Spontaneous rupture of extensor pollicis longus tendon: demonstration of extensor indices proprius transfer technique

СУХОЖИЛИЯ ТРАВМЫ /ХИРРАЗРЫВ СУХОЖИЛИЯ /ХИРРАЗГИБАТЕЛЬ БОЛЬШОГО ПАЛЬЦАТКАНИ ТРАНСПЛАНТАЦИЯПЕРЕСАДКА ТКАНИВОССТАНОВЛЕНИЕ ФУНКЦИЙКЛИНИЧЕСКИЕ СЛУЧАИВ настоящее время при разрыве сухожилия длинного разгибателя большого пальца кисти нет единой схемы хирургического лечения. В статье представлен результат лечения пациента со спонтанным разрывом сухожилия длинного разгибателя большого пальца кисти в IV зоне по Б. Бойчеву, с подтверждением нарушения по данным ультразвукового исследования. В оперативном лечении нами был использован метод Pulvertaft (пересадка сухожилия собственного разгибателя указательного пальца на сухожилие длинного разгибателя большого пальца кисти). Через 3 месяца после операции пациент достиг полного объема движений большим пальцем и показал полное функциональное восстановление. Ультразвуковое исследование может рассматриваться как достаточно точное и экономически выгодное диагностическое обследование при оценке случаев с подозрением на разрыв сухожилия длинного разгибателя большого пальца кисти и тендинозом. Этот случай показывает, что метод пересадки сухожилия собственного разгибателя указательного пальца на сухожилие длинного разгибателя большого пальца кисти является эффективным и надежным хирургическим пособием.Till now no single scheme of surgical treatment has gained wide acceptance in rupture of extensor pollicis longus tendon (EPL). The result of treatment of a patient with spontaneous rupture of EPL in IV zone by B. Boichev with ultrasonographic examination is presented in the paper. In surgical treatment we used Pulvertaft technique in transfer of tendon of m. extensor indicis proprius (EIP) to EPL. After 3 months of surgery the patient showed a full range of motions of the thumb joints and functional restoring. Ultrasonography can be considered as an accurate and cost effective diagnostic investigation in evaluation of cases with the suspected extensor pollicis longus tendon rupture and tendinosis. This case report shows that technique of EIP to EPL transfer is effective and reliable surgical option

Hybrid Approach for Resource Allocation in Cloud Infrastructure Using Random Forest and Genetic Algorithm

In cloud computing, the virtualization technique is a significant technology to optimize the power consumption of the cloud data center. In this generation, most of the services are moving to the cloud resulting in increased load on data centers. As a result, the size of the data center grows and hence there is more energy consumption. To resolve this issue, an efficient optimization algorithm is required for resource allocation. In this work, a hybrid approach for virtual machine allocation based on genetic algorithm (GA) and the random forest (RF) is proposed which belongs to a class of supervised machine learning techniques. The aim of the work is to minimize power consumption while maintaining better load balance among available resources and maximizing resource utilization. The proposed model used a genetic algorithm to generate a training dataset for the random forest model and further get a trained model. The real-time workload traces from PlanetLab are used to evaluate the approach. The results showed that the proposed GA-RF model improves energy consumption, execution time, and resource utilization of the data center and hosts as compared to the existing models. The work used power consumption, execution time, resource utilization, average start time, and average finish time as performance metrics

Neonatal lupus erythematous – A report of three cases

Neonatal lupus erythematosus (NLE) is a rare acquired autoimmune disorder clinically characterized by skin lesions that resemble those of subacute or discoid lupus erythematosus and/or congenital heart bock. Skin and cardiac manifestations coexist only in 10% of the patients. It is caused by transplacental passage of maternal autoantibodies, usually anti-Ro/SS-A and /or anti-La/SS-B and less commonly anti-U1 ribonucleoprotein. Mothers of the infants with NLE are either asymptomatic or diagnosed with autoimmune disease. We describe 3 neonates with clinical and immunological findings compatible with NLE, their progress and outcome

Intelligent Fault-Tolerant Mechanism for Data Centers of Cloud Infrastructure

Fault tolerance in cloud computing is considered as one of the most vital issues to deliver reliable services. Checkpoint/restart is one of the methods used to enhance the reliability of the cloud services. However, many existing methods do not focus on virtual machine (VM) failure that occurs due to the higher response time of a node, byzantine fault, and performance fault, and existing methods also ignore the optimization during the recovery phase. This paper proposes a checkpoint/restart mechanism to enhance reliability of cloud services. Our work is threefold: (1) we design an algorithm to identify virtual machine failure due to several faults; (2) an algorithm to optimize the checkpoint interval time is designed; (3) lastly, the asynchronous checkpoint/restart with log-based recovery mechanism is used to restart the failed tasks. The valuation results obtained using a real-time dataset shows that the proposed model reduces power consumption and improves the performance with a better fault tolerance solution compared to the nonoptimization method

Phenolic compounds isolated from Pilea microphylla prevent radiation-induced cellular DNA damage

