Glacier change along West Antarctica’s Marie Byrd Land Sector and links to inter-decadal atmosphere-ocean variability

Over the past 20 years satellite remote sensing has captured significant downwasting of glaciers that drain the West Antarctic Ice Sheet into the ocean, particularly across the Amundsen Sea Sector. Along the neighbouring Marie Byrd Land Sector, situated west of Thwaites Glacier to Ross Ice Shelf, glaciological change has been only sparsely monitored. Here, we use optical satellite imagery to track grounding-line migration along the Marie Byrd Land Sector between 2003 and 2015, and compare observed changes with ICESat and CryoSat-2-derived surface elevation and thickness change records. During the observational period, 33% of the grounding line underwent retreat, with no significant advance recorded over the remainder of the  ∼ 2200km long coastline. The greatest retreat rates were observed along the 650km-long Getz Ice Shelf, further west of which only minor retreat occurred. The relative glaciological stability west of Getz Ice Shelf can be attributed to a divergence of the Antarctic Circumpolar Current from the continental-shelf break at 135°W, coincident with a transition in the morphology of the continental shelf. Along Getz Ice Shelf, grounding-line retreat reduced by 68% during the CryoSat-2 era relative to earlier observations. Climate reanalysis data imply that wind-driven upwelling of Circumpolar Deep Water would have been reduced during this later period, suggesting that the observed slowdown was a response to reduced oceanic forcing. However, lack of comprehensive oceanographic and bathymetric information proximal to Getz Ice Shelf's grounding zone make it difficult to assess the role of intrinsic glacier dynamics, or more complex ice-sheet–ocean interactions, in moderating this slowdown. Collectively, our findings underscore the importance of spatial and inter-decadal variability in atmosphere and ocean interactions in moderating glaciological change around Antarctica

Reproductive Isolation in a Threespine Stickleback Hybrid Zone

In many estuarine sites, morphological and genetic differences between anadromous and freshwater threespine sticklebacks are maintained despite breeding in sympatry. Here, we investigate the maintenance of this morphological divergence in a natural hybrid zone in the River Tyne, Scotland. We provide a morphological description of the hybrid zone, and using a Bayesian MCMC approach, identified distinct anadromous and freshwater genetic clusters. Anadromous and freshwater sticklebacks breed in spatial and temporal sympatry in the lower reaches of the River Tyne. The frequency of hybrids within these sites (33%) indicates prezygotic isolation is not complete, and suggests that assortative mating is not strong. However, significant heterozygote deficit and cytonuclear disequilibrium in juveniles collected from sympatric sites confirms that barriers to gene flow exist between the morphs in the wild. In addition, we found no evidence of a directional bias in hybridisation, although hybrids with anadromous mothers were more common because anadromous females outnumbered freshwater females within the hybrid zone. We discuss the potential contribution of temporal, spatial, and sexual prezygotic barriers to the observed reproductive isolation as well as postzygotic selection against hybrid zygotes or fry

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease