Anne W.
- Nedzel Jared L.
- Nedzel Jared L.
- Nelson Jemma
- Neri Fidencio J.
- Nguyen Duyen T.
- Nguyen Duyen Y.
- Nicolae Dan L.
- Nierras Concepcion R.
- Nobel Andrew B.
- Nobel Andrew B.
- Noble Michael S.
- Noble Michael S.
- Oliva Meritxell
- Oliva Meritxell
- Ongen Halit
- Ongen Halit
- Palowitch John J.
- Palowitch John J.
- Panousis Nikolaos
- Papasaikas Panagiotis
- Park Yongjin
- Park YoSon
- Park YoSon
- Parsana Princy
- Parsana Princy
- Paten Benedict
- Payne Anthony J.
- Peterson Christine B.
- Peterson Christine B.
- Pierce Brandon L.
- Qi Liqun
- Quan Jie
- Quon Gerald
- Rao Abhi
- Rao Abhi
- Reverter Ferran
- Rinaldi Nicola J.
- Ripke Stephan
- Rizzardi Lindsay F.
- Robinson Karna L.
- Roche Nancy V.
- Roe Brian
- Roe Bryan
- Rohrer Daniel C.
- Rohrer Daniel C.
- Rosenbloom Kate R.
- Ruffier Magali
- Sabatti Chiara
- Sabatti Chiara
- Saha Ashis
- Saha Ashis
- Salvatore Michael
- Salvatore Michael
- Sammeth Michael
- Sandstrom Richard
- Scott Alexandra J.
- Segrè Ayellet V.
- Segrè Ayellet V.
- Shabalin Andrey A.
- Shabalin Andrey A.
- Shad Saboor
- Shad Saboor
- Sheppard Dan
- Shimko Tyler C.
- Siminoff Laura A.
- Singh Shilpi
- Skol Andrew
- Smith Anna M.
- Smith Kevin S.
- Snyder Michael P.
- Sobin Leslie
- Sobin Leslie
- Sodaei Reza
- Stamatoyannopoulos John
- Stephens Matthew
- Stranger Barbara E.
- Stranger Barbara E.
- Stranger Barbara E.
- Strober Benjamin J.
- Strober Benjamin J.
- Struewing Jeffery P.
- Struewing Jeffery P.
- Sul Jae Hoon
- Sul Jae Hoon
- Sullivan Timothy J.
- Tabor David E.
- Tang Hua
- Taylor Kieron
- Teran Nicole A.
- Thomas Jeffrey A.
- Thomas Jeffrey A.
- Tomaszewski Maria M.
- Traino Heather M.
- Trevanion Stephen J.
- Trowbridge Casandra A.
- Tsang Emily K.
- Tsang Emily K.
- Tsang Emily K.
- Tukiainen Taru
- Tukiainen Taru
- Um Ki Sung
- Undale Anita H.
- Urbut Sarah
- Valentino Kimberly M.
- Valley Dana
- Valley Dana R.
- van de Bunt Martijn
- Van Wittenberghe Nicholas
- Vatanian Negin
- Vaught Jimmie B.
- Vivian John
- Volpi Simona
- Volpi Simona
- Walters Gary
- Walters Gary
- Wang Gao
- Wang Li
- Wang Meng
- Washington Michael
- Washington Michael
- Wen Xiaoquan
- Wen Xiaoquan
- Wheeler Joseph
- Wheeler Joseph
- Wright Fred A.
- Wright Fred A.
- Wu Fan
- Xi Hualin S.
- Yeger-Lotem Esti
- Yong Kang Eun
- Zappala Zachary
- Zappala Zachary
- Zaugg Judith B.
- Zerbino Daniel R.
- Zhang Hailei
- Zhang Rui
- Zhou Yi-Hui
- Zhou Yi-Hui
- Zhu Jingchun
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
Characterization of the molecular function of the human genome and its variation across individuals is essential for identifying the cellular mechanisms that underlie human genetic traits and diseases. The Genotype-Tissue Expression (GTEx) project aims to characterize variation in gene expression levels across individuals and diverse tissues of the human body, many of which are not easily accessible. Here we describe genetic effects on gene expression levels across 44 human tissues. We find that local genetic variation affects gene expression levels for the majority of genes, and we further identify inter-chromosomal genetic effects for 93 genes and 112 loci. On the basis of the identified genetic effects, we characterize patterns of tissue specificity, compare local and distal effects, and evaluate the functional properties of the genetic effects. We also demonstrate that multi-tissue, multi-individual data can be used to identify genes and pathways affected by human disease-associated variation, enabling a mechanistic interpretation of gene regulation and the genetic basis of diseas
Mitochondrial physiology
- Author
- >Gonzalez-Francesqua A
- Aasander Frostner Eleonor
- Abdel-Rahman Engy Ali
- Abdul Karim Norwahidah
- Abumrad Nada A
- Acuna-Castroviejo Dario
- Adiele Reginald C
- Ahn Bumsoo
- Alencar MB
- Ali Sameh S
- Almeida Angeles
- Alton Lesley
- Alves Marco G
- Amati Francesca
- Amoedo Nivea Dias
- Amorim Ricardo
- Anderson Ethan J
- Andreadou Ioanna
- Antunes Diana
- Arago Marc
- Aral Cenk
- Arandarcikaite Odeta
- Arias-Reyes Christian
- Armand Anne-Sophie
- Arnould Thierry
- Avram Vlad Florian
- Axelrod Christopher L
- Bailey Damian M
- Bairam Aida
- Bajpeyi Sudip
- Bajzikova Martina
- Bakker Barbara M
- Banni A
- Bardal Tora
- Barlow Jonathan
- Bastos Sant'Anna Silva Ana Carolina
- Batterson Philip
- Battino Maurizio
- Bazil Jason
- Beard Daniel A
- Bednarczyk Piotr
- Beleza Jorge
- Bello Fiona
- Ben-Shachar Dorit
- Bergdahl Andreas
- Berge Rolf K
- Bergmeister Lisa
- Bernardi Paolo
- Berridge Michael V
- Bettinazzi Stefano
- Bishop David
- Blier Pierre U
- Blindheim Dan Filip
- Boardman Neoma T
- Boetker Hans Erik
- Borchard Sabine
- Boros Mihaly
- Borras Consuelo
- Borsheim Elisabet
- Borutaite Vilma
- Botella Javier
- Bouillaud Frederic
- Bouitbir Jamal
- Boushel Robert C
- Bovard Josh
- Bravo-Sagua Roberto
- Breton Sophie
- Brown David A
- Brown Guy C
- Brown Robert A
- Brozinick Joseph T
- Buettner Garry R
- Burtscher Johannes
- Bustos Matilde
- Calabria Elisa
- Calbet Jose A
- Calzia Enrico
- Cannon Daniel T
- Cano Sanchez Maria
- Canto Alvarez Carlos
- Cardinale D
- Cardoso Luiza Helena Daltro
- Carvalho Eugenia
- Casado Pinna Marta
- Cassar Samantha
- Castelo Maria P
- Castilho Roger F
- Cavalcanti-de-Albuquerque Joao Paulo
- Cecatto Cristiane
- Celen Murat C
- Cervinkova Zuzana
- Chabi Beatrice
- Chakrabarti Lisa
- Chakrabarti Sasanka
- Chaurasia Bhagirath
- Chen Qi
- Chicco Adam J
- Chinopoulos Christos
- Chowdhury Subir K
- Cizmarova Beata
- Clementi Emilio
- Coen Paul M
- Cohen Bruce H
- Coker Robert H
- Collin-Chenot Anne
- Coughlan MT
- Coxito Pedro
- Crisostomo Luis
- Crispim Marcell
- Crossland Hannah
