A case of infant botulism in a 4-month-old baby

This case-report highlights: i) the difficulty of IB diagnosis as it is a rare syndrome with subclinical onset, ii) the need for an accurate training for physicians involved in IB management, iii) the efficacy and safety of TEqA in IB treatment, iv) homemade honey is not the only cause of IB

Stroke and migraine is there a possible comorbidity?

The association between migraine and stroke is still a dilemma for neurologists. Migraine is associated with an increased stroke risk and it is considered an independent risk factor for ischaemic stroke in a particular subgroup of patients. The pathogenesis is still unknown even if several studies report some common biochemical mechanisms between these two diseases. A classification of migraine-related stroke that encompasses the full spectrum of the possible relationship between migraine and stroke includes three main entities: coexisting stroke and migraine, stroke with clinical features of migraine, and migraine-induced stroke. The concept of migraine-induced stroke is well represented by migrainous infarction and it is described in the revised classification of the International Headache Society (IHS), representing the strongest demonstration of the relationship between ischaemic stroke and migraine. A very interesting common condition in stroke and migraine is patent foramen ovale (PFO) which could play a pathogenetic role in both disorders. The neuroradiological evidence of subclinical lesions most typical in the white matter and in the posterior artery territories in patients with migraine, opens a new field of research. In conclusion the association between migraine and stroke remains an open question. Solving the above mentioned issues is fundamental to understand the epidemiologic, pathogenetic and clinical aspects of migraine-related stroke

Surface modification of wood using friction

The potential of linear vibration friction as an innovative means of producing increases in both surface density and surface hardness was explored. The influence of processing pressure and time on the degree of surface densification, surface hardness and surface elasticity was investigated. It was found that surface hardness (measured as Brinell hardness) was positively correlated with densification ratio. Furthermore, surface elasticity, that is the ability of the surface to recover elastically after indentation during the Brinell hardness test, could be increased by up to 33% depending on the degree of surface densification. The temperature rise due to friction was also studied. During processing, it was found that the temperature rise on both the radial and tangential surfaces was positively correlated with the processing pressure and tim

Short-range order of compressed amorphous GeSe2

The structure of amorphous GeSe2 (a-GeSe2) has been studied by means of a combination of two-edges X-ray absorption spectroscopy (XAS) and angle-dispersive X-ray diffraction under pressures up to about 30 GPa. Multiple-edge XAS data-analysis of a-GeSe2 at ambient conditions allowed us to reconstruct and compare the first-neighbor distribution function with previous results obtained by neutron diffraction with isotopic substitution. GeSe2 is found to remain amorphous up to the highest pressures attained, and a reversible 1.5 eV red-shift of the Ge K-edge energy indicating metallization, occurs between 10 GPa and 15 GPa. Two compression stages are identified by XAS structure refinement. First, a decrease of the first-neighbor distances up to about 10 GPa, in the same pressure region of a previously observed breakdown of the intermediate-range order. Second, an increase of the Ge-Se distances, bond disorder, and of the coordination number. This stage is related to a reversible non-isostructural transition involving a gradual conversion from tetra- to octa-hedral geometry which is not yet fully completed at 30 GPa

Parameters of wood welding: A study with infrared thermography

Welding of wood is a well-known joining procedure that offers several advantages over traditional mechanical fasteners or gluing. During welding, extensive solid-state transformation phases occur in the so-called melting zone and the heat-affected zone. The nature and the extension of such transformations are correlated to the energy input and thus to the heat generated during the process at the wood joint interface. In the present work the influence of the welding parameters and wood grain orientation on the temperature profile and distribution and final strength of welded connections was investigated. For this purpose, the characteristics of the joints were evaluated with both destructive and non-destructive techniques. Non-destructive evaluation was performed with infrared thermography, which allowed measurement of the maximal and average peak temperature, temperature profile and distribution, and rate of temperature increase. Thus, this technique can also be used to detect welding defects and to provide information on material modification during weldin

Exosome levels in human body fluids: A tumor marker by themselves?

Despite considerable research efforts, the finding of reliable tumor biomarkers remains challenging and unresolved. In recent years a novel diagnostic biomedical tool with high potential has been identified in extracellular nanovesicles or exosomes. They are released by the majority of the cells and contain detailed molecular information on the cell of origin including tumor hallmarks. Exosomes can be isolated from easy accessible body fluids, and most importantly, they can provide several biomarkers, with different levels of specificity. Recent clinical evidence shows that the levels of exosomes released into body fluids may themselves represent a predictive/diagnostic of tumors, discriminating cancer patients from healthy subjects. The aim of this review is to highlight these latest challenging findings to provide novel and groundbreaking ideas for successful tumor early diagnosis and follow-up

Il sé minimale e la tecnologia ibrida bio-macchinale: un contributo alla fenomenologia dell'incorporazione tecnologica

