Hepatic Myofibroblasts: A Heterogeneous and Redox-Modulated Cell Population in Liver Fibrogenesis

During chronic liver disease (CLD) progression, hepatic myofibroblasts (MFs) represent a unique cellular phenotype that plays a critical role in driving liver fibrogenesis and then fibrosis. Although they could originate from different cell types, MFs exhibit a rather common pattern of pro-fibrogenic phenotypic responses, which are mostly elicited or sustained both by oxidative stress and reactive oxygen species (ROS) and several mediators (including growth factors, cytokines, chemokines, and others) that often operate through the up-regulation of the intracellular generation of ROS. In the present review, we will offer an overview of the role of MFs in the fibrogenic progression of CLD from different etiologies by focusing our attention on the direct or indirect role of ROS and, more generally, oxidative stress in regulating MF-related phenotypic responses. Moreover, this review has the purpose of illustrating the real complexity of the ROS modulation during CLD progression. The reader will have to keep in mind that a number of issues are able to affect the behavior of the cells involved: a) the different concentrations of reactive species, b) the intrinsic state of the target cells, as well as c) the presence of different growth factors, cytokines, and other mediators in the extracellular microenvironment or of other cellular sources of ROS

Strain gauge properties of Pd+-ion-implanted polymer:

Pd+ ions (90 keV) were implanted at normal incidence and at room temperature in different highly insulating (>200 GΩ) thermoplastic polymers (poly(methyl methacrylate), polypropylene, polyethylene terephthalate glycol-modified, and polycarbonate). At high fluence and optimized process parameters, the ion implantation gives rise to the formation of a nanocomposite thin surface layer constituted by Pd nanoclusters and carbonaceous material (nanographite/amorphous carbon). The morphological, microstructural, and microanalytical properties of the nanocomposite layers were investigated by He-ion microscopy, glancing incidence X-ray diffraction, and Raman scattering, respectively. The electrical properties were characterized by resistance, van der Pauw, and Hall measurements. We performed accurate simultaneous deformation/bending experiments and electrical resistance measurements. We show that the electrical resistance varies linearly with the mechanical deformation (beam deflection) applied. The experimental results are interpreted by "hopping conductivity" model considering the nanostructure configuration of the nanocomposite layers. A gauge factor in the range between 4 and 8, depending on the ion-implanted polymer, was obtained for prototype strain gauge devices

Hypoxia, Hypoxia-Inducible Factors and Liver Fibrosis

Liver fibrosis is a potentially reversible pathophysiological event, leading to excess deposition of extracellular matrix (ECM) components and taking place as the net result of liver fibrogenesis, a dynamic and highly integrated process occurring during chronic liver injury of any etiology. Liver fibrogenesis and fibrosis, together with chronic inflammatory response, are primarily involved in the progression of chronic liver diseases (CLD). As is well known, a major role in fibrogenesis and fibrosis is played by activated myofibroblasts (MFs), as well as by macrophages and other hepatic cell populations involved in CLD progression. In the present review, we will focus the attention on the emerging pathogenic role of hypoxia, hypoxia-inducible factors (HIFs) and related mediators in the fibrogenic progression of CLD

Visible and Near-Infrared Colors of KBOs and Centaurs from the Second ESO Large Program

International audienc

Visible and near-infrared colors of Transneptunian objects and Centaurs from the second ESO large program

International audienceAims: We investigate color properties and define or check taxonomic classifications of objects observed in our survey. Methods: All observations were performed between October 2006 and September 2007 at the European Southern Observatory 8 m Very Large Telescope, UT1 and UT2 at the Paranal Observatory in Chile. For visible photometry, we used the FORS1 instrument, and for near-infrared, ISAAC. Taxonomic classifications from the Barucci system were assigned using G-mode analysis. Results: We present photometric observations of 23 TNOs and Centaurs, nine of which have never been previously observed. Eighteen of these objects were assigned taxonomic classifications: six BB, four BR, two RR, and six that are given two or more categories due to insufficient data. Three objects that had been previously observed and classified, changed classes most likely due to surface variation: 26375 (1999 DE9), 28978 (Ixion), and 32532 (Thereus). Two objects, 47932 (2000 GN171) and 54598 (Bienor) had absolute magnitude values that were significantly different from previously published results, attributed to extreme lightcurve amplitudes

Visible and Near-infrared Colors of TNOs from the Second ESO Large Program

International audienc

Visible and Near-infrared Colors of TNOs from the Second ESO Large Program

International audienc

A Search for Ethane on Pluto and Triton

International audienc