- Dahdah Norma
- Dalgaard Louise T
- Dambrova Maija
- Danhelovska Tereza
- Darveau Charles A
- Darwin Paula M
- Das Anibh M
- Dash Ranjan K
- Davidova Eliska
- Davis Michael S
- Dayanidhi Sudarshan
- De Bem Andreza Fabro
- De Goede Paul
- De Palma Clara
- De Pinto Vito
- Dela Flemming
- Dembinska-Kiec Aldona
- Detraux Damien
- Devaux Yvan
- Di Marcello Marco
- Di Paola Floriana Jessica
- Dias Candida
- Dias Tania R
- Diederich Marc
- Distefano Giovanna
- Djafarzadeh Siamak
- Doermann Niklas
- Doerrier Carolina
- Dong Lan-Feng
- Donnelly Chris
- Drahota Zdenek
- Duarte Filipe Valente
- Dubouchaud Herve
- Duchen Michael R
- Dumas Jean-Francois
- Durham William J
- Dymkowska Dorota
- Dyrstad Sissel E
- Dyson Alex
- Dzialowski Edward M
- Eaton Simon
- Ehinger Johannes
- Elmer Eskil
- Endlicher Rene
- Engin Ayse B
- Escames Germaine
- Evinova Andrea
- Ezrova Zuzana
- Falk Marni Joy
- Fell David A
- Ferdinandy Peter
- Ferko Miroslav
- Fernandez-Ortiz Marisol
- Fernandez-Vizarra Erika
- Ferreira Julio Cesar Batista
- Ferreira Rita
- Ferri Alessandra
- Fessel Joshua P
- Festuccia WT
- Filipovska Aleksandra
- Fisar Zdenek
- Fischer Christine
- Fischer Michael
- Fisher Gordon
- Fisher Joshua J
- Fontanesi Flavia
- Forbes-Hernandez Tamara Y
- Ford Ellen
- Fornaro Mara
- Fuertes Agudo Marina
- Fulton Montana
- Galina Antonio
- Galkin Alexander
- Gallee Leon
- Galli Gina L
- Gama Perez Pau
- Gan Zhenji
- Ganetzky Rebecca
- Gao Yun
- Garcia Geovana S
- Garcia-Rivas Gerardo
- Garcia-Roves Pablo Miguel
- Garcia-Souza Luiz Felipe
- Garlid Keith D
- Garrabou Gloria
- Garten Antje
- Gastaldelli Amalia
- Gayen Jiaur
- Genders Amanda J
- Genova Maria Luisa
- Giampieri Francesca
- Giovarelli Matteo
- Glatz Jan FC
- Gnaiger Erich
- Goikoetxea Usandizaga Naroa
- Goncalo Teixeira da Silva Rui
- Goncalves Debora Farina
- Gonzalez-Armenta Jenny L
- Gonzalez-Freire Marta
- Gonzalo Hugo
- Goodpaster Bret H
- Gorr Thomas A
- Gourlay Campbell W
- Grams Bente
- Granata Cesare
- Grefte Sander
- Grilo Luis
- Guarch Meritxell Espino
- Gueguen Naig
- Guida G
- Gumeni Sentiljana
- Haas Clarissa B
- Haavik Jan
- Hachmo Yafit
- Haendeler Judith
- Haider Markus
- Hajrulahovic Anesa
- Hamann Andrea
- Han Jin
- Han Woo Hyun
- Hancock Chad R
- Hand Steven C
- Handl Jiri
- Hansikova Hana
- Hardee Justin P
- Hargreaves Ian P
- Harper Mary Ellen
- Harrison David K
- Hassan Hazirah
- Hatokova Zuzana
- Hausenloy Derek J
- Heales Simon JR
- Hecker Matthias
- Heiestad Christina
- Hellgren Kim T
- Henrique Alexandrino
- Hepple Russell T
- Hernansanz-Agustin Pablo
- Hewakapuge Sudinna
- Hickey Anthony J
- Ho Dieu Hien
- Hoehn Kyle L
- Hoel Frederik
- Holland Olivia J
- Holloway Graham P
- Holzner Lorenz
- Hoppel Charles L
- Hoppel Florian
- Hoppeler H
- Houstek Josef
- Huete-Ortega Maria
- Hyrossova Petra
- Iglesias-Gonzalez Javier
- Indiveri Cesare
- Irving Brian A
- Isola Raffaella
- Iyer Shilpa
- Jackson Christophe B
- Jadiya Pooja
- Jana Prado Fabian
- Jandeleit-Dahm K
- Jang David H
- Jang Young C
- Janowska Joanna
- Jansen Kirsten
- Jansen-Duerr Pidder
- Jansone Baiba
- Jarmuszkiewicz Wieslawa
- Jaskiewicz Anna
- Jaspers Richard T
- Jedlicka Jan
- Jerome Estaquier
- Jespersen Nichlas R
- Jha Rajan K
- John G JG
- Joseph Vincent
- Juhasz Laszlo
- Jurczak Michael J
- Jurk Diana
- Jusic Amela
- Kaambre Tuuli
- Kaczor Jan J
- Kainulainen Heikki
- Kampa Rafal Pawel
- Kandel Sunil M
- Kane Daniel A
- Kapferer Werner
- Kapnick Senta
- Kappler Lisa
- Karabatsiakis Alexander
- Karavaeva Iuliia
- Karkucinska-Wieckowska Agnieszka
- Kaur Sarbjot
- Keijer Jaap
- Keller Markus A
- Keppner Gloria
- Khamoui Andy V
- Kidere Dita
- Kilbaugh Todd
- Kim Hyoung Kyu
- Kim Julian KS
- Kimoloi Sammy
- Klepinin Aleksandr
- Klepinina Lyudmila
- Klingenspor Martin
- Klocker Helmut
- Kolasa Iris
- Komlódi Timea
- Koopman Werner JH
- Kopitar-Jerala Natasa
- Kowaltowski Alicia J
- Kozlov Andrey V
- Krajcova Adela
- Krako Jakovljevic Nina
- Kristal Bruce S
- Krycer Jamer R
- Kuang Jujiao
- Kucera Otto
- Kuka Janis
- Kwak Hyo Bum
- Kwast Kurt
- Kwon Oh Sung
- Laasmaa Martin
- Labieniec-Watala Magdalena
- Lagarrigue Sylviane
- Lai Nicola
- Lalic Nebojsa M
- Land John M
- Lane Nick
- Laner Verena
- Lanza Ian R
- Laouafa Sofien
- Laranjinha Joäo
- Larsen Steen
- Larsen Terje S
- Lavery Gareth G
- Lazou Antigone
- Ledo Ana Margarida
- Lee Hong Kyu
- Leeuwenburgh Christiaan
- Lehti Maarit
- Lemieux Helene
- Lenaz Giorgio
- Lerfall Jorgen
- Li Puma Lance
- Li Pingan A
- Liang Liping
- Liepins Edgars
- Lin Chien-Te
- Liu Jiankang
- Lopez Luis C
- Lucchinetti Eliana
- Ma Tao
- Macedo Maria P
- Machado Ivo F
- Maciej Sarah
- MacMillan-Crow Lee Ann
- Magalhaes Jose
- Magri Andrea
- Majtnerova Pavlina
- Makarova Elina
- Makrecka-Kuka Marina
- Malik Afshan N
- Marcouiller Francois
- Marechal Amandine
- Markova Michaela
- Markovic Ivanka
- Martin Daniel S
- Martins Ana Dias
- Martins Joao D
- Maseko Tumisang Edward
- Maull Felicia
- Mazat Jean Pierre
- McKenna Helen T
- McKenzie Matthew
- McMillan Duncan GG
- McStay Gavin P
- Menndham A
- Menze Michael A
- Mercer John R.
- Merz Tamara
- Messina Angela
- Meszaros Andras T
- Methner Axel
- Michalak Slawomir
- Mila Guasch Maria
- Minuzzi Luciele M
- Misirkic Marjanovic Maja
- Moellering Douglas R
- Moisoi Nicoleta
- Molina Anthony JA
- Montaigne David
- Moore Anthony L
- Moore Christy
- Moreau Kerrie
- Moreira Bruno P
- Moreno-Sanchez Rafael
- Mracek Tomas
- Muccini Anna Maria
- Munro Daniel
- Muntane Jordi
- Muntean Danina M
- Murray Andrew J
- Musiol Eva
- Nabben Miranda
- Nair K Sreekumaran
- Nehlin Jan O
- Nemec Michal
- Nesci Salvatore
- Neufer P Darrell
- Neuzil Jiri
- Neviere Remi
- Newsom Sean A.