Riassunto: Questo articolo contribuisce alla ricerca in corso sul sé minimale, la configurazione più semplice dell’identità individuale che affonda le sue radici nelle strutture e negli schemi corporei di base. Il tema del sé minimale sarà trattato da una prospettiva fenomenologica, concentrando l’attenzione sulle problematiche relative all’incorporazione tecnologica. Alcuni tipi di tecnologia come le protesi sono vissute dall’individuo come parte del proprio corpo. Esiste una relazione rilevante, da un punto di vista fenomenologico, tra l’incorporazione di una macchina e l’esperienza minimale del sé? La domanda è cruciale per una nuova generazione di macchine incorporabili, nota come tecnologia ibrida bio-macchinale, che beneficia di significativi progressi nella modellazione digitale dei segnali corporei e nella ricerca sui materiali biointegrati. L’articolo approfondisce la relazione tra la tecnologia ibrida bio-macchinale e il sé minimale discutendo un caso di studio altamente informativo nel campo della tecnologia della visione (protesi visive biomimetiche).Parole chiave: Sé minimale; Incorporazione della tecnologia; Fenomenologia; Tecnologia ibrida bio-macchinale; Protesi biomimetiche Minimal self and bio-machine hybrid technology: A contribution to the phenomenology of technology incorporationAbstract: This article contributes to ongoing research on the minimal self, i.e., the simplest configuration of individual identity, which is rooted in basic body structures and schemes. The topic of minimal selfhood will be treated from a phenomenological perspective, focusing on issues of technology incorporation. Some types of technology, such as prosthetics, are experienced by the user as part of her or his own body. Is there a phenomenologically relevant relationship between the incorporation of a machine and minimal self-experience? The question is crucial for a new generation of incorporable machines, known as bio-machine hybrid technology, which benefits from significant advances in digital modeling of bodily signals as well as research on bio-integrated materials. The article delves into the relationship between bio-machine hybrid technology and the minimal self by discussing a highly informative case study in the field of vision technology (biomimetic visual prostheses).Keywords: Minimal Self; Technology Incorporation; Phenomenology; Bio-Machine Hybrid Technology; Biomimetic Prosthese

BODILY PROCESSING: WHAT PROGRESS HAS BEEN MADE IN UNDERSTANDING THE EMBODIMENT OF COMPUTING SYSTEMS?

In this article I will address the issue of the embodiment of computing systems from the point of view distinctive of the so-called Unconventional Computation, focusing on the paradigm known as Morphological Computation. As a first step, I will contextualize Morphological Computation within the disciplinary field of Embodied Artificial Intelligence: broadly conceived, Embodied Artificial Intelligence may be characterized as embracing both conventional and unconventional approaches to the artificial emulation of natural intelligence. Morphological Computation stands out from other paradigms of unconventional Embodied Artificial Intelligence in that it discloses a new, closer kind of connection between embodiment and computation. I will further my investigation by briefly reviewing the state-of-the-art in Morphological Computation: attention will be given to a very recent trend, whose core concept is that of “organic reconfigurability”. In this direction, as a final step, two advanced cases of study of organic or living morphological computers will be presented and discussed. The prospect is to shed some light on our title question: what progress has been made in understanding the embodiment of computing systems

MEANINGFUL HUMAN-MACHINE INTERACTION: SOME SUGGESTIONS FROM THE PERSPECTIVE OF AUGMENTED INTELLIGENCE

In this article I will address the issue of the meaning of human-machine interaction as it is configured today in the light of substantial results achieved in the design and the manufacture of Artificial Intelligence (AI) systems. My starting point is a refined solution for meaningful AI recently suggested by Froese and Taguchi from the perspective of so-called augmented intelligence. Interpreted as a kind of human-machine interaction, augmented intelligence distinguishes itself by the fact that it merges the interacting poles into a new hybrid entity. After having clarified the technical and the methodological background of my proposal, I will discuss a case of study of so-called bio-synthetic augmentation, where hybridisation overlaps with the cyborgisation of the human body

Physical, chemical and kinetic factors affecting prion infectivity

The mouse-adapted scrapie prion strain RML is one of the most widely used in prion research. The introduction of a cell culture-based assay of RML prions, the scrapie cell assay (SCA) allows more rapid and precise prion titration. A semi-automated version of this assay (ASCA) was applied to explore a range of conditions that might influence the infectivity and properties of RML prions. These include resistance to freeze-thaw procedures; stability to endogenous proteases in brain homogenate despite prolonged exposure to varying temperatures; distribution of infective material between pellet and supernatant after centrifugation, the effect of reducing agents and the influence of detergent additives on the efficiency of infection. Apparent infectivity is increased significantly by interaction with cationic detergents. Importantly, we have also elucidated the relationship between the duration of exposure of cells to RML prions and the transmission of infection. We established that the infection process following contact of cells with RML prions is rapid and followed an exponential time course, implying a single rate-limiting process