Effect of ELF e.m. fields on metalloprotein redox-active sites

The peculiarity of the distribution and geometry of metallic ions in enzymes pushed us to set the hypothesis that metallic ions in active-site act like tiny antennas able to pick up very feeble e.m. signals. Enzymatic activity of Cu2+, Zn2+ Superoxide Dismutase (SOD1) and Fe2+ Xanthine Oxidase (XO) has been studied, following in vitro generation and removal of free radicals. We observed that Superoxide radicals generation by XO is increased by a weak field having the Larmor frequency fL of Fe2+ while the SOD1 kinetics is sensibly reduced by exposure to a weak field having the frequency fL of Cu2+ ion.Comment: 18 pages, 4 figure

Going Beyond the Ensemble Mean: Assessment of Future Floods From Global Multi‐Models

Future changes in the occurrence of flood events can be estimated using multi-model ensembles to inform adaption and mitigation strategies. In the near future, these estimates could be used to guide the updating of exceedance probabilities for flood control design and water resources management. However, the estimate of return levels from ensemble experiments represents a challenge: model runs are affected by biases and uncertainties and by inconsistencies in simulated peak flows when compared with observed data. Moreover, extreme value distributions are generally fit to ensemble members individually and then averaged to obtain the ensemble fit with loss of information. To overcome these limitations, we propose a Bayesian hierarchical model for assessing changes in future peak flows, and the uncertainty coming from global climate, global impact models and their interaction. The model we propose allows use of all members of the ensemble at once for estimating changes in the parameters of an extreme value distribution from historical to future peak flows. The approach is applied to a set of grid-cells in the eastern United States to the full and to a constrained version of the ensemble. We find that, while the dominant source of uncertainty in the changes varies across the domain, there is a consensus on a decrease in flood magnitudes toward the south. We conclude that projecting future flood magnitude under climate change remains elusive due to large uncertainty mostly coming from global models and from the intrinsic uncertain nature of extreme values

A pricing formula for delayed claims: appreciating the past to value the future

We consider the valuation of contingent claims with delayed dynamics in a Samuelson complete market model. We find a pricing formula that can be decomposed into terms reflecting the current market values of the past and the future, showing how the valuation of prospective cashflows cannot abstract away from the contribution of the past. As a practical application, we provide an explicit expression for the market value of human capital in a setting with wage rigidity. The formula we derive has successfully been used to explicitly solve the infinite dimensional stochastic control problems addressed in [7], [6] and [16]

TERRESTRIAL LASER SCANNER DATA TO SUPPORT COASTAL EROSION ANALYSIS: THE CONERO CASE STUDY

In this work a detailed TLS survey was carried out in summer 2012, in the Conero Regional Park (Marche, province of Ancona), along the "spiaggia San Michele" and "spiaggia Sassi Neri". These areas present several sections affected by erosion, rock falls and slope failures. They also belong to a very prestigious place for tourism during the summer season; therefore, deriving a risk map for these areas is really useful. Thanks to the TLS survey, it was possible to obtain a centimetre resolution DTM covering a reach of about 1.5 km of the coast. This high resolution DTM was used to derive some primary topographic attributes that allowed to arrange a preliminary discussion about the likely unstable areas. These topographic information and results will also serve as the reference point for future yearly TLS surveys, which will absolutely help in recognizing any micro changes and slope failures, improving the risk maps

CEH-GEAR: 1 km resolution daily and monthly areal rainfall estimates for the UK for hydrological and other applications

