Aryl hydrocarbon receptor modulation by tuberculosis drugs impairs host defense and treatment outcomes

Animal science

Claudin-targeted suicide gene therapy for claudin-overexpressing tumor cells by using modified clostridium perfringens enterotoxin (CPE)

Bacterial toxins gain growing attention as potential cancer treatment due to their potent cytotoxic effects. Among the very different toxins with diverse modes of action, the Clostridium perfringens enterotoxin (CPE) is in focus to treat solid cancers. This toxin targets the tight junction proteins claudin-3 and -4 (Cldn-3/4), which are frequently overexpressed in solid cancers. Binding to these claudins induces pore formation in the host cell plasma membrane leading to rapid oncoleaking cell death of tumor cells. Based on this, extending the targeting of CPE beyond Cldn-3/4 is of interest, since other claudins, such as claudin-1 or -5 are often overexpressed in various cancer entities such as non-small-cell lung cancer (NSCLC) or papillary thyroid carcinoma. In this chapter we describe the modification of a CPE-encoding vector by structure-directed mutagenesis to either preferentially target Cldn-1 and -5 or to expand targeting to Cldn1-9 for improved broadened cytotoxic targeting of claudin-overexpressing tumors such as but not limited to lung cancer via CPE gene transfer

Detecting Non-Sibling Dependencies in OpenMP Task-Based Applications

International audienceThe advent of the multicore era led to the duplication of functional units through an increasing number of cores. To exploit those processors, a shared-memory parallel programming model is one possible direction. Thus, OpenMP is a good candidate to enable different paradigms: data parallelism (including loop-based directives) and control parallelism, through the notion of tasks with dependencies. But this is the programmer responsibility to ensure that data dependencies are complete such as no data races may happen. It might be complex to guarantee that no issue will occur and that all dependencies have been correctly expressed in the context of nested tasks. This paper proposes an algorithm to detect the data dependencies that might be missing on the OpenMP task clauses between tasks that have been generated by different parents. This approach is implemented inside a tool relying on the OMPT interface