7 research outputs found
The Escitalopram versus Electric Current Therapy for Treating Depression Clinical Study (ELECT-TDCS): rationale and study design of a non-inferiority, triple-arm, placebo-controlled clinical trial
Pervasive gaps in Amazonian ecological research
Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4
While the increasing availability of global databases on ecological communities has advanced our knowledge
of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In
the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of
Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus
crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced
environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian
Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by
2050. This means that unless we take immediate action, we will not be able to establish their current status,
much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio
Pervasive gaps in Amazonian ecological research
Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear understanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5,6,7 vast areas of the tropics remain understudied.8,9,10,11 In the American tropics, Amazonia stands out as the world's most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepresented in biodiversity databases.13,14,15 To worsen this situation, human-induced modifications16,17 may eliminate pieces of the Amazon's biodiversity puzzle before we can use them to understand how ecological communities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple organism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region's vulnerability to environmental change. 15%–18% of the most neglected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lost
Association between temperament dimensions and genetic polymorphisms in depressed patients
Introdução: Formas de categorizar a personalidade foram propostas ao longo da histĂłria e sua associação com transtornos psiquiátricos tem sido extensivamente estudada. Algumas teorias propõem que as vias serotoninĂ©rgicas desempenhariam um papel no desenvolvimento da personalidade e nos transtornos de humor. Estudos tentaram encontrar associações entre polimorfismos genĂ©ticos e traços de personalidade, com resultados conflitantes e grandes diferenças metodolĂłgicas. Objetivo: Investigar a associação entre polimorfismos especĂficos das vias serotoninĂ©rgicas e diferentes domĂnios de temperamentos do inventário de temperamento e caráter de Cloninger (ITC). MĂ©todos Foram selecionados 179 indivĂduos do banco de dados do estudo elect-Tdcs que preencheram o ITC e colheram material genĂ©tico. Regressões lineares mĂşltiplas e de Kernel foram realizadas entre os scores de temperamento do ITC e os polimorfismos 5-HTLPPR, rs6313, rs7997012, rs1800532, rs6295 e rs878567. Resultados: Foi encontrada uma associação entre o polimorfismo rs1800532 e o score de Auto-transcendĂŞncia e entre o rs7997012 com o domĂnio de PersistĂŞncia. Para os demais domĂnios personalidade nĂŁo foi possĂvel encontrar nenhuma associação entre os polimorfismos estudados. ConclusĂŁo: Este estudo contribui para uma maior compreensĂŁo sobre possĂveis associações entre alguns polimorfismos das vias serotoninĂ©rgicas e escores do ITC em uma população de deprimidos no Brasil. PorĂ©m, mais estudos sĂŁo necessários para melhor compreensĂŁo de tais achadosIntroduction: Ways to categorize personality and association with psychiatric disorders have been extensively studied. Some theories propose that serotonergic pathways could be involved in personality development and mood disorders. Previous studies tried to find associations between genetic polymorphisms and personality traits, with conflicting results and major methodological differences. Objective: To investigate an association between specific polymorphisms of serotonergic pathways and temperament scores from Temperament and Character Inventory (TCI). Methods: 179 subjects were selected from the ELECT-tDCS study database. Temperament dimensions were assessed by TCI and genetic material collected. Multiple linear regressions and Kernel regressions were performed between TCI temperament scores and the polymorphisms 5-HTLPPR, rs6313, rs7997012, rs1800532, rs6295 and rs878567. Results: An association was found between rs1800532 polymorphism and Self Transcendence and between rs7997012 and Persistence. For other personality traits it was not possible to find any relationship between the polymorphisms studied. Conclusions: This study contributes to a better understanding of possible associations between certain polymorphisms in the serotonergic pathways and ITC scores in a population of depressed individuals in Brazil. However, further studies are needed to gain a better understanding of these finding
The Escitalopram versus Electric Current Therapy for Treating Depression Clinical Study (ELECT-TDCS): rationale and study design of a non-inferiority, triple-arm, placebo-controlled clinical trial
CONTEXT AND OBJECTIVE: Major depressive disorder (MDD) is a common psychiatric condition, mostly treated with antidepressant drugs, which are limited due to refractoriness and adverse effects. We describe the study rationale and design of ELECT-TDCS (Escitalopram versus Electric Current Therapy for Treating Depression Clinical Study), which is investigating a non-pharmacological treatment known as transcranial direct current stimulation (tDCS).DESIGN AND SETTING: Phase-III, randomized, non-inferiority, triple-arm, placebo-controlled study, ongoing in SĂŁo Paulo, Brazil.METHODS: ELECT-TDCS compares the efficacy of active tDCS/placebo pill, sham tDCS/escitalopram 20 mg/day and sham tDCS/placebo pill, for ten weeks, randomizing 240 patients in a 3:3:2 ratio, respectively. Our primary aim is to show that tDCS is not inferior to escitalopram with a non-inferiority margin of at least 50% of the escitalopram effect, in relation to placebo. As secondary aims, we investigate several biomarkers such as genetic polymorphisms, neurotrophin serum markers, motor cortical excitability, heart rate variability and neuroimaging.RESULTS: Proving that tDCS is similarly effective to antidepressants would have a tremendous impact on clinical psychiatry, since tDCS is virtually devoid of adverse effects. Its ease of use, portability and low price are further compelling characteristics for its use in primary and secondary healthcare. Multimodal investigation of biomarkers will also contribute towards understanding the antidepressant mechanisms of action of tDCS.CONCLUSION: Our results have the potential to introduce a novel technique to the therapeutic arsenal of treatments for depression