4,970 research outputs found
Stability estimates for a twisted rod under terminal loads: a three-dimensional study
The stability of an inextensible unshearable elastic rod with quadratic strain energy density subject to end loads is considered. A self-contained proof in terms of local energy minimizers is presented and optimal bounds are obtained for the problem
Keir Starmer’s chance to sparkle: Labour leader finally puts his working class credentials to work for him
Twisted versus braided magnetic flux ropes in coronal geometry. I. Construction and relaxation.
We introduce a technique for generating tubular magnetic fields with arbitrary axial geometry and internal topology. As an initial application, this technique is used to construct two magnetic flux ropes that have the same sigmoidal tubular shape, but have different internal structures. One is twisted, the other has a more complex braided magnetic field. The flux ropes are embedded above the photospheric neutral line in a quadrupolar linear force-free background. Using resistive-magnetohydrodynamic simulations, we show that both fields can relax to stable force-free equilibria whilst maintaining their tubular structure. Both end states are nonlinear force-free; the twisted field contains a single sign of alpha (the force-free parameter), indicating a twisted flux rope of a single dominant chirality, the braided field contains both signs of alpha, indicating a flux rope whose internal twisting has both positive and negative chirality. The electric current structures in these final states differ significantly between the braided field, which has a diffuse structure, and the twisted field, which displays a clear sigmoid. This difference might be observable
The effects of arthritis gloves on hand pain in people with rheumatoid or inflammatory arthritis : a randomised controlled trial (A-GLOVES TRIAL)
Background: Arthritis (compression) gloves are commonly provided to people with rheumatoid arthritis (RA) and undifferentiated inflammatory arthritis (IA) in the UK health service. These apply pressure and warmth to relieve hand pain, stiffness and improve hand function. A systematic review identified little evidence to support their use.[1]
Objectives: This randomised controlled trial tested effectiveness and cost-effectiveness of mid-finger length compression (intervention) gloves (20% Lycra: commonest glove model provided) with control gloves (i.e. oedema gloves: 11% Lycra: fitted at least one size too big) in people with RA and IA.
Methods: Both gloves, which had similar thermal qualities although the control gloves did not provide compression, were provided by rheumatology occupational therapists, following training.[2] Participants were also given brief advice on hand exercise and joint protection. Adults with RA/IA and persistent hand pain were randomised 1:1 to the two glove types, stratified by disease modifying anti-rheumatic drug (DMARD) change in previous 12 weeks. The primary outcome was dominant hand pain on activity Visual Analogue Scale (VAS:0–10); other outcomes included night hand pain, hand stiffness (both 0–10 VAS); Measure of Activity Performance Hand (MAP-HAND: 0–3). Multiple linear regression was undertaken to estimate the effect of group allocation on hand pain during activity, adjusting for the stratification variable and baseline values. Cost-effectiveness used individual patient level costs (intervention plus healthcare utilisation) and health benefit data (EQ-5D) to calculate costs and QALYs.
Results: 206 participants were randomised (103 to each glove type): median age 59 years [IQR 51,67]; women:166 (81%); mean disease duration: 8.2 (SD 9.5) years; employed:76 (37%); right hand dominant:185 (90%). Of these, 163 (79%) completed 12 week follow-up questionnaires. Both groups reported similar adherence to glove wear (mean 5.2 days/week). At 12 w, hand pain scores in both groups similarly improved: the between-groups mean difference of 0.1 was not statistically significant (95% CI: −0.47 to 0.67; p=0.72). There were no significant differences between groups on any measures, with both groups improving similarly between baseline and 12 w. 73% in both groups considered gloves beneficial. Intervention gloves had higher costs (£552 (SD £464); control £391 (SD £543) but comparable benefits to control gloves. Intervention gloves would cost £83 700 to gain one QALY and were not likely to be cost-effective.