- Norman Jennifer
- Nozickova Katerina
- Nunes Sara
- Nuoffer Jean-Marc
- O'Brien Katie A
- O'Brien Kristin
- O'Gorman Donal
- Olgar Yusuf
- Oliveira Ben
- Oliveira Jorge
- Oliveira Marcos Tulio
- Oliveira Marcus F
- Oliveira Paulo J
- Oliveira Pedro F
- Olsen Rolf Erik
- Orynbayeva Zulfiya
- Osiewacz Heinz D
- Paez Hector
- Pak Youngmi K
- Pallotta Maria L
- Palmeira Carlos M
- Parajuli Nirmala
- Passos Joao F
- Passrugger Manuela
- Patel Hemal H
- Pavlova Nadia
- Pavlovic Kasja
- Pecina Petr
- Pedersen Tina M
- Perales Jose Carles
- Pereira da Silva Grilo da Silva Filomena
- Pereira Rita
- Pereira Susana
- Perez Valencia Juan A
- Perks Kara L
- Pesta Dominik
- Petit Patrice X
- Pettersen Ina Katrine Nitschke
- Pichaud Nicolas
- Pichler Irene
- Piel Sarah
- Pietka Terri A
- Pinho Sonia A
- Pino Maria F
- Pirkmajer Sergej
- Place Nicolas
- Plangger Mario
- Porter Craig
- Porter Richard K
- Preguica Ines
- Prigione Alessandro
- Procaccio Vincent
- Prochownik Edward V
- Prola Alexandre
- Pulinilkunnil Thomas
- Puskarich Michael A
- Puurand Marju
- Radenkovic Filip
- Ramzan Rabia
- Rattan Suresh IS
- Reano Simone
- Reboredo-Rodriguez Patricia
- Rees Bernard B
- Renner-Sattler Kathrin
- Rial Eduardo
- Robinson Matthew M
- Roden Michael
- Rodrigues Ana Sofia
- Rodriguez Enrique
- Rodriguez-Enriquez Sara
- Roesland Gro Vatne
- Rohlena Jakub
- Rolo Anabela Pinto
- Ropelle Eduardo R
- Roshanravan Baback
- Rossignol Rodrigue
- Rossiter Harry B
- Rousar Tomas
- Rubelj Ivica
- Rybacka-Mossakowska Joanna
- Saada Ann
- Safaei Zahra
- Saharnaz Sarlak
- Salin Karine
- Salvadego Desy
- Sandi Carmen
- Saner Nicholas
- Sanz Alberto
- Sazanov Leonid A
- Scatena Roberto
- Schartner Melanie
- Scheibye-Knudsen Morten
- Schilling Jan M
- Schlattner Uwe
- Schoenfeld Peter
- Schots Pauke C
- Schulz Rainer
- Schwarzer Christoph
- Scott Graham R
- Selman Colin
- Shabalina Irina G
- Sharma Pushpa
- Sharma Vipin
- Shevchuk Igor
- Shirazi Reza
- Shiroma Jonathan G
- Siewiera Karolina
- Silber Ariel M
- Silva Ana Maria
- Sims Carrie A
- Singer Dominique
- Singh Brijesh Kumar
- Skolik Robert A
- Smenes Benedikte Therese
- Smith James
- Soares Félix Alexandre Antunes
- Sobotka Ondrej
- Sokolova Inna
- Solesio Maria E
- Sommer Natascha
- Sonkar Vijay K
- Sowton Alice P
- Sparagna Genevieve C
- Sparks Lauren M
- Spinazzi Marco
- Stankova Pavla
- Starr Jonathan
- Stary Creed
- Stelfa Gundega
- Stepto Nigel K
- Stiban Johnny
- Stier Antoine
- Stocker Roland
- Storder Julie
- Sumbalova Zuzana
- Suomalainen Wartiovaara Anu
- Suravajhala Prashanth
- Svalbe Baiba
- Swerdlow Russel H
- Swiniuch Daria
- Szabo Ildiko
- Szewczyk Adam
- Szibor Marten
- Tanaka Masashi
- Tandler Bernard
- Tarnopolsky Mark A
- Tausan Daniel
- Tavernarakis Nektarios
- Teodoro J
- Tepp Kersti
- Thakkar Himani
- Thapa Maheshwo
- Thyfault John P
- Tomar Dhanendra
- Ton Riccardo
- Torp May-Kristin
- Towheed Atif
- Tretter Laszlo
- Trewin Adam J
- Trifunovic Aleksandra
- Trivigno Catherine
- Tronstad Karl Johan
- Trougakos Ioannis P
- Truu Laura
- Tuncay Erkan
- Turan Belma
- Tyrrell Daniel J
- Urban Tomas
- Urner Sofia
- Valentine Joseph Marco
- Van Bergen Nicole J
- Varricchio Frederick
- Vella Joanna
- Vendelin Marko
- Vercesi Anibal E
- Verdaguer Ignasi Bofill
- Vernerova Andrea
- Victor Victor Manuel
- Vidimce Josif
- Vieira Ligo Teixeira Camila
- Viel Christian
- Vieyra Adalberto
- Vilks Karlis
- Villena Joseph A
- Vincent Vinnyfred
- Vinogradov Andrey D
- Viscomi Carlo
- Vitorino Rui Miguel Pinheiro
- Vogt Sebastian
- Volani Chiara
- Volska Kristine
- Votion Dominique-Marie
- Vujacic-Mirski Ksenija
- Wagner Brett A
- Ward Marie Louise
- Warnsmann Verena
- Wasserman David H
- Watala Cezary
- Wei Yau-Huei
- Weissig Volkmar
- Whitfield Jamie
- Wickert Anika
- Wieckowski Mariusz R
- Wiesner Rudolf J
- Williams Caroline M
- Winwood-Smith Hugh
- Wohlgemuth Stephanie E
- Wohlwend Martin
- Wolff Jonci Nikolai
- Wrutniak-Cabello Chantal
- Wuest Rob C I
- Yokota Takashi
- Zablocki Krzysztof
- Zanon Alessandra
- Zanou Nadege
- Zaugg Kathrin
- Zaugg Michael
- Zdrazilova Lucie
- Zhang Yi Zhu
- Zhang Yong
- Zikova Alena
- Zischka Hans
- Zorzano Antonio
- Zvejniece Liga
- Publication venue
- Oroboros Ecosystem
- Publication date
- 20/05/2020
- Field of study
As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery
Mitochondrial physiology
- Author
- Aasander Frostner Eleonor
- Abdel-Rahman Engy Ali
- Abdul Karim Norwahidah
- Abumrad Nada A
- Acuna-Castroviejo Dario
- Adiele Reginald C
- Ahn Bumsoo
- Alencar Mayke Bezerra
- Ali Sameh S
- Almeida Angeles
- Alton Lesley
- Alves Marco G
- Amati Francesca
- Amoedo Nivea Dias
- Amorim Ricardo
- Anderson Ethan J
- Andreadou Ioanna
- Antunes Diana
- Arago Marc
- Aral Cenk
- Arandarcikaite Odeta
- Arias-Reyes Christian
- Armand Anne-Sophie
- Arnould Thierry
- Avram Vlad F
- Axelrod Christopher L
- Bailey Damian M
- Bairam Aida
- Bajpeyi Sudip
- Bajzikova Martina
- Bakker Barbara M
- Banni Aml
- Bardal Tora
- Barlow J
- Bastos Sant'Anna Silva Ana Carolina
- Batterson Philip M
- Battino Maurizio
- Bazil Jason N
- Beard Daniel A
- Bednarczyk Piotr
- Beleza Jorge
- Bello Fiona
- Ben-Shachar Dorit
- Bento Guida Jose Freitas
- Bergdahl Andreas
- Berge Rolf K
- Bergmeister Lisa
- Bernardi Paolo
- Berridge Michael V
- Bettinazzi Stefano
- Bishop David J
- Blier Pierre U
- Blindheim Dan Filip
- Boardman Neoma T
- Boersheim Elisabet
- Boetker Hans Erik
- Borchard Sabine
- Boros Mihaly
- Borras Consuelo
- Borutaite Vilma
- Botella Javier
- Bouillaud Frederic
- Bouitbir Jamal
- Boushel Robert C
- Bovard Josh
- Bravo-Sagua Roberto
- Breton Sophie
- Brown David A
- Brown Guy C
- Brown Robert Andrew
- Brozinick Joseph T
- Buettner Garry R
- Burtscher Johannes