The Centre for Ecology & Hydrology – Gridded Estimates of Areal Rainfall (CEH-GEAR) data set was developed to provide reliable 1 km gridded estimates of daily and monthly rainfall for Great Britain (GB) and Northern Ireland (NI) (together with approximately 3500 km2 of catchment in the Republic of Ireland) from 1890 onwards. The data set was primarily required to support hydrological modelling. The rainfall estimates are derived from the Met Office collated historical weather observations for the UK which include a national database of rain gauge observations. The natural neighbour interpolation methodology, including a normalisation step based on average annual rainfall (AAR), was used to generate the daily and monthly rainfall grids. To derive the monthly estimates, rainfall totals from monthly and daily (when complete month available) rain gauges were used in order to obtain maximum information from the rain gauge network. The daily grids were adjusted so that the monthly grids are fully consistent with the daily grids. The CEH-GEAR data set was developed according to the guidance provided by the British Standards Institution. The CEH-GEAR data set contains 1 km grids of daily and monthly rainfall estimates for GB and NI for the period 1890–2012. For each day and month, CEH-GEAR includes a secondary grid of distance to the nearest operational rain gauge. This may be used as an indicator of the quality of the estimates. When this distance is greater than 100 km, the estimates are not calculated due to high uncertainty

An investigation of grand battement devant at barre, centre, and in motion using kinematics and electromyography

The purpose of this study was to examine grand battement devant in three conditions: at the barre, in the centre, and traveling. The primary focus was to consider weight transfer in the three conditions, and to examine utilisation of the trunk and lower extremity muscles. An extensive review was done in the dance science literature to determine what previous research had been done related to this subject, and to establish what preliminary work might be needed. As indicated by the literature, in order to achieve this research, it was necessary to develop a dance-specific method for the normalisation of surface electromyography data. In phase one of the research, a dance-specific portable anchored dynamometer was developed and tested. The PAD allowed for the collection of maximum voluntary isometric contractions (MVICs), which could then be used to normalise the sEMG data. In phase two of the research, the grand battement was tested in the three conditions, at the barre, in the centre, and traveling. Forty female dancers volunteered (mean age 30.0 ± 13.0 yrs, mean height 1.63 ± 0.06 m, mean mass 59.0 ± 7.4 kg, and 13.9 ± 13.3 yrs of training in ballet and/or modern dance) and were placed in three groups (Training level): beginner (n = 12), intermediate (n = 14) and advanced (n = 14). Dancers executed five grand battement devant in each of the three conditions (Condition) in randomized order. Data were collected with a 7-camera Vicon motion capture system, two Kistler forceplates, and surface electromyography (EMG), using eight muscles bilaterally. Kinematic data were analysed in three intervals: stance to battement initiation, initiation to battement peak, and peak to end. Four variables were investigated: centre of gravity of the full trunk, centre of gravity of the pelvis, centre of gravity of the upper trunk, and centre of mass. EMG data were analysed in four events: stance, initiation, peak, and end. For weight transfer, the main effect of Condition was significant for all four variables in both the x-axis and the y-axis (p < .001). There were no significant differences for Training and no significant Condition x Training interactions. Muscle use varied according to the combination of event and condition that was executed, and these differences were also influenced by the level of training of the dancer and the side of the body used. It is recommended that dance educators consider the importance of allocating sufficient time to each of the three conditions (barre, centre, and traveling), to ensure development of a variety of motor strategies and muscle activation patterns for dance practice.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

A pricing formula for delayed claims: appreciating the past to value the future

We consider the valuation of contingent claims with delayed dynamics in a Samuelson complete market model. We find a pricing formula that can be decomposed into terms reflecting the current market values of the past and the future, showing how the valuation of prospective cashflows cannot abstract away from the contribution of the past. As a practical application, we provide an explicit expression for the market value of human capital in a setting with wage rigidity. The formula we derive has successfully been used to explicitly solve the infinite dimensional stochastic control problems addressed in Biffis et al. (SIAM J Control Optim 58(4):1906–1938, 2020), Djeiche et al. (Stoch Process Appl 145:48–85, 2022) and Biagini et al. (SIAM J Financial Math 13(3):1004–1039, 2022)

Molecular, behavioral and anatomical sophistication in spider webs: insights from spinning gland RNA-seq experiments in primitive and modern spiders.

