837 research outputs found
Fluctuation-Dissipation relations in Driven Granular Gases
We study the dynamics of a 2d driven inelastic gas, by means of Direct
Simulation Monte Carlo (DSMC) techniques, i.e. under the assumption of
Molecular Chaos. Under the effect of a uniform stochastic driving in the form
of a white noise plus a friction term, the gas is kept in a non-equilibrium
Steady State characterized by fractal density correlations and non-Gaussian
distributions of velocities; the mean squared velocity, that is the so-called
{\em granular temperature}, is lower than the bath temperature. We observe that
a modified form of the Kubo relation, which relates the autocorrelation and the
linear response for the dynamics of a system {\em at equilibrium}, still holds
for the off-equilibrium, though stationary, dynamics of the systems under
investigation. Interestingly, the only needed modification to the equilibrium
Kubo relation is the replacement of the equilibrium temperature with an
effective temperature, which results equal to the global granular temperature.
We present two independent numerical experiment, i.e. two different observables
are studied: (a) the staggered density current, whose response to an impulsive
shear is proportional to its autocorrelation in the unperturbed system and (b)
the response of a tracer to a small constant force, switched on at time ,
which is proportional to the mean-square displacement in the unperturbed
system. Both measures confirm the validity of Kubo's formula, provided that the
granular temperature is used as the proportionality factor between response and
autocorrelation, at least for not too large inelasticities.Comment: 11 pages, 7 figures, submitted for publicatio
Dynamics of a tracer granular particle as a non-equilibrium Markov process
The dynamics of a tracer particle in a stationary driven granular gas is
investigated. We show how to transform the linear Boltzmann equation describing
the dynamics of the tracer into a master equation for a continuous Markov
process. The transition rates depend upon the stationary velocity distribution
of the gas. When the gas has a Gaussian velocity probability distribution
function (pdf), the stationary velocity pdf of the tracer is Gaussian with a
lower temperature and satisfies detailed balance for any value of the
restitution coefficient . As soon as the velocity pdf of the gas
departs from the Gaussian form, detailed balance is violated. This
non-equilibrium state can be characterized in terms of a Lebowitz-Spohn action
functional defined over trajectories of time duration . We
discuss the properties of this functional and of a similar functional
which differs from the first for a term which is non-extensive
in time. On the one hand we show that in numerical experiments, i.e. at finite
times , the two functionals have different fluctuations and
always satisfies an Evans-Searles-like symmetry. On the other hand we cannot
observe the verification of the Lebowitz-Spohn-Gallavotti-Cohen (LS-GC)
relation, which is expected for at very large times . We give
an argument for the possible failure of the LS-GC relation in this situation.
We also suggest practical recipes for measuring and
in experiments.Comment: 16 pages, 3 figures, submitted for publicatio
Rapid and Accurate Identification of Nontuberculous Mycobacteria Directly from Positive Primary MGIT Cultures by MALDI-TOF MS
Over the last years, nontuberculous mycobacteria (NTM) have emerged as important human pathogens. Accurate and rapid mycobacterial species identification is needed to successfully diagnose, treat, and manage infections caused by NTM. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry, MALDI-TOF MS, was demonstrated to effectively identify mycobacteria isolates subcultured from solid or liquid media rather than new positive cultures. The present study aims to develop a new extraction protocol to yield rapid and accurate identification of NTM from primary MGIT cultures by MALDI-TOF MS. A total of 60 positive MGIT broths were examined by the Bruker Biotyper system with Mycobacteria Library v. 2.0 (Bruker Daltonics GmbH & Co. KG., Bremen, Germany). The results were compared with those obtained by the molecular method, line probe assay GenoType Mycobacterium CM/AS/NTM-DR. All samples were concordantly identified by MALDI-TOF MS and the molecular test for all the tested mycobacteria. Fifty-seven (95%) MGIT positive cultures for NTM from clinical samples had a MALDI-TOF MS analysis score S ≥ 1.8. Although a small number of strains and a limited diversity of mycobacterial species were analysed, our results suggest that MALDI-TOF MS could represent a promising routine diagnostic tool for identifying mycobacterial species directly from primary liquid culture
Sand stirred by chaotic advection
We study the spatial structure of a granular material, N particles subject to
inelastic mutual collisions, when it is stirred by a bidimensional smooth
chaotic flow. A simple dynamical model is introduced where four different time
scales are explicitly considered: i) the Stokes time, accounting for the
inertia of the particles, ii) the mean collision time among the grains, iii)
the typical time scale of the flow, and iv) the inverse of the Lyapunov
exponent of the chaotic flow, which gives a typical time for the separation of
two initially close parcels of fluid. Depending on the relative values of these
different times a complex scenario appears for the long-time steady spatial
distribution of particles, where clusters of particles may or not appear.Comment: 4 pages, 3 figure
Velocity correlations in dense granular gases
We report the statistical properties of spherical steel particles rolling on
an inclined surface being driven by an oscillating wall. Strong dissipation
occurs due to collisions between the particles and rolling and can be tuned by
changing the number density. The velocities of the particles are observed to be
correlated over large distances comparable to the system size. The distribution
of velocities deviates strongly from a Gaussian. The degree of the deviation,
as measured by the kurtosis of the distribution, is observed to be as much as
four times the value corresponding to a Gaussian, signaling a significant
breakdown of the assumption of negligible velocity correlations in a granular
system.Comment: 4 pages, 4 Figure
Non-Gaussian velocity distributions in excited granular matter in the absence of clustering
The velocity distribution of spheres rolling on a slightly tilted rectangular
