On the formation of Hubble flow in Little Bangs

A dynamical appearance of scaling solutions in the relativistic hydrodynamics applied to describe ultra-relativistic heavy-ion collisions is studied. We consider the boost-invariant cylindrically symmetric systems and the effects of the phase transition are taken into account by using a temperature dependent sound velocity inferred from the lattice simulations of QCD. We find that the transverse flow acquires the scaling form r/t within the short evolution times, 10 - 15 fm, only if the initial transverse flow originating from the pre-equilibrium collective behavior is present at the initial stage of the hydrodynamic evolution. The amount of such pre-equilibrium flow is correlated with the initial pressure gradient; larger gradients require smaller initial flow. The results of the numerical calculations support the phenomenological parameterizations used in the Blast-Wave, Buda-Lund, and Cracow models of the freeze-out process.Comment: 11 page

Nonequilibrium effects in hadronic fireball expansion

We consider a spherical volume of hot and dense hadronic matter (fireball) expanding into a vacuum. It is assumed that initially the fireball matter is in local thermal and chemical equilibrium with vanishing collective velocity. The time evolution of the fireball is studied in parallel within the GiBUU transport model and an ideal hydrodynamic model. The equation of state of an ideal hadronic gas is used in the hydrodynamic calculation. The same set of hadronic species is used in transport and fluid-dynamical simulations. Initial coordinates and momenta of hadrons in transport simulations have been randomly generated by using the Fermi and Bose distributions for (anti)baryons and mesons. The model results for radial profiles of densities and collective velocities of different hadronic species are compared at different times. We find that two considered models predict essential differences in time evolution of hadron abundances, which are especially pronounced for hyperonic species. This gives an evidence of a strong deviation from chemical equilibrium in expanding hadronic matter.Comment: 23 pages, 12 figure

Permanent matching of coupled optical bottle resonators with better than 0.16 GHz precision

The fabrication precision is one of the most critical challenges to the creation of practical photonic circuits composed of coupled high Q-factor microresonators. While very accurate transient tuning of microresonators based on local heating has been reported, the record precision of permanent resonance positioning achieved by post-processing is still within 1 and 5 GHz. Here we demonstrate two coupled bottle microresonators fabricated at the fiber surface with resonances that are matched with a better than 0.16 GHz precision. This corresponds to a better than 0.17 Å precision in the effective fiber radius variation. The achieved fabrication precision is only limited by the resolution of our optical spectrum analyzer and can be potentially improved by an order of magnitude

Anomalous J/psi suppression and charmonium dissociation cross sections

We study $J/\psi$ suppression in Pb+Pb collisions at CERN-SPS energies in hadronic matter with energy- and temperature-dependent charmonium dissociation cross sections calculated in the quark-interchange model of Barnes and Swanson. We find that the variation of J/$\psi$ survival probability from peripheral to central collisions can be explained as induced by hadronic matter absorption in central collisions.Comment: 30 pages, 8 figures, LaTex, changed for the latest NA50 dat

Transposing tirtha: Understanding religious reforms and locative piety in early modern Hinduism

The paper deals with a historical and hitherto obscure case of de-commercialisation of sacred geography of India. Sahajanand Swami, an eighteenth century religious leader from Gujarat who became popular as Bhagwan Swaminarayan took an initiative to eliminate corruption in Dwarka, one of the most sacred destination in Hindu imagination. He also attempted to transpose the piety of Dwarka and recreate a parallel religious experience at Vadtal, an important site in Swaminarayan Hinduism. This process of making sacred sites more egalitarian is classified here as a 'religious reform'. The paper assesses this bivalent pursuit as an institutional reform within religion as well as a religious process in the context of piety, authority and orthodoxy. Through the example of Sahajanand Swami, it is argued to calibrate the colonial paradigm of reform that was largely contextual to social issues and western thought and failed to appreciate the religious reforms of that era. By constructing a nuanced typology of 'religious reform' distinct from 'social reforms', the paper eventually calls for a reassessment of religious figures who have significantly contributed in reforming the Hindu tradition in the medieval and modern era