Conclusions: Compression (intervention) and loose-fitting arthritis (control) gloves had similar effects on hand pain, stiffness and function. Therefore, compression is not the ‘active ingredient’ in arthritis gloves. Loose fitting gloves providing warmth were perceived as equally effective by participants. We do not know if the therapist effect is important or whether ordinary gloves providing warmth would provide similar results.
References:
Hammond, et al. Clin Rehabil 2016 30:213–24.
Prior, et al. Rheumatology 2017. www.abstractsonline.com/pp8/#!/4205
Acknowledgements: This project was funded by the NIHR Research for Patient Benefit Programme (PB-PG-0214–33010). The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health
Magnetic Resonance Spectroscopy discriminates the response to microglial stimulation of wild type and Alzheimer's disease models.
Microglia activation has emerged as a potential key factor in the pathogenesis of Alzheimers disease. Metabolite levels assessed by magnetic resonance spectroscopy (MRS) are used as markers of neuroinflammation in neurodegenerative diseases, but how they relate to microglial activation in health and chronic disease is incompletely understood. Using MRS, we monitored the brain metabolic response to lipopolysaccharides (LPS)-induced microglia activation in vivo in a transgenic mouse model of Alzheimers disease (APP/PS1) and healthy controls (wild-type (WT) littermates) over 4 hours. We assessed reactive gliosis by immunohistochemistry and correlated metabolic and histological measures. In WT mice, LPS induced a microglial phenotype consistent with activation, associated with a sustained increase in macromolecule and lipid levels (ML9). This effect was not seen in APP/PS1 mice, where LPS did not lead to a microglial response measured by histology, but induced a late increase in the putative inflammation marker myoinositol (mI) and metabolic changes in total creatine and taurine previously reported to be associated with amyloid load. We argue that ML9 and mI distinguish the response of WT and APP/PS1 mice to immune mediators. Lipid and macromolecule levels may represent a biomarker of activation of healthy microglia, while mI may not be a glial marker
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Splanchnic metabolism of nutrients and hormones in steers fed alfalfa under conditions of increased absorption of ammonia and L-arginine supply across the portal-drained viscera
Effects of increased ammonia and/or arginine
absorption on net splanchnic (portal-drained viscera
[PDV] plus liver) metabolism of nonnitrogenous
nutrients and hormones in cattle were examined. Six
Hereford × Angus steers (501 ± 1 kg BW) prepared with
vascular catheters for measurements of net flux across
the splanchnic bed were fed a 75% alfalfa:25% (as-fed
basis) corn and soybean meal diet (0.523 MJ of ME/[kg
BW0.75.d]) every 2 h without (27.0 g of N/kg of DM) and
with 20 g of urea/kg of DM (35.7 g of N/kg of DM) in a
split-plot design. Net flux measurements were made
immediately before and after a 72-h mesenteric vein
infusion of L-arginine (15 mmol/h). There were no treatment
effects onPDVor hepaticO2 consumption. Dietary
urea had no effect on splanchnic metabolism of glucose
or L-lactate, but arginine infusion decreased net hepatic
removal of L-lactate when urea was fed (P < 0.01). Net PDV appearance of n-butyrate was increased by arginine
infusion (P < 0.07), and both dietary urea (P <
0.09) and arginine infusion (P < 0.05) increased net
hepatic removal of n-butyrate. Dietary urea also increased
total splanchnic acetate output (P < 0.06),
tended to increase arterial glucagon concentration (P
< 0.11), and decreased arterial ST concentration (P <
0.03). Arginine infusion increased arterial concentration
(P < 0.07) and net PDV release (P < 0.10) and
tended to increase hepatic removal (P < 0.11) of insulin,
as well as arterial concentration (P < 0.01) and total
splanchnic output (P < 0.01) of glucagon. Despite
changes in splanchnic N metabolism, increased ammonia
and arginine absorption had little measurable effect
on splanchnic metabolism of glucose and other nonnitrogenous
components of splanchnic energy metabolism
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