FORMULATION AND EVALUATION OF ORAL FAST DISINTEGRATING TABLET OF IBUPROFEN USING TWO SUPER DISINTEGRANTS

Objective: The aim of the present investigation was to design and evaluate orally disintegrating tablet (ODT) of Ibuprofen, a NSAID drug used for the treatment of arthritis with a view to improve its oral bioavailability. The focus of the current study was to develop ODT of Ibuprofen using super disintegrants for ease of administration and its physicochemical characterization.Methods: Tablets were made from blends by direct compression method. All the ingredients were passed through mesh no. 80. All the ingredients were co-ground in a pestle motor. The resulting blend was lubricated with magnesium stearate and compressed into tablets using the Cadmach single punch (round shaped, 8 mm thick) machine.Results: Physicals parameters of the prepared tablets like Hardness, Weight variation, Friability, thickness, drug content etc. found within the limits. The disintegration time of prepared ODTs was in the range of 45 to 55 seconds. In vitro dispersion time was found to be 22 to 52 seconds which may be attributed to faster uptake of water due to the porous structure formed by super disintegrants. Short disintegration and faster release of ibuprofen were observed with Cross carmellose sodium as compared to sodium starch glycollate.Conclusion: It is concluded that F3 offered the relatively rapid release of Ibuprofen when compared with other formulations. The increase in the concentrations of super disintegrants may lead to increase in the drug release. The formulation prepared with cross carmellose sodium was offered the relatively rapid release of Ibuprofen when compared with other concentrations of both the super disintegrant.Â

Precision and uncertainties in mass scale predictions in SUSY SO(10) with SU(2)_L x SU(2)_R x U(1)_{B-L} x SU(3)_C intermediate breaking

In a class of SUSY SO(10) with $SU(2)_L x SU(2)_R x U(1)_{B-L} x SU(3)_C$ $(g_{2L}\neq g_{2R})$ intermediate gauge symmetry, we observe that the prediction on the unification mass $(M_U)$ is unaffected by Planck-scale-induced gravitational and intermediate-scale-threshold effects, although the intermediate scale $(M_I)$ itself is subject to such corrections. In particular, without invoking the presence of additional lighter scalar degrees of freedom but including plausible and reasonable threshold effects, we find that interesting solutions for neutrino physics corresponding to $M_I\simeq 10^{10}-10^{13}$ GeV and $M_U\simeq (5-6) x 10^{17}$ GeV are permitted in the minimal models. Possibilities of low-mass right-handed gauge bosons corresponding to $M_I\simeq 1-10$ TeV consistent with the CERN-LEP data are pointed out in a number of models when threshold effects are included using effective mass parameters.Comment: 12 pages including 7 tables (Typos corrected as per the published version

PHARMACEUTICAL WORLD WITH INNOVATIVE APPROACHES-A REVIEW

An existing drug in the conventional dosage form is evolution in to novel drug delivery system which can significantly enhances and improves the performance of drug in terms of drug safety, drug efficacy as well as patient compliance. With the help of appropriate novel approaches, an existing drug molecule can get a new life and can be a major advance solution for the problems towards the release of drug at specific site and specific rate. The main aim of novel drug delivery system is to minimize the drug loss and drug degradation which can be achieved by targeting the drug to the site of interest. With the help of soluble or insoluble biodegradable natural and synthetic polymers different novel formulations can be formulated as microparticles, microcapsules, liposomes, neosomes, micelles etc. Targeting is based on active targeting and passive targeting mechanisms for drug release. This review covers the basic information on Novel Drug Delivery Systems (NDDS)

NANOSUSPENSION: A MODERN TECHNOLOGY USED IN DRUG DELIVERY SYSTEM

Nanosuspension consists of the pure poorly water-soluble drug without any matrix material suspended in dispersion. The formulation as nanosuspension is an attractive and promising alternative to solve these problems. Nanosuspension technology solved the problem of drugs which are poorly aqueous soluble and less bioavailability. Stability and bioavailability of the drugs can be improved by Nanosuspension technology. Nanosuspensions are promising candidates that can be used for enhancing the dissolution of poorly water-soluble drugs. Preparation of Nanosuspension is simple and applicable to all drugs which are aqueous insoluble. Nanosuspensions are prepared by using wet mill, high-pressure homogenizer, emulsion‐solvent evaporation, melt emulsification method and supercritical fluid techniques. Nanosuspension can be prepared by using stabilizers, organic solvents and other additives such as buffers, salts, polyols, osmogent and cryoprotectant. Nanosuspensions can be delivered by oral,parenteral, pulmonary and ocular routes. Nanosuspensions can also be used for targeted drug delivery when incorporated in the ocular inserts and mucoadhesive hydrogels

Ichthyofaunal Diversity of Dhansiri River, Dimapur, Nagaland, India

Northeastern India, one of the Ichthyofaunal hot spot areas of our country, is marked by the presence of varied freshwater fishes,a few adapted to torrential waterflow. River Dhansiri is an important river of Dimapur District of Nagaland, India, which flows through Nagaland –Assam border harbouring rich aquatic flora and fauna. Very little studies have been carried out to document the fish biodiversity of the Dhansiri river till date. In the present study an attempt has been made to access the piscine diversity of this river. The survey results in finding of species of 34 fishes belonging to five (5) orders, thirteen (13) families and twenty four (24) genera. Cyprniformes is the dominant order while Osteoglossiformes is the least common

Plasma rich in growth factors (PRGF) in non-surgical periodontal therapy: a randomized clinical trial

Abstract The aim of this split mouth, double blinded, randomized clinical trial was to evaluate the clinical efficacy of use of Plasma rich in growth factors (PRGF) as an adjunct to scaling and root planing (SRP) in the treatment of periodontal pockets. Twenty six patients (15 males, 11 females) diagnosed with generalized periodontitis with Pocket Depth > 5mm and plaque index score 4mm necessitating further treatment after 6-month follow-up were significantly lesser for SRP+PRGF group. The use of PRGF technology in non-surgical periodontal therapy, by single intra-pocket application in to periodontal pockets as an adjunct to SRP, in chronic periodontitis patients, was found to be effective in reduction of pocket depth and gain in clinical attachment level