Elfazepam and Synovex-S Influences on Growth and Carcass Characteristics of Steers Fed Two Dietary Energy Levels

Synovex-S improves the average daily gain and carcass traits of steers and reduces losses under high feed price levels when compared to nonimplanted steers. High energy diets also influence average daily gain (ADG) favorably, but they increase the amount of fat and decrease the protein in carcass soft tissue in comparison to low energy diets

Magnetic Resonance Spectroscopy discriminates the response to microglial stimulation of wild type and Alzheimer's disease models.

Microglia activation has emerged as a potential key factor in the pathogenesis of Alzheimers disease. Metabolite levels assessed by magnetic resonance spectroscopy (MRS) are used as markers of neuroinflammation in neurodegenerative diseases, but how they relate to microglial activation in health and chronic disease is incompletely understood. Using MRS, we monitored the brain metabolic response to lipopolysaccharides (LPS)-induced microglia activation in vivo in a transgenic mouse model of Alzheimers disease (APP/PS1) and healthy controls (wild-type (WT) littermates) over 4 hours. We assessed reactive gliosis by immunohistochemistry and correlated metabolic and histological measures. In WT mice, LPS induced a microglial phenotype consistent with activation, associated with a sustained increase in macromolecule and lipid levels (ML9). This effect was not seen in APP/PS1 mice, where LPS did not lead to a microglial response measured by histology, but induced a late increase in the putative inflammation marker myoinositol (mI) and metabolic changes in total creatine and taurine previously reported to be associated with amyloid load. We argue that ML9 and mI distinguish the response of WT and APP/PS1 mice to immune mediators. Lipid and macromolecule levels may represent a biomarker of activation of healthy microglia, while mI may not be a glial marker

Quantum dynamics in photonic crystals

Employing a recently developed method that is numerically accurate within a model space simulating the real-time dynamics of few-body systems interacting with macroscopic environmental quantum fields, we analyze the full dynamics of an atomic system coupled to a continuum light-field with a gapped spectral density. This is a situation encountered, for example, in the radiation field in a photonic crystal, whose analysis has been so far been confined to limiting cases due to the lack of suitable numerical techniques. We show that both atomic population and coherence dynamics can drastically deviate from the results predicted when using the rotating wave approximation, particularly in the strong coupling regime. Experimental conditions required to observe these corrections are also discussed.Comment: 5 pages, 2 figures Updated with published versio

Turn-Around-Time Improvements for Positive Blood Cultures from Incorporation of Workflow Modifications

Background: Emergence of direct from positive blood culture bottle identification (ID) methods reveal opportunities for improving bacterial ID and select resistance marker detection turn-around-times. Each system has various advantages and disadvantages; each institution must select the method/s that best fit the laboratory and patient needs. Here we elucidate improvements in 24 hour workflow through incorporating multiple rapid technologies for positive blood culture ID into a 24 hour algorithm. Methods: MALDI-TOF (Bruker) analysis with sepsityper extraction (aerobic Gram-positive and anaerobic bacteria); MALDI-TOF analysis with serum separator tube concentration (Gram-negative bacteria); and a FilmArray Blood Culture Panel (Biofire) were utilized. MALDI was utilized on 1st shift for single bacterium positives. FilmArray was performed on 2nd and 3rd shift for aerobic bottles and on 1st shift for gram-positive cocci in clusters and Candida. We examined all events during our pre-modification (September-November 2013) and post-modification (late-December 2014-March 2015) time periods and defined an event as the first positive blood culture for a patient within the examined data period. The Antimicrobial Stewardship Pharmacist (ASP) was notified with identifications and also KPC carbapenemase positives, to implement a carbapenem-resistant Enterobacteriaceae (CRE) empiric treatment algorithm. For KPC positives (CRE) a custom minimum inhibitory concentration (MIC) panel was utilized, replacing a standard susceptibility panel and Etests. Finally, 2nd shift began susceptibility setup on subcultured bloods that had turned positive from 11 p.m.-6 a.m. Results: Pre- and post- workflow modification average turn-around times (TAT) and p-values are shown in the Table. Detection of either the KPC or the mecA marker significantly improved the TAT needed for phenotypic detection of carbapenem or methicillin resistance. KPC was detected in 3 Enterobactericeae. Conclusions: Improvements to patient care are to be determined, but strong collaboration with ASP is anticipated to make a significant impact on patient outcomes. Of note, while having a universal Staphylococcus species target is useful, it can lead to complications with multi-species positive bottles. With the universal Staphylococcus species target, it is not possible to differentiate between a mixed coagulase negative Staphylococcus species (CNSS) versus Staphylococcus aureus when both are present as the CNSS may harbor the mecA target, preventing adequate treatment. Furthermore, a Staphylococcus lugdunensis specific marker would be clinically useful

‘It’s better than daytime television’: questioning the socio-spatial impacts of massage parlours on residential communities

It has been shown that street sex work is problematic for some communities, but there is less evidence of the effects of brothels. Emerging research also suggests that impact discourses outlined by residential communities and in regulatory policies should be critiqued, because they are often based on minority community voices, and limited tangible evidence is used to masquerade wider moral viewpoints about the place of sex work. Using a study of residents living in close proximity to brothels in Blackpool, this paper argues that impact is socially and spatially fluid. Impact needs to be evaluated in a more nuanced manner, which is considerate of the heterogeneity of (even one type of) sex work, and the community in question. Brothels in Blackpool had a variety of roles in the everyday socio-spatial fabric; thus also questioning the common assumption that sex work only impacts negatively on residential communities

New Hamiltonian formalism and quasi-local conservation equations of general relativity

I describe the Einstein's gravitation of 3+1 dimensional spacetimes using the (2,2) formalism without assuming isometries. In this formalism, quasi-local energy, linear momentum, and angular momentum are identified from the four Einstein's equations of the divergence-type, and are expressed geometrically in terms of the area of a two-surface and a pair of null vector fields on that surface. The associated quasi-local balance equations are spelled out, and the corresponding fluxes are found to assume the canonical form of energy-momentum flux as in standard field theories. The remaining non-divergence-type Einstein's equations turn out to be the Hamilton's equations of motion, which are derivable from the {\it non-vanishing} Hamiltonian by the variational principle. The Hamilton's equations are the evolution equations along the out-going null geodesic whose {\it affine} parameter serves as the time function. In the asymptotic region of asymptotically flat spacetimes, it is shown that the quasi-local quantities reduce to the Bondi energy, linear momentum, and angular momentum, and the corresponding fluxes become the Bondi fluxes. The quasi-local angular momentum turns out to be zero for any two-surface in the flat Minkowski spacetime. I also present a candidate for quasi-local {\it rotational} energy which agrees with the Carter's constant in the asymptotic region of the Kerr spacetime. Finally, a simple relation between energy-flux and angular momentum-flux of a generic gravitational radiation is discussed, whose existence reflects the fact that energy-flux always accompanies angular momentum-flux unless the flux is an s-wave.Comment: 36 pages, 3 figures, RevTex

Structural Refinement for the Modal nu-Calculus

We introduce a new notion of structural refinement, a sound abstraction of logical implication, for the modal nu-calculus. Using new translations between the modal nu-calculus and disjunctive modal transition systems, we show that these two specification formalisms are structurally equivalent. Using our translations, we also transfer the structural operations of composition and quotient from disjunctive modal transition systems to the modal nu-calculus. This shows that the modal nu-calculus supports composition and decomposition of specifications.Comment: Accepted at ICTAC 201