- Bustos Matilde
- Calabria Elisa
- Calbet Jose AL
- Calzia Enrico
- Cannon Daniel T
- Cano Sanchez Maria Consolacion
- Canto Alvarez Carles
- Cardinale Daniele A
- Cardoso Luiza HD
- Carvalho Eugenia
- Casado Pinna Marta
- Cassar Samantha
- Castelo Rueda Maria Paulina
- Castilho Roger F
- Cavalcanti-de-Albuquerque Joao Paulo
- Cecatto Cristiane
- Celen Murat C
- Cervinkova Zuzana
- Chabi Beatrice
- Chakrabarti Lisa
- Chakrabarti Sasanka
- Chaurasia Bhagirath
- Chen Quan
- Chicco Adam J
- Chinopoulos Christos
- Chowdhury Subir Kumar
- Cizmarova Beata
- Clementi Emilio
- Coen Paul M
- Cohen Bruce H
- Coker Robert H
- Collin-Chenot Anne
- Coughlan Melinda T
- Coxito Pedro
- Crisostomo Luis
- Crispim Marcell
- Crossland Hannah
- Dahdah Norma Ramon
- Dalgaard Louise T
- Dambrova Maija
- Danhelovska Tereza
- Darveau Charles-A
- Darwin Paula M
- Das Anibh Martin
- Dash Ranjan K
- Davidova Eliska
- Davis Michael S
- Dayanidhi Sudarshan
- De Bem Andreza Fabro
- De Goede Paul
- De Palma Clara
- De Pinto Vito
- Dela Flemming
- Dembinska-Kiec Aldona
- Detraux Damian
- Devaux Yvan
- Di Marcello Marco
- Di Paola Floriana Jessica
- Dias Candida
- Dias Tania R
- Diederich Marc
- Distefano Giovanna
- Djafarzadeh Siamak
- Doermann Niklas
- Doerrier Carolina
- Dong Lan-Feng
- Donnelly Chris
- Drahota Zdenek
- Duarte Filipe Valente
- Dubouchaud Herve
- Duchen Michael R
- Dumas Jean-Francois
- Durham William J
- Dymkowska Dorota
- Dyrstad Sissel E
- Dyson Alex
- Dzialowski Edward M
- Eaton Simon
- Ehinger Johannes K
- Elmer Eskil
- Endlicher Rene
- Engin Ayse Basak
- Escames Germaine
- Evinova Andrea
- Ezrova Zuzana
- Falk Marni J
- Fell David A
- Ferdinandy Peter
- Ferko Miroslav
- Fernandez-Ortiz Marisol
- Fernandez-Vizarra Erika
- Ferreira Julio Cesar B
- Ferreira Rita Maria P
- Ferri Alessandra
- Fessel Joshua Patrick
- Festuccia William T
- Filipovska Aleksandra
- Fisar Zdenek
- Fischer Christine
- Fischer Michael J
- Fisher Gordon
- Fisher Joshua J
- Fontanesi Flavia
- Forbes-Hernandez Tamara Y
- Ford Ellen
- Fornaro Mara
- Fuertes Agudo Marina
- Fulton Montana
- Galina Antonio
- Galkin Alexander
- Gallee Leon
- Galli Gina L J
- Gama Perez Pau
- Gan Zhenji
- Ganetzky Rebecca
- Gao Yun
- Garcia Geovana S
- Garcia-Rivas Gerardo
- Garcia-Roves Pablo Miguel
- Garcia-Souza Luiz F
- Garlid Keith D
- Garrabou Gloria
- Garten Antje
- Gastaldelli Amalia
- Gayen Jiaur
- Genders Amanda J
- Genova Maria Luisa
- Giampieri Francesca
- Giovarelli Matteo
- Glatz Jan FC
- Gnaiger Erich
- Goikoetxea Usandizaga Naroa
- Goncalo Teixeira da Silva Rui
- Goncalves Debora Farina
- Gonzalez- Armenta Jenny L
- Gonzalez-Franquesa Alba
- Gonzalez-Freire Marta
- Gonzalo Hugo
- Goodpaster Bret H
- Gorr Thomas A
- Gourlay Campbell W
- Grams Bente
- Granata Cesare
- Grefte Sander
- Grilo Luis
- Guarch Meritxell Espino
- Gueguen Naig
- Gumeni Sentiljana
- Haas Clarissa
- Haavik Jan
- Hachmo Yafit
- Haendeler Judith
- Haider Markus
- Hajrulahovic Anesa
- Hamann Andrea
- Han Jin
- Han Woo Hyun
- Hancock Chad R
- Hand Steven C
- Handl Jiri
- Hansikova Hana
- Hardee Justin P
- Hargreaves Iain P
- Harper Mary- Ellen
- Harrison David K
- Hassan Hazirah
- Hatokova Zuzana
- Hausenloy Derek J
- Heales Simon JR
- Hecker Matthias
- Heiestad Christina
- Hellgren Kim T
- Henrique Alexandrino
- Hepple Russell T
- Hernansanz- Agustin Pablo
- Hewakapuge Sudinna
- Hickey Anthony J
- Ho Dieu Hien
- Hoehn Kyle L
- Hoel Fredrik
- Holland Olivia J
- Holloway Graham P
- Holzner Lorenz
- Hoppel Charles L
- Hoppel Florian
- Hoppeler Hans
- Houstek Josef
- Huete-Ortega Maria
- Hyrossova Petra
- Iglesias-Gonzalez Javier
- Indiveri Cesare
- Irving Brian A
- Isola Raffaella
- Iyer Shilpa
- Jackson Christopher Benjamin
- Jadiya Pooja
- Jana Prado Fabian
- Jandeleit-Dahm Karin
- Jang David H
- Jang Young Charles
- Janowska Joanna
- Jansen Kirsten M
- Jansen-Duerr Pidder
- Jansone Baiba
- Jarmuszkiewicz Wieslawa
- Jaskiewicz Anna
- Jaspers Richard T
- Jedlicka Jan
- Jerome Estaquier
- Jespersen Nichlas Riise
- Jha Rajan Kumar
- Jones John G
- Joseph Vincent
- Juhasz Laszlo
- Jurczak Michael J
- Jurk Diana
- Jusic Amela
- Kaambre Tuuli
- Kaczor Jan Jacek
- Kainulainen Heikki
- Kampa Rafal Pawel
- Kandel Sunil Mani
- Kane Daniel A
- Kapferer Werner
- Kapnick Senta
- Kappler Lisa
- Karabatsiakis Alexander
- Karavaeva Iuliia
- Karkucinska-Wieckowska Agnieszka
- Kaur Sarbjot
- Keijer Jaap
- Keller Markus A
- Keppner Gloria
- Khamoui Andy V
- Kidere Dita
- Kilbaugh Todd
- Kim Hyoung Kyu
- Kim Julian KS
- Kimoloi Sammy
- Klepinin Aleksandr
- Klepinina Lyudmila
- Klingenspor Martin
- Klocker Helmut
- Kolassa Iris
- Komlodi Timea
- Koopman Werner JH
- Kopitar-Jerala Natasa
- Kowaltowski Alicia J
- Kozlov Andrey V
- Krajcova Adela
- Krako Jakovljevic Nina
- Kristal Bruce S
- Krycer James R
- Kuang Jujiao
- Kucera Otto
- Kuka Janis
- Kwak Hyo Bum
- Kwast Kurt E
- Kwon Oh Sung
- Laasmaa Martin
- Labieniec-Watala Magdalena
- Lagarrigue Sylviane
- Lai Nicola
- Lalic Nebojsa M
- Land John M
- Lane Nick
- Laner Verena
- Lanza Ian R
- Laouafa Sofien
- Laranjinha Joao
- Larsen Steen
- Larsen Terje S
- Lavery Gareth G
- Lazou Antigone
- Ledo Ana Margarida
- Lee Hong Kyu
- Leeuwenburgh Christiaan
- Lehti Maarit
- Lemieux Helene
- Lenaz Giorgio
- Lerfall Joergen
- Li Pingan Andy
- Li Puma Lance
- Liang Liping
- Liepins Edgars
- Lin Chien-Te
- Liu Jiankang
- Lopez Garcia Luis Carlos
- Lucchinetti Eliana
- Ma Tao
- Macedo Maria Paula
- Machado Ivo F
- Maciej Sarah
- MacMillan-Crow Lee Ann
- Magalhaes Jose
- Magri Andrea
- Majtnerova Pavlina
- Makarova Elina
- Makrecka-Kuka Marina
- Malik Afshan N
- Marcouiller Francois
- Marechal Amandine
- Markova Michaela
- Markovic Ivanka
- Martin Daniel S