AbstractSix phenolic compounds namely, quercetin-3-O-rutinoside (1), 3-O-caffeoylquinic acid (2), luteolin-7-O-glucoside (3), apigenin-7-O-rutinoside (4), apigenin-7-O-β-d-glucopyranoside (5) and quercetin (6) were isolated from the whole plant of Pilea microphylla using conventional open-silica gel column chromatography and preparative HPLC. Further, these compounds were characterized by 1D, 2D NMR techniques and high-resolution LC–MS. Compounds 1–3 and 6 exhibited significant antioxidant potential in scavenging free radicals such as DPPH, ABTS and SOD with IC50 of 3.3–20.4μmol/L. The same compounds also prevented lipid peroxidation with IC50 of 10.4–32.2μmol/L. The compounds also significantly prevented the Fenton reagent-induced calf thymus DNA damage. Pre-treatment with compounds 1–3 and 6 in V79 cells attenuated radiation-induced formation of reactive oxygen species, lipid peroxidation, cytotoxicity and DNA damage, correlating the antioxidant activity of polyphenols with their radioprotective effects. Compounds 1, 3 and 6 significantly inhibited lipid peroxidation, presumably due to 3′,4′-catechol ortho-dihydroxy moiety in the B-ring, which has a strong affinity for phospholipid membranes. Oxidation of flavonoids, with catechol structure on B-ring, yields a fairly stable ortho-semiquinone radical by facilitating electron delocalization, which is involved in antioxidant mechanism. Hence, the flavonoid structure, number and location of hydroxyl groups together determine the antioxidant and radioprotection mechanism

Dynamics of phase slips in systems with time-periodic modulation

The Adler equation with time-periodic frequency modulation is studied. A series of resonances between the period of the frequency modulation and the time scale for the generation of a phase slip is identified. The resulting parameter space structure is determined using a combination of numerical continuation, time simulations, and asymptotic methods. Regions with an integer number of phase slips per period are separated by regions with noninteger numbers of phase slips and include canard trajectories that drift along unstable equilibria. Both high- and low-frequency modulation is considered. An adiabatic description of the low-frequency modulation regime is found to be accurate over a large range of modulation periods

Massively parallel quantum chemistry: PFAS on over 1 million cloud vCPUs

Accurate solutions to the electronic Schr\"odinger equation can provide valuable insight for electron interactions within molecular systems, accelerating the molecular design and discovery processes in many different applications. However, the availability of such accurate solutions are limited to small molecular systems due to both the extremely high computational complexity and the challenge of operating and executing these workloads on high-performance compute clusters. This work presents a massively scalable cloud-based quantum chemistry platform by implementing a highly parallelizable quantum chemistry method that provides a polynomial-scaling approximation to full configuration interaction (FCI). Our platform orchestrates more than one million virtual CPUs on the cloud to analyze the bond-breaking behaviour of carbon-fluoride bonds of per- and polyfluoroalkyl substances (PFAS) with near-exact accuracy within the chosen basis set. This is the first quantum chemistry calculation utilizing more than one million virtual CPUs on the cloud and is the most accurate electronic structure computation of PFAS bond breaking to date

Dizajniranje i optimizacija mikrokapsula artemetera za maskiranje gorkog okusa

The objective of the present investigation was to reduce the bitterness of artemether (ARM). Microparticles were prepared by the coacervation method using Eudragit E 100 (EE) as polymer and sodium hydroxide solution as nonsolvent for the polymer. A 32 full factorial design was used for optimization wherein the amount of drug (A) and polymer (B) were selected as independent variables and the bitterness score, particle size and drug release at pH, 1.2 and 6.8 were selected as dependent variables. Optimization was carried out using the desirability function. The optimized microparticles batch was characterized by FT-IR and DSC. Multiple linear regression analysis revealed that reduced bitterness of ARM can be obtained by controlling the drug release of microparticles at pH 6.8 and increasing the amount of EE. The increase in the amount of polymer leads to reduction in drug release from microparticles at pH > 5 due to its insolubility and thus reduces bitterness. However, the increase in the amount of polymer results in improved dissolution, suggesting improved availability of ARM in stomach. Optimized microparticles prepared using 0.04 g of ARM and 15 mL of 1% m/V solution of EE showed complete bitter taste masking with improved drug release at pH 1.2.Cilja ovog rada je bio maskirati gorki okus artemetera (ARM) mikrokapsuliranjem. Mikročestice su pripravljene metodom koacervacije pomoću Eudragita E 100 (EE) kao polimerne komponente i natrijevog hidroksida u kojem se polimer ne otapa. 32 faktorijalni dizajn upotrebljen je za optimizaciju. Količine ljekovite tvari (A) i polimera (B) izabrane su kao nezavisne varijable, a intenzitet gorkog okusa, veličina čestica i oslobađanje ljekovite tvari pri pH 1,2 i 6,8 izabrane su kao zavisne varijable. Optimizirane mikročestice karakterizirane su pomoću FT-IR i DSC. Multipla linearna regresijska analiza otkrila je da se smanjenje gorčine artemetera može postići kontroliranjem oslobađanja ljekovite tvari pri pH 6,8 i povećanjem količine EE. Povećanje količine polimera dovodi do smanjenja oslobađanja ljekovite tvari pri pH > 5 pa se smanjuje i gorčina. Međutim, povećanje količine polimera povećava topljivost ljekovite tvari, a time potencijalno i njenu raspoložljivost u želucu. U optimiziranim mikročesticama pripravljenim pomoću 0,04 g ARM i 15 mL 1% m/v otopine EE potpuno se maskirao gorki okus, a oslobađanje ljekovite tvari pri pH 1,2 bilo je poboljšano