Systemic Therapy in Endometrial Cancer: Recent Advances.

Endometrial cancer is a chemosensitive disease. Studies have established a clear benefit of chemotherapy in advanced stages and trials are ongoing to define its role in early stages as well. As more molecular pathways are being elucidated there is increasing role for targeted agents and future looks quite promising. We did an extensive search both online and offline for all the relevant articles including chemotherapy and targeted therapy for endometrial cancer

On the Design and Analysis of Parallel and Distributed Algorithms

Arrival of multicore systems has enforced a new scenario in computing, the parallel and distributed algorithms are fast replacing the older sequential algorithms, with many challenges of these techniques. The distributed algorithms provide distributed processing using distributed file systems and processing units, while network is modeled as minimum cost spanning tree. On the other hand, the parallel processing chooses different language platforms, data parallel vs. parallel programming, and GPUs. Processing units, memory elements and storage are connected through dynamic distributed networks in the form of spanning trees. The article presents foundational algorithms, analysis, and efficiency considerations.Comment: 9 page

THERMOGRAPHIC APPLICATIONS OF TEMPERATURE SENSITIVE FLUORESCENCE OF SrS:Cu PHOSPHORS

The present work aims at investigating the temperature sensitive fluoro-optic behaviour of Cu-activated strontium sulphide (SrS) phosphors and its possible application in thermography. Accordingly, SrS (Cu) phosphors have been synthesized and painted with the help of adhesive on silica substrate. The excitation and emission spectra of such phosphor coatings have been recorded at room temperature (25C). The temperature dependence of fluorescence intensity and the lifetime of phosphorescence have also been studied. From the systematic variation of these two parameters with temperature, it appears that these phosphors are good candidates for thermographic application, at least, in the temperature range of investigation (25-150C)

On the D0D^0 -- DsD_s lifetime difference and τ→7π+ντ\tau\to 7\pi + \nu_\tau decays

In this paper we discuss some aspects of inclusive decays of charmed mesons and also decays of the $\tau$ lepton into $\nu_\tau + 7\pi$. We find that phase space effects are likely to explain the observed lifetime ratio $\tau(D_s^+) / \tau(D^0)$ = 1.17. In particular one need not appeal to a large annihilation contribution in the inclusive $D^0$ decay which, being absent in $D_s^+$ decays could also contribute to the enhanced $D^0$ decay rate relative to that of the $D_s^+$. Examining a separate problem, we find that the rate for $\tau\to \nu_\tau + 7\pi$ is almost completely dominated by the tiny phase space for the final eight particle state. Using an effective chiral Lagrangian to estimate the matrix element yields a branching ratio into the channel of interest far smaller than the present upper bound.Comment: No figure

On the Riemann-Liouville Fractional q-Integral Operator Involving a Basic Analogue of Fox H-Function

2000 Mathematics Subject Classification: 33D60, 26A33, 33C60The present paper envisages the applications of Riemann-Liouville fractional q-integral operator to a basic analogue of Fox H-function. Results involving the basic hypergeometric functions like Gq(.), Jv(x; q), Yv(x; q),Kv(x; q), Hv(x; q) and various other q-elementary functions associated with the Riemann-Liouville fractional q-integral operator have been deduced as special cases of the main result

On Generalized Weyl Fractional q-Integral Operator Involving Generalized Basic Hypergeometric Functions

Mathematics Subject Classification: 33D60, 33D90, 26A33Fractional q-integral operators of generalized Weyl type, involving generalized basic hypergeometric functions and a basic analogue of Fox’s H-function have been investigated. A number of integrals involving various q-functions have been evaluated as applications of the main results

Insight into Nek2A activity regulation and its pharmacological prospects

Nek2A is an essential component of cell cycle progression. It regulates the reorganization of the microtubule network at the G2/M transition and controls the centriole–centriole linkage of the cells entering mitosis. The overexpression of Nek2A coding gene has been widely reported in several cancer-associated disorders. In order to design a potent inhibitor and to control its expression mechanism, it is important to understand the structural orientation and the underlying molecular mechanisms associated with its activity regulation. In this study we have summarized the important information that will help in understanding the functional and activity regulation of Nek2A splice variants, which will further facilitate in designing a potent inhibitor against the cancer associated cases. We have also presented previously reported studies on the domain specifications and inhibitor biosynthesis that provide an insight into its specific target residue regions for developing active and more potent inhibitors

Rarity of Ceropegia bulbosa Roxb. var. lushii and protocol for its ex-situ conservation in the Indian desert

Over expolitation of tubers of Ceropegia bulbosa var. lushii which is a narrow endemic in the Indian Desert has drastically declined its populations and made it threatened. This was confirmed by its absence at its previously reported sites in Barmer, Jodhpur, Jalore, Jhunjhunun and Jaisalmer. Its occurance in Jhalawar, a previously reported site and at another unreported site at Jalore with density of only 4-12 plants/ha confirmed that it has become rarer. Reasons for declining populations in terms of density and occurrence of C. bulbosa var. lushii due to both extrinsic and intrinsic factors (= threats) have been investigated in this paper. Extrinsic factors include overexploitation of tubers, habitat loss and fragmentation due to mining. Six tubers brought from its native sites regenerated successfully at Desert Botanical Garden , CAZRI, Jodhpur. Intrinsic threats were experimentally assessed by studying its life cycle for three years. Seeds produced by these plants under captivity showed 30-35% germination. Germination, phenology and growth of plants both, from seeds for one year and tubers for three years revealed many sensitive, risk prone stages which indicated potential threat to its regeneration in its native places. These included failure to seed set due to lack of pollinator, falling of immature follicles, exposure of seeds to open sun, sapling damage by wild animals and digging out of perenating tubers by wild ungulates and human being. Both extrinsic and intrinsic factors are responsible for its rarity in the wild. It emerged that for success in its ex-situ conservation, mature seeds, availability of partial shade and safety from wild animals are essential requirements