Current concepts and perspectives in the prevention of age-related macular degeneration

The authors prepare a literature review about the main antioxidants used in daily practice for the prevention of age-related macular degeneration progression (AMD), emphasizing the mechanism of action of each substance as well as the possible complications related to the overuse of such components.Os autores fazem revisão bibliográfica a respeito dos principais antioxidantes utilizados na prática diária atualmente para prevenção da progressão da degeneração macular relacionada com a idade (DMRI), enfatizando o mecanismo de ação de cada substância bem como as possíveis complicações relacionadas ao uso excessivo destes componentes.Universidade Federal de São Paulo (UNIFESP) Departamento de OftalmologiaHospital Angelina CaronPontifícia Universidade Católica do Paraná Departamento de CardiologiaUniversidade Federal de São Paulo (UNIFESP) Departamento de Oftalmologia Programa de Pós-GraduaçãoHospital de Olhos Oeste Paulista Serviço de Cirurgia VitreorretinianaPontifícia Universidade Católica do ParanáNutrimedical CuritibaCentro Oftalmológico de CuritibaUNIFESP, Depto. de OftalmologiaUNIFESP, Depto. de Oftalmologia Programa de Pós-GraduaçãoSciEL

Effects of rosiglitazone on contralateral iliac artery after vascular injury in hypercholesterolemic rabbits

<p>Abstract</p> <p>Background</p> <p>The objective was to evaluate the effects of rosiglitazone on iliac arteries of hypercholesterolemic rabbits undergoing balloon catheter injury in the contralateral iliac arteries.</p> <p>Methods</p> <p>White male rabbits were fed a hypercholesterolemic diet for 6 weeks and divided into two groups as follows: rosiglitazone group, 14 rabbits treated with rosiglitazone (3 mg/Kg body weight/day) during 6 weeks; and control group, 18 rabbits without rosiglitazone treatment. All animals underwent balloon catheter injury of the right iliac artery on the fourteenth day of the experiment.</p> <p>Results</p> <p>There was no significant difference in intima/media layer area ratio between the control group and the rosiglitazone group. Rosiglitazone did not reduce the probability of lesions types I, II, or III (72.73% vs. 92.31%; <it>p </it>= 0.30) and types IV or V (27.27% vs. 7.69%; <it>p </it>= 0.30). There were no differences in the extent of collagen type I and III deposition or in the percentage of animals with macrophages in the intima layer. The percentage of rabbits with smooth muscle cells in the intima layer was higher in rosiglitazone group (<it>p </it>= 0.011).</p> <p>Conclusion</p> <p>These findings demonstrate that rosiglitazone given for 6 weeks did not prevent atherogenesis at a vessel distant from the injury site.</p

Percentage of animals with and without smooth muscle cells in the intima layer

<p><b>Copyright information:</b></p><p>Taken from "Effects of rosiglitazone on contralateral iliac artery after vascular injury in hypercholesterolemic rabbits"</p><p>http://www.thrombosisjournal.com/content/6/1/4</p><p>Thrombosis Journal 2008;6():4-4.</p><p>Published online 16 May 2008</p><p>PMCID:PMC2396603.</p><p></p

Graphics of intima/media layer ratio and histologic classification of lesions

. Intima/media layer area ratio. . Incidence of lesions types according with histological classification.<p><b>Copyright information:</b></p><p>Taken from "Effects of rosiglitazone on contralateral iliac artery after vascular injury in hypercholesterolemic rabbits"</p><p>http://www.thrombosisjournal.com/content/6/1/4</p><p>Thrombosis Journal 2008;6():4-4.</p><p>Published online 16 May 2008</p><p>PMCID:PMC2396603.</p><p></p