- Martins Ana Dias
- Martins Joao D
- Maseko Tumisang Edward
- Maull Felicia
- Mazat Jean-Pierre
- McKenna Helen T
- McKenzie Matthew
- McMillan Duncan GG
- McStay Gavin P
- Mendham Amy
- Menze Michael A
- Mercer John R
- Merz Tamara
- Messina Angela
- Meszaros Andras
- Methner Axel
- Michalak Slawomir
- Mila Guasch Maria
- Minuzzi Luciele M
- Misirkic Marjanovic Maja
- Moellering Douglas R
- Moisoi Nicoleta
- Molina Anthony JA
- Montaigne David
- Moore Anthony L
- Moore Christy
- Moreau Kerrie
- Moreira Bruno P
- Moreno-Sanchez Rafael
- Mracek Tomas
- Muccini Anna Maria
- Munro Daniel
- Muntane Jordi
- Muntean Danina M
- Murray Andrew James
- Musiol Eva
- Nabben Miranda
- Nair K Sreekumaran
- Nehlin Jan O
- Nemec Michal
- Nesci Salvatore
- Neufer P Darrell
- Neuzil Jiri
- Neviere Remi
- Newsom Sean A
- Norman Jennifer
- Nozickova Katerina
- Nunes Sara
- Nuoffer Jean-Marc
- O'Brien Katie A
- O'Brien Kristin
- O'Gorman Donal
- Olgar Yusuf
- Oliveira Ben
- Oliveira Jorge
- Oliveira Marcos Tulio
- Oliveira Marcus F
- Oliveira Paulo J
- Oliveira Pedro Fontes
- Olsen Rolf Erik
- Orynbayeva Zulfiya
- Osiewacz Heinz D
- Paez Hector
- Pak Youngmi Kim
- Pallotta Maria Luigia
- Palmeira Carlos
- Parajuli Nirmala
- Passos Joao F
- Passrugger Manuela
- Patel Hemal H
- Pavlova Nadia
- Pavlovic Kasja
- Pecina Petr
- Pedersen Tina M
- Perales Jose Carles
- Pereira da Silva Grilo da Silva Filomena
- Pereira Rita
- Pereira Susana P
- Perez Valencia Juan Alberto
- Perks Kara L
- Pesta Dominik
- Petit Patrice X
- Pettersen Nitschke Ina Katrine
- Pichaud Nicolas
- Pichler Irene
- Piel Sarah
- Pietka Terri A
- Pinho Sonia A
- Pino Maria F
- Pirkmajer Sergej
- Place Nicolas
- Plangger Mario
- Porter Craig
- Porter Richard K
- Preguica Ines
- Prigione Alessandro
- Procaccio Vincent
- Prochownik Edward V
- Prola Alexandre
- Pulinilkunnil Thomas
- Puskarich Michael A
- Puurand Marju
- Radenkovic Filip
- Ramzan Rabia
- Rattan Suresh IS
- Reano Simone
- Reboredo-Rodriguez Patricia
- Rees Bernard B
- Renner-Sattler Kathrin
- Rial Eduardo
- Robinson Matthew M
- Roden Michael
- Rodrigues Ana Sofia
- Rodriguez Enrique
- Rodriguez-Enriquez Sara
- Roesland Gro Vatne
- Rohlena Jakub
- Rolo Anabela Pinto
- Ropelle Eduardo R
- Roshanravan Baback
- Rossignol Rodrigue
- Rossiter Harry B
- Rousar Tomas
- Rubelj Ivica
- Rybacka-Mossakowska Joanna
- Saada Reisch Ann
- Safaei Zahra
- Salin Karine
- Salvadego Desy
- Sandi Carmen
- Saner Nicholas
- Santos Diana
- Sanz Alberto
- Sardao Vilma
- Sarlak Saharnaz
- Sazanov Leonid A
- Scaife Paula
- Scatena Roberto
- Schartner Melanie
- Scheibye-Knudsen Morten
- Schilling Jan M
- Schlattner Uwe
- Schmitt Sabine
- Schneider Gasser Edith Mariane
- Schoenfeld Peter
- Schots Pauke C
- Schulz Rainer
- Schwarzer Christoph
- Scott Graham R
- Selman Colin
- Sendon Pamella Marie
- Shabalina Irina G
- Sharma Pushpa
- Sharma Vipin
- Shevchuk Igor
- Shirazi Reza
- Shiroma Jonathan G
- Siewiera Karolina
- Silber Ariel M
- Silva Ana Maria
- Sims Carrie A
- Singer Dominique
- Singh Brijesh Kumar
- Skolik Robert A
- Smenes Benedikte Therese
- Smith James
- Soares Felix Alexandre Antunes
- Sobotka Ondrej
- Sokolova Inna
- Solesio Maria E
- Soliz Jorge
- Sommer Natascha
- Sonkar Vijay K
- Sova Marina
- Sowton Alice P
- Sparagna Genevieve C
- Sparks Lauren M
- Spinazzi Marco
- Stankova Pavla
- Starr Jonathan
- Stary Creed
- Stefan Eduard
- Stelfa Gundega
- Stepto Nigel K
- Stevanovic Jelena
- Stiban Johnny
- Stier Antoine
- Stocker Roland
- Storder Julie
- Sumbalova Zuzana
- Suomalainen Anu
- Suravajhala Prashanth
- Svalbe Baiba
- Swerdlow Russell H
- Swiniuch Daria
- Szabo Ildiko
- Szewczyk Adam
- Szibor Marten
- Tanaka Masashi
- Tandler Bernard
- Tarnopolsky Mark A
- Tausan Daniel
- Tavernarakis Nektarios
- Teodoro Joao Soeiro
- Tepp Kersti
- Thakkar Himani
- Thapa Maheshwor
- Thyfault John P
- Tomar Dhanendra
- Ton Riccardo
- Torp May-Kristin
- Torres-Quesada Omar
- Towheed Atif
- Treberg Jason R
- Tretter Laszlo
- Trewin Adam J
- Trifunovic Aleksandra
- Trivigno Catherine
- Tronstad Karl Johan
- Trougakos Ioannis P
- Truu Laura
- Tuncay Erkan
- Turan Belma
- Tyrrell Daniel J
- Urban Tomas
- Urner Sofia
- Valentine Joseph Marco
- Van Bergen Nicole J
- Van der Ende Miranda
- Varricchio Frederick
- Vaupel Peter
- Vella Joanna
- Vendelin Marko
- Vercesi Anibal E
- Verdaguer Ignasi Bofill
- Vernerova Andrea
- Victor Victor Manuel
- Vidimce Josif
- Vieira Ligo Teixeira Camila
- Viel Christian
- Vieyra Adalberto
- Vilks Karlis
- Villena Josep A
- Vincent Vinnyfred
- Vinogradov Andrey D
- Viscomi Carlo
- Vitorino Rui Miguel Pinheiro
- Vlachaki Walker Julia
- Vogt Sebastian
- Volani Chiara
- Volska Kristine
- Votion Dominique-Marie
- Vujacic-Mirski Ksenija
- Wagner Brett A
- Ward Marie Louise
- Warnsmann Verena
- Wasserman David H
- Watala Cezary
- Wei Yau-Huei
- Weinberger Klaus M
- Weissig Volkmar
- White Sarah Haverty
- Whitfield Jamie
- Wickert Anika
- Wieckowski Mariusz R
- Wiesner Rudolf J
- Williams Caroline M
- Winwood-Smith Hugh
- Wohlgemuth Stephanie E
- Wohlwend Martin
- Wolff Jonci Nikolai
- Wrutniak-Cabello Chantal
- Wuest Rob CI
- Yokota Takashi
- Zablocki Krzysztof
- Zanon Alessandra
- Zanou Nadege
- Zaugg Kathrin
- Zaugg Michael
- Zdrazilova Lucie
- Zhang Yizhu
- Zhang Yong
- Zikova Alena
- Zischka Hans
- Zorzano Antonio
- Zujovic Tijana
- Zurmanova Jitka
- Zvejniece Liga
- Publication venue
- Publication date
- 01/01/2020
- Field of study
As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
- Babayan Primo
- Babbage Anne
- Babbage Sarah
- Bach Phil
- Bachatsang Pasang
- Bacon Joanne
- Badri Hummy
- Baertsch Robert
- Bagguley Claire
- Bailey Jonathan
- Bajorek Eva
- Baker Andrew
- Baker Dan
- Baker M.
