Oxidation technology as a decorative coating in the artistic treatment of metal

The task set for this paper is view the process of oxidation on high temperatures during the creation of products of art. The result of the author's analysis shows that said technique could be used in artistic purposes, showcasing the advantages and disadvantages of said method

The main psychological determinants of the participants’ readiness of professional skill competitions to perform successfully

The article presents the results of psychological research and the primary analysis of the results obtained, which allow us to formulate the main psychological determinants of the readiness of the contestants for competitions in professional skills and possible success. The study was conducted by means of questionnaire methods, primary statistical processing (percentage ratio), comparative analysis of the data obtained. The object of the study was the participants of professional skill competitions: winners, prize-winners and contestants who performed unsuccessfully. It was revealed that the winners and prize-winners of professional skill competitions, as well as participants who performed unsuccessfully, actively use psychological and professional techniques, techniques, creativity, and so on in preparation for competitions. The personal and professional qualities of the contestants contributing to their success and possible reasons for unsuccessful performances are noted. The main psychological determinants of the contestants’ readiness for competitions in professional skills and possible success are identified and formulated – personality strength; confidence; a high level of need for achievements and victories; an adequate level of self-esteem; a high level of reflection; competent knowledge of psychological technologies of self-action; a high level of personal and professional qualities development; rational independence in preparation

The use of intermediate inserts for CO 2 laser welding of steel AISI 321 and a Grade 2 titanium alloy

The paper studies the structure, chemical and phase compositions, hardness and strength of welded joints obtained in AISI 321 steel and Grade 2 titanium alloy sheets by CO 2 continuous laser with the use of intermediate Cu, Ni and Ag-Cu-Zn alloy inserts. It is demonstrated that the maximum strength of welded joints is achieved by the welding conditions enabling one to form multiphase structures with intermetallics in the material of a weld, rather than only those based on solid solutions. © 2018 Author(s)

The WW-HECT protein Smurf2 interacts with the Docking Protein NEDD9/HEF1 for Aurora A activation

The multi-functional adaptor protein NEDD9/HEF1/Cas-L regulates cell motility, invasion and cell cycle progression, and plays key roles in cancer progression and metastasis. NEDD9 is localized to the centrosome and is required for activation of Aurora A kinase in mitosis. Here we demonstrate that the HECT-WW protein Smurf2 physically associates with NEDD9 and is required for the stability of NEDD9 protein. Smurf2 depletion results in a marked decrease in NEDD9 protein levels, by facilitating polyubiquitination and proteasomal degradation of NEDD9. Conversely, forced overexpression of Smurf2 results in upregulation of endogenous NEDD9 protein, confirming the role for Smurf2 in NEDD9 stability. Cells with Smurf2 depletion fail to activate Aurora A at the G2/M boundary, leading to a marked delay in mitotic entry. These observations suggest that the stable complex of Smurf2 and NEDD9 is required for timely entry into mitosis via Aurora A activation

Medical and social characteristics of children with tuberculosis in conditions of social insufficiency in the Irkutsk region

Background. In cases of tuberculosis in children, contacts with patients with drug-resistant forms are often detected. Treatment and prevention of the disease is based on these data and adherence to treatment. Aims. To analyze the social status of the family of children with tuberculosis, clinical forms and drug resistance of MBT in patients who are sources of infection in the outbreak for adequate planning of preventive treatment of contact and treatment of children with tuberculosis. Materials and methods. The study involved 150 children with tuberculosis treated in a hospital in 2009-2012 and 142 children - in 2015-2017. We studied social factors and drug resistance of Mycobacterium tuberculosis in adult patients - sources to child transmission. Drug resistance of MBT cultures was determined by Löwenstein - Jensen medium and automated system BACTEC MGIT 960. Results. 50.0 % of children with tuberculosis are patients of preschool age, 33.0 % of children aged under 3 years. From 2009-2012 to 2015-2017 the proportion of socially disadvantaged families fell from 68.0 % to 45.1 %. At the same time the proportion of children with tuberculosis, contracted from a known contact decreased from 70.0 % to 57.0 %. Often children get infected from mother or from several close relatives (mother, father, grandfather, grandmother), TB patients source of infection of children are often diagnosed with infiltrative (21.9-38.3 %) and fibro-cavernous tuberculosis (17.0-21.0 %). To 2015-2017 multi-drug resistance in the nidi was recorded at 52.2 %. The development of tuberculosis in children was facilitated by the defects of preventative measures: absence of BCG vaccination (from 9.0 to 14.0 % of children), the absence of preventive treatment (55.3-67.5 %)

