An Inquiry Regarding the Development of an Effectual Architecture Framework Supporting Next Generation 9-1-1

The emergency 9-1-1 service is a vital part of our nation â„¢s emergency response and disaster preparedness systems. At last count there were 6100 Public Safety Answering Points across the United States, 97 of those reside in the State of Colorado, and the citizens of the United States cannot email, text, or instant message these types of non-traditional communication to those Public Safety Answering Points due to technological limitations. The trends in personal communication technologies are accelerating the obsolescence of the current 9-1-1 systems. The Public Safety Answering Point of today is designed to accept and process voice media only; and proved successful in delivering emergency services in times of personal, regional, and national need. The current circuit-switched infrastructure of the 9-1-1 Public Safety Answering Point network cannot receive digital data (e.g., text messages, email, photographs, and video) from the communication devices commonly used by the public today. A national movement known as Next Generation 9-1-1 is underway that will support non-traditional communication digital data processing in the Public Safety Answering Point. This case study will attempt to determine if practical service oriented architecture methodology can be used in the development of an effectual architecture framework supporting the Next Generation 9-1-1framework and the nontraditional communication technology within the Public Safety Answering Points of Colorado

Leelanau County Inland Lakes Project

Master of ScienceLandscape ArchitectureUniversity of Michiganhttp://deepblue.lib.umich.edu/bitstream/2027.42/114606/2/39015043175614.pd

Disinfection Ability of Bacteriophages Against Listeria Monocytogenes Biofilms

Pathogenic foodborne bacteria, particularly species belonging to Listeria and Salmonella, pose a growing threat to public health because of their ability to form and/or grow within biofilms on various environments, specifically food processing facility. Within a biofilm, bacteria develop increased resistance to common disinfectants, making surface sterilization a challenge for businesses involved in food processing. In order to determine the viability of bacteriophages as an antibiotic alternative, this experiment attempted to explore the bacteriophage growth process as well as bacteriophage efficacy against Listeria monocyogenes as compared to Salmonella enterica serovar Typhimurium. A511 bacteriophage was grown and tested on L. monocytogenes 1/2a using previously studied P22 bacteriophage and S. enterica as a control case. While this experiment was unable to establish a defined efficacy of A511 against L. monocytogenes, repeatable results with Salmonella show promising potential for phage therapies

Activation of inflammatory responses in human U937 macrophages by particulate matter collected from dairy farms: an in vitro expression analysis of pro-inflammatory markers

Abstract Background The purpose of the present study was to investigate activation of inflammatory markers in human macrophages derived from the U937 cell line after exposure to particulate matter (PM) collected on dairy farms in California and to identify the most potent components of the PM. Methods PM from different dairies were collected and tested to induce an inflammatory response determined by the expression of various pro-inflammatory genes, such as Interleukin (IL)-8, in U937 derived macrophages. Gel shift and luciferase reporter assays were performed to examine the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and Toll-like-receptor 4 (TLR4). Results Macrophage exposure to PM derived from dairy farms significantly activated expression of pro-inflammatory genes, including IL-8, cyclooxygenase 2 and Tumor necrosis factor-alpha, which are hallmarks of inflammation. Acute phase proteins, such as serum amyloid A and IL-6, were also significantly upregulated in macrophages treated with PM from dairies. Coarse PM fractions demonstrated more pro-inflammatory activity on an equal-dose basis than fine PM. Urban PM collected from the same region as the dairy farms was associated with a lower concentration of endotoxin and produced significantly less IL-8 expression compared to PM collected on the dairy farms. Conclusion The present study provides evidence that the endotoxin components of the particles collected on dairies play a major role in mediating an inflammatory response through activation of TLR4 and NF-κB signaling

Percussion Convocation

Program listing performers and works performe

The SPARC Toroidal Field Model Coil Program

The SPARC Toroidal Field Model Coil (TFMC) Program was a three-year effort between 2018 and 2021 that developed novel Rare Earth Yttrium Barium Copper Oxide (REBCO) superconductor technologies and then successfully utilized these technologies to design, build, and test a first-in-class, high-field (~20 T), representative-scale (~3 m) superconducting toroidal field coil. With the principal objective of demonstrating mature, large-scale, REBCO magnets, the project was executed jointly by the MIT Plasma Science and Fusion Center (PSFC) and Commonwealth Fusion Systems (CFS). The TFMC achieved its programmatic goal of experimentally demonstrating a large-scale high-field REBCO magnet, achieving 20.1 T peak field-on-conductor with 40.5 kA of terminal current, 815 kN/m of Lorentz loading on the REBCO stacks, and almost 1 GPa of mechanical stress accommodated by the structural case. Fifteen internal demountable pancake-to-pancake joints operated in the 0.5 to 2.0 nOhm range at 20 K and in magnetic fields up to 12 T. The DC and AC electromagnetic performance of the magnet, predicted by new advances in high-fidelity computational models, was confirmed in two test campaigns while the massively parallel, single-pass, pressure-vessel style coolant scheme capable of large heat removal was validated. The REBCO current lead and feeder system was experimentally qualified up to 50 kA, and the crycooler based cryogenic system provided 600 W of cooling power at 20 K with mass flow rates up to 70 g/s at a maximum design pressure of 20 bar-a for the test campaigns. Finally, the feasibility of using passive, self-protection against a quench in a fusion-scale NI TF coil was experimentally assessed with an intentional open-circuit quench at 31.5 kA terminal current.Comment: 17 pages 9 figures, overview paper and the first of a six-part series of papers covering the TFMC Progra