- Baker Richard
- Bakis Michele
- Baldwin Jennifer
- Banda Michael
- Banerjee Ruby
- Bao Jingyue
- Bao Qiyu
- Bao Weidong
- Bao Weidong
- Baptiste Pertrice
- Barbaria Joseph A.
- Barbe Valérie
- Bardill Simon
- Barker Daniel
- Barker Darren
- Barker Gary
- Barlow Karen
- Baron Laurent
- Barrett Anika
- Bartlett Rebecca
- Basham Victoria
- Bashman David
- Basu Suba
- Bateman Alex
- Bates Karen
- Battles John
- Batzer Mark
- Baumgart Cornelia
- Baumohl Jason
- Baynes Caroline
- Bayul Tashi
- Beall Keith
- Beard Lisa
- Beard Susan
- Beare David
- Beasley Alastair
- Beasley Helen
- Beasley Oliver
- Beaucham Leslie
- Beaudet Arthur
- Beck Alfred
- Beck Stephen
- Becker Michael
- Bell Emma
- Bell George I.
- Bellard Terell M.
- Bellerby Damian
- Bellerby Tristram
- Belter Edward A., Jr.
- Bemrose Richard
- Benard Michael Anthony
- BenKahla Alia
- Benke J
- Benner William
- Bennett James
- Bensasson Douda
- Bentley Andrew
- Bentley Dan
- Bentley David
- Berardinis Véronique de
- Bercovitz John
- Berghoff Amy
- Bergmann Anne
- Berkowicz Nicolas
- Berks Mary
- Berks Michael
- Bethel Graeme
- Beugelsdijk Tony J.
- Bhakta Rita
- Bhuchar Venita
- Bi Shihua
- Bian Xuemeng
- Bieri Tamberlyn
- Bimage Kesha E.
- Bird Christine
- Birditt Brian
- Birney Ewan
- Birney Ewan
- Birren Bruce
- Bissell Helen
- Biswalo Kaneza
- Bituin Aleksandr
- Black Stacey
- Blackburne-Maze Suzanne
- Blair Jessica Anne
- Blakey Sarah
- Blanks Tia
- Blasiar Darin
- Blazej Robert
- Blitshsteyn Berta
- Blomstrom David B.
- Bloom Scott
- Bloom Toby
- Blumer Heather
- Blye Jason
- Blyth Peter R.
- Blöcker Helmut
- Boatright Elizabeth
- Boehm John
- Boen Juanan
- Boguslavskiy Leonid
- Bolton Christel
- Bolund Lars
- Bondoc Marnel
- Bonfield James
- Bonnett Ralph
- Bonnin David
- Border Richard
- Borowsky Mark
- Borzym Katja
- Boukhgalter Boris
- Bowen Eric
- Bradley Amanda
- Bradshaw-Cordum Holly
- Brady Nicola
- Brandriff Brigitte F.
- Brannon Wade
- Branscomb Elbert
- Bray Jason
- Bray-Allen Sarah
- Brettin Thomas
- Bridgeman Anne
- Bridgers Michael
- Brimhall Angela K.
- Brokstein Peter
- Brook Jonathan
- Brooking Shane
- Brottier Philippe
- Brown Andrew
- Brown Clive
- Brown Jacqui
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- Yu Jun
- Yu Jun
- Yuan Kaiwen
- Yuan Ye
- Yuan Yida
- Yue Shujie
- Yumae Brian
- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world
- Author
- Abad Pedro
- Abbara Suhny
- Abbasi Taimur
- Abbott Brian
- Abdel Aziz Islam Shawky
- Abdulla Jawdat
- Abikhzer Gad
- Abohashem Shady
- Abougabal Mahasen
- Abramson Sandra
- Abrihan Paz
- Acuña Arturo Romero
- Affandi Erwin
- Afzal Muhammad Shehzad
- Agolti Mariela
- Agranovich Svetlana
- Aguadé-Bruix Santiago
- Aguero Roberto Nicolas
- Ahmed Hassan Mohamed Ismail
- Ahmed Taghreed
- Akhter Afroza
- Al Dhuhli Humoud
- Al Kindi Faiza
- Al-Abboud Tarek
- Al-Bulushi Naeema
- Al-Mallah Mouaz
- Alak Maria del Carmen
- Alam Edison
- Alaoui Nadia Ismaili
- Alasnag Mirvat
- Albadr Amjed
- Albalooshi Batool
- Albano Domenico
- Alberguina Lucia Graciela
- Albernaz Siqueira Maria Helena
- Alexanderson-Rosas Erick
- Alfaro Ana
- Ali Mohamed Mandour
- Alkadhi Hatem
- Alkandari Faridah
- Allam Adel
- Allarakha Mohammad Aaftaab
- Almeida Augusto
- Almousalli Omar
- Alongi Pierpaolo
- Alonso Omar
- Alves Togni Paulo Henrique
- Alves Wilson Furlan
- Ananthasubramaniam Karthikeyan
- Anderson Jill
- Andrade Jose Henrique
- Andrade Luciana
- Angelidis George
- Anselmi Carlos
- Ansheles Alexey
- Araújo Roberta
- Archontaki Aikaterini
- Arnone Gaspare
- Arnous Samer
- Arnson Yoav
- Arroñada Guillermo
- Arturo Harold
- Asano Hiroshi
- Ascani Sebastian Perez
- Asfour Ahmed
- Askew Jeffrey
- Assadi Majid
- Astesiano Alfredo
- Astesiano Andrea
- Attanasio Lea
- Atyani Said
- Ayala Sandra
- Ayetey Harold
- Ayodele Tolulope
- Azevedo Guilherme
- Bagatin Elisa
- Bailly Matthieu
- Baldari Sergio
- Balmer-Swain Mallory
- Bang Ji-In
- Banthia Nilesh
- Bar-Shalom Rachel
- Barette Rene
- Baric Ana
- Barneveld Peter
- Barragan Adriana Puente
- Barragan Erika
- Barroso Asela
- Basavaraj Ashok Gangasandra
- Batinic Tonci
- Batista Juan Felipe
- Batyrkhanov Daultai
- Bauckneht Matteo
- Baugh Dainia
- Bayer Richard R.
- Bedi Punit
- Bejai Shereen
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- Benedek Imre
- Benedek Theodora
- Benitez Luis
- Benlabgaa Rabie
- Bennie George
- Benteo Pablo
- Beretta Mario
- Berman Daniel S.
- Bernheim Adam
- Bertelli Paolo
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- Better Nathan
- Beuzeville Scott
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- Biggans Thomas
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- Blankstein Ron
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- Buechel Ronny Ralf
- Buga Klara
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- Burke Floyd W.
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- Butler Patrick
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- Calcott Jennifer
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- Canderoli Alejandro
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- Chen Tiffany
- Cheung Stephen
- Chierichetti Franca
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- Cho Sang-Geon
- Choi Andrew
- Choi Andrew
- Choi Andrew D.
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- Clarcq James
- Cognigni Luciano Martin
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- Cohen Yosef A.
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- de Amorim Fernandes Fernando
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- Gutierrez Yamile Marcos
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- Guzzo Miguel Angel
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- Hapkido Habusari
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- Hidayat Basuki
- Hildre Dimmen Jenni-Mari
- Hill Gregory
- Hinterleitner Gerd
- Hirschfeld Cole B.
- Hirschfeld Cole B.
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- Jaimes Claudia
- Jain Shashank
- Janardhanan Rajesh
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- Jawa Zabah
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- Nørgaard Bjarne Linde
- O'Brien Julie
- O'Rourke Edward
- O'Sullivan Patricia
- Obaldo Jerry
- Occleshaw Christopher
- Ohta Yasutoshi
- Oikonomou Anastasia
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- Okayama Satoshi
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- Raggi Paolo
- Raimondi Gustavo
- Rajbanshi Bijoy
- Rajvong Sonexay
- Ramamurti Suresh
- Ramkumar Prasad Guntur
- Rampin Lucia
- Ramírez Nelsy Gonzalez
- Randazzo Michael
- Randazzo Michael J.