Economic feasibility of corporate structure creation

© International Economic Society. The development of a modern region economic system is determined not only by natural and climatic conditions and resource opportunities, but also by the entrepreneurship and the efficiency of corporate structure activities, whose man-agement mechanism ensures the realization of the economic potential concerning the used items and production factors. The corporations, as an association of legal entities and individuals provide more than half of the regional budget reve-nues, jobs, enterprise profits, GRP, etc. in order to realize their financial interests under the leadership of a central ad-ministrative apparatus. At the same time, the performance of enterprises included in the composition of corporate struc-tures is not so unambiguous. In this regard, a special interest appears regarding the issue of their entry economic feasi-bility into corporations. This article evaluates the economic feasibility of corporate structure creation based on a com-parative analysis of production and investment activity results concerning Bashneft, Tatneft and TAIF group of enter-prises. The study was based on the principles of a systematic approach using a wide range of general scientific methods and techniques, namely: comparison methods; coefficients, balance method, horizontal and vertical analysis; the method of situational analysis; the graphical methods of data processing, etc

Regional market of medical equipment: Perspectives of development

© Medwell Journals, 2016.The level and quality of life of population are determined by the state of its health and that of health care system which largely depends on material and technical base of health care institutions and their provision with medical equipment. In countries with developed market economies, medical industry is one of the leading sectors in terms of revenue from the export of its products. At the same time, the share of domestic enterprises in the Russian market of medical equipment and medical products is reduced. For this, in high-tech segments the import share is 100% of total consumption of products. Despite the development of the latest achievements of medical science by the leading medical institutions of the Russian Federation, quality and effectiveness of medical care currently is not satisfactory. This is due to insufficient public funding for health care with high (up to 80%) level of depreciation of current medical equipment and need in supplying medical institutions with new medical equipment, low susceptibility of management to social and managerial innovations in the social sphere in general and health care in particular. The study investigates the problems and development prospects of regional market of medical equipment. Interpretation of the content of regional market of medical equipment is given, its dual nature is revealed the segmentation of medical equipment market is presented in view of features of producer and consumer behavior within the territorial localized formations

Regulation of the apoptotic genes in breast cancer cells by the transcription factor CTCF

CTCF is a highly conserved and ubiquitous transcription factor with versatile functions. We previously demonstrated that elevated protein levels of CTCF in breast cancer cells were associated with the specific anti-apoptotic function of CTCF. We used proteomics and microarray approaches to identify regulatory targets of CTCF specific for breast cancer cells. Among the CTCF identified targets were proteins involved in the control of apoptosis. A proapoptotic protein, Bax, negatively regulated by CTCF, was chosen for further investigation. Repression of the human Bax gene at the transcriptional level by CTCF in breast cancer cells was confirmed by real-time PCR. Two CTCF binding sites within the Bax promoter were identified by electrophoretic mobility shift assay and footprinting. In reporter assays, the Bax-luciferase reporter construct, containing CTCF-binding sites, was negatively regulated by CTCF. In vivo, CTCF occupied its binding sites in breast cancer cells and tissues, as confirmed by chromatin immunoprecipitation assay. Our findings suggest a possible mechanism of the specific CTCF anti-apoptotic function in breast cancer cells whereby CTCF is bound to the Bax promoter, resulting in repression of Bax and inhibition of apoptosis; depletion of CTCF leads to activation of Bax and apoptotic death. CTCF binding sites in the Bax promoter are unmethylated in all cells and tissues inspected. Therefore, specific CTCF interaction with the Bax promoter in breast cancer cells, and the functional outcome, may depend on a combination of epigenetic factors characteristic for these cells. Interestingly, CTCF appears to be a negative regulator of other proapoptotic genes (for example, Fas, Apaf-1, TP531NP1). Conversely, stimulating effects of CTCF on the anti-apoptotic genes (Bcl-2, Bag-3) have been observed. Taken together, these findings suggest that specific mechanisms have evolved in breast cancer cells to protect them from apoptosis; regulation of apoptotic genes by CTCF appears to be one of the resistance strategies