two dimensional surface is obtained by high speed imaging. The particles are
excited by periodic forcing of one of the side walls. Our data suggests that
strongly non-Gaussian velocity distributions can occur in dilute granular
materials even in the absence of significant density correlations or
clustering. When the surface on which the particles roll is tilted further to
introduce stronger gravitation, the collision frequency with the driving wall
increases and the velocity component distributions approach Gaussian
distributions of different widths.Comment: 4 pages, 5 figures. Additional information at
http://physics.clarku.edu/~akudrolli/nls.htm
Contribution to the bryological knowledge of the Tuscan-Emilian Apennines (Northern Italy)
The inventory of the bryophytes collected during the annual excursion of the Working Group for Bryology of the Italian Botanical Society is reported. This excursion was held in 2018 on the northern slope of the Tuscan-Emilian Apennines National Park, in the Administrative Region of Emilia-Romagna. The field work led to the finding of 113 taxa (24 liverworts and 89 mosses), including eight new records and seven confirmations for this Region. The occurrence of rare taxa for Italy (Scapania uliginosa, Rhizomnium pseudopunctatum, Racomitrium fasciculare, Scorpidium cossonii, Grimmia lisae, Orthotrichum pulchellum) is highlighted
Recovery of adrenal insufficiency is frequent after adjuvant mitotane therapy in patients with adrenocortical carcinoma
Mitotane is a steroidogenesis inhibitor and adrenolytic drug used for treatment of adrenocortical cancer (ACC). Mitotane therapy causes adrenal insufficiency requiring glucocorticoid replacement in all patients. However, it is unclear whether chronic therapy with mitotane induces complete destruction of zona fasciculata and whether hypothalamic-pituitary-adrenal (HPA) axis can recover after treatment cessation. Our objective was to assess the HPA axis recovery in a cohort of patients after cessation of adjuvant mitotane therapy for ACC. We retrospectively reviewed patient files with stage I-II-III ACC in two referral centers in Canada and Italy. Data on demographics, tumor characteristics, hormonal profile, and HPA axis were collected. Data from 23 patients with pathologically proven ACC treated with adjuvant mitotane for a minimum of two years were analyzed. Eight patients were males and 15 were females and the median age was 41 years old (range 18 to 73). After mitotane cessation, 18/23 (78.3%) patients achieved a complete HPA axis recovery while 3/23 (13.0%) were unable to tolerate glucocorticoid withdrawal despite having normal hormonal test values and 2/23 (8.7%) never achieved recovery. The mean time interval between mitotane cessation and HPA axis recovery was 2.7 years. A high proportion of patients achieved HPA axis recovery following cessation of mitotane adjuvant therapy. However, complete recovery was often delayed up to 2.5 years and regular assessment of the hormonal profile is required
Fluctuations in granular gases
A driven granular material, e.g. a vibrated box full of sand, is a stationary
system which may be very far from equilibrium. The standard equilibrium
statistical mechanics is therefore inadequate to describe fluctuations in such
a system. Here we present numerical and analytical results concerning energy
and injected power fluctuations. In the first part we explain how the study of
the probability density function (pdf) of the fluctuations of total energy is
related to the characterization of velocity correlations. Two different regimes
are addressed: the gas driven at the boundaries and the homogeneously driven
gas. In a granular gas, due to non-Gaussianity of the velocity pdf or lack of
homogeneity in hydrodynamics profiles, even in the absence of velocity
correlations, the fluctuations of total energy are non-trivial and may lead to
erroneous conclusions about the role of correlations. In the second part of the
chapter we take into consideration the fluctuations of injected power in driven
granular gas models. Recently, real and numerical experiments have been
interpreted as evidence that the fluctuations of power injection seem to
satisfy the Gallavotti-Cohen Fluctuation Relation. We will discuss an
alternative interpretation of such results which invalidates the
Gallavotti-Cohen symmetry. Moreover, starting from the Liouville equation and
using techniques from large deviation theory, the general validity of a
Fluctuation Relation for power injection in driven granular gases is
questioned. Finally a functional is defined using the Lebowitz-Spohn approach
for Markov processes applied to the linear inelastic Boltzmann equation
relevant to describe the motion of a tracer particle. Such a functional results
to be different from injected power and to satisfy a Fluctuation Relation.Comment: 40 pages, 18 figure
Collision statistics of driven granular materials
We present an experimental investigation of the statistical properties of
spherical granular particles on an inclined plane that are excited by an
oscillating side-wall. The data is obtained by high-speed imaging and particle
tracking techniques. We identify all particles in the system and link their
positions to form trajectories over long times. Thus, we identify particle
collisions to measure the effective coefficient of restitution and find a broad
distribution of values for the same impact angles. We find that the energy
inelasticity can take on values greater than one, which implies that the
rotational degrees play an important role in energy transfer. We also measure
the distance and the time between collision events in order to directly
determine the distribution of path lengths and the free times. These
distributions are shown to deviate from expected theoretical forms for elastic
spheres, demonstrating the inherent clustering in this system. We describe the
data with a two-parameter fitting function and use it to calculated the mean
free path and collision time. We find that the ratio of these values is
consistent with the average velocity. The velocity distribution are observed to
be strongly non-Gaussian and do not demonstrate any apparent universal
behavior. We report the scaling of the second moment, which corresponds to the
granular temperature, and higher order moments as a function of distance from
the driving wall. Additionally, we measure long time correlation functions in
both space and in the velocities to probe diffusion in a dissipative gas.Comment: 12 pages, 4 figures, uses revtex
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