- Ranser Sara
- Rawashdeh Mohammad
- Rayo Madrid Juan Ignacio
- Redruello Marcela
- Regaieg Hamza
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- Rey Cristina Rodríguez
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- Rofe Christopher
- Roifman Idan
- Rojas Juan Carlos
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- Romero Romina Lorena
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- Roque Vanegas Hector Bladimir
- Rorie Mark
- Rosales Uvera Sandra Graciela
- Rossini Pierluigi
- Rostami Maryam Tajik
- Rovaletti Federico
- Rozikhodjaeva Gulnora
- Rubini Giuseppe
- Ruiz Diego
- Ruiz Joaquín
- Rumberger John
- Russell Raymond
- Russo Vincenzo
- Rutherford Natalie
- Ryzhkova Daria
- Ríos Raúl Araujo
- Rønnow Sand Niels Peter
- Saadullah Mohammad
- Sabharwal Nikant
- Sabra Philip
- Sacchetti Gian Mauro
- Sadler Diego
- Saifullina Guzaliya
- Saito Masaki
- Sakanyan Mari
- Sakata Sakata Yasushi
- Salehi Hamid
- Salobir Barbara Gužic
- Sambuceti Gianmario
- Samuel Anthony
- San Miguel Lucas
- Sanches Adelina
- Sandoval Sigelinda
- Santana Sara
- Sara da Silva Leonardo
- Sarai Masayoshi
- Saranovic Dragana Sobic
- Sarda-Mantel Laure
- Sasse Alexander
- Sato Daisuke
- Satyr Maryna
- Saunders Connor
- Saxena Sudhir
- Sayman Haluk
- Sazonova Svetlana
- Scarano Massimo
- Scarlett Luke
- Schemmer Mary
- Schmidt Erzsébet
- Schneider Roman P.
- Schoepf U. Joseph
- Schofield Rebecca
- Scholte Arthur
- Scholtens Asbjørn
- Scholtz Leonie
- Schvartzman Paulo
- Sciagrà Roberto
- Sebikali Mugisha Julius
- Sekar Ramkumar
- Sellem Ali
- Semple Thomas
- Seneviratne Sujith
- Sengupta Shantanu
- Senra Tiago
- Sereegotov Erdenechimeg
- Sergienko Vladimir
- Sergienko Vladimir
- Sevilla Ana
- Shaaban Mahmoud
- Shah Nishant
- Shah Nishant R.
- Shah Samir
- Shalev Aryeh
- Shanbhag Sujata
- Sharma Gaurav
- Sharma Naveen
- Shaw Leslee J.
- Shaw Leslee J.
- Shayani Steven
- Shetty Deepa
- Shiozaki Afonso
- Shiraishi Shinya
- Shirani Jamshid
- Shirka Ervina
- Shivaram Pushpa
- Shrestha Ganesh
- Shulman Jonathan
- Shurupova Irina
- Sierra-Galan Lilia M.
- Sierra-Galan Lilia M.
- Sigman Steven
- Silva Fábio Martins
- Simanek Milan
- Simon Mitch
- Simonsson Magnus
- Singh Bhanupriya
- Singh Santosh
- Sinitsyn Valentin
- Siqueira Cristiano
- Siu Silvia
- Slart Riemer
- Slim Ahmad
- Small Gary
- Smanio Paola
- Smith Alexandra
- Smith David
- So Young
- Soares Carlos Eduardo
- Soeriadi Erwin Affandi
- Solanki Vijay
- Solari Lucrecia
- Soldat-Stankovic Valentina
- Soli Idrissa Adamou
- Soman Prem
- Sood Aditya
- Sood Ashwani
- Sperandio Massimiliano
- Spiro Bernardo
- Srichai-Parsia Monvadi Barbara
- Stan Claudiu Adrian
- Stankovic Sinisa
- Stanton Tony
- Stavrou Petros
- Stefanelli Antonella
- Steffensen Rolf
- Strada Bruno
- Streeter James
- Strouhal Peter
- Stuart Murch
- Stubbs Michael
- Subedi Deepak
- Sueldo Claudio Pereyra
- Sun Kai
- Suwa Yoshinobu
- Swainson Ian
- Syawaluddin Hilman
- Syed Ghulam
- Szilveszter Balint
- T Albert
- Tacher Vania
- Tag Naima
- Takanami Kentaro
- Takehana Kazuya
- Taki Junichi
- Taleb Sara
- Tamaki Nagara
- Tandon Vikas
- Tang Gongshun
- Tang Jeanelle Margareth
- Taniguchi Yasuyo
- Taubman Kim
- Tawakol Ahmed
- Taylor Andrew
- Tecson Bettina
- Teragawa Hiroki
- Theng Youdaline
- Thientunyakit Tanyaluck
- Thimister Paul
- Thomas Dustin
- Thomas Paul
- Thomassen Anders
- Thompson Randall
- Thu Phyo Si
- To Andrew
- Tomas Miguel Santaularia
- Tomizawa Nobuo
- Topping William
- Torbet Tara
- Torreao Jorge
- Torres Rafael
- Traverso Sonia
- Traverzo Sonia Simona
- Trifonova Tatjana
- Trinidad Desiree
- Trivedi Adwait
- Tsujita Kenichi
- Tweed Katharine
- Udugama Chandraguptha
- Uellendahl Marly
- Ullery Shawn
- Umeji Kyoko
- Unger Steven
- Unzek Samuel
- Upton Anthony
- Uretsky Seth
- Uson Kristine Joy
- Ussov Wladimir Yurievich
- Uusitalo Valtteri
- Uy Mila
- Vajauskas Donatas
- Vakhromeeva Margarita
- Valiullina Nailya
- Vallejo Enrique
- Valles Mario
- Vallurupalli Srikanth
- Vallée Jean-Paul
- Valsamaki Pipitsa
- Vamadevan Shankar
- Van Asperen Erik-Jan
- Van De Heyning Caroline M.
- Van Gaal William
- Van Pelt Niels
- Vangu Mboyo
- Vargas Luis Salazar
- Vasquez Andres
- Vavlukis Marija
- Velez Mayra Sanchez
- Veltman Niels
- Ventroni Guido
- Vergel Damiana
- Verjans Johan
- Verma Atul
- Verma Vikas
- Verschure Derk
- Veríssimo Otávia
- Villines Todd C.
- Villines Todd C.
- Vitola Joao V.
- Vitola Joao V.
- Vondrak Andrej
- Voutnis Demetrius
- Vuuren Magritha Jv
- Várady Edit
- Vázquez Manuel Castillo
- Wagenaar Nils
- Wakabayashi Yasushi
- Waller Alfonso
- Waltrick Roberto
- Wang Ellen
- Wang Jian
- Wang Ximing
- Wang Yifan
- Wang Yining
- Wang Zhao-Qian
- Ward Parker
- Wayne Victor
- Weihmuller Juan Sebastian
- Weir-Mccall Jonathan
- Weiss Konrad
- Weissman Gaby
- Wesbey George
- White James
- White Kelly
- Williams Michelle C.
- Williams Michelle C.
- Wilson Peter
- Winchester David
- Winchester David
- Wolcan Juan
- Wolinsky David
- Won Kyoung Sook
- Wong David
- Wong Kirby
- Wu Jiang
- Wu Zhifang
- Xia Liming
- Xiao Jiangxi
- Xu Lei
- Xu Zhuoran
- Yamada Shinichiro
- Yamazaki Shinya
- Yang Youyou
- Yew Min Sen
- Yin Wu
- Yoneyama Tatsuya
- Yost Sandra
- Young Calum
- Younger John
- Younis Muhammad Numair
- Yu Jianqun
- Yuan Li
- Zaid Eed Abu
- Zakavi Seyed Rasoul
- Zapparoli Marcello
- Zavadovsky Konstantin
- Zeffiro Susana
- Zeidán Nahla
- Zerahn Bo
- Zgaljardic Michael
- Zhang Longjiang
- Zhang Tong
- Zhang Xiaoli
- Zhang Yong-Gao
- Zhu Li
- Zhuravlev Kirill
- Zoboli Stefania
- Zukotynski Katherine
- Zuluaga Alejandro
- Øvrehus Kristian Altern
- Štalc Monika
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic.
Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality.
Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States.
Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis.
Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection
Genetic effects on gene expression across human tissues
- Author
- Abell Nathan S.
- Addington Anjene M.
- Addington Anjene M.
- Aguet François
- Akey Joshua M.
- Ardlie Kristin G.
- Balliu Brunilda
- Barcus Mary E.
- Barker Laura K.
- Barshir Ruth
- Basha Omer
- Bates Daniel
- Battle Alexis
- Bogu Gireesh K.