RNA-seq experiments conducted in 454 sequencers were carried out to produce 87.000 short-reads representing the transcriptome of two spiders'spinning glands. We produced sequences from (i) Actinopus sp., a spider from the Mygalomorphae clade, and (ii) Gasteracantha cancriformis, an Orbicularia spider. Mygalomorphae spiders are known to retain a number of primitive morphological and behavioral characters. They use mixtures of a primitive web, soil, and plants only to cover a burrow they make on the ground for shelter and predation.On the other hand, Orbicularia spiders show a number of derivative spider's characters and they are capable to build different and complex silks used in a variety of situations. It is interesting to note that the complexity of web production, usage and behavior in these spiders is reflected both by (i) the variety of the repertoire of protein molecules (spidroins) they use to make their webs and (ii) the complexity of their anatomical spinning gland apparatu used to produce silk. Here we have first conducted a broad analysis of the spinning gland transcriptome in both spiders producing unigenes and categorizing annotated genes in biological functions.Then we started to analyze the number and variety of spider silk proteins and families found in different spider clades.We have shown that spiders using web only for a limited number of situations present a less sophisticated morphological spinning apparatus and produce a small repertoire of spidroin molecules. Phylogenetic analyses were conductedin the 3'region of spidroins and we try to relate (i) the evolution of silk protein families,(ii) the evolutionary complexification of silk production behavior and web usage, and (iii) the appearance of new specialized spinning glands along the evolution of specimens and clades in the Araneae order

Optimal portfolio choice with path dependent labor income: the infinite horizon case

We consider an infinite horizon portfolio problem with borrowing constraints, in which an agentreceives labor income which adjusts to financial market shocks in a path dependent way. Thispath-dependency is the novelty of the model, and leads to an infinite dimensional stochasticoptimal control problem. We solve the problem completely, and find explicitly the optimalcontrols in feedback form. This is possible because we are able to find an explicit solutionto the associated infinite dimensional Hamilton-Jacobi-Bellman (HJB) equation, even if stateconstraints are present. To the best of our knowledge, this is the first infinite dimensionalgeneralization of Merton’s optimal portfolio problem for which explicit solutions can be found.The explicit solution allows us to study the properties of optimal strategies and discuss theirfinancial implications

Making better use of local data in flood frequency estimation

Flood frequency estimates are an essential part of flood risk management. They are an important ingredient of many important decisions, informing the cost-effectiveness, design and operation of flood defences, flood mapping and planning decisions in flood risk areas. They also inform the National Flood Risk Assessment, the setting of insurance premiums and long-term investment planning. Methods described in the Flood Estimation Handbook (FEH) published in 1999, and many subsequent updates, are considered the industry standard for flood estimation in the UK. They are used extensively by hydrologists from both the public and private sectors. Flood frequency estimates – also known as design flood estimates – are associated with many sources of uncertainty. These hydrological uncertainties often constitute the most uncertain component in any flood study. Uncertainty can lead to difficulty in having confidence in the outputs of studies, whether these are for investment planning, insurance, asset design, development planning or other purposes. As a result, there is considerable benefit to be gained from any reduction in the uncertainty of flood frequency estimation. There are many supplementary sources of information that can help to refine estimates of design floods and potentially reduce uncertainty. Examples include long-term flood history, river level records, photographs of floods and information obtained from field visits. These and similar types of information are defined as ‘local data’. The FEH Local research project aimed to: quantify the uncertainty of design floods estimated from FEH methods develop procedures and guidance for incorporating local and historical data into flood estimation to reduce uncertainties The primary objective of this report is to describe the reviews and research carried out during the FEH Local project. Another output from the project was a document giving guidance to practitioners on how to estimate uncertainty in flood frequency and how to find and incorporate local data. The practitioner guidance, ‘Using Local Data to Reduce Uncertainty in Flood Frequency Estimation’, will be disseminated early in 2017. This report aims to avoid duplication with the practitioner guidance and so is intended mainly for those with an interest in the background to the methods presented in the guidance