Опыт использования краткосрочных курсов химиотерапии в лечении туберкулеза с множественной лекарственной устойчивостью возбудителя у детей с разным ВИЧ-статусом

The objective: to study the time frames and efficacy of treatment for tuberculosis with confirmed and suspected multiple drug resistance (MDR) in children with different HIV status.Subjects and methods. The method of continuous sampling was used in the study which included 21 children with MDR tuberculosis, they all had been exposed to MDR TB and were treated in hospital. 3 children had concurrent HIV.Results. The duration of the intensive care phase in HIV negative children (19 people) made: 60 doses – 1 (5.3%) child, 90 doses – 11 (57.9%) children, 120 doses – 2 (10.5%) children, 180 doses – 3 (15.8%) children, 240 doses – 1 (4.3%) child. The duration of the continuation phase was the following: 120 doses – 1 (4.3%) child, 150 doses – 1 (5.3%) children, 180 doses – 12 (63.1%) children, 270 doses – 1 (5.3%) children, 320 doses – 3 (15.8%) children.The duration of the intensive phase of treatment in 3 children with concurrent MDR TB and HIV infection made 180 doses in 2 (66.6%) children and 240 doses in 1 (33.4%) child. The continuation phase included 180 doses in 2 (66.6%) children and 320 in 1 (33.4%) child respectively.Outcomes of the main course of chemotherapy were favorable in the majority of the cases - inflammatory changes resolved, focuses consolidated and fibrosis formed in the lung tissue.Conclusion. Should children have negative results of sputum tests, the treatment is prescribed based on the results of drug susceptibility tests of the index case. If limited tuberculous lesions are diagnosed, the duration of treatment of children with MDR can be shorter. The outcomes of short-course treatment in children with tuberculosis are favorable, changes in the lungs have resolved and thickened more frequently. In children with HIV infection, low adherence to HIV treatment in socially disadvantaged families requires long-term directly observed tuberculosis chemotherapy combined with antiretroviral therapy.Цель исследования: изучить сроки и эффективность лечения туберкулеза с установленной и предполагаемой множественной лекарственной устойчивостью (МЛУ) возбудителя у детей с разным ВИЧ-статусом.Материалы и методы. В исследование методом сплошной выборки включен 21 ребенок, больной туберкулезом с МЛУ (все из очагов МЛУ-туберкулеза) находившийся на стационарном лечении. У 3 детей имелось сочетание с ВИЧ-инфекцией.Результаты исследования. Длительность фазы интенсивной терапии у детей с ВИЧ-негативным статусом (19 детей) составила: 60 доз – 1 (5,3%) ребенок, 90 доз – 11 (57,9%) детей, 120 доз – 2 (10,5%) ребенка, 180 доз – 3 (15,8%) ребенка, 240 доз – 1 (4,3%) ребенок. Длительность фазы продолжения лечения: 120 доз у 1 (4,3%) ребенка, 150 доз у 1 (5,3%) ребенка, 180 доз у 12 (63,1%) детей, 270 доз у 1 (5,3%) ребенка, 320 доз у 3 (15,8%) детей.Длительность фазы интенсивной терапии у 3 детей при сочетании МЛУ-туберкулеза и ВИЧ-инфекции была 180 доз у 2 (66,6%) детей и 240 доз ‒ у 1 (33,4%) ребенка. Фаза продолжения составила 180 доз у 2 (66,6%) детей и 320 ‒ у 1 (33,4%) ребенка соответственно.Исходы основного курса химиотерапии в большинстве случаев хорошие – рассасывание воспалительных изменений, уплотнение очагов и фиброзирование легочной ткани.Заключение. У больных туберкулезом детей при отсутствии бактериовыделения лечение назначается по результатам тестов на лекарственную чувствительность у источника инфекции. Ограниченность выявленного туберкулезного процесса позволяет сокращать срок лечения детей и при МЛУ возбудителя. Исходы укороченных курсов лечения у детей с туберкулезом благоприятные, чаще рассасывание и уплотнение изменений в легких. У детей с ВИЧ-инфекцией низкая приверженность к лечению ВИЧ-инфекции в социально неблагополучных семьях требует длительно