- Branton Philip A.
- Bridge Jason
- Brigham Lori E.
- Brown Andrew A.
- Brown Christopher D.
- Bustamante Carlos D.
- Carithers Latarsha J.
- Castel Stephane E.
- Chan Joanne
- Chen Lin S.
- Chiang Colby
- Claussnitzer Melina
- Conrad Donald F.
- Cox Nancy J.
- Craft Brian
- Cummings Beryl B.
- Damani Farhan N.
- Davis David A.
- Davis Joe R.
- Delaneau Olivier
- Demanelis Kathryn
- Dermitzakis Emmanouil T.
- Diegel Morgan
- Doherty Jennifer A.
- Engelhardt Barbara E.
- Eskin Eleazar
- Feinberg Andrew P.
- Fernando Marian S.
- Ferreira Pedro G.
- Flicek Paul
- Foster Barbara A.
- Frésard Laure
- Gamazon Eric R.
- Garrido-Martín Diego
- Gelfand Ellen T.
- Getz Gad
- Gewirtz Ariel D.H.
- Gillard Bryan M.
- Gliner Genna
- Gloudemans Michael J.
- Goldman Mary
- Gould Sarah E.
- Guan Ping
- Guigó Roderic
- Hadley Kane
- Haeussler Maximilian
- Hall Ira M.
- Halow Jessica
- Han Buhm
- Handsaker Robert E.
- Hansen Kasper D.
- Hariharan Pushpa
- Hasz Richard
- Haugen Eric
- He Amy Z.
- He Yuan
- Hickey Peter F.
- Hormozdiari Farhad
- Hou Lei
- Howald Cedric
- Huang Katherine H.
- Hunter Marcus
- Hunter Steven
- Im Hae Kyung
- Jasmine Farzana
- Jewell Scott D.
- Jian Ruiqi
- Jiang Lihua
- Jo Brian
- Johns Christopher
- Johnson Audra
- Johnson Mark
- Juettemann Thomas
- Kang Eun Yong
- Karasik Ellen
- Karczewski Konrad J.
- Kashin Seva
- Kaul Rajinder
- Kellis Manolis
- Kent W. James
- Kibriya Muhammad G.
- Kim Yungil
- Kim-Hellmuth Sarah
- Koester Susan
- Koester Susan E.
- Kopen Gene
- Kumar Rachna
- Lappalainen Tuuli
- Lee Christopher M.
- Lee Kristen
- Leinweber William F.
- Lek Monkol
- Li Gen
- Li Jin Billy
- Li Qin
- Li Xiao
- Li Xin
- Lin Jessica
- Lin Shin
- Linder Sandra
- Linke Caroline
- Little A. Roger
- Liu Boxiang
- Liu Yaping
- Lockart Nicole C.
- Lockhart Nicole C.
- Lonsdale John T.
- MacArthur Daniel G.
- Mangul Serghei
- Martin Casey
- Mash Deborah C.
- Matose Takunda
- Maurano Matthew T.
- McCarthy Mark I.
- McDonald Alisa
- McDowell Ian C.
- McLean Jeffrey A.
- Mestichelli Bernadette
- Miklos Mark
- Mohammadi Pejman
- Molinie Benoit
- Monlong Jean
- Montgomery Stephen B.
- Montroy Robert G.
- Moore Helen M.
- Mosavel Maghboeba
- Moser Michael T.
- Muñoz-Aguirre Manuel
- Myer Kevin
- Ndungu Anne W.
- Nedzel Jared L.
- Nelson Jemma
- Neri Fidencio J.
- Nguyen Duyen T.
- Nguyen Duyen Y.
- Nicolae Dan L.
- Nierras Concepcion R.
- Nobel Andrew B.
- Noble Michael S.
- Oliva Meritxell
- Ongen Halit
- Palowitch John J.
- Panousis Nikolaos
- Papasaikas Panagiotis
- Park Yongjin
- Park YoSon
- Parsana Princy
- Paten Benedict
- Payne Anthony J.
- Peterson Christine B.
- Pierce Brandon L.
- Qi Liqun
- Quan Jie
- Quon Gerald
- Rao Abhi
- Reverter Ferran
- Rinaldi Nicola J.
- Ripke Stephan
- Rizzardi Lindsay F.
- Robinson Karna L.
- Roche Nancy V.
- Roe Bryan
- Rohrer Daniel C.
- Rosenbloom Kate R.
- Ruffier Magali
- Sabatti Chiara
- Saha Ashis
- Salvatore Michael
- Sammeth Michael
- Sandstrom Richard
- Scott Alexandra J.
- Segrè Ayellet V.
- Shabalin Andrey A.
- Shad Saboor
- Sheppard Dan
- Shimko Tyler C.
- Siminoff Laura A.
- Singh Shilpi
- Skol Andrew
- Smith Anna M.
- Smith Kevin S.
- Snyder Michael P.
- Sobin Leslie
- Sodaei Reza
- Stamatoyannopoulos John
- Stephens Matthew
- Stranger Barbara E.
- Strober Benjamin J.
- Struewing Jeffery P.
- Sul Jae Hoon
- Sullivan Timothy J.
- Tabor David E.
- Tang Hua
- Taylor Kieron
- Teran Nicole A.
- Thomas Jeffrey A.
- Tomaszewski Maria M.
- Traino Heather M.
- Trevanion Stephen J.
- Trowbridge Casandra A.
- Tsang Emily K.
- Tukiainen Taru
- Um Ki Sung
- Undale Anita H.
- Urbut Sarah
- Valentino Kimberly M.
- Valley Dana
- Van De Bunt Martijn
- Van Wittenberghe Nicholas
- Vatanian Negin
- Vaught Jimmie B.
- Vivian John
- Volpi Simona
- Walters Gary
- Wang Gao
- Wang Li
- Wang Meng
- Washington Michael
- Wen Xiaoquan
- Wheeler Joseph
- Wright Fred A.
- Wu Fan
- Xi Hualin S.
- Yeger-Lotem Esti
- Zappala Zachary
- Zaugg Judith B.
- Zerbino Daniel R.
- Zhang Hailei
- Zhang Rui
- Zhou Yi-Hui
- Zhu Jingchun
- Publication venue
- Publication date
- 01/01/2017
- Field of study
Characterization of the molecular function of the human genome and its variation across individuals is essential for identifying the cellular mechanisms that underlie human genetic traits and diseases. The Genotype-Tissue Expression (GTEx) project aims to characterize variation in gene expression levels across individuals and diverse tissues of the human body, many of which are not easily accessible. Here we describe genetic effects on gene expression levels across 44 human tissues. We find that local genetic variation affects gene expression levels for the majority of genes, and we further identify inter-chromosomal genetic effects for 93 genes and 112 loci. On the basis of the identified genetic effects, we characterize patterns of tissue specificity, compare local and distal effects, and evaluate the functional properties of the genetic effects. We also demonstrate that multi-tissue, multi-individual data can be used to identify genes and pathways affected by human disease-associated variation, enabling a mechanistic interpretation of gene regulation and the genetic basis of disease
Branch duct-type intraductal papillary mucinous neoplasm presenting as paraneoplastic small plaque para-psoriasis
- Publication venue
- 'Medknow'
- Publication date
- 01/01/2018
- Field of study
To present and discuss a novel association between branch duct-type intraductal papillary mucinous neoplasm and paraneoplastic parapsoriasis. We present the case of a middle-aged male presenting with skin lesions that were suggestive of parapsoriasis, resistant to treatment, and in whom a diagnosis of branch-type intraductal papillary mucinous neoplasm of the pancreas was eventually made. A curative Whipple's surgery led to complete resolution of the skin lesions within 3 weeks. Paraneoplastic parapsoriasis in association with intraductal papillary mucinous pancreatic neoplasm has never been reported before
Inhibition of invasion, angiogenesis, tumor growth, and metastasis by adenovirus-mediated transfer of antisense uPAR and MMP-9 in non–small cell lung cancer cells
- Author
- Publication venue
- 'American Association for Cancer Research (AACR)'
- Publication date
- Field of study
Working area and angle of attack in three cranial base approaches: Pterional, orbitozygomatic, and maxillary extension of the orbitozygomatic approach [2] (multiple letters)
- Author
- Publication venue
- Barrow - St. Joseph\u27s Scholarly Commons
- Publication date
- 01/12/2002
- Field of study