Charmonium in a weakly coupled quark-gluon plasma

We present a model of charmonium as two heavy quarks propagating classically in a weakly coupled quark-gluon plasma. The quarks interact via a static, color-dependent potential and also suffer collisions with the plasma particles. We calculate the radiation width of the color octet state (for fixed, classical $q\bar q$ separation) and find that it is long-lived provided a finite gluon mass is used to provide a threshold energy.Comment: 7 pages in plain LaTeX + 3 figures packed with uufiles; slight changes to comply with referees, added one referenc

Formal support for informal caregivers to older persons with dementia through the course of the disease: an exploratory, cross-sectional study

Background: In European countries, knowledge about availability and utilization of support for informal caregivers caring for older persons (>= 65 years) with dementia (PwD) is lacking. To be able to evaluate and develop the dementia support system for informal caregivers to PwD, a survey of European support systems and professionals involved is needed. The aim of this study was to explore support for informal caregivers to PwD in European countries. We investigated the availability and utilization of support in each of the participating countries, and the professional care providers involved, through the dementia disease. Methods: A mapping system was used in 2010-2011 to gather information about estimations of availability, utilization, and professional providers of support to informal caregivers caring for PwD. Data collected was representing each country as a whole. Results: There was high availability of counselling, caregiver support, and education from the diagnosis to the intermediate stage, with a decrease in the late to end of life stage. Utilization was low, although there was a small increase in the intermediate stage. Day care and respite care were highly available in the diagnosis to the intermediate stage, with a decrease in the late to end of life stage, but both types of care were utilized by few or no caregivers through any of the disease stages. Professionals specialized in dementia (Bachelor to Master's degree) provided counselling and education, whereas caregiver support for informal caregivers and day care, respite care, and respite care at home were provided by professionals with education ranging from upper secondary schooling to a Master's degree. Conclusions: Counselling, caregiver support, and education were highly available in European countries from diagnosis to the intermediate stage of the dementia disease, decreasing in the late/end of life stages but were rarely utilized. Countries with care systems based on national guidelines for dementia care seem to be more aware of the importance of professionals specialized in dementia care when providing support to informal caregivers. Mapping the systems of support for informal caregivers of PwD is a valuable tool for evaluating existing systems, internationally, nationally and locally for policy making

Human keratinocytes are vanilloid resistant

BACKGROUND: Use of capsaicin or resiniferatoxin (RTX) as analgesics is an attractive therapeutic option. RTX opens the cation channel inflammatory pain/vanilloid receptor type 1 (TRPV1) permanently and selectively removes nociceptive neurons by Ca(2+)-cytotoxicity. Paradoxically, not only nociceptors, but non-neuronal cells, including keratinocytes express full length TRPV1 mRNA, while patient dogs and experimental animals that underwent topical treatment or anatomically targeted molecular surgery have shown neither obvious behavioral, nor pathological side effects. METHODS: To address this paradox, we assessed the vanilloid sensitivity of the HaCaT human keratinocyte cell line and primary keratinocytes from skin biopsies. RESULTS: Although both cell types express TRPV1 mRNA, neither responded to vanilloids with Ca(2+)-cytotoxicity. Only ectopic overproduction of TRPV1 rendered HaCaT cells sensitive to low doses (1-50 nM) of vanilloids. The TRPV1-mediated and non-receptor specific Ca(2+)-cytotoxicity ([RTX]>15 microM) could clearly be distinguished, thus keratinocytes were indeed resistant to vanilloid-induced, TRPV1-mediated Ca(2+)-entry. Having a wider therapeutic window than capsaicin, RTX was effective in subnanomolar range, but even micromolar concentrations could not kill human keratinocytes. Keratinocytes showed orders of magnitudes lower TRPV1 mRNA level than sensory ganglions, the bona fide therapeutic targets in human pain management. In addition to TRPV1, TRPV1b, a dominant negative splice variant was also noted in keratinocytes. CONCLUSION: TRPV1B expression, together with low TRPV1 expression, may explain the vanilloid paradox: even genuinely TRPV1 mRNA positive cells can be spared with therapeutic (up to micromolar) doses of RTX. This additional safety information might be useful for planning future human clinical trials